Therapeutic delivery最新文献_第3页

Alternative photosensitizer penetration depth evaluation in ex vivo human eyes for photodynamic antimicrobial therapy. 光动力抗菌剂在离体人眼中的替代光敏剂渗透深度评价。

IF 3

Therapeutic delivery Pub Date : 2025-06-01 Epub Date: 2025-04-16 DOI: 10.1080/20415990.2025.2491293

James M Lai, Katherine Krishna, Brandon Chou, Justin Chen, Kyle Rowley, Juan Carlos Navia, Heather Durkee, Mariela C Aguilar, Katrina Llanes, Noel Ziebarth, Jaime D Martinez, Darlene Miller, Harry W Flynn, Guillermo Amescua, Jean-Marie Parel

{"title":"Alternative photosensitizer penetration depth evaluation in ex vivo human eyes for photodynamic antimicrobial therapy.","authors":"James M Lai, Katherine Krishna, Brandon Chou, Justin Chen, Kyle Rowley, Juan Carlos Navia, Heather Durkee, Mariela C Aguilar, Katrina Llanes, Noel Ziebarth, Jaime D Martinez, Darlene Miller, Harry W Flynn, Guillermo Amescua, Jean-Marie Parel","doi":"10.1080/20415990.2025.2491293","DOIUrl":"10.1080/20415990.2025.2491293","url":null,"abstract":"Purpose: Fungal keratitis has a poor prognosis given deep penetration into the corneal stroma. While Rose Bengal photodynamic antimicrobial therapy (RB-PDAT) is a promising adjunct treatment for refractory cases, poor penetration limits its effectiveness. This study explores the penetration depth of alternative photosensitizers to address this issue.Methods: Thirty-five human corneas were soaked for 30 minutes in 0.0075% solution of Rose Bengal disodium (n = 5), Rose Bengal lactone (n = 5), Erythrosin B disodium (n = 5), Erythrosin B lactone (n = 5), Eosin Y disodium (n = 5), Methylene blue (n = 5), or NaCl (control, n = 5). Confocal microscopy was used to assess penetration depth.Results: All photosensitizers penetrated greater into the cornea as compared to control. There was no significant difference in penetration between Rose Bengal lactone and Rose Bengal disodium (RB lactone: 106 ± 11 µm vs RB disodium: 99 ± 13 µm, p > 0.05). The penetration depths of the alternative photosensitizers was significantly greater than either Rose Bengal formulation (Erythrosin Blactone: 192 ± 31 µm, Erythrosin B disodium: 163 ± 13 µm, Eosin Y disodium: 249 ± 31 µm, Methylene Blue: 355 ± 151 µm).Conclusions: Alternative photosensitizers exhibit superior penetration compared to Rose Bengal. However, antimicrobial efficacy and corneal safety require more robust evaluation before clinical use.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"519-526"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advantages and therapeutic applications of different semisolids as vehicles for nano-based systems. 不同半固体作为纳米系统载体的优势和治疗应用。

IF 3

Therapeutic delivery Pub Date : 2025-06-01 Epub Date: 2025-03-21 DOI: 10.1080/20415990.2025.2483151

Eman Samy Shalaby, Samy I Shalaby, Shaymaa A Ismail

引用次数: 0

Development of high-solubility amorphous sulfasalazine: effect of hydrogen bonding. 高溶解度非晶磺胺嘧啶的研制：氢键效应。

IF 3

Therapeutic delivery Pub Date : 2025-06-01 Epub Date: 2025-04-09 DOI: 10.1080/20415990.2025.2491291

Sama Hamzehlou, Elaheh Rahimpour, Anahita Fathi Azarbayjani, Abolghasem Jouyban

{"title":"Development of high-solubility amorphous sulfasalazine: effect of hydrogen bonding.","authors":"Sama Hamzehlou, Elaheh Rahimpour, Anahita Fathi Azarbayjani, Abolghasem Jouyban","doi":"10.1080/20415990.2025.2491291","DOIUrl":"10.1080/20415990.2025.2491291","url":null,"abstract":"Introduction: Sulphasalazine (Sulf) is a class IV compound with low aqueous solubility and low permeability which limit its therapeutic activity. This work aims to apply choline chloride (CC) and choline hydroxide (CH) as a hydrogen bond acceptor with Sulf for the production of Sulf salt.Materials and method: New compounds were prepared and characterized by XRD, DSC, and FT-IR. Drug solubility was evaluated in different media including pure water, and buffer pH 1.2, 4.5, and 6.8 were evaluated.Results: The diffractogram pattern of the Sulf-CH shows a smooth and low-intensity diffraction which may indicate amorphization of the drug molecule. The FT-IR spectra confirm participation of the carboxyl group of Sulf in the formation of hydrogen bonding between Sulf and CH through salt formation which helps to enhance drug solubility. Solubility of Sulf-CH significantly increased up to 10,000-folds in pure water. Sulf-CC caused up to 2-folds enhancement in drug solubility.Conclusion: The difference in the solubility of Sulf-CC and Sulf-CH may suggest that each of these compounds involve different intermolecular interactions which were also confirmed by FT-IR, XRD, and DSC results. This effect can influence drug bioavailability and enhance its therapeutic efficacy.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"527-533"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How does mathematical modeling improve our understanding and design of biological immunomodulators? 数学建模如何提高我们对生物免疫调节剂的理解和设计？

IF 3

Therapeutic delivery Pub Date : 2025-05-18 DOI: 10.1080/20415990.2025.2506980

Jonathon DeBonis, Oleg A Igoshin

引用次数: 0

Advanced delivery systems for oxygen therapeutics: center around red blood cells. 氧气治疗的先进输送系统：以红细胞为中心。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-03-09 DOI: 10.1080/20415990.2025.2475737

Wujie Zhang, Michael Navin

引用次数: 0

Correction. 修正。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-02-21 DOI: 10.1080/20415990.2025.2469959

引用次数: 0

Evaluation of chloramphenicol derivative N-phenyl 2, 2 dichloroacetamide anticancer and antibacterial properties. 氯霉素衍生物n -苯基2,2二氯乙酰胺的抗癌和抗菌性能评价。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-03-10 DOI: 10.1080/20415990.2025.2476928

Arwa Al Khatib, Anas Abed, Hamdi Nsairat, Mohamed El-Tanani, Muhammad Yaqoob, Hisham Al-Obaidi

引用次数: 0

Next-gen ferulic acid-stabilized gold nanoparticles: exploring their sensing capabilities and therapeutic efficacy. 新一代阿魏酸稳定金纳米颗粒：探索其传感能力和治疗效果。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-03-20 DOI: 10.1080/20415990.2025.2472733

Atiya Kaleem, Aisha Sana, Rafia Usman Khan, Safila Naveed, Fatima Qamar, Syeda Zainab, Javed Iqbal, Brijesh Sathian

{"title":"Next-gen ferulic acid-stabilized gold nanoparticles: exploring their sensing capabilities and therapeutic efficacy.","authors":"Atiya Kaleem, Aisha Sana, Rafia Usman Khan, Safila Naveed, Fatima Qamar, Syeda Zainab, Javed Iqbal, Brijesh Sathian","doi":"10.1080/20415990.2025.2472733","DOIUrl":"10.1080/20415990.2025.2472733","url":null,"abstract":"Aim: This study focuses on the synthesis and evaluation of innovative gold nanoparticles (AuNps) stabilized by short-chain ferulic acid (FA), specifically 4-hydroxy-3-methoxy-cinnamic acid.Methods: We analyzed the size and distribution of FA-TSC-AuNps and FA-NaBH4-AuNps, with the reduction kinetics of Au3 + to Au0. The electronic and optical properties of these AuNps were scrutinized using UV-visible, AFM, and FT-IR.Results: AFM distinctly showcased spherical particles, average diameters of 4 ± 1 nm for FA-TSC-AuNps and 11 ± 1 nm for FA-NaBH4-AuNps systems. In the DPPH assay, the anti-scavenging activity recorded values of: FA at 15.4% ± 0.32, FA-TSC-AuNps at an impressive 86.8% ± 0.32, and FA-NaBH4-AuNps at 61.5% ± 0.22. The ABTS assay yielded results of: FA at 13%, FA-TSC-AuNps at 70.14%, and FA-NaBH4-AuNps at a remarkable 92.8%. Catalytic investigations revealed that both facilitated the swift conversion of p-nitrophenol to p-aminophenol. Additionally successful chemo sensing capabilities were assessed, particularly in relation to ciprofloxacin antibiotic by distinct shift in color signifies the effective detection capability of both sensory systems for the drug. Moreover, with FA-TSC-AuNps exhibiting significant sensitivity toward aluminum.Conclusion: These nanoparticles suggest promising avenues for drug system modifications and enhancements, highlighting their multifaceted potential in both catalytic and chemo sensing applications.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"447-457"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug delivery systems incorporating bile salts: advancements since the conception of bilosomes. 含胆盐的药物输送系统：自胆囊体概念以来的进展。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI: 10.1080/20415990.2025.2469488

Mohammad A Obeid, Marta Ruano-Aldea, Reinaldo Acevedo, Virgil Schjins, Manal M Alsaadi, Valerie A Ferro

{"title":"Drug delivery systems incorporating bile salts: advancements since the conception of bilosomes.","authors":"Mohammad A Obeid, Marta Ruano-Aldea, Reinaldo Acevedo, Virgil Schjins, Manal M Alsaadi, Valerie A Ferro","doi":"10.1080/20415990.2025.2469488","DOIUrl":"10.1080/20415990.2025.2469488","url":null,"abstract":"This review explores the advancements in drug delivery systems that incorporate bile salts since bilosomes that were developed over 20 years ago. Bile salts, recognized for their unique amphiphilic properties, have emerged as versatile agents in enhancing solubility, stability, and bioavailability of various therapeutics. We discuss the innovative formulations developed, including micelles, liposomes, and nanoparticles, that leverage bile salts to facilitate targeted and sustained release. The review also highlights the mechanisms by which bile salts improve drug absorption, particularly for hydrophobic compounds, and examines the evolving regulatory landscape surrounding these systems. Furthermore, we address challenges faced in clinical translation and future directions for research, emphasizing the potential of bile salt-based systems in personalized medicine. Our evaluation highlights the significant role of bile salts in advancing drug delivery technologies and their promise for improving therapeutic outcomes.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"487-500"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective release of Eryngium maritimum L. callus extract via encapsulation in multilayered liposomes for skin delivery. 通过封装在多层脂质体中有效释放海腥草茧提取物，用于皮肤给药。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-02-28 DOI: 10.1080/20415990.2025.2470614

Euihyun Kim, Jihyeon Jang, Myeong-Jin Lim, Soo-Yun Kim, Seon Kyu Yun, Jihyeok Song, Hyo Hyun Seo, Jeong Hun Lee, Sang Hyun Moh

{"title":"Effective release of Eryngium maritimum L. callus extract via encapsulation in multilayered liposomes for skin delivery.","authors":"Euihyun Kim, Jihyeon Jang, Myeong-Jin Lim, Soo-Yun Kim, Seon Kyu Yun, Jihyeok Song, Hyo Hyun Seo, Jeong Hun Lee, Sang Hyun Moh","doi":"10.1080/20415990.2025.2470614","DOIUrl":"10.1080/20415990.2025.2470614","url":null,"abstract":"Aims: This study aimed to evaluate the potential of Eryngium maritimum L. (EM) callus media filtrate (ECMF) for enhanced skin delivery through multilayered liposomes (MLs).Materials & methods: ECMF was applied to human skin cells to assess its antioxidant, anti-inflammatory, and skin barrier-enhancing properties. ECMF was encapsulated in MLs to enhance delivery efficiency, creating a formulation called Cellbiome. Clinical trials involving human participants were conducted to compare its effects with traditional formulations, assessing parameters such as skin density, hydration, elasticity, and wrinkle reduction.Results: Cellbiome significantly improved skin density and moisturization, outperforming conventional formulations. ML encapsulation facilitated deeper penetration of active ingredients beyond the stratum corneum, leading to synchronized improvements in multiple skin parameters, including elasticity, wrinkle reduction, and overall skin health. Transcriptomic and metabolomic analyses further confirmed ECMF's bioactivity and its role in skin improvement.Conclusions: ML-based formulations, such as Cellbiome, offer superior efficacy in skincare applications compared to conventional methods. This study underscores the importance of advanced delivery technologies in cosmetics and highlights the need for further research to optimize the benefits of natural extracts like EM for human skin, potentially advancing dermatological and cosmeceutical applications.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"459-473"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0