Therapeutic delivery最新文献_第2页

Comprehensive insights into glioblastoma multiforme: drug delivery challenges and multimodal treatment strategies. 全面了解多形性胶质母细胞瘤：给药挑战和多模式治疗策略。

IF 3

Therapeutic delivery Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1080/20415990.2024.2415281

Ashish Dhiman, Dhwani Rana, Derajram Benival, Kalpna Garkhal

引用次数: 0

Bioinspired caffeic acid-laden milk protein-based nanoparticles targeting folate receptors for breast cancer treatment. 基于生物启发的含咖啡酸牛奶蛋白的纳米颗粒，靶向叶酸受体治疗乳腺癌。

IF 3

Therapeutic delivery Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.1080/20415990.2024.2433938

Sally Safwat, Rania A H Ishak, Rania M Hathout, Nahed D Mortada

{"title":"Bioinspired caffeic acid-laden milk protein-based nanoparticles targeting folate receptors for breast cancer treatment.","authors":"Sally Safwat, Rania A H Ishak, Rania M Hathout, Nahed D Mortada","doi":"10.1080/20415990.2024.2433938","DOIUrl":"10.1080/20415990.2024.2433938","url":null,"abstract":"Aims: Breast cancer is the second leading cause of death worldwide. Conventional chemotherapeutic therapies lack the specific targeting effect toward the cancerous cells resulting in extensive side effects. Our current study endeavors to prepare novel bioinspired folic acid-functionalized caffeic acid (CA)-loaded casein nanoparticles (CS NPs) for curbing breast cancer.Methods: CA-CS NPs were prepared by simple coacervation method followed by lyophilization. Functionalized CS NPs were achieved using folic acid as the targeting moiety. Entire comparative characterization between unconjugated and conjugated NPs were implemented in terms of size, polydispersity index, surface charge, 1H-NMR, surface morphology, in-vitro drug release, sterilization, cytotoxicity, and animal studies.Results: Conjugated NPs attained PS = 157.23 ± 2.64 nm, PDI = 0.309 ± 0.199, ZP = -25.53 ± 2.31 mV and IC50 = 40 ± 2.9 µg/ml. Significant reduction in the biochemical marker levels of Carcino-embryonic antigen, carbohydrate antigen 15-3, and malondialdehyde while increased superoxide dismutase levels were achieved in the tumor -induced rats treated by the conjugated NPs. Histopathological examinations showed great improvement in the mammary and necrotic regions.Conclusion: The present work paves the road of 'back to nature' approach in designing biocompatible bioinspired conjugated nanocarriers for the diagnosis and treatment of various diseases.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"43-61"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

September 2024 therapeutic delivery: industry update. 2024年9月治疗递送：行业更新。

IF 3

Therapeutic delivery Pub Date : 2025-01-01 Epub Date: 2024-12-18 DOI: 10.1080/20415990.2024.2442298

Elaine Harris

引用次数: 0

Iron oxide nanoparticles: a versatile nanoplatform for the treatment and diagnosis of ovarian cancer. 氧化铁纳米颗粒：用于卵巢癌治疗和诊断的多功能纳米平台。

IF 3

Therapeutic delivery Pub Date : 2024-12-26 DOI: 10.1080/20415990.2024.2442301

Neelam Poonia, Vipan Kumar, Rudra Narayan Subudhi, Manoj Dalabehera, Anupama Setia, Kundan Singh Bora, Vimal Arora

{"title":"Iron oxide nanoparticles: a versatile nanoplatform for the treatment and diagnosis of ovarian cancer.","authors":"Neelam Poonia, Vipan Kumar, Rudra Narayan Subudhi, Manoj Dalabehera, Anupama Setia, Kundan Singh Bora, Vimal Arora","doi":"10.1080/20415990.2024.2442301","DOIUrl":"https://doi.org/10.1080/20415990.2024.2442301","url":null,"abstract":"Ovarian cancer remains one of the main causes of human mortality, accounting for millions of deaths every year. Despite of several clinical options such as chemotherapy, photodynamic therapy (PDT), hormonal treatment, radiation therapy, and surgery to manage this disease, the mortality rate is still very high. This alarming statistic highlights the urgent need for innovative approaches to improve both diagnosis and treatment. Success stories of iron oxide nanoparticles, i.e. Ferucarbotran (Resovist®) and Ferrixan (Cliavist®) for liver imaging, CNS (Central nervous system) imaging, cell labeling, etc. have motivated researchers to explore these nanocarriers for treatment and diagnosis of different diseases. Iron oxide nanoparticles have improved the therapeutic efficacy of anticancer drugs through targeted delivery, heat/ROS (reactive oxygen species) generation on application of external energy and have also shown great potential as contrast agents for magnetic resonance imaging (MRI). Their unique magnetic properties enable sensitive imaging, and surface modification allows the attachment of specific biomolecules for targeted detection of ovarian cancer cells. Their unique properties, viz. magnetic responsiveness and surface functionalization, make them versatile tools for enhancing both imaging and therapeutic outcomes. Present article reviews the literature on the synthesis, functionalization, and applications of iron oxide nanoparticles in management of ovarian cancer.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poloxamer 188 stabilized poly (ε-caprolactone) microspheres of voriconazole for targeting pulmonary aspergillosis. 波洛沙姆188稳定聚（ε-己内酯）伏立康唑微球治疗肺曲霉病。

IF 3

Therapeutic delivery Pub Date : 2024-12-23 DOI: 10.1080/20415990.2024.2441647

Aayush Singh, Atul Mourya, Hoshiyar Singh, Gopal Bajad, Bhavana Bojja, Shristi Arya, Shalini Devi, Santosh Kumar Guru, Jitender Madan

{"title":"Poloxamer 188 stabilized poly (ε-caprolactone) microspheres of voriconazole for targeting pulmonary aspergillosis.","authors":"Aayush Singh, Atul Mourya, Hoshiyar Singh, Gopal Bajad, Bhavana Bojja, Shristi Arya, Shalini Devi, Santosh Kumar Guru, Jitender Madan","doi":"10.1080/20415990.2024.2441647","DOIUrl":"https://doi.org/10.1080/20415990.2024.2441647","url":null,"abstract":"Aim: Voriconazole (VRZ) is highly effective in treating invasive pulmonary aspergillosis (IPA), in addition to hepatotoxicity. Therefore, the current study focuses on the development and characterization of voriconazole-loaded microspheres (VRZ@PCL MSPs) to augment pulmonary localization and antifungal efficacy.Methods: VRZ@PCL MSPs were fabricated by using the o/w emulsion method. The optimized F3VRZ@PCL MSPs were subjected to physicochemical characterization, in vitro release, hemocompatibility, antifungal efficacy as well as pharmacokinetic and biodistribution evaluation.Results: The optimized F3VRZ@MSPs exhibited a particle size (10.90 ± 2.61 µm), entrapment efficiency (19.35 ± 2.47%), drug loading (3.22 ± 0.41%) with sustained release behavior up to 24 h and hemocompatibility upto 50 µg/mL. Results of antifungal testing indicated the superior antifungal potential of F3VRZ@PCL MSPs as compared to free VRZ and nystatin. In vivo pharmacokinetic evaluation in Sprague-Dawley rats displayed 12.5-fold and 4.5-fold increments, respectively, in t1/2 and AUC0-t of F3VRZ@PCL MSPs as compared to free VRZ. Moreover, F3VRZ@PCL MSPs displayed relatively higher lung targeting with a drug targeting index (DTI) of 0.213 as compared to DTI of 0.037 of free VRZ.Conclusion: In conclusion, F3VRZ@PCL MSPs offer a promising approach for sustained and targeted delivery of VRZ and hold the potential to offer high therapeutic efficacy in the treatment of IPA.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical dutasteride for androgenic alopecia: current state and prospects. 局部杜他雄胺治疗雄激素性脱发：现状和前景。

IF 3

Therapeutic delivery Pub Date : 2024-12-06 DOI: 10.1080/20415990.2024.2437973

Jayanaraian F M Andrade, Andrew Verbinnen, Andrew Bakst, Marcílio Cunha-Filho, Guilherme M Gelfuso, Taís Gratieri

引用次数: 0

The simultaneous use of nanovesicles and magnetic nanoparticles for cancer targeting and imaging. 将纳米微粒和磁性纳米微粒同时用于癌症靶向和成像。

IF 3

Therapeutic delivery Pub Date : 2024-11-20 DOI: 10.1080/20415990.2024.2426447

Sara Salatin, Maryam Azarfarin, Afsaneh Farjami, Samin Hamidi

{"title":"The simultaneous use of nanovesicles and magnetic nanoparticles for cancer targeting and imaging.","authors":"Sara Salatin, Maryam Azarfarin, Afsaneh Farjami, Samin Hamidi","doi":"10.1080/20415990.2024.2426447","DOIUrl":"https://doi.org/10.1080/20415990.2024.2426447","url":null,"abstract":"Cancer is increasingly being recognized as a global health issue with considerable unmet medical need. Despite the rapid progression of anticancer pharmaceuticals, there are still significant challenges for the effective management of cancer. In many circumstances, cancer cells are difficult to detect and treat. Combination of nanovesicles (NVs) and magnetic nanoparticles (MNPs), referred as magnetic nanovesicles (MNVs), is now well recognized as a potential theranostic option for improving cancer treatment outcomes and reducing adverse effects. MNVs can be used for monitoring the long-term fate and functional benefits of cancer therapy. Moreover, MNV-mediated hyperthermia mechanism has been explored as a potential technique for triggering cancer cell death, and/or controlled release of laden cargo. In this review, we focus on the unique characteristics of MNVs as a promising avenue for targeted drug delivery, diagnosis, and treatments of cancer or tumor. Moreover, we discuss critical considerations related to the issues raised in this area, which will guide future research toward better anti-cancer therapeutics for clinical applications.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phage therapeutic delivery methods and clinical trials for combating clinically relevant pathogens. 抗击临床相关病原体的噬菌体治疗传递方法和临床试验。

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Therapeutic delivery Pub Date : 2024-11-15 DOI: 10.1080/20415990.2024.2426824

Heba Mohammed Refat M Selim, Fatma Alzahraa M Gomaa, Mohammad Y Alshahrani, Radwa N Morgan, Khaled M Aboshanab

引用次数: 0

Microencapsulation techniques for developing cannabidiol formulations: a review. 用于开发大麻二酚配方的微胶囊技术：综述。

IF 3

Therapeutic delivery Pub Date : 2024-11-12 DOI: 10.1080/20415990.2024.2421155

Ariel Gustavo Garro, Soledad Ravetti, Sofía Gisella Brignone, Agustín Luna, Natalia Angel Villegas, Agustina Gaitán, Santiago Daniel Palma

引用次数: 0

Industry Update: the latest developments in the field of therapeutic delivery, July 2024. 行业最新动态：2024 年 7 月治疗给药领域的最新发展。