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The Tokushima journal of experimental medicine最新文献

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Pathogenic T cell cytokines in multiple sclerosis 多发性硬化症中的致病性T细胞因子
The Tokushima journal of experimental medicine Pub Date : 2019-10-14 DOI: 10.1084/jem.20190460
Catriona A Wagner, Pamela J. Roqué, J. Goverman
{"title":"Pathogenic T cell cytokines in multiple sclerosis","authors":"Catriona A Wagner, Pamela J. Roqué, J. Goverman","doi":"10.1084/jem.20190460","DOIUrl":"https://doi.org/10.1084/jem.20190460","url":null,"abstract":"This review summarizes our current understanding of how specific cytokines produced by pathogenic CD4 T cells contribute to central nervous system autoimmune disease. Data obtained from animal models and patients with multiple sclerosis are discussed.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77265513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis 纯合子SFTPA1突变驱动特发性肺纤维化患者II型肺泡上皮细胞坏死
The Tokushima journal of experimental medicine Pub Date : 2019-10-10 DOI: 10.1084/jem.20182351
Akio Takezaki, S. Tsukumo, Y. Setoguchi, J. Ledford, H. Goto, K. Hosomichi, H. Uehara, Y. Nishioka, K. Yasutomo
{"title":"A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis","authors":"Akio Takezaki, S. Tsukumo, Y. Setoguchi, J. Ledford, H. Goto, K. Hosomichi, H. Uehara, Y. Nishioka, K. Yasutomo","doi":"10.1084/jem.20182351","DOIUrl":"https://doi.org/10.1084/jem.20182351","url":null,"abstract":"We identify a homozygous mutation in SFTPA1 in patients with idiopathic pulmonary fibrosis (IPF). The mutation causes increased necroptosis of type II alveolar epithelial cells through the IRE1α–JNK axis, which highlights the necroptosis pathway as a therapeutic target for IPF.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"59 1","pages":"2724 - 2735"},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80602377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1 真菌菌群的调节是由几丁质结合受体FIBCD1调控的
The Tokushima journal of experimental medicine Pub Date : 2019-10-10 DOI: 10.1084/jem.20182244
J. B. Moeller, Irina Leonardi, A. Schlosser, A. Flamar, N. Bessman, G. Putzel, T. Thomsen, Mark A. Hammond, C. S. Jepsen, K. Skjødt, E. Füchtbauer, D. Farber, G. Sørensen, I. Iliev, U. Holmskov, D. Artis
{"title":"Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1","authors":"J. B. Moeller, Irina Leonardi, A. Schlosser, A. Flamar, N. Bessman, G. Putzel, T. Thomsen, Mark A. Hammond, C. S. Jepsen, K. Skjødt, E. Füchtbauer, D. Farber, G. Sørensen, I. Iliev, U. Holmskov, D. Artis","doi":"10.1084/jem.20182244","DOIUrl":"https://doi.org/10.1084/jem.20182244","url":null,"abstract":"In the present study, Moeller et al. identify a previously unrecognized pathway through which intestinal epithelial cells expressing the novel chitin-binding receptor FIBCD1 can recognize and control intestinal fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"4 1","pages":"2689 - 2700"},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90540898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model 小胶质细胞驱动apoe依赖性脑损伤小鼠模型的神经变性
The Tokushima journal of experimental medicine Pub Date : 2019-10-10 DOI: 10.1084/jem.20190980
Yang Shi, Melissa Manis, J. Long, Kairuo Wang, P. Sullivan, Javier Remolina Serrano, Rosa Hoyle, D. Holtzman
{"title":"Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model","authors":"Yang Shi, Melissa Manis, J. Long, Kairuo Wang, P. Sullivan, Javier Remolina Serrano, Rosa Hoyle, D. Holtzman","doi":"10.1084/jem.20190980","DOIUrl":"https://doi.org/10.1084/jem.20190980","url":null,"abstract":"Shi et al. find that microglia, instead of tau-induced direct neurotoxicity, are the driving force of neurodegeneration in a tauopathy mouse model. Microglia are also required for tau pathogenesis. In addition, apoE strongly regulates neurodegeneration in the setting of tauopathy predominantly by modulating microglial function.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"280 1","pages":"2546 - 2561"},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89900988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 218
Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression. 特异性靶向CD163+ tam可调动炎症单核细胞，促进T细胞介导的肿瘤消退。
The Tokushima journal of experimental medicine Pub Date : 2019-10-07 Epub Date: 2019-08-02 DOI: 10.1084/jem.20182124
Anders Etzerodt, Kyriaki Tsalkitzi, Maciej Maniecki, William Damsky, Marcello Delfini, Elodie Baudoin, Morgane Moulin, Marcus Bosenberg, Jonas Heilskov Graversen, Nathalie Auphan-Anezin, Søren Kragh Moestrup, Toby Lawrence
{"title":"Specific targeting of CD163<sup>+</sup> TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression.","authors":"Anders Etzerodt, Kyriaki Tsalkitzi, Maciej Maniecki, William Damsky, Marcello Delfini, Elodie Baudoin, Morgane Moulin, Marcus Bosenberg, Jonas Heilskov Graversen, Nathalie Auphan-Anezin, Søren Kragh Moestrup, Toby Lawrence","doi":"10.1084/jem.20182124","DOIUrl":"10.1084/jem.20182124","url":null,"abstract":"<p><p>Tumor-associated macrophages (TAMs) play critical roles in tumor progression but are also capable of contributing to antitumor immunity. Recent studies have revealed an unprecedented heterogeneity among TAMs in both human cancer and experimental models. Nevertheless, we still understand little about the contribution of different TAM subsets to tumor progression. Here, we demonstrate that CD163-expressing TAMs specifically maintain immune suppression in an experimental model of melanoma that is resistant to anti-PD-1 checkpoint therapy. Specific depletion of the CD163<sup>+</sup> macrophages results in a massive infiltration of activated T cells and tumor regression. Importantly, the infiltration of cytotoxic T cells was accompanied by the mobilization of inflammatory monocytes that significantly contributed to tumor regression. Thus, the specific targeting of CD163<sup>+</sup> TAMs reeducates the tumor immune microenvironment and promotes both myeloid and T cell-mediated antitumor immunity, illustrating the importance of selective targeting of tumor-associated myeloid cells in a therapeutic context.</p>","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"20 1","pages":"2394-2411"},"PeriodicalIF":0.0,"publicationDate":"2019-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85169244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung 肺间质驻留记忆CD8+ T细胞维持一线上皮记忆
The Tokushima journal of experimental medicine Pub Date : 2019-09-26 DOI: 10.1084/jem.20190557
S. Takamura, Shigeki Kato, Chihiro Motozono, T. Shimaoka, S. Ueha, K. Matsuo, Kosuke Miyauchi, Tomoko Masumoto, Asami Katsushima, T. Nakayama, M. Tomura, K. Matsushima, M. Kubo, M. Miyazawa
{"title":"Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung","authors":"S. Takamura, Shigeki Kato, Chihiro Motozono, T. Shimaoka, S. Ueha, K. Matsuo, Kosuke Miyauchi, Tomoko Masumoto, Asami Katsushima, T. Nakayama, M. Tomura, K. Matsushima, M. Kubo, M. Miyazawa","doi":"10.1084/jem.20190557","DOIUrl":"https://doi.org/10.1084/jem.20190557","url":null,"abstract":"Tissue-resident lung memory CD8+ TRM cells in the lung interstitium and airways are compartmentally separated from TEM cells, and lung airway TRM cells are primarily maintained by the continuous seeding of cells from the lung interstitium.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"11 1","pages":"2736 - 2747"},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81468621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 49
CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways CXCR6调节组织驻留记忆CD8 T细胞向气道的定位
The Tokushima journal of experimental medicine Pub Date : 2019-09-26 DOI: 10.1084/jem.20181308
Alexander N. Wein, S. McMaster, S. Takamura, P. Dunbar, Emily K. Cartwright, Sarah L. Hayward, Daniel T McManus, T. Shimaoka, S. Ueha, T. Tsukui, Tomoko Masumoto, M. Kurachi, K. Matsushima, J. Kohlmeier
{"title":"CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways","authors":"Alexander N. Wein, S. McMaster, S. Takamura, P. Dunbar, Emily K. Cartwright, Sarah L. Hayward, Daniel T McManus, T. Shimaoka, S. Ueha, T. Tsukui, Tomoko Masumoto, M. Kurachi, K. Matsushima, J. Kohlmeier","doi":"10.1084/jem.20181308","DOIUrl":"https://doi.org/10.1084/jem.20181308","url":null,"abstract":"Lung TRM cells are present in both the interstitium and airways, but factors regulating their localization to these distinct sites are unknown. This work shows that the CXCR6/CXCL16 axis governs the partitioning of TRM cells to different compartments of the lung and maintains the airway TRM cell pool.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"1999 1","pages":"2748 - 2762"},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78111487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 191
Gasdermins and their role in immunity and inflammation 气门菌及其在免疫和炎症中的作用
The Tokushima journal of experimental medicine Pub Date : 2019-09-23 DOI: 10.1084/jem.20190545
Pontus Orning, E. Lien, K. Fitzgerald
{"title":"Gasdermins and their role in immunity and inflammation","authors":"Pontus Orning, E. Lien, K. Fitzgerald","doi":"10.1084/jem.20190545","DOIUrl":"https://doi.org/10.1084/jem.20190545","url":null,"abstract":"Pyroptosis is an important component of the innate immune system. Gasdermin D, the mediator of pyroptosis, has been shown to be crucial for optimal defense against microbial infection. In this review, the authors discuss gasdermin D and its role in disease.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"15 1","pages":"2453 - 2465"},"PeriodicalIF":0.0,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87584802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 169
A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2–mediated inflammation CCL1/ ccr8依赖的前馈机制驱动ILC2在2型介导的炎症中的功能
The Tokushima journal of experimental medicine Pub Date : 2019-09-19 DOI: 10.1084/jem.20182111
L. Knipfer, A. Schulz-Kuhnt, Markus Kindermann, Vicky Greif, C. Symowski, D. Voehringer, M. Neurath, I. Atreya, S. Wirtz
{"title":"A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2–mediated inflammation","authors":"L. Knipfer, A. Schulz-Kuhnt, Markus Kindermann, Vicky Greif, C. Symowski, D. Voehringer, M. Neurath, I. Atreya, S. Wirtz","doi":"10.1084/jem.20182111","DOIUrl":"https://doi.org/10.1084/jem.20182111","url":null,"abstract":"Knipfer et al. identify a critical role for the type 2–related chemokine receptor CCR8 on ILC2 functions during type 2 immune responses. CCR8 supports ILC2 survival by autocrine secretion of the ligand CCL1. The authors demonstrate that CCL1/CCR8 signaling protects against helminth infections.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"4 1","pages":"2763 - 2777"},"PeriodicalIF":0.0,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90318525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 36
Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids 皮质类固醇选择性抑制低亲和记忆性CD8+ T细胞
The Tokushima journal of experimental medicine Pub Date : 2019-09-19 DOI: 10.1084/jem.20190738
Akihiro Tokunaga, D. Sugiyama, Y. Maeda, A. B. Warner, K. Panageas, S. Ito, Y. Togashi, Chika Sakai, J. Wolchok, H. Nishikawa
{"title":"Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids","authors":"Akihiro Tokunaga, D. Sugiyama, Y. Maeda, A. B. Warner, K. Panageas, S. Ito, Y. Togashi, Chika Sakai, J. Wolchok, H. Nishikawa","doi":"10.1084/jem.20190738","DOIUrl":"https://doi.org/10.1084/jem.20190738","url":null,"abstract":"Corticosteroids inhibit antitumor immune responses of immune checkpoint blockade in a dose- and timing-dependent manner. Memory CD8+ T cells with low TCR affinity are selectively suppressed by corticosteroids, necessitating careful and thoughtful corticosteroid use.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"25 1","pages":"2701 - 2713"},"PeriodicalIF":0.0,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85445607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 70
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