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Interleukin-4 receptor signaling modulates neuronal network activity 白细胞介素-4受体信号传导调节神经网络活动
The Tokushima journal of experimental medicine Pub Date : 2022-05-19 DOI: 10.1084/jem.20211887
Nicholas Hanuscheck, Carine Thalman, M. Domingues, Samantha Schmaul, M. Muthuraman, Florian Hetsch, Manuela Ecker, Heiko Endle, Mohammadsaleh Oshaghi, G. Martino, T. Kuhlmann, K. Bozek, Tim van Beers, S. Bittner, Jakob von Engelhardt, J. Vogt, C. Vogelaar, F. Zipp
{"title":"Interleukin-4 receptor signaling modulates neuronal network activity","authors":"Nicholas Hanuscheck, Carine Thalman, M. Domingues, Samantha Schmaul, M. Muthuraman, Florian Hetsch, Manuela Ecker, Heiko Endle, Mohammadsaleh Oshaghi, G. Martino, T. Kuhlmann, K. Bozek, Tim van Beers, S. Bittner, Jakob von Engelhardt, J. Vogt, C. Vogelaar, F. Zipp","doi":"10.1084/jem.20211887","DOIUrl":"https://doi.org/10.1084/jem.20211887","url":null,"abstract":"Neuroimmune interaction influences essential CNS processes. Hanuscheck et al. report on the expression of interleukin-4 receptor alpha at presynaptic terminals in mouse and the human brain. The modulation of neuronal IL-4R signaling alters the neuronal transcriptome, impacts synaptic transmission, and causes anxiety-related behavior.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73666337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Matrix reboot: IL-17 signals CAFs to create a second tumor T cell checkpoint 基质重启:IL-17信号CAFs创建第二个肿瘤T细胞检查点
The Tokushima journal of experimental medicine Pub Date : 2022-05-18 DOI: 10.1084/jem.20220444
M. McGeachy
{"title":"Matrix reboot: IL-17 signals CAFs to create a second tumor T cell checkpoint","authors":"M. McGeachy","doi":"10.1084/jem.20220444","DOIUrl":"https://doi.org/10.1084/jem.20220444","url":null,"abstract":"IL-17 promotes collagen deposition by cancer-associated fibroblasts and enhances immune exclusion of tumors.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73731252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons ATP通过感觉神经元和中间神经元之间的串扰将炎症传播到其他肢体
The Tokushima journal of experimental medicine Pub Date : 2022-05-17 DOI: 10.1084/jem.20212019
R. Hasebe, K. Murakami, Masaya Harada, N. Halaka, H. Nakagawa, F. Kawano, Y. Ohira, T. Kawamoto, F. Yull, T. Blackwell, J. Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, N. Watanabe, H. Hotta, T. Yamashita, D. Kamimura, Yuki Tanaka, M. Murakami
{"title":"ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons","authors":"R. Hasebe, K. Murakami, Masaya Harada, N. Halaka, H. Nakagawa, F. Kawano, Y. Ohira, T. Kawamoto, F. Yull, T. Blackwell, J. Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, N. Watanabe, H. Hotta, T. Yamashita, D. Kamimura, Yuki Tanaka, M. Murakami","doi":"10.1084/jem.20212019","DOIUrl":"https://doi.org/10.1084/jem.20212019","url":null,"abstract":"Local inflammation spreads to remote positions via sensory neuron–interneuron crosstalk using ATP. This neural pathway, or remote inflammation gateway reflex, may be a therapeutic target for inflammatory diseases with remote inflammation, such as rheumatoid arthritis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86780798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans GIMAP6调节小鼠和人的自噬、免疫能力和炎症
The Tokushima journal of experimental medicine Pub Date : 2022-05-13 DOI: 10.1084/jem.20201405
Yikun Yao, Ping Du Jiang, B. Chao, D. Çağdaş, S. Kubo, Arasu Balasubramaniyam, Yu Zhang, B. Shadur, A. NaserEddin, L. Folio, Benjamin Schwarz, Eric Bohrnsen, Lixin Zheng, Matthew Lynberg, Simone Gottlieb, Michael A. Leney-Greene, Ann Y. Park, I. Tezcan, A. Akdoğan, R. Gocmen, S. Onder, A. Rosenberg, E. Soilleux, Errin Johnson, P. Jackson, J. Demeter, Samuel D. Chauvin, F. Paul, M. Selbach, H. Bulut, M. Clatworthy, Z. Tuong, Hanlin Zhang, B. Stewart, C. Bosio, P. Stepensky, S. Clare, S. Ganesan, J. Pascall, O. Daumke, G. Butcher, A. McMichael, A. Simon, M. Lenardo
{"title":"GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans","authors":"Yikun Yao, Ping Du Jiang, B. Chao, D. Çağdaş, S. Kubo, Arasu Balasubramaniyam, Yu Zhang, B. Shadur, A. NaserEddin, L. Folio, Benjamin Schwarz, Eric Bohrnsen, Lixin Zheng, Matthew Lynberg, Simone Gottlieb, Michael A. Leney-Greene, Ann Y. Park, I. Tezcan, A. Akdoğan, R. Gocmen, S. Onder, A. Rosenberg, E. Soilleux, Errin Johnson, P. Jackson, J. Demeter, Samuel D. Chauvin, F. Paul, M. Selbach, H. Bulut, M. Clatworthy, Z. Tuong, Hanlin Zhang, B. Stewart, C. Bosio, P. Stepensky, S. Clare, S. Ganesan, J. Pascall, O. Daumke, G. Butcher, A. McMichael, A. Simon, M. Lenardo","doi":"10.1084/jem.20201405","DOIUrl":"https://doi.org/10.1084/jem.20201405","url":null,"abstract":"Yao et al. describe GIMAP6 deficiency in humans and mice showing immune dysfunction and susceptibility to bacterial infections. They find impaired autophagy in GIMAP6-deficient immune cells and define a functional complex composed of GIMAP6, GIMAP7, and GABARAPL2.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89330039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Role of adipose tissue macrophages in obesity-related disorders 脂肪组织巨噬细胞在肥胖相关疾病中的作用
The Tokushima journal of experimental medicine Pub Date : 2022-05-11 DOI: 10.1084/jem.20211948
S. Chakarov, Camille Blériot, F. Ginhoux
{"title":"Role of adipose tissue macrophages in obesity-related disorders","authors":"S. Chakarov, Camille Blériot, F. Ginhoux","doi":"10.1084/jem.20211948","DOIUrl":"https://doi.org/10.1084/jem.20211948","url":null,"abstract":"As the first immune cells to colonize tissues and long-lived resident cells, macrophages play important roles in tissue functions during early development, homeostasis, and disease. Here, Chakarov et al. discuss macrophage origin and functions in adipose tissue and how these features are modulated in obesity.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76313113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Calcium burns beige. 钙燃烧成米色。
The Tokushima journal of experimental medicine Pub Date : 2022-05-02 Epub Date: 2022-04-12 DOI: 10.1084/jem.20220382
Jakub Bunk, Lawrence Kazak
{"title":"Calcium burns beige.","authors":"Jakub Bunk, Lawrence Kazak","doi":"10.1084/jem.20220382","DOIUrl":"10.1084/jem.20220382","url":null,"abstract":"<p><p>In this issue of Journal of Experimental Medicine, Yin et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212491) discover that loss of FNIP1 is associated with browning of white adipose tissue, which they propose is driven by decreased calcium uptake into the ER.</p>","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74720451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation 在高尔基体中捕获CDC42 c末端变异体驱动pyrin炎性体过度活化
The Tokushima journal of experimental medicine Pub Date : 2022-04-28 DOI: 10.1084/jem.20211889
Masahiko Nishitani-Isa, Kojiro Mukai, Y. Honda, H. Nihira, Takayuki Tanaka, H. Shibata, K. Kodama, E. Hiejima, K. Izawa, Yuri Kawasaki, M. Osawa, Yu Katata, Sachiko Onodera, Tatsuya Watanabe, T. Uchida, S. Kure, J. Takita, O. Ohara, M. Saito, R. Nishikomori, T. Taguchi, Y. Sasahara, T. Yasumi
{"title":"Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation","authors":"Masahiko Nishitani-Isa, Kojiro Mukai, Y. Honda, H. Nihira, Takayuki Tanaka, H. Shibata, K. Kodama, E. Hiejima, K. Izawa, Yuri Kawasaki, M. Osawa, Yu Katata, Sachiko Onodera, Tatsuya Watanabe, T. Uchida, S. Kure, J. Takita, O. Ohara, M. Saito, R. Nishikomori, T. Taguchi, Y. Sasahara, T. Yasumi","doi":"10.1084/jem.20211889","DOIUrl":"https://doi.org/10.1084/jem.20211889","url":null,"abstract":"Using induced pluripotent stem cells carrying CDC42R186C, trapping of CDC42 C-terminal variants within the Golgi apparatus is shown to trigger autoinflammation by promoting pyrin inflammasome assembly through a mechanism independent of their GTPase activity.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"82 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73056184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model EP3增强小鼠肝纤维化模型中NK细胞对肝星状细胞的粘附和细胞毒性
The Tokushima journal of experimental medicine Pub Date : 2022-04-14 DOI: 10.1084/jem.20212414
Xixi Tao, Rui Zhang, Ronglu Du, Tingting Yu, H. Yang, Jiwen Li, Yuhong Wang, Qian Liu, Shengkai Zuo, Xi Wang, M. Lazarus, Lu Zhou, Bangmao Wang, Yingjia Yu, Yujun Shen
{"title":"EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model","authors":"Xixi Tao, Rui Zhang, Ronglu Du, Tingting Yu, H. Yang, Jiwen Li, Yuhong Wang, Qian Liu, Shengkai Zuo, Xi Wang, M. Lazarus, Lu Zhou, Bangmao Wang, Yingjia Yu, Yujun Shen","doi":"10.1084/jem.20212414","DOIUrl":"https://doi.org/10.1084/jem.20212414","url":null,"abstract":"Tao et al. describe that activation of E-prostanoid 3 receptor (EP3) ameliorates injury-induced liver fibrosis through promoting NK cell adhesion and killing of activated hepatic stellate cells in mice, indicating that EP3 may serve as a potential therapeutic target for liver fibrosis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73013768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Toward an understanding of allogeneic conflict in pregnancy and transplantation 对妊娠和移植中同种异体冲突的理解
The Tokushima journal of experimental medicine Pub Date : 2022-04-13 DOI: 10.1084/jem.20211493
Samarth S Durgam, M. Alegre, A. Chong
{"title":"Toward an understanding of allogeneic conflict in pregnancy and transplantation","authors":"Samarth S Durgam, M. Alegre, A. Chong","doi":"10.1084/jem.20211493","DOIUrl":"https://doi.org/10.1084/jem.20211493","url":null,"abstract":"Discussion on the divergent immunological effects of pregnancy on T cell and humoral immunity, how prior pregnancy impacts responses upon alloantigen re-encounter in the context of solid organ transplantation, and potential strategies for controlling pregnancy-dependent allosensitization.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76374254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics FNIP1通过塑造细胞内钙动力学调节小鼠脂肪细胞褐变和全身葡萄糖稳态
The Tokushima journal of experimental medicine Pub Date : 2022-04-12 DOI: 10.1084/jem.20212491
Yujing Yin, Dengqiu Xu, Yan Mao, Liwei Xiao, Zongchao Sun, Jing Liu, Danxia Zhou, Zhisheng Xu, Lin Liu, Tingting Fu, Chenyun Ding, Qiqi Guo, Wanping Sun, Zheng Zhou, Likun Yang, Yuhuan Jia, Xinyi Chen, Z. Gan
{"title":"FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics","authors":"Yujing Yin, Dengqiu Xu, Yan Mao, Liwei Xiao, Zongchao Sun, Jing Liu, Danxia Zhou, Zhisheng Xu, Lin Liu, Tingting Fu, Chenyun Ding, Qiqi Guo, Wanping Sun, Zheng Zhou, Likun Yang, Yuhuan Jia, Xinyi Chen, Z. Gan","doi":"10.1084/jem.20212491","DOIUrl":"https://doi.org/10.1084/jem.20212491","url":null,"abstract":"Metabolically beneficial beige adipocytes offer tremendous potential to treat obesity and metabolic diseases. Yin et al. show that FNIP1 acts as a negative regulator of beige adipocyte thermogenesis to control systemic glucose homeostasis through modulating the ER Ca2+-ATPase SERCA.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76288431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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