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Novel therapeutic approaches for the management of hepatitis infections. 治疗肝炎感染的新疗法。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.4155/tde-2023-0074
Aswin Damodaran, Subin Mary Zachariah, Sreeja Chandrasekharan Nair
{"title":"Novel therapeutic approaches for the management of hepatitis infections.","authors":"Aswin Damodaran, Subin Mary Zachariah, Sreeja Chandrasekharan Nair","doi":"10.4155/tde-2023-0074","DOIUrl":"10.4155/tde-2023-0074","url":null,"abstract":"<p><p>Hepatitis B virus (HBV) & hepatitis C virus (HCV) infection is a substantial reason for morbidity and mortality around the world. Chronic hepatitis B (CHB) infection is connected with an enhanced risk of liver cirrhosis, liver decompensation and hepatocellular carcinoma (HCC). Conventional therapy do face certain challenges, for example, poor tolerability and the growth of active resistance. Thus, novel treatment procedures are essential to accomplish the initiation of strong and stable antiviral immune reactions of the individuals. This review explores the current nanotechnology-based carriers for drug and vaccine delivery to treat HBV and HCV.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"211-232"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paclitaxel-loaded niosomes in combination with metformin: development, characterization and anticancer potentials. 与二甲双胍联用的紫杉醇载药新体：开发、表征和抗癌潜力。
IF 4.2
Therapeutic delivery Pub Date : 2024-02-01 Epub Date: 2024-01-12 DOI: 10.4155/tde-2023-0089
Taqwa Al-Kofahi, Bahaa Altrad, Haneen Amawi, Alaa A Aljabali, Yousef M Abul-Haija, Mohammad A Obeid
{"title":"Paclitaxel-loaded niosomes in combination with metformin: development, characterization and anticancer potentials.","authors":"Taqwa Al-Kofahi, Bahaa Altrad, Haneen Amawi, Alaa A Aljabali, Yousef M Abul-Haija, Mohammad A Obeid","doi":"10.4155/tde-2023-0089","DOIUrl":"10.4155/tde-2023-0089","url":null,"abstract":"<p><p><b>Aim:</b> This study aims to assess the efficacy of free and niosomes-loaded paclitaxel combined with the anti-diabetic drug metformin. <b>Methods:</b> Paclitaxel was successfully encapsulated in all niosome formulations, using microfluidic mixing, with a maximum encapsulation efficiency of 11.9%. <b>Results:</b> The half maximal inhibitory concentration (IC<sub>50</sub>) for free paclitaxel in T47D cells was significantly reduced from 0.2 to 0.048 mg/ml when combined with metformin 40 mg. The IC<sub>50</sub> of paclitaxel was significantly reduced when loaded in niosomes to less than 0.06 mg/ml alone or with metformin. <b>Conclusion:</b> Paclitaxel combination (free or loaded into niosomes) with metformin significantly improved the anticancer efficacy of paclitaxel, which can serve as a method to reduce the paclitaxel dose and its associated side effects.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"109-118"},"PeriodicalIF":4.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aquasomes nanoformulation for controlled release of drug and improved effectiveness against bacterial infections. 用于控制药物释放和提高抗细菌感染效力的水瘤纳米制剂。
IF 4.2
Therapeutic delivery Pub Date : 2024-02-01 Epub Date: 2024-01-04 DOI: 10.4155/tde-2023-0096
Bhuvaneshwari Shanmugam, Umashankar Marakanam Srinivasan
{"title":"Aquasomes nanoformulation for controlled release of drug and improved effectiveness against bacterial infections.","authors":"Bhuvaneshwari Shanmugam, Umashankar Marakanam Srinivasan","doi":"10.4155/tde-2023-0096","DOIUrl":"10.4155/tde-2023-0096","url":null,"abstract":"<p><p><b>Aim:</b> The study aimed to develop and evaluate an aquasome drug-delivery system for controlled drug delivery of cefprozil monohydrate. <b>Materials & methods:</b> Aquasomes were prepared by the spinal method with a calcium phosphate core, sugar-coated using cellobiose and drug-loaded by adsorption. The formulations were characterized for size, morphology and drug release. An antibacterial study was conducted for Gram-positive and -negative bacteria. <b>Results:</b> It showed particle size of 2791.9 nm, zeta potential of -0.3 mV with good stability, and 99.08% of drug loading and drug release were controlled and prolonged, achieving 56% within 8 h and possessing potential for 100% release beyond 12 h. <b>Conclusion:</b> An aquasome drug-delivery system was developed for novel controlled drug delivery for pharmaceutical antibiotic therapeutics.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"95-107"},"PeriodicalIF":4.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139088691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid-based nanocarriers for enhanced delivery of plant-derived bioactive molecules: a comprehensive review. 基于脂质的纳米载体用于增强植物生物活性分子的递送：全面综述。
IF 4.2
Therapeutic delivery Pub Date : 2024-02-01 Epub Date: 2024-01-12 DOI: 10.4155/tde-2023-0116
Pavithra Kothapalli, Manimaran Vasanthan
{"title":"Lipid-based nanocarriers for enhanced delivery of plant-derived bioactive molecules: a comprehensive review.","authors":"Pavithra Kothapalli, Manimaran Vasanthan","doi":"10.4155/tde-2023-0116","DOIUrl":"10.4155/tde-2023-0116","url":null,"abstract":"<p><p>Bioactive compounds derived from plants have been investigated for treating various pathological conditions. However, the utilization of these compounds has challenges such as instability, low solubility and bioavailability. To overcome these challenges, the encapsulation of bioactive molecules with in a novel nano carrier system enabling effective delivery and clinical translation has become essential. Lipid-based nanocarriers provide versatile platforms for encapsulating and delivering bioactive compounds and overcome the challenges. These novel carriers can improve solubility, stability, improved drug retention and therapeutic efficacy of plant derived bioactive compounds. The current review evaluates the challenges in delivery of plant bioactives and highlights the potential of various lipid-based nano carriers designed to improve its therapeutic efficacy.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"135-155"},"PeriodicalIF":4.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry update: the latest developments in the field of therapeutic delivery, October 2023. 行业更新：2023 年 10 月治疗传递领域的最新发展。
IF 4.2
Therapeutic delivery Pub Date : 2024-02-01 Epub Date: 2024-01-10 DOI: 10.4155/tde-2023-0139
Peter Timmins
{"title":"Industry update: the latest developments in the field of therapeutic delivery, October 2023.","authors":"Peter Timmins","doi":"10.4155/tde-2023-0139","DOIUrl":"10.4155/tde-2023-0139","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"77-94"},"PeriodicalIF":4.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139404499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel polysaccharides-bile acid-cyclodextrin gel systems and effects on cellular viability and bioenergetic parameters. 新型多糖-胆汁酸-环糊精凝胶系统及其对细胞活力和生物能参数的影响。
IF 4.2
Therapeutic delivery Pub Date : 2024-02-01 Epub Date: 2024-01-05 DOI: 10.4155/tde-2023-0063
Bozica Kovacevic, Corina Mihaela Ionescu, Melissa Jones, Susbin Raj Wagle, Thomas Foster, Michael Lewkowicz, Elaine Ym Wong, Maja Ðanić, Momir Mikov, Armin Mooranian, Hani Al-Salami
{"title":"Novel polysaccharides-bile acid-cyclodextrin gel systems and effects on cellular viability and bioenergetic parameters.","authors":"Bozica Kovacevic, Corina Mihaela Ionescu, Melissa Jones, Susbin Raj Wagle, Thomas Foster, Michael Lewkowicz, Elaine Ym Wong, Maja Ðanić, Momir Mikov, Armin Mooranian, Hani Al-Salami","doi":"10.4155/tde-2023-0063","DOIUrl":"10.4155/tde-2023-0063","url":null,"abstract":"<p><p><b>Aim:</b> The novel hydrogel systems made from sodium alginate, pectin, beta-cyclodextrin and deoxycholic acid (DCA) were proposed as potential drug-delivery matrices. <b>Materials & methods:</b> To ensure biocompatibility, rheological parameters were examined and hydrogels' effects on bioenergetic parameters and cellular viability on murine hepatic, and muscle and pancreatic beta cells. <b>Results & conclusion:</b> All hydrogels show non-Newtonian, shear thinning behavior. Cells displayed various oxygen-dependent viability patterns, with the bile acid overall adversely affecting their biological activities. All cells performed best under normoxia, with pancreatic beta cells displaying the most profound oxygen-dependent viability behavior. The cells tolerated the addition of a moderate concentration of beta-cyclodextrin to the polymer matrix.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"119-134"},"PeriodicalIF":4.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cationic microemulsion of voriconazole for the treatment of fungal keratitis: in vitro and in vivo evaluation. 用于治疗真菌性角膜炎的伏立康唑阳离子微乳剂：体外和体内评估。
IF 4.2
Therapeutic delivery Pub Date : 2024-01-05 DOI: 10.4155/tde-2023-0069
Parasuraman Mohan, Jothimani Rajeswari, Karthikeyan Kesavan
{"title":"Cationic microemulsion of voriconazole for the treatment of fungal keratitis: <i>in vitro</i> and <i>in vivo</i> evaluation.","authors":"Parasuraman Mohan, Jothimani Rajeswari, Karthikeyan Kesavan","doi":"10.4155/tde-2023-0069","DOIUrl":"https://doi.org/10.4155/tde-2023-0069","url":null,"abstract":"<p><p><b>Aim:</b> This investigation aimed to develop a voriconazole-loaded chitosan-coated cationic microemulsion (CVME) to treat fungal keratitis. <b>Methods:</b> Microemulsions were prepared using water titration, and the optimized microemulsion was coated with chitosan to prepare CVME. The physicochemical parameters, ocular irritation potential, <i>in vitro</i> antifungal efficacy and <i>in vitro</i> release studies were performed. The <i>in vivo</i> antifungal efficacy study was conducted in a fungal infection-induced rabbit eye model. <b>Results:</b> The developed CVME displayed acceptable physicochemical properties and excellent mucoadhesive behavior and showed a sustained release profile. <i>Ex vivo</i> and <i>in vivo</i> studies concluded that higher permeability and improved antifungal efficacy were observed for CVME than drug suspension (DS). <b>Conclusion:</b> The prepared CVME7 is a viable alternative to treating fungal keratitis with existing approaches.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of deoxycholic acid-based hydrogels on hepatic, muscle and pancreatic beta cells. 脱氧胆酸水凝胶对肝脏、肌肉和胰腺β细胞的影响
IF 4.2
Therapeutic delivery Pub Date : 2024-01-05 DOI: 10.4155/tde-2023-0054
Bozica Kovacevic, Melissa Jones, Susbin Raj Wagle, Corina Mihaela Ionescu, Thomas Foster, Maja Đanić, Momir Mikov, Armin Mooranian, Hani Al-Salami
{"title":"The effect of deoxycholic acid-based hydrogels on hepatic, muscle and pancreatic beta cells.","authors":"Bozica Kovacevic, Melissa Jones, Susbin Raj Wagle, Corina Mihaela Ionescu, Thomas Foster, Maja Đanić, Momir Mikov, Armin Mooranian, Hani Al-Salami","doi":"10.4155/tde-2023-0054","DOIUrl":"https://doi.org/10.4155/tde-2023-0054","url":null,"abstract":"<p><p><b>Aim:</b> The aim of this study is to test the biocompatibility of hydrogels with polysaccharides and bile acids on three murine cell lines. <b>Materials & methods:</b> Novel hydrogels containing poloxamer 407, polysaccharides (starch, pectin, acacia, carboxymethyl and methyl 2-hydroxyethyl cellulose) and deoxycholic acid were prepared using cold method, sterilized and used in biological assays to determine effects on hepatic, muscle, and pancreatic beta cells. <b>Results and conclusion:</b> Hydrogels with deoxycholic acid had tissue-depending effects on cellular survival and bioenergetics, resulting in the best cellular viability and bioenergetics within pancreatic beta cells. Further research is needed as proposed hydrogels may be beneficial for cell delivery systems of pancreatic beta cells.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanotherapeutics for the delivery of antifungal drugs. 用于输送抗真菌药物的纳米疗法。
IF 4.2
Therapeutic delivery Pub Date : 2024-01-04 DOI: 10.4155/tde-2023-0090
Blessing Atim Aderibigbe
{"title":"Nanotherapeutics for the delivery of antifungal drugs.","authors":"Blessing Atim Aderibigbe","doi":"10.4155/tde-2023-0090","DOIUrl":"https://doi.org/10.4155/tde-2023-0090","url":null,"abstract":"<p><p>The treatment of fungal infections is challenging with high death rates reported among immunocompromised patients. The currently available antifungals suffer from poor bioavailability and solubility, pharmacokinetics, and drug resistance, with limited cellular uptake. The clinical pipeline of new antifungals is dry. The incorporation of antifungal drugs into polymer-based nanocarriers to form nanotherapeutics is a promising approach to enhance the therapeutic outcomes of the available antifungal drugs. This review summarizes different polymer-based nanotherapeutics strategies that have been explored for the delivery of antifungals, resulting in enhanced therapeutic outcomes, such as improved pharmacokinetics, targeted/sustained delivery, prolonged drug circulation, retention of the drugs at the localized site of action, and overcoming drug resistance when compared with the free antifungal drugs.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139088692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
January 2024 industry update. 2024 年 1 月行业更新。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-05-09 DOI: 10.1080/20415990.2024.2346045
Patrick Lim, Nebojsa Stilinovic, Armin Mooranian, Hani Al-Salami
{"title":"January 2024 industry update.","authors":"Patrick Lim, Nebojsa Stilinovic, Armin Mooranian, Hani Al-Salami","doi":"10.1080/20415990.2024.2346045","DOIUrl":"https://doi.org/10.1080/20415990.2024.2346045","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":"15 6","pages":"393-398"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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