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Propranolol HCL-loaded liposomes for intranasal delivery: in vitro and ex vivo evaluation of optimized formulation using design of experiments. 经鼻给药的盐酸普萘洛尔脂质体:利用实验设计对优化配方进行体外和离体评价。
IF 4.2
Therapeutic delivery Pub Date : 2023-11-01 Epub Date: 2023-11-28 DOI: 10.4155/tde-2023-0044
Vishal Kumar, Nethish Kumaar R, D Aswin, Sreeja C Nair
{"title":"Propranolol HCL-loaded liposomes for intranasal delivery: <i>in vitro</i> and <i>ex vivo</i> evaluation of optimized formulation using design of experiments.","authors":"Vishal Kumar, Nethish Kumaar R, D Aswin, Sreeja C Nair","doi":"10.4155/tde-2023-0044","DOIUrl":"10.4155/tde-2023-0044","url":null,"abstract":"<p><p><b>Aim:</b> To develop a propranolol HCL-loaded liposomal nasal formulation for migraine prophylaxis. <b>Materials & methods:</b> Formulated the liposomes through thin layer hydration method and optimized via design of experiments (DOE). The prepared liposomes were characterized for particle size, zeta potential, PDI, drug entrapment and drug loading. Assessed for <i>in vitro</i> release kinetics, <i>ex vivo</i> permeability, histopathology and stability. <b>Results:</b> Optimized liposomes: 135.52 ± 5.87 nm, -19.9 ± 0.075 mV, 95.41 ± 0.05% entrapment, 43.37 ± 0.02% loading. Showed immediate (30.07 ± 2.09%) and sustained release (95.69 ± 4.58%) over 10 h. Enhanced permeation compared with controls; well-tolerated histopathologically. <b>Conclusion:</b> Liposomal formulation offers promise for intranasal propranolol HCL delivery in migraine prophylaxis, with stability under refrigeration.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"705-720"},"PeriodicalIF":4.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138446322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In situ gastric floating gel of atazanavir sulphate for sustained release: formulation, optimization and evaluation. 用于持续释放的硫酸阿扎那韦原位胃漂浮凝胶：配方、优化和评估。
IF 4.2
Therapeutic delivery Pub Date : 2023-10-01 Epub Date: 2023-12-06 DOI: 10.4155/tde-2023-0037
Rajashree Masareddy, Pradnya Sandure, Archana Patil, Yadishma Gaude, Arpana Patil
{"title":"<i>In situ</i> gastric floating gel of atazanavir sulphate for sustained release: formulation, optimization and evaluation.","authors":"Rajashree Masareddy, Pradnya Sandure, Archana Patil, Yadishma Gaude, Arpana Patil","doi":"10.4155/tde-2023-0037","DOIUrl":"10.4155/tde-2023-0037","url":null,"abstract":"<p><p><b>Aim:</b> Atazanavir sulphate belongs to BCS class II drug, its oral bioavailability is limited due to its rapid first-pass metabolism and P-gp efflux. <b>Materials & methods:</b> The <i>in situ</i> floating gel using the complexed drug was prepared by ion gelation method and optimized the formulation as per 3<sup>2</sup> full factorial design. <b>Results:</b> Floating lag time of optimized formulation was found to be 18 s and percentage drug release of 94.18 ± 0.18 % at the end of 16 h. The concentration of gelling polymer affects drug release and a floating lag time and <i>vice versa</i>. <b>Conclusion:</b> <i>In situ</i> floating gel of atazanavir sulphate was found promising to sustain drug release due to an increased gastric residence time, which leads to enhanced potential therapy.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"619-633"},"PeriodicalIF":4.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation, optimization and evaluation of amisulpride-loaded niosomal intranasal gel for brain targeting. 用于脑部靶向治疗的氨磺必利鼻腔内凝胶的配制、优化和评估。
IF 4.2
Therapeutic delivery Pub Date : 2023-10-01 Epub Date: 2023-12-05 DOI: 10.4155/tde-2023-0059
Vinayak S Patil, Kishori P Sutar, Rachana D Pockle, Siddarth Usulkar, Vishwanath A Jadhav
{"title":"Formulation, optimization and evaluation of amisulpride-loaded niosomal intranasal gel for brain targeting.","authors":"Vinayak S Patil, Kishori P Sutar, Rachana D Pockle, Siddarth Usulkar, Vishwanath A Jadhav","doi":"10.4155/tde-2023-0059","DOIUrl":"10.4155/tde-2023-0059","url":null,"abstract":"<p><p><b>Aim:</b> To develop stable non-ionic surfactant vesicles containing amisulpride (AMS) to improve brain uptake via nose to brain mechanism. <b>Methods:</b> Niosomes were developed using a modified ethanol injection technique, optimized using 3<sup>2</sup> factorial design and evaluated for the vesicle size (VS), percent encapsulation efficiency (EE), zeta potential (ZP) and % cumulative drug release (%CDR). <b>Results:</b> Optimized niosomes (Span-60: cholesterol ratio 0:1) showed 191.4 nm VS, 84.25% EE, -38.2 ZP and 81.31% CDR. <i>In situ</i> gel with these niosomes displayed 78% CDR. TEM analysis revealed spherical niosomes. Pharmacokinetic and brain tissue distribution studies in rats showed enhanced plasma and brain concentrations, indicating successful brain targeting. <b>Conclusion:</b> This strategy demonstrates improved AMS permeation via the nasal cavity, enhancing bioavailability for treating schizophrenia.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"635-647"},"PeriodicalIF":4.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of inorganic ions in wound healing: an insight into the various approaches for localized delivery. 无机离子在伤口愈合中的作用:对局部递送的各种方法的洞察。
IF 4.2
Therapeutic delivery Pub Date : 2023-10-01 Epub Date: 2023-11-28 DOI: 10.4155/tde-2023-0036
M C Linju, M R Rekha
{"title":"Role of inorganic ions in wound healing: an insight into the various approaches for localized delivery.","authors":"M C Linju, M R Rekha","doi":"10.4155/tde-2023-0036","DOIUrl":"10.4155/tde-2023-0036","url":null,"abstract":"<p><p>Recently, the role of inorganic ions has been explored for its wound-healing applications. Ions do play key role in the normal functioning of the skin, including the epidermal barrier property, maintaining redox balance, enzymatic activities, tissue remodeling, etc. The care of chronic wounds is a concern and new cost-effective therapeutic strategies that modulate the wound microenvironment and cell behaviour are needed. First, this review illustrates the ions that play a role in wound healing and their molecular mechanisms that are accountable for modifying the wound. Further, the emerging strategies using metal ions to modulate the healing will be discussed. In this direction, localized delivery of inorganic ions of importance using advanced wound care biomaterials for wound healing applications is discussed.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"649-667"},"PeriodicalIF":4.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138446323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential of DNA nanotechnology to advance multiple therapeutic systems. DNA纳米技术推进多种治疗系统的潜力。
IF 4.2
Therapeutic delivery Pub Date : 2023-10-01 Epub Date: 2023-11-28 DOI: 10.4155/tde-2023-0060
Igor L Medintz, Divita Mathur
{"title":"The potential of DNA nanotechnology to advance multiple therapeutic systems.","authors":"Igor L Medintz, Divita Mathur","doi":"10.4155/tde-2023-0060","DOIUrl":"10.4155/tde-2023-0060","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"615-618"},"PeriodicalIF":4.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138446324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of poly-L-ornithine-bile acid nano hydrogels on cellular bioactivity and potential pharmacological applications. 聚l -鸟氨酸胆汁酸纳米水凝胶对细胞生物活性的影响及其潜在的药理应用。
IF 4.2
Therapeutic delivery Pub Date : 2023-09-05 DOI: 10.4155/tde-2023-0034
Bozica Kovacevic, Melissa Jones, Susbin Raj Wagle, Corina Mihaela Ionescu, Thomas Foster, Maja Đanić, Momir Mikov, Armin Mooranian, Hani Al-Salami
{"title":"Influence of poly-L-ornithine-bile acid nano hydrogels on cellular bioactivity and potential pharmacological applications.","authors":"Bozica Kovacevic,&nbsp;Melissa Jones,&nbsp;Susbin Raj Wagle,&nbsp;Corina Mihaela Ionescu,&nbsp;Thomas Foster,&nbsp;Maja Đanić,&nbsp;Momir Mikov,&nbsp;Armin Mooranian,&nbsp;Hani Al-Salami","doi":"10.4155/tde-2023-0034","DOIUrl":"https://doi.org/10.4155/tde-2023-0034","url":null,"abstract":"<p><p><b>Aim:</b> Cellular bioactivity and pathophysiological changes associated with chronic disorders are considered pivotal detrimental factors when developing novel formulations for biomedical applications. <b>Methods:</b> This paper investigates the use of bile acids and synthetic polypeptide poly-L-ornithine (PLO) in formulations and their impacts on a variety of cell lines, with a particular focus on their cellular bioactivity. <b>Results:</b> The hepatic cell line was the most negatively affected by the presence of PLO, while the muscle and beta-pancreatic cell lines did not show as profound of a negative impact of PLO on cellular viability. PLO was the least disruptive regarding mitochondrial function for muscle and beta cells. <b>Conclusion:</b> The addition of bile acids generally decreased mitochondrial respiration and altered bioenergetic parameters in all cell lines.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10508281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging nanotechnology backed formulations for the management of atopic dermatitis. 新兴的纳米技术支持治疗特应性皮炎的配方。
IF 4.2
Therapeutic delivery Pub Date : 2023-09-01 Epub Date: 2023-09-06 DOI: 10.4155/tde-2023-0033
Ranjit Kumar Mahato, Mohini Singh, Hemanta Pathak, Niva Rani Gogoi, Rikynjai Kharbithai, Pinky Chowrasia, Pankaj Lochan Bora, Tumpa Sarkar, Bani Kumar Jana, Bhaskar Mazumder
{"title":"Emerging nanotechnology backed formulations for the management of atopic dermatitis.","authors":"Ranjit Kumar Mahato, Mohini Singh, Hemanta Pathak, Niva Rani Gogoi, Rikynjai Kharbithai, Pinky Chowrasia, Pankaj Lochan Bora, Tumpa Sarkar, Bani Kumar Jana, Bhaskar Mazumder","doi":"10.4155/tde-2023-0033","DOIUrl":"10.4155/tde-2023-0033","url":null,"abstract":"<p><p>Atopic dermatitis is a prevalent chronic skin inflammation affecting 2.1 to 4.1% of adults globally. The complexity of its pathogenesis and the relapsing nature make it challenging to treat. Current treatments follow European Academy of Dermatology and Venerology guidelines, but advanced cases with recurring lesions lack effective therapies. To address this gap, researchers are exploring nanotechnology for targeted drug delivery. Nanoparticles offer benefits such as improved drug retention, stability, controlled release and targeted delivery through the disrupted epidermal barrier. This integrated review evaluates the current state of AD treatment and highlights the potential of novel nano-formulations as a promising approach to address the disease.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"543-569"},"PeriodicalIF":4.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10162612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Internal stimuli-responsive nanocarriers for controlled anti-cancer drug release: a review. 内刺激反应型纳米载体抗癌药物控释研究进展。
IF 4.2
Therapeutic delivery Pub Date : 2023-09-01 Epub Date: 2023-10-25 DOI: 10.4155/tde-2023-0041
Baji Baba Shaik, Naresh Kumar Katari, Sreekanth B Jonnalagadda
{"title":"Internal stimuli-responsive nanocarriers for controlled anti-cancer drug release: a review.","authors":"Baji Baba Shaik, Naresh Kumar Katari, Sreekanth B Jonnalagadda","doi":"10.4155/tde-2023-0041","DOIUrl":"10.4155/tde-2023-0041","url":null,"abstract":"<p><p>Cancer disease is one of the most frequent life-threatening, with a high fatality rate worldwide. However, recent immunotherapy studies in various tumours have yielded unsatisfactory outcomes, with just a few individuals experiencing long-term responses. To overcome these issues, nowadays internal stimuli-responsive nanocarriers have been widely exploited to transport a wide range of active substances, including peptides, genes and medicines. These nanosystems could be chemically adjusted to produce target-based drug release at the target location, minimizing pathological and physiological difficulties while increasing therapeutic efficiency. This review highlights the various types of internal stimuli-responsive nanocarriers and applications in cancer diagnosis. This study can provide inspiration and impetus for exploiting more promising internal stimuli-responsive nanosystems for drug delivery.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"595-613"},"PeriodicalIF":4.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intranasal nanoparticulate delivery systems for neurodegenerative disorders: a review. 神经退行性疾病的鼻内纳米颗粒递送系统：综述。
IF 4.2
Therapeutic delivery Pub Date : 2023-09-01 Epub Date: 2023-09-11 DOI: 10.4155/tde-2023-0019
Someshbabu Ramesh Babu, Harshith Hosahalli Shekara, Ashish Kumar Sahoo, Pyda Venkata Harsha Vardhan, Nitheesh Thiruppathi, Madhugiri Prakash Venkatesh
{"title":"Intranasal nanoparticulate delivery systems for neurodegenerative disorders: a review.","authors":"Someshbabu Ramesh Babu, Harshith Hosahalli Shekara, Ashish Kumar Sahoo, Pyda Venkata Harsha Vardhan, Nitheesh Thiruppathi, Madhugiri Prakash Venkatesh","doi":"10.4155/tde-2023-0019","DOIUrl":"10.4155/tde-2023-0019","url":null,"abstract":"<p><p>Neurodegenerative diseases are a significant cause of mortality worldwide, and the blood-brain barrier (BBB) poses a significant challenge for drug delivery. An intranasal route is a prominent approach among the various methods to bypass the BBB. There are different pathways involved in intranasal drug delivery. The drawbacks of this method include mucociliary clearance, enzymatic degradation and poor drug permeation. Novel nanoformulations and intranasal drug-delivery devices offer promising solutions to overcome these challenges. Nanoformulations include polymeric nanoparticles, lipid-based nanoparticles, microspheres, liposomes and noisomes. Additionally, intranasal devices could be utilized to enhance drug-delivery efficacy. Therefore, intranasal drug-delivery systems show potential for treating neurodegenerative diseases through trigeminal or olfactory pathways, which can significantly improve patient outcomes.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"571-594"},"PeriodicalIF":4.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10570420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry update: the latest developments in the field of therapeutic delivery, July 2023. 行业更新：治疗递送领域的最新进展，2023年7月。
IF 4.2
Therapeutic delivery Pub Date : 2023-09-01 Epub Date: 2023-10-03 DOI: 10.4155/tde-2023-0085
Peter Timmins
{"title":"Industry update: the latest developments in the field of therapeutic delivery, July 2023.","authors":"Peter Timmins","doi":"10.4155/tde-2023-0085","DOIUrl":"10.4155/tde-2023-0085","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"527-541"},"PeriodicalIF":4.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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