基于丙三醇胆酸的纳米颗粒保护听觉细胞免受氧化应激：一项体外研究。

IF 3 Q2 PHARMACOLOGY & PHARMACY

Therapeutic delivery Pub Date : 2024-04-01 Epub Date: 2024-03-12 DOI:10.4155/tde-2023-0099

Susbin Raj Wagle, Bozica Kovacevic, Corina Mihaela Ionescu, Thomas Foster, Melissa Jones, Momir Mikov, Andrew Wise, Armin Mooranian, Hani Al-Salami

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引用次数: 0

摘要

目的：过多的自由基会导致感音神经性听力损失（SNHL）的氧化应激和线粒体功能障碍。抗氧化剂普布洛尔具有良好的前景，但其有限的生物利用度和内耳屏障阻碍了对感音神经性听力损失的有效治疗。方法：为了解决这一问题，我们开发了含有聚合物和石胆酸的普布酚载纳米颗粒，并在豪斯耳研究所-科蒂细胞器官上进行了测试。结果基于普罗布考的纳米颗粒有效减少了氧化应激诱导的细胞凋亡，提高了细胞活力，改善了普罗布考的吸收并促进了线粒体功能。此外，它们还能通过红细胞核因子 2 相关因子 2/血红素加氧酶 1 途径减少活性氧。结论这种创新的纳米粒子系统具有预防氧化应激相关听力损伤的潜力，为治疗急性咽喉炎提供了有效的解决方案。

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Probucol-bile acid based nanoparticles protect auditory cells from oxidative stress: an in vitro study.

Aim: Excessive free radicals contribute to oxidative stress and mitochondrial dysfunction in sensorineural hearing loss (SNHL). The antioxidant probucol holds promise, but its limited bioavailability and inner ear barriers hinder effective SNHL treatment. Methodology: We addressed this by developing probucol-loaded nanoparticles with polymers and lithocholic acid and tested them on House Ear Institute-Organ of Corti cells. Results: Probucol-based nanoparticles effectively reduced oxidative stress-induced apoptosis, enhanced cellular viability, improved probucol uptake and promoted mitochondrial function. Additionally, they demonstrated the capacity to reduce reactive oxygen species through the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway. Conclusion: This innovative nanoparticle system holds the potential to prevent oxidative stress-related hearing impairment, providing an effective solution for SNHL.

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来源期刊

Therapeutic delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.