Therapeutic delivery最新文献

The simultaneous use of nanovesicles and magnetic nanoparticles for cancer targeting and imaging. 将纳米微粒和磁性纳米微粒同时用于癌症靶向和成像。

IF 3

Therapeutic delivery Pub Date : 2024-11-20 DOI: 10.1080/20415990.2024.2426447

Sara Salatin, Maryam Azarfarin, Afsaneh Farjami, Samin Hamidi

{"title":"The simultaneous use of nanovesicles and magnetic nanoparticles for cancer targeting and imaging.","authors":"Sara Salatin, Maryam Azarfarin, Afsaneh Farjami, Samin Hamidi","doi":"10.1080/20415990.2024.2426447","DOIUrl":"https://doi.org/10.1080/20415990.2024.2426447","url":null,"abstract":"Cancer is increasingly being recognized as a global health issue with considerable unmet medical need. Despite the rapid progression of anticancer pharmaceuticals, there are still significant challenges for the effective management of cancer. In many circumstances, cancer cells are difficult to detect and treat. Combination of nanovesicles (NVs) and magnetic nanoparticles (MNPs), referred as magnetic nanovesicles (MNVs), is now well recognized as a potential theranostic option for improving cancer treatment outcomes and reducing adverse effects. MNVs can be used for monitoring the long-term fate and functional benefits of cancer therapy. Moreover, MNV-mediated hyperthermia mechanism has been explored as a potential technique for triggering cancer cell death, and/or controlled release of laden cargo. In this review, we focus on the unique characteristics of MNVs as a promising avenue for targeted drug delivery, diagnosis, and treatments of cancer or tumor. Moreover, we discuss critical considerations related to the issues raised in this area, which will guide future research toward better anti-cancer therapeutics for clinical applications.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phage therapeutic delivery methods and clinical trials for combating clinically relevant pathogens. 抗击临床相关病原体的噬菌体治疗传递方法和临床试验。

IF 3

Therapeutic delivery Pub Date : 2024-11-15 DOI: 10.1080/20415990.2024.2426824

Heba Mohammed Refat M Selim, Fatma Alzahraa M Gomaa, Mohammad Y Alshahrani, Radwa N Morgan, Khaled M Aboshanab

引用次数: 0

Zein decorated rifaximin nanosuspension: approach for sustained release and anti-bacterial efficacy enhancement. Zein 修饰的利福昔明纳米悬浮液：持续释放和提高抗菌功效的方法。

IF 3

Therapeutic delivery Pub Date : 2024-11-12 DOI: 10.1080/20415990.2024.2418799

Atul Mourya, Mayank Handa, Kanchan Singh, Suresh Chintalapati, Jitender Madan, Rahul Shukla

{"title":"Zein decorated rifaximin nanosuspension: approach for sustained release and anti-bacterial efficacy enhancement.","authors":"Atul Mourya, Mayank Handa, Kanchan Singh, Suresh Chintalapati, Jitender Madan, Rahul Shukla","doi":"10.1080/20415990.2024.2418799","DOIUrl":"https://doi.org/10.1080/20415990.2024.2418799","url":null,"abstract":"Aim: The goal of the present work was to formulate zein-decorated rifaximin (RFX) nanosuspension to attain sustained release as well as effectiveness against Escherichia coli (E. coli).Methods: The RFX nanosuspension was fabricated by using antisolvent addition method followed by coating using hydroalcoholic zein solution. The optimized RFX-NS and RFX-NS@zein was lyophilized for further spectroscopic evaluations. In vitro antibacterial potential was elucidated using well diffusion method whereas MIC value was determined by microbroth dilution method against E. coli for RFX-NS and pure RFX.Results: Box-Behnken Design was employed to assess the effects of independent variables on quality target product profile of RFX-NS. Optimized RFX-NS depicted particle size of 193.5 ± 4.45 nm with 76.49 ± 1.71% drug content. The significant change in particle size and zeta potential confirmed the formation of zein coated RFX-NS (RFX-NS@zein). In vitro release study depicted, 96.91 ± 1.21% release of RFX from RFX-NS in 6 h whereas 97.47 ± 1.99% RFX release was observed from RFX-NS@zein at the end of 12 h. Antibacterial assay of RFX-NS and free RFX against E. coli displayed MIC value of 15.44 ± 0.01 μg/ml and 72.96 ± 0.25 μg/ml, respectively.Conclusion: The results highlighted a significance of nanosuspension for improving the solubility of RFX and its antibacterial potential against E. coli.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing. 海藻酸钠/羧甲基纤维素凝胶配方，含用于伤口愈合的蓝花楹植物提取物。

IF 3

Therapeutic delivery Pub Date : 2024-11-12 DOI: 10.1080/20415990.2024.2418800

Sindi P Ndlovu, Shirley C M Motaung, Samson A Adeyemi, Philemon Ubanako, Lindokuhle M Ngema, Thierry Youmbi Fonkui, Derek Tantoh Ndinteh, Pradeep Kumar, Yahya E Choonara, Blessing A Aderibigbe

引用次数: 0

Microencapsulation techniques for developing cannabidiol formulations: a review. 用于开发大麻二酚配方的微胶囊技术：综述。

IF 3

Therapeutic delivery Pub Date : 2024-11-12 DOI: 10.1080/20415990.2024.2421155

Ariel Gustavo Garro, Soledad Ravetti, Sofía Gisella Brignone, Agustín Luna, Natalia Angel Villegas, Agustina Gaitán, Santiago Daniel Palma

引用次数: 0

Artemisinin emulgel ameliorates cartilage degradation in knee osteoarthritis: in vitro and in vivo studies. 青蒿素凝胶改善膝关节骨关节炎软骨退化：体外和体内研究

IF 3

Therapeutic delivery Pub Date : 2024-11-06 DOI: 10.1080/20415990.2024.2418281

Samiksha Thote, Atul Mourya, Shristi Arya, Hoshiyar Singh, Prashanth Kumar, Santosh Kumar Guru, Jitender Madan

{"title":"Artemisinin emulgel ameliorates cartilage degradation in knee osteoarthritis: in vitro and in vivo studies.","authors":"Samiksha Thote, Atul Mourya, Shristi Arya, Hoshiyar Singh, Prashanth Kumar, Santosh Kumar Guru, Jitender Madan","doi":"10.1080/20415990.2024.2418281","DOIUrl":"https://doi.org/10.1080/20415990.2024.2418281","url":null,"abstract":"Aim: Laboratory scale-up of artemisinin-loaded emulgel (ART-emulgel) was carried out and characterized for therapeutic performance in osteoarthritis (OA).Materials & methods: The solubility of ART in various oils, surfactants and co-surfactants were screened for construction of pseudo ternary phase diagram (TPD), followed by scale-up of artemisinin loaded nanoemulsion (ART-NE). ART-NE was amalgamated with Carbopol Ultrez 10-NF to prepare ART-emulgel that was later characterized in vitro and in vivo to analyze therapeutic efficacy in monosodium-iodoacetate (MIA) induced knee OA.Results: The droplet diameter of ART-NE was estimated to be 104.3 ± 2.593 nm with a polydispersity index of 0.245 ± 0.019 in addition to ζ-potential of 0.434 ± 0.028 mV. Steady-state flux and permeability coefficient for ART-emulgel were estimated to be 0.651 ± 0.031 µg.cm2/h and 0.245 ± 0.011 cm/h, respectively. ART-emulgel demonstrated 43.18% reduction in COX-2 level; 52.28% drop in IL-1β, and 88.78% alleviation of Tumor Necrosis Factor-α (TNF-α) level when compared with monosodium-iodoacetate induced OA rats. ART-emulgel and injectable ART (intra-articular; I.A) portrayed minor synovial erosion compared with blank and diclofenac emulgel. Histopathological evidences indicated restoration of cartilage integrity followed by reduction of OARSI scores in ART-emulgel when compared with disease control animals.Conclusion: ART-emulgel is a potential dosage form for translating into a clinically viable product for the management of OA.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-17"},"PeriodicalIF":3.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive insights into glioblastoma multiforme: drug delivery challenges and multimodal treatment strategies. 全面了解多形性胶质母细胞瘤：给药挑战和多模式治疗策略。

IF 3

Therapeutic delivery Pub Date : 2024-10-24 DOI: 10.1080/20415990.2024.2415281

Ashish Dhiman, Dhwani Rana, Derajram Benival, Kalpna Garkhal

引用次数: 0

Atorvastatin loaded glycerosomal patch as an effective transdermal drug delivery: optimization and evaluation. 阿托伐他汀负载甘油囊贴片作为一种有效的透皮给药：优化与评估。

IF 3

Therapeutic delivery Pub Date : 2024-10-21 DOI: 10.1080/20415990.2024.2408218

Pravin Patil, Mrunal Rahangdale, Krutika Sawant

引用次数: 0

Industry Update: the latest developments in the field of therapeutic delivery, July 2024. 行业最新动态：2024 年 7 月治疗给药领域的最新发展。

IF 3

Therapeutic delivery Pub Date : 2024-10-18 DOI: 10.1080/20415990.2024.2414732

Peter Timmins

引用次数: 0

Strategies for transportation of peptides across the skin for treatment of multiple diseases. 跨皮肤运输肽以治疗多种疾病的策略。

IF 3

Therapeutic delivery Pub Date : 2024-10-16 DOI: 10.1080/20415990.2024.2411943

Janhavi Bhavsar, Kaustubh Kasture, Bhagyashree V Salvi, Pravin Shende

{"title":"Strategies for transportation of peptides across the skin for treatment of multiple diseases.","authors":"Janhavi Bhavsar, Kaustubh Kasture, Bhagyashree V Salvi, Pravin Shende","doi":"10.1080/20415990.2024.2411943","DOIUrl":"https://doi.org/10.1080/20415990.2024.2411943","url":null,"abstract":"An established view in genetic engineering dictates an increase in the discovery of therapeutic peptides to enable the treatment of multiple diseases. The use of hypodermic needle for delivery of proteins and peptides occurs due to the hydrophilic nature, sensitivity toward proteolytic enzymes and high molecular weight. The non-invasive nature of the transdermal delivery technique offers multiple advantages over the invasive route to release drugs directly into the systemic circulation to enhance bioavailability, better patient compliance, reduced toxicity and local irritability. The transdermal route seems highly desirable from the pharmaco-therapeutic and patient compliance point of view, however, the lipophilic barrier of skin restricts the application. The use of several techniques like electrical methods (iontophoresis, sonophoresis etc.), chemical penetration enhancers (e.g. protease inhibitors, penetration enhancers, etc.) and nanocarriers (dendrimers, lipid nanocapsules, etc.) are utilized to improve the passage of drug molecules across the biomembranes. Additionally, such clinical interventions facilitate the physicochemical characteristics of peptides, to enable effective preservation, conveyance and release of therapeutic agents. Moreover, strategies ensure the attainment of the intended targets and enhance treatment outcomes for multiple diseases. This review article focuses on the techniques of peptide transportation across the skin to advance the delivery approaches and therapeutic efficiency.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0