Next-gen ferulic acid-stabilized gold nanoparticles: exploring their sensing capabilities and therapeutic efficacy.

IF 2.2 Q2 PHARMACOLOGY & PHARMACY

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-03-20 DOI:10.1080/20415990.2025.2472733

Atiya Kaleem, Aisha Sana, Rafia Usman Khan, Safila Naveed, Fatima Qamar, Syeda Zainab, Javed Iqbal, Brijesh Sathian

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引用次数: 0

Abstract

Aim: This study focuses on the synthesis and evaluation of innovative gold nanoparticles (AuNps) stabilized by short-chain ferulic acid (FA), specifically 4-hydroxy-3-methoxy-cinnamic acid.

Methods: We analyzed the size and distribution of FA-TSC-AuNps and FA-NaBH4-AuNps, with the reduction kinetics of Au3 + to Au0. The electronic and optical properties of these AuNps were scrutinized using UV-visible, AFM, and FT-IR.

Results: AFM distinctly showcased spherical particles, average diameters of 4 ± 1 nm for FA-TSC-AuNps and 11 ± 1 nm for FA-NaBH4-AuNps systems. In the DPPH assay, the anti-scavenging activity recorded values of: FA at 15.4% ± 0.32, FA-TSC-AuNps at an impressive 86.8% ± 0.32, and FA-NaBH4-AuNps at 61.5% ± 0.22. The ABTS assay yielded results of: FA at 13%, FA-TSC-AuNps at 70.14%, and FA-NaBH4-AuNps at a remarkable 92.8%. Catalytic investigations revealed that both facilitated the swift conversion of p-nitrophenol to p-aminophenol. Additionally successful chemo sensing capabilities were assessed, particularly in relation to ciprofloxacin antibiotic by distinct shift in color signifies the effective detection capability of both sensory systems for the drug. Moreover, with FA-TSC-AuNps exhibiting significant sensitivity toward aluminum.

Conclusion: These nanoparticles suggest promising avenues for drug system modifications and enhancements, highlighting their multifaceted potential in both catalytic and chemo sensing applications.

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新一代阿魏酸稳定金纳米颗粒：探索其传感能力和治疗效果。

目的：研究以短链阿魏酸（FA）为稳定剂的新型金纳米粒子（AuNps）的合成及性能评价。方法：分析FA-TSC-AuNps和FA-NaBH4-AuNps的大小和分布，以及Au3 +还原到Au0的动力学。这些AuNps的电子和光学性质使用紫外可见，AFM和FT-IR进行了仔细检查。结果：AFM显示明显的球形颗粒，FA-TSC-AuNps系统的平均直径为4±1 nm， FA-NaBH4-AuNps系统的平均直径为11±1 nm。在DPPH实验中，FA的抗清除活性记录值为15.4%±0.32，FA- tsc - aunps的抗清除活性记录值为86.8%±0.32，FA- nabh4 - aunps的抗清除活性记录值为61.5%±0.22。ABTS测定的结果是：FA为13%，FA- tsc - aunps为70.14%，FA- nabh4 - aunps为92.8%。催化研究表明，两者都促进了对硝基酚到对氨基酚的快速转化。此外，评估了成功的化学感应能力，特别是环丙沙星抗生素，通过颜色的明显变化表明两种感觉系统对药物的有效检测能力。此外，FA-TSC-AuNps对铝表现出显著的敏感性。结论：这些纳米颗粒为药物系统修饰和增强提供了有希望的途径，突出了它们在催化和化学传感应用中的多方面潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.