用于治疗真菌性角膜炎的伏立康唑阳离子微乳剂：体外和体内评估。

IF 3 Q2 PHARMACOLOGY & PHARMACY

Therapeutic delivery Pub Date : 2024-01-05 DOI:10.4155/tde-2023-0069

Parasuraman Mohan, Jothimani Rajeswari, Karthikeyan Kesavan

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引用次数: 0

摘要

目的：本研究旨在开发一种载入伏立康唑的壳聚糖包被阳离子微乳剂（CVME），用于治疗真菌性角膜炎。制备方法采用水滴定法制备微乳剂，将优化后的微乳剂包覆壳聚糖制备CVME。进行了理化参数、眼刺激潜能、体外抗真菌药效和体外释放研究。在真菌感染诱导的兔眼模型中进行了体内抗真菌药效研究。结果显示所开发的 CVME 具有可接受的理化特性和优异的粘附性，并显示出持续释放特性。体内外研究结果表明，与药物混悬液（DS）相比，CVME 的渗透性更高，抗真菌效果更好。结论制备的 CVME7 是现有方法治疗真菌性角膜炎的可行替代品。

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Cationic microemulsion of voriconazole for the treatment of fungal keratitis: in vitro and in vivo evaluation.

Aim: This investigation aimed to develop a voriconazole-loaded chitosan-coated cationic microemulsion (CVME) to treat fungal keratitis. Methods: Microemulsions were prepared using water titration, and the optimized microemulsion was coated with chitosan to prepare CVME. The physicochemical parameters, ocular irritation potential, in vitro antifungal efficacy and in vitro release studies were performed. The in vivo antifungal efficacy study was conducted in a fungal infection-induced rabbit eye model. Results: The developed CVME displayed acceptable physicochemical properties and excellent mucoadhesive behavior and showed a sustained release profile. Ex vivo and in vivo studies concluded that higher permeability and improved antifungal efficacy were observed for CVME than drug suspension (DS). Conclusion: The prepared CVME7 is a viable alternative to treating fungal keratitis with existing approaches.

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来源期刊

Therapeutic delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.