小胶质细胞驱动apoe依赖性脑损伤小鼠模型的神经变性

The Tokushima journal of experimental medicine Pub Date : 2019-10-10 DOI:10.1084/jem.20190980

Yang Shi, Melissa Manis, J. Long, Kairuo Wang, P. Sullivan, Javier Remolina Serrano, Rosa Hoyle, D. Holtzman

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引用次数: 218

摘要

Shi等人发现，在牛头病小鼠模型中，小胶质细胞而不是tau诱导的直接神经毒性是神经退行性变的驱动力。小胶质细胞也是tau发病所必需的。此外，apoE主要通过调节小胶质细胞功能，在牛头病的情况下强烈调节神经退行性变。

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Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

Shi et al. find that microglia, instead of tau-induced direct neurotoxicity, are the driving force of neurodegeneration in a tauopathy mouse model. Microglia are also required for tau pathogenesis. In addition, apoE strongly regulates neurodegeneration in the setting of tauopathy predominantly by modulating microglial function.

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The Tokushima journal of experimental medicine

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