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Exploring delivery systems for targeted nanotechnology-based gene therapy in the inner ear. 探索基于纳米技术的内耳靶向基因治疗输送系统。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-26 DOI: 10.1080/20415990.2024.2389032
Thomas Foster, Patrick Lim, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Armin Mooranian, Hani Al-Salami
{"title":"Exploring delivery systems for targeted nanotechnology-based gene therapy in the inner ear.","authors":"Thomas Foster, Patrick Lim, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Armin Mooranian, Hani Al-Salami","doi":"10.1080/20415990.2024.2389032","DOIUrl":"10.1080/20415990.2024.2389032","url":null,"abstract":"<p><p>Hearing loss places a significant burden on our aging population. However, there has only been limited progress in developing therapeutic techniques to effectively mediate this condition. This review will outline several of the most commonly utilized practices for the treatment of sensorineural hearing loss before exploring more novel techniques currently being investigated via both <i>in vitro</i> and <i>in vivo</i> research. This review will place particular emphasis on novel gene-delivery technologies. Primarily, it will focus on techniques used to deliver genes that have been shown to encourage the proliferation and differentiation of sensory cells within the inner ear and how these technologies may be translated into providing clinically useful results for patients.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"801-818"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Localized tacrolimus therapy: innovations in peripheral nerve regeneration through advanced drug delivery systems. 局部他克莫司疗法：通过先进的给药系统实现周围神经再生的创新。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-04 DOI: 10.1080/20415990.2024.2392481
Elena Millesi, Flavia Millesi, Julian S Rechberger, David J Daniels, Christine Radtke, Samir Mardini
{"title":"Localized tacrolimus therapy: innovations in peripheral nerve regeneration through advanced drug delivery systems.","authors":"Elena Millesi, Flavia Millesi, Julian S Rechberger, David J Daniels, Christine Radtke, Samir Mardini","doi":"10.1080/20415990.2024.2392481","DOIUrl":"10.1080/20415990.2024.2392481","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"743-748"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and characterization of fullerene-based nanocarrier for targeted delivery of quercetin to the brain. 用于向大脑定向输送槲皮素的富勒烯基纳米载体的合成与表征。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-05 DOI: 10.1080/20415990.2024.2365620
Amit Kumar Palai, Amit Kumar, Farhan Mazahir, Ankita Sharma, Awesh K Yadav
{"title":"Synthesis and characterization of fullerene-based nanocarrier for targeted delivery of quercetin to the brain.","authors":"Amit Kumar Palai, Amit Kumar, Farhan Mazahir, Ankita Sharma, Awesh K Yadav","doi":"10.1080/20415990.2024.2365620","DOIUrl":"10.1080/20415990.2024.2365620","url":null,"abstract":"<p><p><b>Aim:</b> Preparation of quercetin fullerene conjugate (QFC) for nose-to-brain delivery and their <i>in vitro</i> and <i>ex vivo</i> characterizations.<b>Methods:</b> Carboxylated fullerene was converted into acetylated fullerene and quercetin was conjugated and physically adsorbed on acetylated fullerene.<b>Results:</b> The particle size and zeta potential of QFC and chitosan-coated QFC (CC-QFC) were found to be 179.2 ± 1.10, 293.4 ± 2.757, -5.28 ± 1.43 and 11.6 ± 0.4 respectively. The entrapment efficiency, loading efficiency of QFC were found to be 85.55% and 42.77%. The MTT assay revealed 80.69% SH-SY5Y cell viability at a concentration of 50 μg/ml. CC-QFC showed remarkable (89.20%) <i>ex vivo</i> mucoadhesive properties compared with QFC (66.67%). Further study showed no significant ciliotoxicity by CC-QFC.<b>Conclusion:</b> The obtained results suggested the potential of CC-QFC for treatment in Alzheimer's disease.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"545-559"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting superficial cancers with gold nanoparticles: a review of current research. 用金纳米粒子靶向浅表癌症：当前研究综述。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-24 DOI: 10.1080/20415990.2024.2395249
Susana M Gomes, Maria Manuela Gaspar, João Mp Coelho, Catarina Pinto Reis
{"title":"Targeting superficial cancers with gold nanoparticles: a review of current research.","authors":"Susana M Gomes, Maria Manuela Gaspar, João Mp Coelho, Catarina Pinto Reis","doi":"10.1080/20415990.2024.2395249","DOIUrl":"10.1080/20415990.2024.2395249","url":null,"abstract":"<p><p>Superficial cancers typically refer to cancers confined to the surface layers of tissue. Low-targeting therapies or side effects prompt exploration of novel therapeutic approaches. Gold nanoparticles (AuNPs), due to their unique optical properties, serve as effective photosensitizers, enabling tumor ablation through photothermal therapy (PTT). PTT induced by AuNPs can be achieved through light sources externally applied to the skin. Near-infrared radiation is the main light candidate due to its deep tissue penetration capability. This review explores recent advancements in AuNP-based PTT for superficial cancers, specifically breast, head and neck, thyroid, bladder and prostate cancers. Additionally, challenges and future directions in utilizing AuNPs for cancer treatment are discussed, emphasizing the importance of balancing efficacy with safety in clinical applications.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"781-799"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing therapy with nano-based delivery systems: exploring the bioactive properties and effects of apigenin. 利用纳米给药系统增强治疗效果：探索芹菜素的生物活性特性和作用。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-11 DOI: 10.1080/20415990.2024.2386928
Girish Kumar, Pushpika Jain, Tarun Virmani, Ashwani Sharma, Md Sayeed Akhtar, Saad A Aldosari, Mohd Faiyaz Khan, Sofia O D Duarte, Pedro Fonte
{"title":"Enhancing therapy with nano-based delivery systems: exploring the bioactive properties and effects of apigenin.","authors":"Girish Kumar, Pushpika Jain, Tarun Virmani, Ashwani Sharma, Md Sayeed Akhtar, Saad A Aldosari, Mohd Faiyaz Khan, Sofia O D Duarte, Pedro Fonte","doi":"10.1080/20415990.2024.2386928","DOIUrl":"https://doi.org/10.1080/20415990.2024.2386928","url":null,"abstract":"<p><p>Apigenin, a potent natural flavonoid, has emerged as a key therapeutic agent due to its multifaceted medicinal properties in combating various diseases. However, apigenin's clinical utility is greatly limited by its poor water solubility, low bioavailability and stability issues. To address these challenges, this review paper explores the innovative field of nanotechnology-based delivery systems, which have shown significant promise in improving the delivery and effectiveness of apigenin. This paper also explores the synergistic potential of co-delivering apigenin with conventional therapeutic agents. Despite the advantageous properties of these nanoformulations, critical challenges such as scalable production, regulatory approvals and comprehensive long-term safety assessments remain key hurdles in their clinical adoption which must be addressed for commercialization of apigenin-based formulations.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":"15 9","pages":"717-735"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced bioavailability and efficacy in antimalarial treatment through QbD approach enteric encased inclusion delivery. 通过 QbD 方法肠溶包合物给药提高抗疟治疗的生物利用度和疗效。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-03 DOI: 10.1080/20415990.2024.2377948
Neha Bajwa, Preet Amol Singh, Sumant Kumar, Girish Chandra Arya, Ashish Baldi
{"title":"Enhanced bioavailability and efficacy in antimalarial treatment through QbD approach enteric encased inclusion delivery.","authors":"Neha Bajwa, Preet Amol Singh, Sumant Kumar, Girish Chandra Arya, Ashish Baldi","doi":"10.1080/20415990.2024.2377948","DOIUrl":"10.1080/20415990.2024.2377948","url":null,"abstract":"<p><p><b>Aim:</b> In this study, we aimed to prepare enteric encapsulated spheroids containing inclusion complex using quality by design approach.<b>Methods:</b> A Box-Behnken design was employed to determine effects of variables on selected responses. Risk assessment was conducted using Ishikawa fishbone diagram. A model with a <i>p</i>-value was less than 0.5 for being a significant error of model was determined based on significance 'lack of fit' value. Spheroids were formulated using the extrusion spheronization technique and were characterized using analytical techniques.<b>Results:</b> <i>In vitro</i> release was performed in both acidic (pH 1.2) and simulated intestinal (pH 6.8) conditions. Permeability studies demonstrated tenfold enhancement compared with arteether. <i>In vivo</i> studies further validated increase of 51.8% oral bioavailability. <i>Ex vivo</i> studies revealed 3.4-fold enhancement in antimalarial activity compared with arteether.<b>Conclusion:</b> These findings highlight effectiveness of inclusion complexation technique as a viable approach to enhance solubility and bioavailability for drugs with low aqueous solubility.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"653-666"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry update: the latest developments in the field of therapeutic delivery, April 2024. 行业更新：2024 年 4 月治疗传递领域的最新发展。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI: 10.1080/20415990.2024.2376520
Peter Timmins
{"title":"Industry update: the latest developments in the field of therapeutic delivery, April 2024.","authors":"Peter Timmins","doi":"10.1080/20415990.2024.2376520","DOIUrl":"10.1080/20415990.2024.2376520","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"639-651"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanotechnology-driven therapies for neurodegenerative diseases: a comprehensive review. 神经退行性疾病的纳米技术驱动疗法：综述。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-19 DOI: 10.1080/20415990.2024.2401307
Jessica López-Espinosa, Peter Park, Morgan Holcomb, Biana Godin, Sonia Villapol
{"title":"Nanotechnology-driven therapies for neurodegenerative diseases: a comprehensive review.","authors":"Jessica López-Espinosa, Peter Park, Morgan Holcomb, Biana Godin, Sonia Villapol","doi":"10.1080/20415990.2024.2401307","DOIUrl":"10.1080/20415990.2024.2401307","url":null,"abstract":"<p><p>Neurological diseases, characterized by neuroinflammation and neurodegeneration, impose a significant global burden, contributing to substantial morbidity, disability and mortality. A common feature of these disorders, including stroke, traumatic brain injury and Alzheimer's disease, is the impairment of the blood-brain barrier (BBB), a critical structure for maintaining brain homeostasis. The compromised BBB in neurodegenerative conditions poses a significant challenge for effective treatment, as it allows harmful substances to accumulate in the brain. Nanomedicine offers a promising approach to overcoming this barrier, with nanoparticles (NPs) engineered to deliver therapeutic agents directly to affected brain regions. This review explores the classification and design of NPs, divided into organic and inorganic categories and further categorized based on their chemical and physical properties. These characteristics influence the ability of NPs to carry and release therapeutic agents, target specific tissues and ensure appropriate clearance from the body. The review emphasizes the potential of NPs to enhance the diagnosis and treatment of neurodegenerative diseases through targeted delivery, improved drug bioavailability and real-time therapeutic efficacy monitoring. By addressing the challenges of the compromised BBB and targeting inflammatory biomarkers, NPs represent a cutting-edge strategy in managing neurological disorders, promising better patient outcomes.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"997-1024"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and optimization of guaifenesin sustained release mini-tablets for adult and geriatric patients. 开发和优化用于成人和老年患者的愈创木酚缓释小药片。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-10-03 DOI: 10.1080/20415990.2024.2406216
Mahshid Samadi, Mitra Jelvehgari, Sara Salatin
{"title":"Development and optimization of guaifenesin sustained release mini-tablets for adult and geriatric patients.","authors":"Mahshid Samadi, Mitra Jelvehgari, Sara Salatin","doi":"10.1080/20415990.2024.2406216","DOIUrl":"10.1080/20415990.2024.2406216","url":null,"abstract":"<p><p><b>Aim:</b> The main aim of this study was to formulate and optimize sustained release mini-tablets of guaifenesin.<b>Materials & methods:</b> Guaifenesin granules were successfully prepared using different blend ratios of carnauba wax to drug by melt granulation method. The properties of granules were further modified by combining them with ethyl cellulose. The obtained granules were then mixed and compressed into mini-tablets using a tablet press machine. The resulting mini-tablets were characterized in terms of weight, thickness, hardness, drug content and <i>in vitro</i> drug release.<b>Results:</b> Mini-tablets with 1:6 carnauba wax to drug ratio showed superior physicochemical characteristics, releasing about 100.03% of guaifenesin over 8 h. Ethyl cellulose offers a great potential to accurately control drug release from mini-tablets.<b>Conclusion:</b> The prepared mini-tablets seem to be a very promising alternative to guaifenesin conventional formulations and can be used in adults and elderly people.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"859-869"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates in the field of therapeutic delivery in June 2024. 2024 年 6 月治疗给药领域的行业动态。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-10-11 DOI: 10.1080/20415990.2024.2408214
Mengistie Diress, Armin Mooranian, Hani Al-Salami
{"title":"Industry updates in the field of therapeutic delivery in June 2024.","authors":"Mengistie Diress, Armin Mooranian, Hani Al-Salami","doi":"10.1080/20415990.2024.2408214","DOIUrl":"https://doi.org/10.1080/20415990.2024.2408214","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":"15 11","pages":"819-828"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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