真菌菌群的调节是由几丁质结合受体FIBCD1调控的

The Tokushima journal of experimental medicine Pub Date : 2019-10-10 DOI:10.1084/jem.20182244

J. B. Moeller, Irina Leonardi, A. Schlosser, A. Flamar, N. Bessman, G. Putzel, T. Thomsen, Mark A. Hammond, C. S. Jepsen, K. Skjødt, E. Füchtbauer, D. Farber, G. Sørensen, I. Iliev, U. Holmskov, D. Artis

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引用次数: 19

摘要

在本研究中，Moeller等人发现了一种以前未被识别的途径，通过该途径，表达新型几丁质结合受体ficd1的肠上皮细胞可以识别和控制肠道真菌定植，限制真菌生态失调，并抑制肠道炎症。

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Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

In the present study, Moeller et al. identify a previously unrecognized pathway through which intestinal epithelial cells expressing the novel chitin-binding receptor FIBCD1 can recognize and control intestinal fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.

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The Tokushima journal of experimental medicine

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