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Preparation, characterization and in vitro evaluation of 5-fluorouracil loaded into chitosan-acacia gum nanoparticles. 壳聚糖-金合欢胶纳米颗粒负载的 5-氟尿嘧啶的制备、表征和体外评价。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-12 DOI: 10.4155/tde-2023-0136
Hasan Al-Nasrawi, Naeem Shalan, Bassam M Abualsoud, Hamdi Nsairat
{"title":"Preparation, characterization and <i>in vitro</i> evaluation of 5-fluorouracil loaded into chitosan-acacia gum nanoparticles.","authors":"Hasan Al-Nasrawi, Naeem Shalan, Bassam M Abualsoud, Hamdi Nsairat","doi":"10.4155/tde-2023-0136","DOIUrl":"10.4155/tde-2023-0136","url":null,"abstract":"<p><p><b>Aim:</b> In this study, we prepared, characterized and <i>in vitro</i> evaluated a 5-fluorouracil (5-FU)-loaded chitosan-acacia gum nanoparticles. <b>Methods:</b> Nanoparticles were characterized for their size, charge, morphology and encapsulation efficiency (EE%) followed by cellular investigations against HT-29 colon cancer cell line. <b>Results:</b> The nanoparticles exhibited a spherical morphological size with 94.42% EE%. Free 5-FU showed a fast and fully cumulative release after 6 h while 5-FU loaded into CS-AG NPs showed good entrapment and slow, prolonged 5-FU release even after 24 h. Enhanced IC<sub>50</sub> for the 5-FU loaded NPs compared with free 5-FU against HT-29 colon cancer cell line was reported with high selectivity compared with normal fibroblast cells. <b>Conclusion:</b> 5-FU loaded NPs is promising nano-therapy against colon cancer.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chia nanoemulsion: anti-inflammatory mechanism, biological behavior and cellular interactions. 奇异果纳米乳液：抗炎机制、生物行为和细胞相互作用。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-12 DOI: 10.4155/tde-2023-0088
Luana Barbosa Correa, Natália Cristina Gomes-da-Silva, Clenilton Costa Dos Santos, Luciana Magalhães Rebelo Alencar, Maria das Graças Muller de Oliveira Henriques, Prapanna Bhattarai, Lin Zhu, Pedro Filho Noronha Souza, Elaine Cruz Rosas, Ralph Santos-Oliveira
{"title":"Chia nanoemulsion: anti-inflammatory mechanism, biological behavior and cellular interactions.","authors":"Luana Barbosa Correa, Natália Cristina Gomes-da-Silva, Clenilton Costa Dos Santos, Luciana Magalhães Rebelo Alencar, Maria das Graças Muller de Oliveira Henriques, Prapanna Bhattarai, Lin Zhu, Pedro Filho Noronha Souza, Elaine Cruz Rosas, Ralph Santos-Oliveira","doi":"10.4155/tde-2023-0088","DOIUrl":"10.4155/tde-2023-0088","url":null,"abstract":"<p><p><b>Aim:</b> This study explores chia oil, rich in ω-3 fatty acids and nutraceutical components, as a potential remedy for diseases, especially those linked to inflammation and cancer. <b>Methods/materials:</b> A chia oil-based nanoemulsion, developed through single emulsification, underwent comprehensive analysis using various techniques. <i>In vitro</i> and <i>in vivo</i> assays, including macrophage polarization, nitrite and cytokine production, cellular uptake and biodistribution, were conducted to assess the anti-inflammatory efficacy. <b>Results & conclusion:</b> Results reveal that the chia nanoemulsion significantly inhibits inflammation, outperforming pure oil with twice the efficacy. Enhanced uptake by macrophage-like cells and substantial accumulation in key organs indicate its potential as an economical and effective anti-inflammatory nanodrug, addressing global economic and health impacts of inflammation-related diseases.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delivery of nano-emulgel carrier: optimization, evaluation and in vivo anti-inflammation estimations for osteoarthritis. 纳米软凝胶载体的输送：骨关节炎的优化、评估和体内抗炎估计。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-01 Epub Date: 2024-02-15 DOI: 10.4155/tde-2023-0109
Rajni, Kamal Shah, Hitesh Kumar Dewangan
{"title":"Delivery of nano-emulgel carrier: optimization, evaluation and <i>in vivo</i> anti-inflammation estimations for osteoarthritis.","authors":"Rajni, Kamal Shah, Hitesh Kumar Dewangan","doi":"10.4155/tde-2023-0109","DOIUrl":"10.4155/tde-2023-0109","url":null,"abstract":"<p><p><b>Aim:</b> Optimization and evaluation of Aceclofenac nanoemulgel for treatment for rheumatoid arthritis and reduction of GI irritation and enhancement of bioavaibility. <b>Materials & methods:</b> Different batches of emulgel and selected batch was proceeded for characterization like particle size, scanning electron microscopy, drug ingredient, <i>in vitro</i> release, Fourier transform infrared and x-ray diffraction <i>in vitro</i> inflammation and gel evaluation such as (spreadability, swelling index), <i>ex vitro</i> permeation, skin irritation and <i>in vivo</i> anti-inflammatory. <b>Result:</b> Emulgel showed nanometri size sustained release (79.96% in 6 h), compatibility and anti-inflammatory activity compared with pure drug. Concluded that emulgels had better (nearly twice as good) anti-inflammatory action as the commercial product. <b>Conclusion:</b> Compared with the commercial gel, the emulgel's anti-inflammatory effect had a quicker onset and a longer duration of action.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"181-192"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alopecia areata: review of epidemiology, pathophysiology, current treatments and nanoparticulate delivery system. 斑秃：流行病学、病理生理学、当前治疗方法和纳米颗粒给药系统综述。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-01 Epub Date: 2024-03-07 DOI: 10.4155/tde-2023-0071
Robel Singh, Pawan Kumar, Davinder Kumar, Navidha Aggarwal, Hitesh Chopra, Virender Kumar
{"title":"Alopecia areata: review of epidemiology, pathophysiology, current treatments and nanoparticulate delivery system.","authors":"Robel Singh, Pawan Kumar, Davinder Kumar, Navidha Aggarwal, Hitesh Chopra, Virender Kumar","doi":"10.4155/tde-2023-0071","DOIUrl":"10.4155/tde-2023-0071","url":null,"abstract":"<p><p>Alopecia areata (AA) is a kind of alopecia that affects hair follicles and nails. It typically comes with round patches and is a type of nonscarring hair loss. Various therapies are accessible for the management and treatment of AA, including topical, systemic and injectable modalities. It is a very complex type of autoimmune disease and is identified as round patches of hair loss and may occur at any age. This review paper highlights the epidemiology, clinical features, pathogenesis and new treatment options for AA, with a specific emphasis on nanoparticulate drug-delivery systems. By exploring these innovative treatment approaches, researchers aim to enhance the effectiveness and targeted delivery of therapeutic agents, ultimately improving outcomes for individuals living with AA.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"193-210"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
November 2023 industry update. 2023 年 11 月行业更新。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-01 Epub Date: 2024-02-06 DOI: 10.4155/tde-2024-0012
Elaine Harris
{"title":"November 2023 industry update.","authors":"Elaine Harris","doi":"10.4155/tde-2024-0012","DOIUrl":"10.4155/tde-2024-0012","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"157-163"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation and evaluation of itraconazole-loaded nanoemulgel for efficient topical delivery to treat fungal infections. 用于治疗真菌感染的高效局部给药伊曲康唑纳米凝胶的制备与评估。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-01 Epub Date: 2024-01-29 DOI: 10.4155/tde-2023-0062
Archana S Patil, Samradni S Chougale, Umashri Kokatanr, Sujay Hulyalkar, Ravindra D Hiremath, Veerkumar Japti, Rajashree Masareddy
{"title":"Formulation and evaluation of itraconazole-loaded nanoemulgel for efficient topical delivery to treat fungal infections.","authors":"Archana S Patil, Samradni S Chougale, Umashri Kokatanr, Sujay Hulyalkar, Ravindra D Hiremath, Veerkumar Japti, Rajashree Masareddy","doi":"10.4155/tde-2023-0062","DOIUrl":"10.4155/tde-2023-0062","url":null,"abstract":"<p><p><b>Aim:</b> The clinical application of conventional oral dosage form of itraconazole is limited due to its poor bioavailability. The aim of the study was to develop nanoemulgel of Itraconazole for topical delivery. <b>Method:</b> Nanoemulsions were prepared, optimized and further incorporated into a gel and evaluated for homogeneity, pH, viscosity, spreadability, <i>in vitro</i> drug release and skin irritation studies. <b>Results:</b> Cumulative drug release from nanoemulsions was within the range of 37.24 to 47.63% at 10 h. Drug release % for all the nanoemulgel formulations at10 h was 32.39, 39.75 and 45.9% respectively. Nanoemulgel was non-irritant as demonstrated by skin irritation studies in animals. <b>Conclusion:</b> Itraconazole nanoemulgels were proved to be potential for effective topical delivery of drug with enhanced bioavailability.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"165-179"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel therapeutic approaches for the management of hepatitis infections. 治疗肝炎感染的新疗法。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.4155/tde-2023-0074
Aswin Damodaran, Subin Mary Zachariah, Sreeja Chandrasekharan Nair
{"title":"Novel therapeutic approaches for the management of hepatitis infections.","authors":"Aswin Damodaran, Subin Mary Zachariah, Sreeja Chandrasekharan Nair","doi":"10.4155/tde-2023-0074","DOIUrl":"10.4155/tde-2023-0074","url":null,"abstract":"<p><p>Hepatitis B virus (HBV) & hepatitis C virus (HCV) infection is a substantial reason for morbidity and mortality around the world. Chronic hepatitis B (CHB) infection is connected with an enhanced risk of liver cirrhosis, liver decompensation and hepatocellular carcinoma (HCC). Conventional therapy do face certain challenges, for example, poor tolerability and the growth of active resistance. Thus, novel treatment procedures are essential to accomplish the initiation of strong and stable antiviral immune reactions of the individuals. This review explores the current nanotechnology-based carriers for drug and vaccine delivery to treat HBV and HCV.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"211-232"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aquasomes nanoformulation for controlled release of drug and improved effectiveness against bacterial infections. 用于控制药物释放和提高抗细菌感染效力的水瘤纳米制剂。
IF 4.2
Therapeutic delivery Pub Date : 2024-02-01 Epub Date: 2024-01-04 DOI: 10.4155/tde-2023-0096
Bhuvaneshwari Shanmugam, Umashankar Marakanam Srinivasan
{"title":"Aquasomes nanoformulation for controlled release of drug and improved effectiveness against bacterial infections.","authors":"Bhuvaneshwari Shanmugam, Umashankar Marakanam Srinivasan","doi":"10.4155/tde-2023-0096","DOIUrl":"10.4155/tde-2023-0096","url":null,"abstract":"<p><p><b>Aim:</b> The study aimed to develop and evaluate an aquasome drug-delivery system for controlled drug delivery of cefprozil monohydrate. <b>Materials & methods:</b> Aquasomes were prepared by the spinal method with a calcium phosphate core, sugar-coated using cellobiose and drug-loaded by adsorption. The formulations were characterized for size, morphology and drug release. An antibacterial study was conducted for Gram-positive and -negative bacteria. <b>Results:</b> It showed particle size of 2791.9 nm, zeta potential of -0.3 mV with good stability, and 99.08% of drug loading and drug release were controlled and prolonged, achieving 56% within 8 h and possessing potential for 100% release beyond 12 h. <b>Conclusion:</b> An aquasome drug-delivery system was developed for novel controlled drug delivery for pharmaceutical antibiotic therapeutics.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"95-107"},"PeriodicalIF":4.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139088691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paclitaxel-loaded niosomes in combination with metformin: development, characterization and anticancer potentials. 与二甲双胍联用的紫杉醇载药新体：开发、表征和抗癌潜力。
IF 4.2
Therapeutic delivery Pub Date : 2024-02-01 Epub Date: 2024-01-12 DOI: 10.4155/tde-2023-0089
Taqwa Al-Kofahi, Bahaa Altrad, Haneen Amawi, Alaa A Aljabali, Yousef M Abul-Haija, Mohammad A Obeid
{"title":"Paclitaxel-loaded niosomes in combination with metformin: development, characterization and anticancer potentials.","authors":"Taqwa Al-Kofahi, Bahaa Altrad, Haneen Amawi, Alaa A Aljabali, Yousef M Abul-Haija, Mohammad A Obeid","doi":"10.4155/tde-2023-0089","DOIUrl":"10.4155/tde-2023-0089","url":null,"abstract":"<p><p><b>Aim:</b> This study aims to assess the efficacy of free and niosomes-loaded paclitaxel combined with the anti-diabetic drug metformin. <b>Methods:</b> Paclitaxel was successfully encapsulated in all niosome formulations, using microfluidic mixing, with a maximum encapsulation efficiency of 11.9%. <b>Results:</b> The half maximal inhibitory concentration (IC<sub>50</sub>) for free paclitaxel in T47D cells was significantly reduced from 0.2 to 0.048 mg/ml when combined with metformin 40 mg. The IC<sub>50</sub> of paclitaxel was significantly reduced when loaded in niosomes to less than 0.06 mg/ml alone or with metformin. <b>Conclusion:</b> Paclitaxel combination (free or loaded into niosomes) with metformin significantly improved the anticancer efficacy of paclitaxel, which can serve as a method to reduce the paclitaxel dose and its associated side effects.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"109-118"},"PeriodicalIF":4.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid-based nanocarriers for enhanced delivery of plant-derived bioactive molecules: a comprehensive review. 基于脂质的纳米载体用于增强植物生物活性分子的递送：全面综述。
IF 4.2
Therapeutic delivery Pub Date : 2024-02-01 Epub Date: 2024-01-12 DOI: 10.4155/tde-2023-0116
Pavithra Kothapalli, Manimaran Vasanthan
{"title":"Lipid-based nanocarriers for enhanced delivery of plant-derived bioactive molecules: a comprehensive review.","authors":"Pavithra Kothapalli, Manimaran Vasanthan","doi":"10.4155/tde-2023-0116","DOIUrl":"10.4155/tde-2023-0116","url":null,"abstract":"<p><p>Bioactive compounds derived from plants have been investigated for treating various pathological conditions. However, the utilization of these compounds has challenges such as instability, low solubility and bioavailability. To overcome these challenges, the encapsulation of bioactive molecules with in a novel nano carrier system enabling effective delivery and clinical translation has become essential. Lipid-based nanocarriers provide versatile platforms for encapsulating and delivering bioactive compounds and overcome the challenges. These novel carriers can improve solubility, stability, improved drug retention and therapeutic efficacy of plant derived bioactive compounds. The current review evaluates the challenges in delivery of plant bioactives and highlights the potential of various lipid-based nano carriers designed to improve its therapeutic efficacy.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"135-155"},"PeriodicalIF":4.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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