纳米软凝胶载体的输送:骨关节炎的优化、评估和体内抗炎估计。

IF 3 Q2 PHARMACOLOGY & PHARMACY
Therapeutic delivery Pub Date : 2024-03-01 Epub Date: 2024-02-15 DOI:10.4155/tde-2023-0109
Rajni, Kamal Shah, Hitesh Kumar Dewangan
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引用次数: 0

摘要

目的:优化和评估用于治疗类风湿性关节炎的醋氯芬酸纳米凝胶,减少对胃肠道的刺激并提高其生物可溶性。材料与方法:对不同批次的凝胶进行表征,如粒度、扫描电子显微镜、药物成分、体外释放、傅立叶变换红外线和 X 射线衍射、体外炎症和凝胶评估,如(铺展性、膨胀指数)、体外渗透、皮肤刺激性和体内抗炎性。结果与纯药物相比,凝胶显示出纳米级的持续释放(6 小时内释放 79.96%)、相容性和抗炎活性。结论是,乳凝胶的抗炎作用比商用产品更好(几乎是后者的两倍)。结论与市售凝胶相比,润肤凝胶的抗炎作用起效更快,持续时间更长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Delivery of nano-emulgel carrier: optimization, evaluation and in vivo anti-inflammation estimations for osteoarthritis.

Aim: Optimization and evaluation of Aceclofenac nanoemulgel for treatment for rheumatoid arthritis and reduction of GI irritation and enhancement of bioavaibility. Materials & methods: Different batches of emulgel and selected batch was proceeded for characterization like particle size, scanning electron microscopy, drug ingredient, in vitro release, Fourier transform infrared and x-ray diffraction in vitro inflammation and gel evaluation such as (spreadability, swelling index), ex vitro permeation, skin irritation and in vivo anti-inflammatory. Result: Emulgel showed nanometri size sustained release (79.96% in 6 h), compatibility and anti-inflammatory activity compared with pure drug. Concluded that emulgels had better (nearly twice as good) anti-inflammatory action as the commercial product. Conclusion: Compared with the commercial gel, the emulgel's anti-inflammatory effect had a quicker onset and a longer duration of action.

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来源期刊
Therapeutic delivery
Therapeutic delivery PHARMACOLOGY & PHARMACY-
CiteScore
5.50
自引率
0.00%
发文量
25
期刊介绍: Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.
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