Jonathan G. Pol, Pamela Caudana, J. Paillet, E. Piaggio, G. Kroemer
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Effects of interleukin-2 in immunostimulation and immunosuppression
Distinctions in the nature and spatiotemporal expression of IL-2R subunits on conventional versus regulatory T cells are exploited to manipulate IL-2 immunomodulatory effects. Particularly, low-dose IL-2 and some recombinant derivatives are being evaluated to enhance/inhibit immune responses for therapeutic purposes.
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