FNIP1通过塑造细胞内钙动力学调节小鼠脂肪细胞褐变和全身葡萄糖稳态

The Tokushima journal of experimental medicine Pub Date : 2022-04-12 DOI:10.1084/jem.20212491

Yujing Yin, Dengqiu Xu, Yan Mao, Liwei Xiao, Zongchao Sun, Jing Liu, Danxia Zhou, Zhisheng Xu, Lin Liu, Tingting Fu, Chenyun Ding, Qiqi Guo, Wanping Sun, Zheng Zhou, Likun Yang, Yuhuan Jia, Xinyi Chen, Z. Gan

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引用次数: 6

摘要

有益代谢的米色脂肪细胞为治疗肥胖和代谢疾病提供了巨大的潜力。Yin等人的研究表明，FNIP1作为米色脂肪细胞产热的负调节因子，通过调节ER Ca2+- atp酶SERCA来控制全身葡萄糖稳态。

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FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics

Metabolically beneficial beige adipocytes offer tremendous potential to treat obesity and metabolic diseases. Yin et al. show that FNIP1 acts as a negative regulator of beige adipocyte thermogenesis to control systemic glucose homeostasis through modulating the ER Ca2+-ATPase SERCA.

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The Tokushima journal of experimental medicine

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