Therapeutic delivery最新文献_第5页

Therapeutic Delivery - Industry Update covering February 2024. 治疗传递--2024 年 2 月行业更新。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-03 DOI: 10.1080/20415990.2024.2365614

Iain Simpson

引用次数: 0

Artemisinin emulgel ameliorates cartilage degradation in knee osteoarthritis: in vitro and in vivo studies. 青蒿素凝胶改善膝关节骨关节炎软骨退化：体外和体内研究

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-11-06 DOI: 10.1080/20415990.2024.2418281

Samiksha Thote, Atul Mourya, Shristi Arya, Hoshiyar Singh, Prashanth Kumar, Santosh Kumar Guru, Jitender Madan

{"title":"Artemisinin emulgel ameliorates cartilage degradation in knee osteoarthritis: in vitro and in vivo studies.","authors":"Samiksha Thote, Atul Mourya, Shristi Arya, Hoshiyar Singh, Prashanth Kumar, Santosh Kumar Guru, Jitender Madan","doi":"10.1080/20415990.2024.2418281","DOIUrl":"10.1080/20415990.2024.2418281","url":null,"abstract":"Aim: Laboratory scale-up of artemisinin-loaded emulgel (ART-emulgel) was carried out and characterized for therapeutic performance in osteoarthritis (OA).Materials & methods: The solubility of ART in various oils, surfactants and co-surfactants were screened for construction of pseudo ternary phase diagram (TPD), followed by scale-up of artemisinin loaded nanoemulsion (ART-NE). ART-NE was amalgamated with Carbopol Ultrez 10-NF to prepare ART-emulgel that was later characterized in vitro and in vivo to analyze therapeutic efficacy in monosodium-iodoacetate (MIA) induced knee OA.Results: The droplet diameter of ART-NE was estimated to be 104.3 ± 2.593 nm with a polydispersity index of 0.245 ± 0.019 in addition to ζ-potential of 0.434 ± 0.028 mV. Steady-state flux and permeability coefficient for ART-emulgel were estimated to be 0.651 ± 0.031 µg.cm2/h and 0.245 ± 0.011 cm/h, respectively. ART-emulgel demonstrated 43.18% reduction in COX-2 level; 52.28% drop in IL-1β, and 88.78% alleviation of Tumor Necrosis Factor-α (TNF-α) level when compared with monosodium-iodoacetate induced OA rats. ART-emulgel and injectable ART (intra-articular; I.A) portrayed minor synovial erosion compared with blank and diclofenac emulgel. Histopathological evidences indicated restoration of cartilage integrity followed by reduction of OARSI scores in ART-emulgel when compared with disease control animals.Conclusion: ART-emulgel is a potential dosage form for translating into a clinically viable product for the management of OA.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"939-955"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing. 海藻酸钠/羧甲基纤维素凝胶配方，含用于伤口愈合的蓝花楹植物提取物。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-11-12 DOI: 10.1080/20415990.2024.2418800

Sindi P Ndlovu, Shirley C M Motaung, Samson A Adeyemi, Philemon Ubanako, Lindokuhle M Ngema, Thierry Youmbi Fonkui, Derek Tantoh Ndinteh, Pradeep Kumar, Yahya E Choonara, Blessing A Aderibigbe

{"title":"Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing.","authors":"Sindi P Ndlovu, Shirley C M Motaung, Samson A Adeyemi, Philemon Ubanako, Lindokuhle M Ngema, Thierry Youmbi Fonkui, Derek Tantoh Ndinteh, Pradeep Kumar, Yahya E Choonara, Blessing A Aderibigbe","doi":"10.1080/20415990.2024.2418800","DOIUrl":"10.1080/20415990.2024.2418800","url":null,"abstract":"Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing.Materials & methods: Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of Capparis sepiaria. The formulations were characterized using appropriate techniques.Results: The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and in vitro whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study.Conclusion: The gels' distinct features reveal their potential application as wound dressings for burn wounds.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"921-937"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Rose Bengal penetration in ex vivo human corneas using iontophoresis. 利用离子透入技术提高罗斯孟加拉红在体外人类角膜中的渗透率。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-07-18 DOI: 10.1080/20415990.2024.2371778

James M Lai, Justin Chen, Juan Carlos Navia, Heather Durkee, Alex Gonzalez, Cornelis Rowaan, Timothy Arcari, Mariela C Aguilar, Katrina Llanes, Noel Ziebarth, Jaime D Martinez, Darlene Miller, Harry W Flynn, Guillermo Amescua, Jean-Marie Parel

{"title":"Enhancing Rose Bengal penetration in ex vivo human corneas using iontophoresis.","authors":"James M Lai, Justin Chen, Juan Carlos Navia, Heather Durkee, Alex Gonzalez, Cornelis Rowaan, Timothy Arcari, Mariela C Aguilar, Katrina Llanes, Noel Ziebarth, Jaime D Martinez, Darlene Miller, Harry W Flynn, Guillermo Amescua, Jean-Marie Parel","doi":"10.1080/20415990.2024.2371778","DOIUrl":"10.1080/20415990.2024.2371778","url":null,"abstract":"Aim: Rose Bengal photodynamic antimicrobial therapy (RB-PDAT) has poor corneal penetration, limiting its efficacy against acanthamoeba keratitis (AK). Iontophoresis enhances corneal permeation of charged molecules, piquing interest in its effects on RB in ex vivo human corneas.Methods: Five donor whole globes each underwent iontophoresis with RB, soaking in RB, or were soaked in normal saline (controls). RB penetration and corneal thickness was assessed using confocal microscopy.Results: Iontophoresis increased RB penetration compared with soaking (177 ± 9.5 μm vs. 100 ± 5.7 μm, p < 0.001), with no significant differences in corneal thickness between groups (460 ± 87 μm vs. 407 ± 69 μm, p = 0.432).Conclusion: Iontophoresis significantly improves RB penetration and its use in PDAT could offer a novel therapy for acanthamoeba keratitis. Further studies are needed to validate clinical efficacy.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"567-575"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring delivery systems for targeted nanotechnology-based gene therapy in the inner ear. 探索基于纳米技术的内耳靶向基因治疗输送系统。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-26 DOI: 10.1080/20415990.2024.2389032

Thomas Foster, Patrick Lim, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Armin Mooranian, Hani Al-Salami

引用次数: 0

Localized tacrolimus therapy: innovations in peripheral nerve regeneration through advanced drug delivery systems. 局部他克莫司疗法：通过先进的给药系统实现周围神经再生的创新。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-04 DOI: 10.1080/20415990.2024.2392481

Elena Millesi, Flavia Millesi, Julian S Rechberger, David J Daniels, Christine Radtke, Samir Mardini

引用次数: 0

Synthesis and characterization of fullerene-based nanocarrier for targeted delivery of quercetin to the brain. 用于向大脑定向输送槲皮素的富勒烯基纳米载体的合成与表征。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-05 DOI: 10.1080/20415990.2024.2365620

Amit Kumar Palai, Amit Kumar, Farhan Mazahir, Ankita Sharma, Awesh K Yadav

引用次数: 0

Targeting superficial cancers with gold nanoparticles: a review of current research. 用金纳米粒子靶向浅表癌症：当前研究综述。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-24 DOI: 10.1080/20415990.2024.2395249

Susana M Gomes, Maria Manuela Gaspar, João Mp Coelho, Catarina Pinto Reis

引用次数: 0

Enhancing therapy with nano-based delivery systems: exploring the bioactive properties and effects of apigenin. 利用纳米给药系统增强治疗效果：探索芹菜素的生物活性特性和作用。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-11 DOI: 10.1080/20415990.2024.2386928

Girish Kumar, Pushpika Jain, Tarun Virmani, Ashwani Sharma, Md Sayeed Akhtar, Saad A Aldosari, Mohd Faiyaz Khan, Sofia O D Duarte, Pedro Fonte

引用次数: 0

Enhanced bioavailability and efficacy in antimalarial treatment through QbD approach enteric encased inclusion delivery. 通过 QbD 方法肠溶包合物给药提高抗疟治疗的生物利用度和疗效。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-03 DOI: 10.1080/20415990.2024.2377948

Neha Bajwa, Preet Amol Singh, Sumant Kumar, Girish Chandra Arya, Ashish Baldi

{"title":"Enhanced bioavailability and efficacy in antimalarial treatment through QbD approach enteric encased inclusion delivery.","authors":"Neha Bajwa, Preet Amol Singh, Sumant Kumar, Girish Chandra Arya, Ashish Baldi","doi":"10.1080/20415990.2024.2377948","DOIUrl":"10.1080/20415990.2024.2377948","url":null,"abstract":"Aim: In this study, we aimed to prepare enteric encapsulated spheroids containing inclusion complex using quality by design approach.Methods: A Box-Behnken design was employed to determine effects of variables on selected responses. Risk assessment was conducted using Ishikawa fishbone diagram. A model with a p-value was less than 0.5 for being a significant error of model was determined based on significance 'lack of fit' value. Spheroids were formulated using the extrusion spheronization technique and were characterized using analytical techniques.Results: In vitro release was performed in both acidic (pH 1.2) and simulated intestinal (pH 6.8) conditions. Permeability studies demonstrated tenfold enhancement compared with arteether. In vivo studies further validated increase of 51.8% oral bioavailability. Ex vivo studies revealed 3.4-fold enhancement in antimalarial activity compared with arteether.Conclusion: These findings highlight effectiveness of inclusion complexation technique as a viable approach to enhance solubility and bioavailability for drugs with low aqueous solubility.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"653-666"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0