Yikun Yao, Ping Du Jiang, B. Chao, D. Çağdaş, S. Kubo, Arasu Balasubramaniyam, Yu Zhang, B. Shadur, A. NaserEddin, L. Folio, Benjamin Schwarz, Eric Bohrnsen, Lixin Zheng, Matthew Lynberg, Simone Gottlieb, Michael A. Leney-Greene, Ann Y. Park, I. Tezcan, A. Akdoğan, R. Gocmen, S. Onder, A. Rosenberg, E. Soilleux, Errin Johnson, P. Jackson, J. Demeter, Samuel D. Chauvin, F. Paul, M. Selbach, H. Bulut, M. Clatworthy, Z. Tuong, Hanlin Zhang, B. Stewart, C. Bosio, P. Stepensky, S. Clare, S. Ganesan, J. Pascall, O. Daumke, G. Butcher, A. McMichael, A. Simon, M. Lenardo
{"title":"GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans","authors":"Yikun Yao, Ping Du Jiang, B. Chao, D. Çağdaş, S. Kubo, Arasu Balasubramaniyam, Yu Zhang, B. Shadur, A. NaserEddin, L. Folio, Benjamin Schwarz, Eric Bohrnsen, Lixin Zheng, Matthew Lynberg, Simone Gottlieb, Michael A. Leney-Greene, Ann Y. Park, I. Tezcan, A. Akdoğan, R. Gocmen, S. Onder, A. Rosenberg, E. Soilleux, Errin Johnson, P. Jackson, J. Demeter, Samuel D. Chauvin, F. Paul, M. Selbach, H. Bulut, M. Clatworthy, Z. Tuong, Hanlin Zhang, B. Stewart, C. Bosio, P. Stepensky, S. Clare, S. Ganesan, J. Pascall, O. Daumke, G. Butcher, A. McMichael, A. Simon, M. Lenardo","doi":"10.1084/jem.20201405","DOIUrl":null,"url":null,"abstract":"Yao et al. describe GIMAP6 deficiency in humans and mice showing immune dysfunction and susceptibility to bacterial infections. They find impaired autophagy in GIMAP6-deficient immune cells and define a functional complex composed of GIMAP6, GIMAP7, and GABARAPL2.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20201405","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Yao et al. describe GIMAP6 deficiency in humans and mice showing immune dysfunction and susceptibility to bacterial infections. They find impaired autophagy in GIMAP6-deficient immune cells and define a functional complex composed of GIMAP6, GIMAP7, and GABARAPL2.
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