小胶质细胞驱动apoe依赖性脑损伤小鼠模型的神经变性

The Tokushima journal of experimental medicine Pub Date : 2019-10-10 DOI:10.1084/jem.20190980

Yang Shi, Melissa Manis, J. Long, Kairuo Wang, P. Sullivan, Javier Remolina Serrano, Rosa Hoyle, D. Holtzman

{"title":"小胶质细胞驱动apoe依赖性脑损伤小鼠模型的神经变性","authors":"Yang Shi, Melissa Manis, J. Long, Kairuo Wang, P. Sullivan, Javier Remolina Serrano, Rosa Hoyle, D. Holtzman","doi":"10.1084/jem.20190980","DOIUrl":null,"url":null,"abstract":"Shi et al. find that microglia, instead of tau-induced direct neurotoxicity, are the driving force of neurodegeneration in a tauopathy mouse model. Microglia are also required for tau pathogenesis. In addition, apoE strongly regulates neurodegeneration in the setting of tauopathy predominantly by modulating microglial function.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"280 1","pages":"2546 - 2561"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"218","resultStr":"{\"title\":\"Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model\",\"authors\":\"Yang Shi, Melissa Manis, J. Long, Kairuo Wang, P. Sullivan, Javier Remolina Serrano, Rosa Hoyle, D. Holtzman\",\"doi\":\"10.1084/jem.20190980\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Shi et al. find that microglia, instead of tau-induced direct neurotoxicity, are the driving force of neurodegeneration in a tauopathy mouse model. Microglia are also required for tau pathogenesis. In addition, apoE strongly regulates neurodegeneration in the setting of tauopathy predominantly by modulating microglial function.\",\"PeriodicalId\":23015,\"journal\":{\"name\":\"The Tokushima journal of experimental medicine\",\"volume\":\"280 1\",\"pages\":\"2546 - 2561\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"218\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Tokushima journal of experimental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1084/jem.20190980\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190980","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 218

摘要

Shi等人发现，在牛头病小鼠模型中，小胶质细胞而不是tau诱导的直接神经毒性是神经退行性变的驱动力。小胶质细胞也是tau发病所必需的。此外，apoE主要通过调节小胶质细胞功能，在牛头病的情况下强烈调节神经退行性变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

Shi et al. find that microglia, instead of tau-induced direct neurotoxicity, are the driving force of neurodegeneration in a tauopathy mouse model. Microglia are also required for tau pathogenesis. In addition, apoE strongly regulates neurodegeneration in the setting of tauopathy predominantly by modulating microglial function.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The Tokushima journal of experimental medicine

自引率

0.00%

发文量