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Exploring magnesium myristate for its dual functionality as a binder and lubricant in the formulation of tablet. 探索肉豆蔻酸镁在片剂配方中作为粘合剂和润滑剂的双重功能。
IF 4.2
Therapeutic delivery Pub Date : 2024-04-01 Epub Date: 2024-02-29 DOI: 10.4155/tde-2023-0101
Rachana Pockle, Rajashree Masareddy, Vijay Bambulkar, Rishabh Desai, Sai Kiran
{"title":"Exploring magnesium myristate for its dual functionality as a binder and lubricant in the formulation of tablet.","authors":"Rachana Pockle, Rajashree Masareddy, Vijay Bambulkar, Rishabh Desai, Sai Kiran","doi":"10.4155/tde-2023-0101","DOIUrl":"10.4155/tde-2023-0101","url":null,"abstract":"<p><p><b>Purpose:</b> To explore 'magnesium myristate' for its dual functionality as a lubricant and binder in the formulation of tablets. <b>Methods:</b> Using (DoE), tablet formulations using magnesium myristate and conventional excipients (magnesium stearate and PVP K30) were developed by wet granulation technique. The prepared granules and formulated tablets were evaluated for pre- and post-compression parameters, respectively. <b>Results:</b> Magnesium myristate exhibited excellent flow properties. The optimized formulations containing magnesium myristate exhibited increased hardness and <i>in vitro</i> drug release in comparison to conventional excipients. <i>f</i><sub>2</sub> similarity index for <i>in vitro</i> drug release showed no significant variations with optimized formulations and with the marketed formulations. <b>Conclusion:</b> Magnesium myristate shows a promising replacement for conventional excipients as both a lubricant and binder in tablet formulation.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"253-266"},"PeriodicalIF":4.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating anti-cancer activity of dual-loaded liposomes with thymoquinone and vitamin C. 研究胸腺醌和维生素 C 双载脂质体的抗癌活性
IF 4.2
Therapeutic delivery Pub Date : 2024-04-01 Epub Date: 2024-03-07 DOI: 10.4155/tde-2023-0140
Ahmed Munef, Zainab Lafi, Naeem Shalan
{"title":"Investigating anti-cancer activity of dual-loaded liposomes with thymoquinone and vitamin C.","authors":"Ahmed Munef, Zainab Lafi, Naeem Shalan","doi":"10.4155/tde-2023-0140","DOIUrl":"10.4155/tde-2023-0140","url":null,"abstract":"<p><p><b>Background:</b> Thymoquinone (TQ) and vitamin C (Vit C) have demonstrated individual anticancer effects in various studies. TQ exhibits inhibitory properties against tumor growth, induces apoptosis, while Vit C protects against DNA damage and oxidative stress. <b>Aim:</b> Formulation of TQ and Vit C combination into liposomes using two methods and investigate the synergistic anticancer. <b>Method:</b> Liposomal preparations were characterized, and the purity of drug components was confirmed using encapsulation efficiency (EE %). <b>Results:</b> <i>In vitro</i> cell viability studies demonstrated the inhibitory effect of TQ and Vit C against colorectal (HT29, 5.5 ± 0.9 μM) and lung cancer (A549, 6.25 ± 0.9 μM) cell lines with combination index <1. <b>Conclusion:</b> The formulation of TQ and Vit C displayed synergistic anticancer activity.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"267-278"},"PeriodicalIF":4.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are mathematical equations important for improving drug-delivery devices performances? 数学公式对提高给药装置的性能重要吗？
IF 4.2
Therapeutic delivery Pub Date : 2024-04-01 Epub Date: 2024-02-15 DOI: 10.4155/tde-2023-0125
Fabio Pizzetti, Giuseppe Perale, Maurizio Masi, Filippo Rossi
{"title":"Are mathematical equations important for improving drug-delivery devices performances?","authors":"Fabio Pizzetti, Giuseppe Perale, Maurizio Masi, Filippo Rossi","doi":"10.4155/tde-2023-0125","DOIUrl":"10.4155/tde-2023-0125","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"233-236"},"PeriodicalIF":4.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probucol-bile acid based nanoparticles protect auditory cells from oxidative stress: an in vitro study. 基于丙三醇胆酸的纳米颗粒保护听觉细胞免受氧化应激：一项体外研究。
IF 4.2
Therapeutic delivery Pub Date : 2024-04-01 Epub Date: 2024-03-12 DOI: 10.4155/tde-2023-0099
Susbin Raj Wagle, Bozica Kovacevic, Corina Mihaela Ionescu, Thomas Foster, Melissa Jones, Momir Mikov, Andrew Wise, Armin Mooranian, Hani Al-Salami
{"title":"Probucol-bile acid based nanoparticles protect auditory cells from oxidative stress: an <i>in vitro</i> study.","authors":"Susbin Raj Wagle, Bozica Kovacevic, Corina Mihaela Ionescu, Thomas Foster, Melissa Jones, Momir Mikov, Andrew Wise, Armin Mooranian, Hani Al-Salami","doi":"10.4155/tde-2023-0099","DOIUrl":"10.4155/tde-2023-0099","url":null,"abstract":"<p><p><b>Aim:</b> Excessive free radicals contribute to oxidative stress and mitochondrial dysfunction in sensorineural hearing loss (SNHL). The antioxidant probucol holds promise, but its limited bioavailability and inner ear barriers hinder effective SNHL treatment. <b>Methodology:</b> We addressed this by developing probucol-loaded nanoparticles with polymers and lithocholic acid and tested them on House Ear Institute-Organ of Corti cells. <b>Results:</b> Probucol-based nanoparticles effectively reduced oxidative stress-induced apoptosis, enhanced cellular viability, improved probucol uptake and promoted mitochondrial function. Additionally, they demonstrated the capacity to reduce reactive oxygen species through the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway. <b>Conclusion:</b> This innovative nanoparticle system holds the potential to prevent oxidative stress-related hearing impairment, providing an effective solution for SNHL.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"237-252"},"PeriodicalIF":4.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and evaluation of amylose-mefenamic acid conjugates as colon-targeting prodrugs. 作为结肠靶向原药的直链淀粉-甲灭酸共轭物的合成与评估。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-18 DOI: 10.4155/tde-2023-0106
Shraddha Chugh, Mousmee Sharma, Harish Mudila, Parteek Prasher
{"title":"Synthesis and evaluation of amylose-mefenamic acid conjugates as colon-targeting prodrugs.","authors":"Shraddha Chugh, Mousmee Sharma, Harish Mudila, Parteek Prasher","doi":"10.4155/tde-2023-0106","DOIUrl":"10.4155/tde-2023-0106","url":null,"abstract":"<p><p><b>Aim:</b> Amide-linked amylose-based prodrugs were developed for colon-targeted release of mefenamic acid. <b>Materials & methods:</b> Activation of prodrug was studied spectrophotometrically, enzyme-linked immunosorbent assay appraised cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition at different concentrations of the prodrug, the behavior of prodrug under physiological conditions was monitored by scanning electron microscopy. <b>Results:</b> Prodrug was poorly activated in the enzyme-free simulated gastric media and simulated intestinal media (SIM) but preincubation in pancreatin followed by treatment in aminopeptidase containing SIM led to a significant activation of prodrug. <b>Conclusion:</b> Amide-linked amylose-mefenamic acid conjugates showed a slow release in simulated gastric media and a controlled release in SIM with pancreatin playing an important role in drug release.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chia nanoemulsion: anti-inflammatory mechanism, biological behavior and cellular interactions. 奇异果纳米乳液：抗炎机制、生物行为和细胞相互作用。
IF 3
Therapeutic delivery Pub Date : 2024-03-12 DOI: 10.4155/tde-2023-0088
Luana Barbosa Correa, Natália Cristina Gomes-da-Silva, Clenilton Costa Dos Santos, Luciana Magalhães Rebelo Alencar, Maria das Graças Muller de Oliveira Henriques, Prapanna Bhattarai, Lin Zhu, Pedro Filho Noronha Souza, Elaine Cruz Rosas, Ralph Santos-Oliveira
{"title":"Chia nanoemulsion: anti-inflammatory mechanism, biological behavior and cellular interactions.","authors":"Luana Barbosa Correa, Natália Cristina Gomes-da-Silva, Clenilton Costa Dos Santos, Luciana Magalhães Rebelo Alencar, Maria das Graças Muller de Oliveira Henriques, Prapanna Bhattarai, Lin Zhu, Pedro Filho Noronha Souza, Elaine Cruz Rosas, Ralph Santos-Oliveira","doi":"10.4155/tde-2023-0088","DOIUrl":"10.4155/tde-2023-0088","url":null,"abstract":"<p><p><b>Aim:</b> This study explores chia oil, rich in ω-3 fatty acids and nutraceutical components, as a potential remedy for diseases, especially those linked to inflammation and cancer. <b>Methods/materials:</b> A chia oil-based nanoemulsion, developed through single emulsification, underwent comprehensive analysis using various techniques. <i>In vitro</i> and <i>in vivo</i> assays, including macrophage polarization, nitrite and cytokine production, cellular uptake and biodistribution, were conducted to assess the anti-inflammatory efficacy. <b>Results & conclusion:</b> Results reveal that the chia nanoemulsion significantly inhibits inflammation, outperforming pure oil with twice the efficacy. Enhanced uptake by macrophage-like cells and substantial accumulation in key organs indicate its potential as an economical and effective anti-inflammatory nanodrug, addressing global economic and health impacts of inflammation-related diseases.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation, characterization and in vitro evaluation of 5-fluorouracil loaded into chitosan-acacia gum nanoparticles. 壳聚糖-金合欢胶纳米颗粒负载的 5-氟尿嘧啶的制备、表征和体外评价。
IF 3
Therapeutic delivery Pub Date : 2024-03-12 DOI: 10.4155/tde-2023-0136
Hasan Al-Nasrawi, Naeem Shalan, Bassam M Abualsoud, Hamdi Nsairat
{"title":"Preparation, characterization and <i>in vitro</i> evaluation of 5-fluorouracil loaded into chitosan-acacia gum nanoparticles.","authors":"Hasan Al-Nasrawi, Naeem Shalan, Bassam M Abualsoud, Hamdi Nsairat","doi":"10.4155/tde-2023-0136","DOIUrl":"10.4155/tde-2023-0136","url":null,"abstract":"<p><p><b>Aim:</b> In this study, we prepared, characterized and <i>in vitro</i> evaluated a 5-fluorouracil (5-FU)-loaded chitosan-acacia gum nanoparticles. <b>Methods:</b> Nanoparticles were characterized for their size, charge, morphology and encapsulation efficiency (EE%) followed by cellular investigations against HT-29 colon cancer cell line. <b>Results:</b> The nanoparticles exhibited a spherical morphological size with 94.42% EE%. Free 5-FU showed a fast and fully cumulative release after 6 h while 5-FU loaded into CS-AG NPs showed good entrapment and slow, prolonged 5-FU release even after 24 h. Enhanced IC<sub>50</sub> for the 5-FU loaded NPs compared with free 5-FU against HT-29 colon cancer cell line was reported with high selectivity compared with normal fibroblast cells. <b>Conclusion:</b> 5-FU loaded NPs is promising nano-therapy against colon cancer.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delivery of nano-emulgel carrier: optimization, evaluation and in vivo anti-inflammation estimations for osteoarthritis. 纳米软凝胶载体的输送：骨关节炎的优化、评估和体内抗炎估计。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-01 Epub Date: 2024-02-15 DOI: 10.4155/tde-2023-0109
Rajni, Kamal Shah, Hitesh Kumar Dewangan
{"title":"Delivery of nano-emulgel carrier: optimization, evaluation and <i>in vivo</i> anti-inflammation estimations for osteoarthritis.","authors":"Rajni, Kamal Shah, Hitesh Kumar Dewangan","doi":"10.4155/tde-2023-0109","DOIUrl":"10.4155/tde-2023-0109","url":null,"abstract":"<p><p><b>Aim:</b> Optimization and evaluation of Aceclofenac nanoemulgel for treatment for rheumatoid arthritis and reduction of GI irritation and enhancement of bioavaibility. <b>Materials & methods:</b> Different batches of emulgel and selected batch was proceeded for characterization like particle size, scanning electron microscopy, drug ingredient, <i>in vitro</i> release, Fourier transform infrared and x-ray diffraction <i>in vitro</i> inflammation and gel evaluation such as (spreadability, swelling index), <i>ex vitro</i> permeation, skin irritation and <i>in vivo</i> anti-inflammatory. <b>Result:</b> Emulgel showed nanometri size sustained release (79.96% in 6 h), compatibility and anti-inflammatory activity compared with pure drug. Concluded that emulgels had better (nearly twice as good) anti-inflammatory action as the commercial product. <b>Conclusion:</b> Compared with the commercial gel, the emulgel's anti-inflammatory effect had a quicker onset and a longer duration of action.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"181-192"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alopecia areata: review of epidemiology, pathophysiology, current treatments and nanoparticulate delivery system. 斑秃：流行病学、病理生理学、当前治疗方法和纳米颗粒给药系统综述。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-01 Epub Date: 2024-03-07 DOI: 10.4155/tde-2023-0071
Robel Singh, Pawan Kumar, Davinder Kumar, Navidha Aggarwal, Hitesh Chopra, Virender Kumar
{"title":"Alopecia areata: review of epidemiology, pathophysiology, current treatments and nanoparticulate delivery system.","authors":"Robel Singh, Pawan Kumar, Davinder Kumar, Navidha Aggarwal, Hitesh Chopra, Virender Kumar","doi":"10.4155/tde-2023-0071","DOIUrl":"10.4155/tde-2023-0071","url":null,"abstract":"<p><p>Alopecia areata (AA) is a kind of alopecia that affects hair follicles and nails. It typically comes with round patches and is a type of nonscarring hair loss. Various therapies are accessible for the management and treatment of AA, including topical, systemic and injectable modalities. It is a very complex type of autoimmune disease and is identified as round patches of hair loss and may occur at any age. This review paper highlights the epidemiology, clinical features, pathogenesis and new treatment options for AA, with a specific emphasis on nanoparticulate drug-delivery systems. By exploring these innovative treatment approaches, researchers aim to enhance the effectiveness and targeted delivery of therapeutic agents, ultimately improving outcomes for individuals living with AA.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"193-210"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
November 2023 industry update. 2023 年 11 月行业更新。
IF 4.2
Therapeutic delivery Pub Date : 2024-03-01 Epub Date: 2024-02-06 DOI: 10.4155/tde-2024-0012
Elaine Harris
{"title":"November 2023 industry update.","authors":"Elaine Harris","doi":"10.4155/tde-2024-0012","DOIUrl":"10.4155/tde-2024-0012","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"157-163"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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