Chia nanoemulsion: anti-inflammatory mechanism, biological behavior and cellular interactions.

IF 3 Q2 PHARMACOLOGY & PHARMACY

Therapeutic delivery Pub Date : 2024-03-12 DOI:10.4155/tde-2023-0088

Luana Barbosa Correa, Natália Cristina Gomes-da-Silva, Clenilton Costa Dos Santos, Luciana Magalhães Rebelo Alencar, Maria das Graças Muller de Oliveira Henriques, Prapanna Bhattarai, Lin Zhu, Pedro Filho Noronha Souza, Elaine Cruz Rosas, Ralph Santos-Oliveira

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引用次数: 0

Abstract

Aim: This study explores chia oil, rich in ω-3 fatty acids and nutraceutical components, as a potential remedy for diseases, especially those linked to inflammation and cancer. Methods/materials: A chia oil-based nanoemulsion, developed through single emulsification, underwent comprehensive analysis using various techniques. In vitro and in vivo assays, including macrophage polarization, nitrite and cytokine production, cellular uptake and biodistribution, were conducted to assess the anti-inflammatory efficacy. Results & conclusion: Results reveal that the chia nanoemulsion significantly inhibits inflammation, outperforming pure oil with twice the efficacy. Enhanced uptake by macrophage-like cells and substantial accumulation in key organs indicate its potential as an economical and effective anti-inflammatory nanodrug, addressing global economic and health impacts of inflammation-related diseases.

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奇异果纳米乳液：抗炎机制、生物行为和细胞相互作用。

目的：本研究探讨了奇异果油，它富含ω-3 脂肪酸和营养保健成分，是治疗疾病，尤其是与炎症和癌症有关的疾病的一种潜在疗法。方法/材料：利用各种技术对通过单一乳化技术开发的基于奇异果油的纳米乳液进行了综合分析。进行了体外和体内试验，包括巨噬细胞极化、亚硝酸盐和细胞因子的产生、细胞吸收和生物分布，以评估其抗炎功效。结果与结论结果显示，奇异果纳米乳液能显著抑制炎症，其功效是纯油的两倍。巨噬细胞的吸收能力增强以及在关键器官中的大量积累表明，它有潜力成为一种经济、有效的抗炎纳米药物，从而解决炎症相关疾病对全球经济和健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.