GIMAP6调节小鼠和人的自噬、免疫能力和炎症

The Tokushima journal of experimental medicine Pub Date : 2022-05-13 DOI:10.1084/jem.20201405

Yikun Yao, Ping Du Jiang, B. Chao, D. Çağdaş, S. Kubo, Arasu Balasubramaniyam, Yu Zhang, B. Shadur, A. NaserEddin, L. Folio, Benjamin Schwarz, Eric Bohrnsen, Lixin Zheng, Matthew Lynberg, Simone Gottlieb, Michael A. Leney-Greene, Ann Y. Park, I. Tezcan, A. Akdoğan, R. Gocmen, S. Onder, A. Rosenberg, E. Soilleux, Errin Johnson, P. Jackson, J. Demeter, Samuel D. Chauvin, F. Paul, M. Selbach, H. Bulut, M. Clatworthy, Z. Tuong, Hanlin Zhang, B. Stewart, C. Bosio, P. Stepensky, S. Clare, S. Ganesan, J. Pascall, O. Daumke, G. Butcher, A. McMichael, A. Simon, M. Lenardo

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引用次数: 3

摘要

Yao等人描述了人类和小鼠的GIMAP6缺乏，表现出免疫功能障碍和对细菌感染的易感性。他们在GIMAP6缺陷的免疫细胞中发现了受损的自噬，并定义了一个由GIMAP6、GIMAP7和GABARAPL2组成的功能复合物。

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GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans

Yao et al. describe GIMAP6 deficiency in humans and mice showing immune dysfunction and susceptibility to bacterial infections. They find impaired autophagy in GIMAP6-deficient immune cells and define a functional complex composed of GIMAP6, GIMAP7, and GABARAPL2.

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The Tokushima journal of experimental medicine

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