Therapeutic delivery最新文献_第4页

Next-gen ferulic acid-stabilized gold nanoparticles: exploring their sensing capabilities and therapeutic efficacy. 新一代阿魏酸稳定金纳米颗粒：探索其传感能力和治疗效果。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-03-20 DOI: 10.1080/20415990.2025.2472733

Atiya Kaleem, Aisha Sana, Rafia Usman Khan, Safila Naveed, Fatima Qamar, Syeda Zainab, Javed Iqbal, Brijesh Sathian

{"title":"Next-gen ferulic acid-stabilized gold nanoparticles: exploring their sensing capabilities and therapeutic efficacy.","authors":"Atiya Kaleem, Aisha Sana, Rafia Usman Khan, Safila Naveed, Fatima Qamar, Syeda Zainab, Javed Iqbal, Brijesh Sathian","doi":"10.1080/20415990.2025.2472733","DOIUrl":"10.1080/20415990.2025.2472733","url":null,"abstract":"Aim: This study focuses on the synthesis and evaluation of innovative gold nanoparticles (AuNps) stabilized by short-chain ferulic acid (FA), specifically 4-hydroxy-3-methoxy-cinnamic acid.Methods: We analyzed the size and distribution of FA-TSC-AuNps and FA-NaBH4-AuNps, with the reduction kinetics of Au3 + to Au0. The electronic and optical properties of these AuNps were scrutinized using UV-visible, AFM, and FT-IR.Results: AFM distinctly showcased spherical particles, average diameters of 4 ± 1 nm for FA-TSC-AuNps and 11 ± 1 nm for FA-NaBH4-AuNps systems. In the DPPH assay, the anti-scavenging activity recorded values of: FA at 15.4% ± 0.32, FA-TSC-AuNps at an impressive 86.8% ± 0.32, and FA-NaBH4-AuNps at 61.5% ± 0.22. The ABTS assay yielded results of: FA at 13%, FA-TSC-AuNps at 70.14%, and FA-NaBH4-AuNps at a remarkable 92.8%. Catalytic investigations revealed that both facilitated the swift conversion of p-nitrophenol to p-aminophenol. Additionally successful chemo sensing capabilities were assessed, particularly in relation to ciprofloxacin antibiotic by distinct shift in color signifies the effective detection capability of both sensory systems for the drug. Moreover, with FA-TSC-AuNps exhibiting significant sensitivity toward aluminum.Conclusion: These nanoparticles suggest promising avenues for drug system modifications and enhancements, highlighting their multifaceted potential in both catalytic and chemo sensing applications.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"447-457"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug delivery systems incorporating bile salts: advancements since the conception of bilosomes. 含胆盐的药物输送系统：自胆囊体概念以来的进展。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI: 10.1080/20415990.2025.2469488

Mohammad A Obeid, Marta Ruano-Aldea, Reinaldo Acevedo, Virgil Schjins, Manal M Alsaadi, Valerie A Ferro

{"title":"Drug delivery systems incorporating bile salts: advancements since the conception of bilosomes.","authors":"Mohammad A Obeid, Marta Ruano-Aldea, Reinaldo Acevedo, Virgil Schjins, Manal M Alsaadi, Valerie A Ferro","doi":"10.1080/20415990.2025.2469488","DOIUrl":"10.1080/20415990.2025.2469488","url":null,"abstract":"This review explores the advancements in drug delivery systems that incorporate bile salts since bilosomes that were developed over 20 years ago. Bile salts, recognized for their unique amphiphilic properties, have emerged as versatile agents in enhancing solubility, stability, and bioavailability of various therapeutics. We discuss the innovative formulations developed, including micelles, liposomes, and nanoparticles, that leverage bile salts to facilitate targeted and sustained release. The review also highlights the mechanisms by which bile salts improve drug absorption, particularly for hydrophobic compounds, and examines the evolving regulatory landscape surrounding these systems. Furthermore, we address challenges faced in clinical translation and future directions for research, emphasizing the potential of bile salt-based systems in personalized medicine. Our evaluation highlights the significant role of bile salts in advancing drug delivery technologies and their promise for improving therapeutic outcomes.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"487-500"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective release of Eryngium maritimum L. callus extract via encapsulation in multilayered liposomes for skin delivery. 通过封装在多层脂质体中有效释放海腥草茧提取物，用于皮肤给药。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-02-28 DOI: 10.1080/20415990.2025.2470614

Euihyun Kim, Jihyeon Jang, Myeong-Jin Lim, Soo-Yun Kim, Seon Kyu Yun, Jihyeok Song, Hyo Hyun Seo, Jeong Hun Lee, Sang Hyun Moh

{"title":"Effective release of Eryngium maritimum L. callus extract via encapsulation in multilayered liposomes for skin delivery.","authors":"Euihyun Kim, Jihyeon Jang, Myeong-Jin Lim, Soo-Yun Kim, Seon Kyu Yun, Jihyeok Song, Hyo Hyun Seo, Jeong Hun Lee, Sang Hyun Moh","doi":"10.1080/20415990.2025.2470614","DOIUrl":"10.1080/20415990.2025.2470614","url":null,"abstract":"Aims: This study aimed to evaluate the potential of Eryngium maritimum L. (EM) callus media filtrate (ECMF) for enhanced skin delivery through multilayered liposomes (MLs).Materials & methods: ECMF was applied to human skin cells to assess its antioxidant, anti-inflammatory, and skin barrier-enhancing properties. ECMF was encapsulated in MLs to enhance delivery efficiency, creating a formulation called Cellbiome. Clinical trials involving human participants were conducted to compare its effects with traditional formulations, assessing parameters such as skin density, hydration, elasticity, and wrinkle reduction.Results: Cellbiome significantly improved skin density and moisturization, outperforming conventional formulations. ML encapsulation facilitated deeper penetration of active ingredients beyond the stratum corneum, leading to synchronized improvements in multiple skin parameters, including elasticity, wrinkle reduction, and overall skin health. Transcriptomic and metabolomic analyses further confirmed ECMF's bioactivity and its role in skin improvement.Conclusions: ML-based formulations, such as Cellbiome, offer superior efficacy in skincare applications compared to conventional methods. This study underscores the importance of advanced delivery technologies in cosmetics and highlights the need for further research to optimize the benefits of natural extracts like EM for human skin, potentially advancing dermatological and cosmeceutical applications.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"459-473"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advantages and drawbacks of eco-friendly nano-delivery systems. 生态友好型纳米输送系统的优缺点。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-03-11 DOI: 10.1080/20415990.2025.2477441

Constantin Cerbu, Emilia Trif

引用次数: 0

Exosomes in glioma: mechanistic insights on biological, therapeutic, and diagnostic perspective. 神经胶质瘤中的外泌体：生物学、治疗和诊断角度的机制见解。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-02-16 DOI: 10.1080/20415990.2025.2466410

Reetika Tandon, Samarth Kumar, Mayank Handa, Nidhi Srivastava

引用次数: 0

Novel nanostructured lipid carriers with lurasidone hydrochloride for intranasal administration for improved bioavailability. 新型纳米结构脂质载体盐酸鲁拉西酮鼻内给药以提高生物利用度。

IF 3

Therapeutic delivery Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI: 10.1080/20415990.2025.2477440

Tanvi Kadam, Surendra Agrawal, Saritha Shetty

{"title":"Novel nanostructured lipid carriers with lurasidone hydrochloride for intranasal administration for improved bioavailability.","authors":"Tanvi Kadam, Surendra Agrawal, Saritha Shetty","doi":"10.1080/20415990.2025.2477440","DOIUrl":"10.1080/20415990.2025.2477440","url":null,"abstract":"Aim: This research aims to develop nanostructured lipid carriers containing Lurasidone hydrochloride (LH) with Quality by Design (QbD) methodology to enhance its bioavailability, given LH's low water solubility (0.224 mg/ml) and bioavailability (9-19%).Material and methods: The optimized LH-NLC formulation contains Glyceryl monostearate (GMS) as solid lipid, Caproyl 90 as liquid lipid and co-surfactant, and Tween 80 as surfactant. The hot emulsification method was used to formulate the LH-NLC using a three-factor, three-level Box-Behnken design (BBD)for ascertaining functional relationships between particle size and entrapment efficiency (EE). Particle size, polydispersity index (PDI), zeta potential, surface morphology, percentage EE, and in vitro and ex-vivo release were assessed. Wistar rats were used to estimate plasma drug concentration after LH-NLC administration.Results: The developed formulation exhibited a particle size of 190.98 ± 4.72 nm, zeta potential of + 17.47 mV, and encapsulation efficiency of 94 ± 1.26% w/w. LH-NLCs showed a drug release rate of 95.37% within 24 hours. Intranasal administration of LH-NLCs resulted in 5.16 times higher bioavailability compared to intranasally administered lurasidone.Conclusion: The study successfully applied QbD methodology to develop NLCs for LH with enhanced bioavailability, demonstrating improved drug entrapment and delivery efficacy for treating psychosis.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"419-429"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Industry update: the latest developments in the field of therapeutic delivery, February 2025. 行业更新：治疗递送领域的最新进展，2025年2月。

IF 3

Therapeutic delivery Pub Date : 2025-04-16 DOI: 10.1080/20415990.2025.2492539

Louise Rosenmayr-Templeton

引用次数: 0

Naturally derived hydrogels for wound healing. 用于伤口愈合的天然水凝胶。

IF 3

Therapeutic delivery Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1080/20415990.2025.2457928

Duy Toan Pham, Ngo Thi Ngoc Thuy, Nguyen Thi Phuong Thao, Le Thi Nhi, Bui Thi Phuong Thuy

{"title":"Naturally derived hydrogels for wound healing.","authors":"Duy Toan Pham, Ngo Thi Ngoc Thuy, Nguyen Thi Phuong Thao, Le Thi Nhi, Bui Thi Phuong Thuy","doi":"10.1080/20415990.2025.2457928","DOIUrl":"10.1080/20415990.2025.2457928","url":null,"abstract":"Natural hydrogels have garnered increasing attention due to their natural origins and beneficial roles in wound healing. Hydrogel water-retaining capacity and excellent biocompatibility create an ideal moist environment for wound healing, thereby enhancing cell proliferation and tissue regeneration. For this reason, naturally derived hydrogels formulated from biomaterials such as chitosan, alginate, gelatin, and fibroin are highly promising due to their biodegradability and low immunogenic responses. Recent integrated approaches to utilizing new technologies with bioactive agents have significantly improved the mechanical properties of hydrogels and the controlled release and delivery of active compounds, thereby increasing the efficiency of the treatment processes. Herein, this review highlights the advantages and the challenges of natural hydrogels in wound healing, focusing on their mechanical strength, controlled degradation rates, safety and efficiency validation, and the potential for incorporating advanced technologies such as tissue engineering and gene therapy for utilization in personalized medicine.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"349-363"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-generation pharmaceuticals: the rise of sildenafil citrate ODF for the treatment of men with erectile dysfunction. 下一代药物：柠檬酸西地那非用于治疗男性勃起功能障碍的兴起。

IF 3

Therapeutic delivery Pub Date : 2025-04-01 Epub Date: 2025-01-12 DOI: 10.1080/20415990.2024.2445501

Emmanuele A Jannini, Shivani Ohri Vignesh, Tarek Hassan

{"title":"Next-generation pharmaceuticals: the rise of sildenafil citrate ODF for the treatment of men with erectile dysfunction.","authors":"Emmanuele A Jannini, Shivani Ohri Vignesh, Tarek Hassan","doi":"10.1080/20415990.2024.2445501","DOIUrl":"10.1080/20415990.2024.2445501","url":null,"abstract":"Orodispersible film (ODF) is one of the novel formulations that disintegrate rapidly in the mouth without the requisite for water compared to other conventional oral solid dosage formulations. This delivery system serves as a convenient mode of administration, especially in patients who have dysphagia and fluid restriction, being beneficial to pediatric, geriatric, and bedridden patients. A novel sildenafil ODF containing sildenafil citrate is formulated to be used in patients with erectile dysfunction (ED). This review discusses the advantages of ODF in improving compliance and satisfaction in these patients and describes the manufacturing techniques, evaluation tests, bioequivalence, and stability studies of sildenafil ODF. This formulation offers unique benefit to patients with ED by improving their acceptance and compliance and respecting their privacy and the need for a discreet treatment. Moreover, the comparison of pharmacokinetic parameters between the sildenafil ODF administered with and without water and the conventional film-coated tablet were similar. It also demonstrated reliable performance that yielded a consistent product, meeting all specifications at release and after three weeks of storage under stressed conditions (60°C). Sildenafil ODF warrants improved ease of intake, taste, portability, storage, and compliance among ED patients, making it the potential most preferred formulation and drug of choice.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"365-378"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight on the biomimetic of lysozyme interaction with functionalized iron oxide nanoparticles. 溶菌酶与功能化氧化铁纳米颗粒相互作用的仿生研究。

IF 3

Therapeutic delivery Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1080/20415990.2025.2467029

Wael M Elshemey, Ahmed M Elgharib, Abdo A Elfiky, Mohamed M Fathy

{"title":"Insight on the biomimetic of lysozyme interaction with functionalized iron oxide nanoparticles.","authors":"Wael M Elshemey, Ahmed M Elgharib, Abdo A Elfiky, Mohamed M Fathy","doi":"10.1080/20415990.2025.2467029","DOIUrl":"10.1080/20415990.2025.2467029","url":null,"abstract":"Introduction: Lysozyme is a globular hydrolytic enzyme whose tissue level is imperative for various clinical diagnostics. High levels of lysozyme are related to several inflammatory disorders, that breakdown cartilaginous tissues. Recently nanostructures have become widely used as modulators for enzyme activity.Areas covered: This study delves into the influential role played by surface-modified iron oxide nanoparticles (IONPs) as novel lysozyme nano-inhibitors. Stern-Volmer plots results for lysozyme interaction with Cit-IONPs and Thy-IONPs reveal dynamic quenching constant (KSV) of 40.075 and 65.714 ml/mg, binding constant (Kb) of 1.539 × 103 and 4.418 × 103 ml/mg, and binding free energy (∆G°binding) of -43.563 KJ. mol-1 and -49.821 KJ. mol-1, respectively. Upon interaction with IONPs, the catalytic activity of lysozyme decreases due to conjugation with Thy-IONPs and Cit-IONPs compared to the free form of the enzyme. Computational approaches show that the citrate and thymoquinone molecules have binding affinities with lysozyme active residues of about -4.3 and -4.7 kcal/mol, respectively.Expert opinion/commentary: Both formulations of IONPs demonstrate high affinity toward lysozyme proteins. This work shows a higher binding affinity between lysozyme and Thy-IONPs than with Cit-IONPs. These findings suggest that Thy-IONPs represent a promising class of nano-inhibitors for lysozyme, opening new avenues for treating disorders associated with lysozyme overexpression.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"315-326"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0