Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression

A. Etzerodt, Kyriaki Tsalkitzi, M. Maniecki, W. Damsky, Marcello Delfini, E. Baudoin, Morgane Moulin, M. Bosenberg, J. Graversen, N. Auphan-Anezin, S. Moestrup, T. Lawrence
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引用次数: 131

Abstract

Etzerodt et al. show that the specific targeting of CD163+ macrophages in melanoma drives inflammatory monocyte influx and promotes antitumor immunity, illustrating the importance of selective targeting of tumor-associated myeloid cells for achieving optimal therapeutic responses.
特异性靶向CD163+ tam可调动炎症单核细胞,促进T细胞介导的肿瘤消退
Etzerodt等人的研究表明,在黑色素瘤中特异性靶向CD163+巨噬细胞可驱动炎性单核细胞内流并促进抗肿瘤免疫,这说明了选择性靶向肿瘤相关骨髓细胞对于实现最佳治疗反应的重要性。
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