Yang Shi, Melissa Manis, J. Long, Kairuo Wang, P. Sullivan, Javier Remolina Serrano, Rosa Hoyle, D. Holtzman
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引用次数: 218
Abstract
Shi et al. find that microglia, instead of tau-induced direct neurotoxicity, are the driving force of neurodegeneration in a tauopathy mouse model. Microglia are also required for tau pathogenesis. In addition, apoE strongly regulates neurodegeneration in the setting of tauopathy predominantly by modulating microglial function.
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