Pre-treatment red cell index and metastasis status as independent predictors of overall survival in Jordanian breast cancer patients receiving chemotherapy

Q1 Environmental Science

Toxicology Reports Pub Date : 2025-06-19 DOI:10.1016/j.toxrep.2025.102077

Amjad Z. Alrosan , Tahani Alwidyan , Ghaith B. Heilat , Aseel O. Rataan , Khaled Alrosan

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Abstract

Breast cancer (BC) poses a global health challenge, necessitating accessible prognostic biomarkers. Systemic inflammatory markers from complete blood counts, such as neutrophil-to-lymphocyte ratio (NLR) and red cell index (RCI), have shown prognostic potential. This retrospective study evaluated the prognostic significance of pre-treatment NLR and RCI for overall survival (OS) in 144 Jordanian BC patients (KAUH, 2011–2025) undergoing chemotherapy. Kaplan-Meier analysis revealed that high pre-treatment NLR (≥ 4.25) and high RCI (≥ 0.02) were significantly associated with shorter OS. Multivariate Cox regression identified elevated pre-treatment RCI (≥ 0.02) and metastasis at diagnosis as independent predictors of increased mortality and worse OS. A significant association between high NLR and RCI values was also observed, suggesting a link between systemic inflammation and erythrocytic dysregulation. In conclusion, pre-treatment RCI and metastasis are strong independent predictors of OS in this cohort, with RCI demonstrating substantial prognostic value.

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治疗前红细胞指数和转移状态作为接受化疗的约旦乳腺癌患者总生存期的独立预测因子

乳腺癌（BC）是一个全球性的健康挑战，需要可获得的预后生物标志物。来自全血细胞计数的全身炎症标志物，如中性粒细胞与淋巴细胞比率（NLR）和红细胞指数（RCI），已显示出预后潜力。本回顾性研究评估了144例约旦BC化疗患者（KAUH, 2011-2025）治疗前NLR和RCI对总生存期（OS）的预后意义。Kaplan-Meier分析显示，高预处理NLR（≥4.25）和高RCI（≥0.02）与较短的OS显著相关。多因素Cox回归发现，治疗前RCI升高（≥0.02）和诊断时的转移是死亡率升高和生存期恶化的独立预测因素。高NLR和RCI值之间的显著关联也被观察到，提示全身性炎症和红细胞失调之间的联系。总之，在该队列中，治疗前RCI和转移是OS强有力的独立预测因素，RCI具有重要的预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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