EP3增强小鼠肝纤维化模型中NK细胞对肝星状细胞的粘附和细胞毒性

The Tokushima journal of experimental medicine Pub Date : 2022-04-14 DOI:10.1084/jem.20212414

Xixi Tao, Rui Zhang, Ronglu Du, Tingting Yu, H. Yang, Jiwen Li, Yuhong Wang, Qian Liu, Shengkai Zuo, Xi Wang, M. Lazarus, Lu Zhou, Bangmao Wang, Yingjia Yu, Yujun Shen

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引用次数: 9

摘要

Tao等人描述了E-prostanoid 3受体(EP3)的激活通过促进NK细胞粘附和杀死小鼠活化的肝星状细胞来改善损伤性肝纤维化，这表明EP3可能是肝纤维化的潜在治疗靶点。

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EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model

Tao et al. describe that activation of E-prostanoid 3 receptor (EP3) ameliorates injury-induced liver fibrosis through promoting NK cell adhesion and killing of activated hepatic stellate cells in mice, indicating that EP3 may serve as a potential therapeutic target for liver fibrosis.

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The Tokushima journal of experimental medicine

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