Therapeutic delivery最新文献_第3页

PROTEX platforms as molecular navigators in oral squamous cell carcinoma. PROTEX平台在口腔鳞状细胞癌中的分子导航作用。

IF 3.4

Therapeutic delivery Pub Date : 2026-07-01 Epub Date: 2026-07-20 DOI: 10.1080/20415990.2026.2705088

Debnath Das, Sourabh Kumar, Nisha Bharti, Viresh Kumar, Rohit Sharma, Balak Das Kurmi, Manish Kumar

引用次数: 0

Formulation and in vitro-in silico characterization of prolonged-release prednisolone acetate spheroids. 醋酸泼尼松龙缓释球体的制备及体外硅表征。

IF 3.4

Therapeutic delivery Pub Date : 2026-07-01 Epub Date: 2026-08-27 DOI: 10.1080/20415990.2026.2721793

Aleksandra Ćoškov, Nemanja Todorović, Senka Popović, Doroteja Arbutina, Nebojša Kladar, Nataša Milošević, Mladena Lalić-Popović

{"title":"Formulation and in vitro-in silico characterization of prolonged-release prednisolone acetate spheroids.","authors":"Aleksandra Ćoškov, Nemanja Todorović, Senka Popović, Doroteja Arbutina, Nebojša Kladar, Nataša Milošević, Mladena Lalić-Popović","doi":"10.1080/20415990.2026.2721793","DOIUrl":"10.1080/20415990.2026.2721793","url":null,"abstract":"Aims: The aims of this study were to develop alginate-based spheroid formulations for the prolonged release of prednisolone acetate, their in vitro and in silico characterization, and identification of formulation key factors influencing drug release behavior.Methods: Prednisolone acetate spheroids were prepared by extrusion using 2% and 2.5% sodium alginate solutions and different needle diameters. Spheroids containing 30 mg of the drug were filled into gastro-resistant capsules, while controls contained pure drug. Content of prednisolone acetate and calcium, loss on drying, flow properties, dissolution behavior, FTIR spectra, and in silico regional absorption, using GastroPlus were evaluated.Results: Spheroid formulations with similar drug composition exhibited excellent flowability. Dissolution studies revealed that the release profiles of prednisolone acetate from the produced formulations differ significantly when compared to the pure substance dissolution profile. In silico model predicted the highest absorption rate in the cecum and the ascending colon.Conclusion: Spheroids derived from sodium alginate have demonstrated the ability to provide prolonged release of prednisolone acetate. Sodium alginate concentration and needle diameter were identified as key formulation factors; their increase enhanced the spheroid resistance to the simulated experimental conditions.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"663-674"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric nanoparticle platforms for ibrutinib delivery: tackling solubility, CYP3A4-mediated metabolism, and resistance to facilitate BTK-targeted therapy in solid tumours. 用于伊鲁替尼递送的聚合物纳米颗粒平台：解决溶解度，cyp3a4介导的代谢，以及促进实体肿瘤btk靶向治疗的耐药性。

IF 3.4

Therapeutic delivery Pub Date : 2026-07-01 Epub Date: 2026-08-25 DOI: 10.1080/20415990.2026.2721795

Yash Dhananand Sonawane, Sankha Bhattacharya

{"title":"Polymeric nanoparticle platforms for ibrutinib delivery: tackling solubility, CYP3A4-mediated metabolism, and resistance to facilitate BTK-targeted therapy in solid tumours.","authors":"Yash Dhananand Sonawane, Sankha Bhattacharya","doi":"10.1080/20415990.2026.2721795","DOIUrl":"10.1080/20415990.2026.2721795","url":null,"abstract":"Because of its poor aqueous solubility, low oral bioavailability, extensive cytochrome P450 3A4 (CYP3A4)-mediated metabolism, and acquired resistance, ibrutinib, a first-in-class covalent Bruton's tyrosine kinase (BTK) inhibitor, has shown limited efficacy in solid tumors despite revolutionizing the treatment of B-cell malignancies. Despite growing evidence linking BTK and 65-kDa Bruton's tyrosine kinase isoform (p65BTK) signaling to nuclear factor kappa-B (NF-κB) and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT)-mediated tumor progression, immune evasion, and therapeutic resistance, these limitations have limited its therapeutic repurposing in breast, lung, colorectal cancer (CRC), and glioblastoma. While acknowledging the variable clinical applicability of the enhanced permeability and retention (EPR) effect in human tumors, this review critically assesses recent developments in polymeric nanoparticle (PNP)-based delivery systems for Ibrutinib, highlighting their potential to improve drug stability, enable sustained and stimuli-responsive release, enhance tumor accumulation, and facilitate active ligand-mediated targeting. A thorough literature search of PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar found studies published between 2010 and 2026. Preclinical data collectively show that PNPs improve antitumor efficacy, alter the tumor microenvironment, inhibit drug resistance and cancer stemness, lower systemic toxicity, and offer a promising platform for the clinical translation of precision BTK-targeted nanomedicine in solid tumors.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"759-787"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative evaluation of ultracentrifugation and PEG-based precipitation of mesenchymal stem cell‑derived extracellular vesicles: equivalent functionality with enhanced practicality. 间充质干细胞来源的细胞外囊泡的超离心和聚乙二醇沉淀的比较评价：同等功能和增强的实用性。

IF 3.4

Therapeutic delivery Pub Date : 2026-07-01 Epub Date: 2026-08-12 DOI: 10.1080/20415990.2026.2715875

Aishwarya Sivakumar, Vijayalakshmi Kumaravel, Senthamizh Gopal, Raghu Babu Pothireddy

{"title":"Comparative evaluation of ultracentrifugation and PEG-based precipitation of mesenchymal stem cell‑derived extracellular vesicles: equivalent functionality with enhanced practicality.","authors":"Aishwarya Sivakumar, Vijayalakshmi Kumaravel, Senthamizh Gopal, Raghu Babu Pothireddy","doi":"10.1080/20415990.2026.2715875","DOIUrl":"10.1080/20415990.2026.2715875","url":null,"abstract":"Aim: The isolation efficiency of extracellular vesicles (EVs) is essential to ensure their purity and biological properties. Ultracentrifugation is a traditional method which utilizes high centrifugal forces to separate EVs based on their density. The polyethylene glycol (PEG)-based precipitation method is a scalable and cost-efficient alternative to ultracentrifugation. In this study, two popular techniques used for the isolation of EVs from umbilical cord tissue-derived mesenchymal stem cells (UCT-MSCs): ultracentrifugation and polyethylene glycol PEG-based precipitation methods are examined.Materials and methods: The UCT-MSCs were cultured in a xeno-free environment using human platelet lysate (hPL) to avoid the risk of xenogenic contamination. The MSCs and EVs were characterized to confirm their physical and functional properties. Cytotoxicity was analyzed in both normal and cancer cells, and the cell migration assay was conducted on cancer cells treated with the EVs to examine the biocompatibility and migratory effects.Results and conclusions: The similarity in physical, molecular, and functional characterization of UC-EVs and PEG-EVs suggests that PEG-based precipitation maintained the integrity and biological properties of EVs. Overall, the PEG-based precipitation method for EVs isolation is safe and efficient, making them suitable for regeneration and cancer research.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"637-647"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turmeric nanovesicles loaded with vitamins C and E attenuate oxidative stress and improve cognitive outcomes in rats with memory deficits. 含有维生素C和E的姜黄纳米囊泡可以减轻氧化应激，改善记忆缺陷大鼠的认知结果。

IF 3.4

Therapeutic delivery Pub Date : 2026-07-01 Epub Date: 2026-08-26 DOI: 10.1080/20415990.2026.2715894

Amina Jiyah, Ibrahim Bulama, Andrew Onu, Abubakar Yaya Gimba, Abdullahi Yahya Abbas, Yusuf Saidu, Lawal Suleiman Bilbis, Suleiman Alhaji Muhammad

{"title":"Turmeric nanovesicles loaded with vitamins C and E attenuate oxidative stress and improve cognitive outcomes in rats with memory deficits.","authors":"Amina Jiyah, Ibrahim Bulama, Andrew Onu, Abubakar Yaya Gimba, Abdullahi Yahya Abbas, Yusuf Saidu, Lawal Suleiman Bilbis, Suleiman Alhaji Muhammad","doi":"10.1080/20415990.2026.2715894","DOIUrl":"10.1080/20415990.2026.2715894","url":null,"abstract":"Aim: Oxidative stress (OS) contributes to Alzheimer's disease (AD) pathology. Vitamins C and E target OS, but their efficacies are limited by poor intracellular delivery. Encapsulation in nanovesicles (NVs) may improve targeted delivery for AD treatment.Methods: Forty-five rats were randomly assigned to nine groups (n = 5 per group): normal control, scopolamine control, vitamin C, vitamin E, vitamin C + E, turmeric NVs (TNV), TNV-C, TNV-E, and donepezil. Treatment was administered intraperitoneally (IP) for one week before induction of the AD-like model using daily IP administration of scopolamine and continued for two weeks. During this time, behavioral activities were conducted, and brain tissues were collected for analysis.Results: Vitamins C and E showed encapsulation efficiencies of 12.36 ± 1.01% and 55.24 ± 5.82%, with loading capacities of 14.34 ± 1.37% and 40.70 ± 3.52, respectively. TNV-C and TNV-E increased brain levels of vitamins E and C, enhanced antioxidant defense and cognitive abilities, and reduced acetylcholinesterase activity in dementia rats. TNV-C and TNV-E also protected against neuroinflammation and neuritic plaque formation. Vitamin-loaded TNVs were more effective than free vitamins in improving antioxidant status and cognitive outcomes in AD rats.Conclusion: This study highlights the potential of vitamin-loaded NVs as therapeutics for AD.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"649-662"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capsaicin and diclofenac coloaded nanoemulsion gel optimized by quality by design approach of for the treatment of rheumatoid arthritis. 采用设计方法对治疗类风湿性关节炎的辣椒素双氯芬酸负载纳米乳凝胶进行了质量优化。

IF 3.4

Therapeutic delivery Pub Date : 2026-07-01 Epub Date: 2026-08-11 DOI: 10.1080/20415990.2026.2700163

Saurabh Mittal, Indu Singh, Rupali Verma, Mahima Gupta, Shikha Baghel Chauhan, Sushama Talegaonkar

{"title":"Capsaicin and diclofenac coloaded nanoemulsion gel optimized by quality by design approach of for the treatment of rheumatoid arthritis.","authors":"Saurabh Mittal, Indu Singh, Rupali Verma, Mahima Gupta, Shikha Baghel Chauhan, Sushama Talegaonkar","doi":"10.1080/20415990.2026.2700163","DOIUrl":"10.1080/20415990.2026.2700163","url":null,"abstract":"Aims: Rheumatoid arthritis (RA) is a chronic inflammatory disorder associated with progressive joint damage and pain. The present study aimed to develop and optimize a capsaicin - diclofenac-loaded nanoemulgel incorporating clove and olive oil for enhanced topical delivery and therapeutic efficacy in RA management.Materials and methods: Central composite design was employed to optimize nanoemulsion composition using oil (5-10%) and Smix (15-20%) as independent variables. The optimized formulation was characterized for particle size, polydispersity index (PDI), zeta potential, transmittance, morphology, rheology, antioxidant activity, cytotoxicity, cell viability, and skin permeation behavior.Results: Optimized formulation exhibited particle size below 200 nm, PDI below 0.3, zeta potential below -10 mV, and transmittance of 92.6%, indicating good stability. Microscopic studies confirmed spherical globules. The nanoemulgel showed skin-compatible pH and non-Newtonian rheological behavior. Enhanced in vitro permeation, deeper skin penetration, and superior antioxidant activity (76.80 ± 2.90%) were observed compared to the conventional suspension. The formulation also demonstrated higher cytotoxicity against inflammatory U937 macrophage-like cells (58.2% at 50 μg/mL), lower IC50 (28.8 μg/mL), and improved MG-63 cell viability (85.8%).Conclusions: The developed nanoemulgel demonstrated improved physicochemical characteristics, enhanced skin permeation, and promising anti-inflammatory potential, suggesting its suitability as an effective topical delivery system for rheumatoid arthritis management.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"675-692"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering strategies and translational progress in targeted nanoparticle drug delivery. 靶向纳米颗粒给药的工程策略和转化进展。

IF 3.4

Therapeutic delivery Pub Date : 2026-07-01 Epub Date: 2026-08-03 DOI: 10.1080/20415990.2026.2713917

Nithya Ajay, Anu Shibi Anilkumar, Ramakrishnan Veerabathiran

{"title":"Engineering strategies and translational progress in targeted nanoparticle drug delivery.","authors":"Nithya Ajay, Anu Shibi Anilkumar, Ramakrishnan Veerabathiran","doi":"10.1080/20415990.2026.2713917","DOIUrl":"10.1080/20415990.2026.2713917","url":null,"abstract":"Introduction: Nanoparticle-based drug delivery has emerged as a transformative approach in modern therapeutics, offering improved targeting efficiency, enhanced pharmacokinetics, and reduced systemic toxicity compared to conventional drug delivery systems.Areas covered: This review comprehensively examines major nanocarrier platforms, including lipid-based, polymeric, inorganic, and hybrid systems, with emphasis on their structural design and functional properties. It further explores current advancements in targeting strategies, including passive targeting via the enhanced permeability and retention (EPR) effect and active targeting through ligand-receptor interactions involving antibodies, peptides, aptamers, and small molecules. Key biological and technological barriers to clinical translation are also discussed, such as tumor heterogeneity, abnormal vasculature, dense extracellular matrix, immune clearance, and limited cellular uptake. Additionally, emerging stimuli-responsive systems, including pH-, redox-, and enzyme-sensitive nanocarriers, are highlighted for their role in controlled and site-specific drug release.Expert opinion/commentary: Despite significant progress, the clinical translation of nanomedicine remains constrained by biological complexities and scalability challenges. Future advancements integrating biomimetic strategies, multifunctional design, and artificial intelligence-driven modeling are expected to enhance targeting precision, biocompatibility, and translational success.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"693-717"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavonoid nanoformulations for cutaneous administration: overcoming delivery barriers for targeted therapeutics and bioavailability enhancement. 用于皮肤给药的类黄酮纳米制剂：克服靶向治疗的递送障碍和生物利用度增强。

IF 3.4

Therapeutic delivery Pub Date : 2026-06-01 Epub Date: 2026-07-03 DOI: 10.1080/20415990.2026.2696196

Aya Said, Eman M El-Marakby, Mona M A Abdel-Mottaleb, Amany O Kamel

{"title":"Flavonoid nanoformulations for cutaneous administration: overcoming delivery barriers for targeted therapeutics and bioavailability enhancement.","authors":"Aya Said, Eman M El-Marakby, Mona M A Abdel-Mottaleb, Amany O Kamel","doi":"10.1080/20415990.2026.2696196","DOIUrl":"10.1080/20415990.2026.2696196","url":null,"abstract":"Flavonoids represent one of the most pharmacologically diverse classes of natural polyphenols, demonstrating broad therapeutic potential in oncology, neurodegeneration, cardiovascular, and metabolic disorders. However, their clinical utility has been limited by intrinsic physicochemical deficiencies, including low aqueous solubility, chemical instability, and extensive first-pass metabolism. Traditional formulation strategies have proven inadequate at overcoming these barriers. Nano-enabled delivery platforms circumvent these limitations through rational nanocarrier design, effectively enhancing dissolution kinetics, protecting labile compounds from degradation, and modulating tissue distribution. This comprehensive review critically examines the current landscape of flavonoid-loaded nanoformulations on the recent advancements (2020-2025), with a particular emphasis on cutaneous delivery (topical/transdermal), elucidating formulation-driven mechanisms of bioavailability enhancement. Furthermore, it critically highlights the growing significance of co-delivery approaches of flavonoids with other therapeutic agents or with each other within advanced nanoplatforms in improving therapeutic benefits or diminishing the drug's adverse effects. Nano-engineered delivery platforms effectively neutralize the bioavailability constraints of flavonoids, unlocking their full pharmacological potential and elevating clinical therapeutic efficacy.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-21"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination therapy strategies for diabetic foot ulcers: synthesizing antibiotics, growth factors, and nanocarriers in modern wound management. 糖尿病足溃疡的联合治疗策略：合成抗生素、生长因子和纳米载体在现代伤口管理中的应用。

IF 3.4

Therapeutic delivery Pub Date : 2026-06-01 Epub Date: 2026-07-09 DOI: 10.1080/20415990.2026.2699574

Priyanshu Pathak, Shatrudhan Prajapati, Shikha Yadav

{"title":"Combination therapy strategies for diabetic foot ulcers: synthesizing antibiotics, growth factors, and nanocarriers in modern wound management.","authors":"Priyanshu Pathak, Shatrudhan Prajapati, Shikha Yadav","doi":"10.1080/20415990.2026.2699574","DOIUrl":"10.1080/20415990.2026.2699574","url":null,"abstract":"Diabetic foot ulcers (DFUs) are serious complications of diabetes, and consist of chronic wound healing, chronic biofilm infection, impaired angiogenesis, oxidized stress, and persistent inflammation. Standard treatments such as systemic antibiotics and growth factors have been found to be ineffective due to poor tissue penetration, degradation and antimicrobial resistance. The aim of this review is to critically analyze advanced strategies for combination therapy using antibiotics, growth factors and/or nanocarriers in order to better manage DFU. Literature was searched in PubMed, Scopus, Web of Science, and Google Scholar databases from January 2010 to March 2026 using keywords related to DFUs, antibiotics, growth factors, nanocarriers, biofilms, and wound healing. Combination nanotherapeutic systems exhibited potential to improve local drug delivery, disrupt biofilms, promote angiogenesis and support tissue regeneration. Stimuli-responsive and sequential-release platforms could enhance therapeutic precision by synchronizing antimicrobial and regenerative functions. Controlled release and modulation of the wound microenvironment are also enhanced by engineering scaffolds and multifunctional biomaterials. Yet the hurdles of biosafety, oxidative cytotoxicity, manufacturing scale-up, regulatory approval, and extended clinical duration remain significant obstacles to translation. Advanced multifunctional nanotherapeutics represent promising emerging strategies for precision-based DFU treatment and may improve infection control, tissue regeneration, and clinical healing outcomes.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-18"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ternary co-encapsulation in electrospun PVA fibers: release kinetics and mechanisms. 静电纺PVA纤维的三元共包封：释放动力学和机制。

IF 3.4

Therapeutic delivery Pub Date : 2026-06-01 Epub Date: 2026-06-24 DOI: 10.1080/20415990.2026.2692882

Andrea Ximena Esparza Monroy, Rebeca Betancourt Galindo, Antonio Serguei Ledezma Pérez, Arxel De León Santillán, Roberto Espinoza Neira, Carmen Natividad Alvarado Canché, Christian Chapa González, Perla Elvia García-Casillas

{"title":"Ternary co-encapsulation in electrospun PVA fibers: release kinetics and mechanisms.","authors":"Andrea Ximena Esparza Monroy, Rebeca Betancourt Galindo, Antonio Serguei Ledezma Pérez, Arxel De León Santillán, Roberto Espinoza Neira, Carmen Natividad Alvarado Canché, Christian Chapa González, Perla Elvia García-Casillas","doi":"10.1080/20415990.2026.2692882","DOIUrl":"10.1080/20415990.2026.2692882","url":null,"abstract":"Aims: This study aimed to develop and evaluate a ternary co-encapsulation system based on electrospun poly(vinyl alcohol) (PVA) nanofibers containing Aloe vera extract, methylglyoxal (MGO), and collagen for multifunctional wound-healing applications with controlled therapeutic delivery.Materials and methods: Electrospun nanofibers were characterized by scanning electron microscopy and FTIR spectroscopy. Swelling, degradation, and in vitro release profiles were evaluated under physiological conditions. Release kinetics were analyzed using Korsmeyer-Peppas and Weibull models. Antimicrobial activity against Escherichia coli and Staphylococcus aureus was assessed according to JIS Z 2801. Cytocompatibility was evaluated using human fibroblast cultures following ISO 10993-5 guidelines.Results: The co-encapsulated nanofibers exhibited homogeneous morphology with fiber diameters of 350-500 nm and preserved bioactive agents´ integrity. The system showed a biphasic release profile, with rapid Aloe vera release (~80% within 4 h) followed by sustained MGO and collagen release up to 160 h. Release behavior involved coupled diffusion, polymer relaxation, and partial matrix dissolution. The ternary system demonstrated strong antimicrobial activity, achieving approximately 99.4% inhibition of E. coli, while maintaining excellent cytocompatibility with cell viability above 100%.Conclusions: The ternary co-encapsulation strategy synergistic antimicrobial and regenerative effects through controlled multi-agent delivery in electrospun PVA wound-dressing platforms.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"1-12"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0