Therapeutic delivery最新文献

Development and evaluation of targeted liposomes for improved doxorubicin and quercetin delivery for MDR breast cancer. 靶向脂质体用于改善多药耐多药乳腺癌阿霉素和槲皮素递送的开发和评价。

IF 2.2

Therapeutic delivery Pub Date : 2025-10-14 DOI: 10.1080/20415990.2025.2570635

Shreastha Gautam, Rashmi Maurya, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi

{"title":"Development and evaluation of targeted liposomes for improved doxorubicin and quercetin delivery for MDR breast cancer.","authors":"Shreastha Gautam, Rashmi Maurya, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi","doi":"10.1080/20415990.2025.2570635","DOIUrl":"https://doi.org/10.1080/20415990.2025.2570635","url":null,"abstract":"Introduction: Breast cancer remains one of the leading causes of cancer-related deaths among women worldwide. Despite the availability of chemotherapeutics, such as doxorubicin, treatment efficacy, is often hampered by multidrug resistance, largely driven by efflux transporters like P-glycoprotein.Aim & objectives: This study aimed to develop and evaluate a targeted liposomal system for the co-delivery of doxorubicin and quercetin to overcome multidrug resistance in breast cancer cells. The objective was to enhance therapeutic efficacy while minimizing systemic toxicity.Method: Liposomes were prepared using the thin-film hydration method and optimized via Box-Behnken Design. Two formulations, doxorubicin and quercetin liposomes (DOX-QCT-LIPO) and Trastuzumab conjugated (TmAb-DOX-QCT-LIPO), were characterized for vesicle size, PDI, and entrapment efficiency. Their cytotoxicity (MTT assay) and cellular uptake (FACS) were tested in MCF-7 and MCF-7/ADR cell lines.Results: Optimized formulations exhibited nanoscale size, uniform distribution, and high drug encapsulation. Tmab-DOX-QCT-LIPO showed significantly enhanced cytotoxicity and uptake in MDR breast cancer cells compared to free DOX and non-targeted liposomes, indicating effective bypass of efflux mechanisms via HER2-mediated endocytosis.Conclusion: TmAb-DOX-QCT-LIPO demonstrated superior anticancer potential by integrating dual-drug loading, P-gp inhibition, and HER2-targeted uptake, offering a promising therapeutic strategy against MDR breast cancer.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-15"},"PeriodicalIF":2.2,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are hydrogels suitable for delivery of cisplatin to the microenvironment in breast cancer treatment: a meta-analysis. 水凝胶是否适合在乳腺癌治疗的微环境中递送顺铂：一项荟萃分析。

IF 2.2

Therapeutic delivery Pub Date : 2025-10-09 DOI: 10.1080/20415990.2025.2570632

Amir Hossein Izadi Nazar, Roya Safari Faramani, Yasin Roushani Roudsari, Faranak Aghaz

{"title":"Are hydrogels suitable for delivery of cisplatin to the microenvironment in breast cancer treatment: a meta-analysis.","authors":"Amir Hossein Izadi Nazar, Roya Safari Faramani, Yasin Roushani Roudsari, Faranak Aghaz","doi":"10.1080/20415990.2025.2570632","DOIUrl":"https://doi.org/10.1080/20415990.2025.2570632","url":null,"abstract":"Background: Breast cancer is the most commonly diagnosed cancer for women. Cisplatin is one the most potent chemotherapeutic drugs we know in breast cancer, but its systemic toxicity limits its clinical application. Hydrogels are a local drug delivery system that limits the systemic toxicity of drugs and improves their efficacy.Objectives: This systematic review and meta-analysis evaluated the preclinical efficacy of cisplatin-loaded hydrogels for breast cancer treatment.Methods: We had a systematic search on different databases, including PubMed, Scopus, MEDLINE, Embase, Google Scholar, and the Web of Science, to find relative papers.Results: There was no statistically significant difference in cell viability between the cisplatin-loaded hydrogel and free cisplatin groups. However, the IC50 values were significantly higher in the treatment group, which means the cytotoxicity was reduced in the cisplatin-loaded hydrogel; then, we subgrouped them based on cell line and treatment duration; no significant difference was observed between the subgroups.Conclusions: This meta-analysis evaluated cisplatin-loaded hydrogels versus free cisplatin in breast cancer treatment. Contrary to expectations, no significant difference in cell viability was found, indicating hydrogels did not enhance therapeutic efficacy. However, a significantly higher IC50 with hydrogels suggests reduced instantaneous drug concentration due to sustained release.Prospero: CRD42025641451.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing delivery of specialized pro-resolving mediators for oral inflammation via smart hydrogels and biomaterials. 通过智能水凝胶和生物材料优化口腔炎症专用促溶解介质的递送。

IF 2.2

Therapeutic delivery Pub Date : 2025-10-06 DOI: 10.1080/20415990.2025.2570109

Alexis Gaudin, Solène Tessier, Léna Guyon, Ove A Peters

{"title":"Optimizing delivery of specialized pro-resolving mediators for oral inflammation via smart hydrogels and biomaterials.","authors":"Alexis Gaudin, Solène Tessier, Léna Guyon, Ove A Peters","doi":"10.1080/20415990.2025.2570109","DOIUrl":"https://doi.org/10.1080/20415990.2025.2570109","url":null,"abstract":"Chronic oral inflammatory diseases such as pulpitis, periodontitis, and peri-implantitis pose significant clinical challenges, often resulting in irreversible tissue loss despite the application of current therapies. Specialized pro-resolving mediators (SPMs) offer a novel therapeutic paradigm by actively promoting the resolution of inflammation and tissue regeneration without compromising host defense. However, the clinical translation of SPMs is hindered by their rapid degradation, low bioavailability, and poor localization to inflamed tissues. Smart biomaterial-based delivery systems, particularly stimuli-responsive hydrogels, have emerged as promising platforms to overcome these barriers. These systems enable controlled, localized, and environment-triggered release of SPMs, enhancing their stability and therapeutic efficacy. Preclinical studies in models of oral inflammation demonstrate that hydrogel-mediated SPM delivery not only resolves inflammation but also preserves tissue structure and promotes regeneration. Future strategies will focus on optimizing dosing protocols, ensuring long-term bioactivity, and addressing regulatory and manufacturing challenges to enable clinical adoption. By enhancing the delivery and sustained bioactivity of SPMs, biomaterial-based strategies have the potential to fundamentally transform the management of oral inflammatory diseases and advance regenerative dental therapies.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical potential of CAR T cell-derived extracellular vesicles (CAR-EVs) in cancer therapy: a cell-free approach. CAR- T细胞衍生细胞外囊泡（CAR- evs）在癌症治疗中的临床潜力：一种无细胞方法。

IF 2.2

Therapeutic delivery Pub Date : 2025-10-05 DOI: 10.1080/20415990.2025.2569298

Vaijayanti Kale, Ganesh Ingavle

{"title":"Clinical potential of CAR T cell-derived extracellular vesicles (CAR-EVs) in cancer therapy: a cell-free approach.","authors":"Vaijayanti Kale, Ganesh Ingavle","doi":"10.1080/20415990.2025.2569298","DOIUrl":"https://doi.org/10.1080/20415990.2025.2569298","url":null,"abstract":"Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary cancer treatment, but it has severe side effects. Extracellular vesicles (EVs), nanovesicles released by CAR T cells, known as CAR T-cell-derived EVs (CAR-EVs), are a potential alternative owing to their role in intercellular communication. This review comprehensively explores the clinical potential of CAR-EVs for cancer therapy, starting with their biogenesis and cargo, which include unique therapeutic molecules. It reviews the mechanisms underlying CAR-EV-mediated anticancer effects and presents preclinical evidence demonstrating efficacy across various cancers, including hematological malignancies and solid tumors. The review further discusses preclinical data and advantages over existing CAR T-cell therapies, emphasizing the need for future clinical studies to assess the safety and efficacy of CAR-EVs in cancer patients. This review also summarizes preliminary findings and challenges, proposing strategies to improve EV targeting and cargo delivery. Additionally, this review highlights unexplored aspects of EV biology in the context of CAR T-cell therapies. In conclusion, CAR-EVs offer a viable option for cancer therapy, with potential advantages over conventional CAR T-cell therapies. However, future research is needed to optimize manufacturing, distribution, and clinical application for achieve maximum therapeutic efficacy and favorable patient outcomes.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-19"},"PeriodicalIF":2.2,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing nanoparticles for phytochemical delivery: a comprehensive review of safety and therapeutic potential. 利用纳米颗粒传递植物化学物质：安全性和治疗潜力的综合综述。

IF 2.2

Therapeutic delivery Pub Date : 2025-10-04 DOI: 10.1080/20415990.2025.2570638

Sharon Oladipupo, Damilare Emmanuel Rotimi, Emmanuel Henry Ezenabor, Adebola Busola Ojo, Oluwatomisin Aderonke Akinsola, Oluwafemi Adeleke Ojo

{"title":"Harnessing nanoparticles for phytochemical delivery: a comprehensive review of safety and therapeutic potential.","authors":"Sharon Oladipupo, Damilare Emmanuel Rotimi, Emmanuel Henry Ezenabor, Adebola Busola Ojo, Oluwatomisin Aderonke Akinsola, Oluwafemi Adeleke Ojo","doi":"10.1080/20415990.2025.2570638","DOIUrl":"https://doi.org/10.1080/20415990.2025.2570638","url":null,"abstract":"Nanoparticle encapsulation has emerged as a relevant technology with the potential to revolutionize multiple fields, including medicine, food technology, cosmetics, and environmental monitoring. This review discusses the fundamental aspects of nanoparticle encapsulation, highlighting its benefits, such as enhanced solubility, stability, and bioavailability of phytochemicals. The data for this report were obtained via an extensive review of the peer-reviewed scientific literature. We reviewed various types of nanoparticles used in encapsulation, the efficacy of nanoparticle-encapsulated phytochemicals, and the challenges faced, including formulation complexity and regulatory hurdles. The review also considers current and future applications, providing examples of how advanced technologies such as artificial intelligence and novel manufacturing methods contribute to innovation in this field. As nanoparticle technology progresses, addressing safety and regulatory issues will be critical for its successful integration and commercialization. This review underscores the promising future of nanoparticle technology.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-15"},"PeriodicalIF":2.2,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the hypoglycemic potential of HuGLP-1-loaded bilosomes in controlling type 2 diabetes mellitus. 探讨携带huglp -1的胆小体在控制2型糖尿病中的降糖潜能。

IF 2.2

Therapeutic delivery Pub Date : 2025-09-09 DOI: 10.1080/20415990.2025.2557183

Mayur Kedarnath Vidhate, Shyam Sudhakar Gomte, Naveen Singh, Dimpal Suthar, Aakanchha Jain

{"title":"Exploring the hypoglycemic potential of HuGLP-1-loaded bilosomes in controlling type 2 diabetes mellitus.","authors":"Mayur Kedarnath Vidhate, Shyam Sudhakar Gomte, Naveen Singh, Dimpal Suthar, Aakanchha Jain","doi":"10.1080/20415990.2025.2557183","DOIUrl":"https://doi.org/10.1080/20415990.2025.2557183","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) is the most devastating disease and it necessitates therapeutic intervention for its effective management. Human Glucagon-like peptide-1 (HuGLP-1) is the potential candidate in the treatment of T2DM; however, it limits its utilization owing to its solubility and stability issues.Aims: The current investigation aims to develop HuGLP-1-loaded bilosomes as a novel strategy for managing T2DM.Materials and methods: The HuGLP-1-loaded bilosomes were developed and characterized for its size, polydispersity index, surface charge, entrapment efficiency, morphology, drug release, and stability studies. The hypoglycemic potential and histopathology were studied using streptozotocin-induced diabetic rats.Results: Bilosomes were successfully developed with size of 197.96 ± 0.61 nm, polydispersity index 0.191 ± 0.01 and surface charge of -27.63 ± 1.02 mV. The in vitro release of HuGLP-1-loaded bilosomes showed sustained release profile of HuGLP-1 extending over 24-h period, in compared to plain HuGLP-1 solution, and follows Weibull release kinetics model. The HuGLP-1-loaded bilosomes revealed significant hypoglycemic effects in comparison to both oral and subcutaneous HuGLP-1 solutions. Histopathological evaluations revealed that HuGLP-1-loaded bilosomes showed promising improvement in histology of liver, kidney, and intestines.Conclusion: The HuGLP-1-loaded bilosomes were found to be potential therapeutic approach for the effective management of T2DM.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-16"},"PeriodicalIF":2.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, development, and evaluation of magnetic nanoparticles and docetaxel-loaded nanosystem for brain targeting. 磁性纳米粒子和多西他赛负载的脑靶向纳米系统的设计、开发和评估。

IF 2.2

Therapeutic delivery Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1080/20415990.2025.2541573

Himanshu Gandhi, Deepak Kumar, Sandip Ghosh, Biswarup Basu, Deepak N Kapoor

{"title":"Design, development, and evaluation of magnetic nanoparticles and docetaxel-loaded nanosystem for brain targeting.","authors":"Himanshu Gandhi, Deepak Kumar, Sandip Ghosh, Biswarup Basu, Deepak N Kapoor","doi":"10.1080/20415990.2025.2541573","DOIUrl":"10.1080/20415990.2025.2541573","url":null,"abstract":"Objectives: The study aimed to investigate superparamagnetic iron oxide nanoparticles (SPIONs) as carriers for brain-targeted delivery of the anticancer drug docetaxel (DTX). The use of an externally positioned magnet was explored to achieve targeted delivery to specific regions of interest, enhancing SPIONs' accumulation and retention within the brain.Methods: SPIONs were synthesized using the co-precipitation method. Docetaxel-loaded SPION-PLGA nanoparticles (G-SPIO/DTX-PLGA-NPs) were subsequently prepared using a solvent evaporation process and further coated with glutathione (GSH) to enhance brain targeting in male Wistar rats.Results: The G-SPIO/DTX-PLGA-NPs demonstrated a particle size of 190 ± 5.11 nm and a zeta potential of -27.6 ± 0.36 mV. Drug release studies indicated an initial burst release of 15.03 ± 2.33% at 1 h and a sustained release of 78.78 ± 3.50% at 96 h. Cytotoxicity studies revealed significantly higher cell death (84.71%) with the G-SPIO/DTX-PLGA-NPs compared to DTX alone (72.29%), with a 3.39-fold (p < 0.001) reduction in IC50 values. In vivo biodistribution analysis showed that magnetically guided G-SPIO/DTX-PLGA-NPs achieved brain tissue concentrations 21.94 times (p < 0.05) higher than free DTX and 1.46 times higher than non-magnetically guided G-SPIO/DTX-PLGA-NPs.Conclusion: The study established G-SPIO/DTX-PLGA-NPs as effective SPION-based carriers for targeted docetaxel delivery to the brain.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"819-834"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissolving microneedle patches for transdermal delivery of paroxetine: in-vitro, ex-vivo studies and its PBPK modeling. 溶解微针贴剂用于帕罗西汀透皮给药：体外、离体研究及其PBPK模型。

IF 2.2

Therapeutic delivery Pub Date : 2025-09-01 Epub Date: 2025-08-03 DOI: 10.1080/20415990.2025.2542721

Muhammad Sikandar, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Farrukh Rafiq Ahmed, Fahad Siddiqui, Muhammad Talha Saleem, Asma Irshad

{"title":"Dissolving microneedle patches for transdermal delivery of paroxetine: in-vitro, ex-vivo studies and its PBPK modeling.","authors":"Muhammad Sikandar, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Farrukh Rafiq Ahmed, Fahad Siddiqui, Muhammad Talha Saleem, Asma Irshad","doi":"10.1080/20415990.2025.2542721","DOIUrl":"10.1080/20415990.2025.2542721","url":null,"abstract":"Background: Paroxetine HCl (PRX-HCl), an antidepressant, has poor water solubility and low oral bioavailability with 50% being metabolized in the liver. The oral formulations have multiple side effects. The present work aimed to develop dissolving microneedle patches (MNPs) of PRX-HCl to resolve low bioavailability and side effect issues while achieving enhanced transdermal delivery.Materials and methods: Three silicone templates of varying dimensions were used to fabricate 27 blank and nine PRX-HCl MNPs with PVP and PVA through mold casting method. MNPs were evaluated for physicochemical properties, in-vitro release, and ex-vivo permeation. The optimized MNP was further analyzed for FTIR, DSC, skin penetration, in-silico PBPK modeling, and stability.Results: MNPs from the optimized formulation successfully created microchannels in rat skin, demonstrated higher permeation than control MNPs with a flux of 146.18 ± 13.42 µg/cm2/h, presented a decrease in lag phase and an increase in drug plasma Cmax and AUC compared to PAXIL CR 12.5 mg oral, and showed higher stability in the room and refrigerator conditions.Conclusion: The prepared MNPs were stable and can deliver PRX-HCl sufficiently across skin barrier with enhanced bioavailability compared to oral administration at similar doses and thus be a better alternative to already available delivery systems for PRX-HCl.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"835-851"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing therapeutic delivery of microneedles through gas-propelled technology. 通过气体推进技术优化微针的治疗递送。

IF 2.2

Therapeutic delivery Pub Date : 2025-09-01 Epub Date: 2025-06-29 DOI: 10.1080/20415990.2025.2527022

Zhicheng Xiao, Xin Pan, Junhuang Jiang, Zhengwei Huang

引用次数: 0

Unlocking the full potential of piperine-loaded nanocarriers for cancer treatment. 释放装载胡椒碱的纳米载体用于癌症治疗的全部潜力。

IF 2.2

Therapeutic delivery Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI: 10.1080/20415990.2025.2542107

Girish Kumar, Beatriz Ruivinho, Tarun Virmani, Pedro Brandão, Priti Choudhary, Neeraj Kumar Chouhan, Manish Kumar, Abhishek Sharma, Md Sayeed Akhtar, Obaid Afzal, Sadaf Farooqui, Sofia O D Duarte, Pedro Fonte

{"title":"Unlocking the full potential of piperine-loaded nanocarriers for cancer treatment.","authors":"Girish Kumar, Beatriz Ruivinho, Tarun Virmani, Pedro Brandão, Priti Choudhary, Neeraj Kumar Chouhan, Manish Kumar, Abhishek Sharma, Md Sayeed Akhtar, Obaid Afzal, Sadaf Farooqui, Sofia O D Duarte, Pedro Fonte","doi":"10.1080/20415990.2025.2542107","DOIUrl":"10.1080/20415990.2025.2542107","url":null,"abstract":"In the twenty-first century, cancer continues to be a significant worldwide health concern that requires immediate and ongoing attention. Currently, chemotherapeutic treatments are constrained by various limitations, including drug resistance, nonspecific distribution, and organ toxicity. These difficulties highlight the need for safer and more efficient substitutes, like Piperine (PPN), a bioactive alkaloid obtained from Piper longum and Piper nigrum, as a viable option for cancer therapy. The diverse pharmacological characteristics of PPN, such as anti-inflammatory, antioxidant, and anticancer, make it an intriguing natural substance. However, the poor aqueous solubility, low penetration, and poor pharmacokinetic behaviors of PPNs impede its clinical translation. The design of nanoformulations of PPNs can be a promising approach to overcome its limitations, improving therapeutic effectiveness and bioavailability, while facilitating targeted delivery and synergistic effect toward cancer therapy. The current review provides an in-depth overview of the latest developments in PPN-based nanoformulations, highlighting their potential to address persistent problems in cancer treatment and pave the way for their integration into clinical oncology.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"881-901"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0