ATP通过感觉神经元和中间神经元之间的串扰将炎症传播到其他肢体

The Tokushima journal of experimental medicine Pub Date : 2022-05-17 DOI:10.1084/jem.20212019

R. Hasebe, K. Murakami, Masaya Harada, N. Halaka, H. Nakagawa, F. Kawano, Y. Ohira, T. Kawamoto, F. Yull, T. Blackwell, J. Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, N. Watanabe, H. Hotta, T. Yamashita, D. Kamimura, Yuki Tanaka, M. Murakami

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引用次数: 8

摘要

局部炎症通过ATP通过感觉神经元-神经元间串扰向远处扩散。这种神经通路，或远端炎症通道反射，可能是具有远端炎症的炎症性疾病，如类风湿关节炎的治疗靶点。

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ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons

Local inflammation spreads to remote positions via sensory neuron–interneuron crosstalk using ATP. This neural pathway, or remote inflammation gateway reflex, may be a therapeutic target for inflammatory diseases with remote inflammation, such as rheumatoid arthritis.

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The Tokushima journal of experimental medicine

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