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Delivering Volume 15: welcome to another year of Therapeutic Delivery! 交付》第 15 卷：欢迎来到《治疗交付》的又一年！
IF 4.2
Therapeutic delivery Pub Date : 2023-12-20 DOI: 10.4155/tde-2023-0126
Rebecca Turner
{"title":"Delivering Volume 15: welcome to another year of <i>Therapeutic Delivery</i>!","authors":"Rebecca Turner","doi":"10.4155/tde-2023-0126","DOIUrl":"https://doi.org/10.4155/tde-2023-0126","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A narrative review on Naringin and Naringenin as a possible bioenhancer in various drug-delivery formulations. 关于柚皮苷和柚皮苷在各种给药配方中可能用作生物增效剂的综述。
IF 4.2
Therapeutic delivery Pub Date : 2023-12-01 Epub Date: 2023-12-13 DOI: 10.4155/tde-2023-0086
Pradeepti Ganesh, Vanishree Suresh, Manoj Kumar Narasimhan, Sarvesh Sabarathinam
{"title":"A narrative review on Naringin and Naringenin as a possible bioenhancer in various drug-delivery formulations.","authors":"Pradeepti Ganesh, Vanishree Suresh, Manoj Kumar Narasimhan, Sarvesh Sabarathinam","doi":"10.4155/tde-2023-0086","DOIUrl":"10.4155/tde-2023-0086","url":null,"abstract":"<p><p>Naringenin belongs to the flavanones and is mainly found in fruits (grapefruit and oranges) and vegetables. Naringenin exhibits lipid-lowering and insulin-like characteristics and is used to treat osteoporosis, cancer and cardiovascular disorders. Their incorporation into drug formulations offers several advantages, including enhanced solubility, improved bioavailability and targeted delivery. Naringin-based formulations are beneficial in cancer, for example controlling breast and prostate cancer by inhibition of CYP19. Naringin suppresses the PI3K/AKT signalling pathway, it triggers autophagy, which effectively halts the proliferation of gastric cancer cells. Naringin and naringenin co-administration or pre-administration has enhanced the target drug's potency and produced a synergistic effect. This published study demonstrates the potential applications of Naringin and Naringenin as recognized bio-enhancers.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"763-774"},"PeriodicalIF":4.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticle-based delivery platforms for the enhanced oral delivery of peptides/proteins. 基于纳米颗粒的递送平台，用于增强多肽/蛋白质的口服递送。
IF 4.2
Therapeutic delivery Pub Date : 2023-12-01 Epub Date: 2023-12-19 DOI: 10.4155/tde-2023-0048
Sara Salatin, Soheila Montazersaheb, Afsaneh Farjami, Samin Hamidi
{"title":"Nanoparticle-based delivery platforms for the enhanced oral delivery of peptides/proteins.","authors":"Sara Salatin, Soheila Montazersaheb, Afsaneh Farjami, Samin Hamidi","doi":"10.4155/tde-2023-0048","DOIUrl":"10.4155/tde-2023-0048","url":null,"abstract":"<p><p>Biopharmaceutical products are currently well-established in nearly all branches of medicine and are believed to have great potential for the treatment of a broad spectrum of diseases. Peptide/protein drugs exhibit a predominant class of new biopharmaceuticals coming on the market in recent years. Oral delivery of peptides/proteins as a non-invasive therapeutic technique has become an appealing alternative to the parenteral route. However, the efficient oral delivery of peptides/proteins is limited because of their high molecular weight, poor stability and low biodistribution. Nanoparticles (NPs) have shown excellent results in peptide/protein delivery research. In this paper, the use of NPs as delivery systems for peptides/proteins and their ability to be efficiently delivered via the oral route have been described.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"795-815"},"PeriodicalIF":4.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered exosomes: a promising vehicle in cancer therapy. 工程外泌体：一种前景广阔的癌症治疗工具。
IF 4.2
Therapeutic delivery Pub Date : 2023-12-01 Epub Date: 2023-12-20 DOI: 10.4155/tde-2023-0131
Farkhondeh Pooresmaeil, Sahar Andi, Behnam Hasannejad-Asl, Shahla Takamoli, Azam Bolhassani
{"title":"Engineered exosomes: a promising vehicle in cancer therapy.","authors":"Farkhondeh Pooresmaeil, Sahar Andi, Behnam Hasannejad-Asl, Shahla Takamoli, Azam Bolhassani","doi":"10.4155/tde-2023-0131","DOIUrl":"10.4155/tde-2023-0131","url":null,"abstract":"<p><p>During the past few decades, researchers have attempted to discover an effective treatment for cancer. Exosomes are natural nanovesicles released by various cells and play a role in communication between cells. While natural exosomes have high clinical potential, their inherent limitations have prompted researchers to design exosomes with improved therapeutic properties. To achieve this purpose, researchers have undertaken exosome engineering to modify the surface properties or internal composition of exosomes. After these modifications, engineered exosomes can be used as carriers for delivery of chemotherapeutic agents, targeted drug delivery or development of cancer vaccines. The present study provides an overview of exosomes, including their biogenesis, biological functions, isolation techniques, engineering methods, and potential applications in cancer therapy.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"775-794"},"PeriodicalIF":4.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality by design-assisted development of D-α-tocopherol polyethylene glycol 1000 succinate-incorporated gefitinib-loaded cationic liposome(s). 通过设计辅助开发D-α-生育酚聚乙二醇1000琥珀酸-吉非替尼负载阳离子脂质体的质量。
IF 4.2
Therapeutic delivery Pub Date : 2023-12-01 Epub Date: 2023-11-29 DOI: 10.4155/tde-2023-0075
Lopamudra Mishra, Shuvadip Bhowmik, Rajveer Singh, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi
{"title":"Quality by design-assisted development of D-α-tocopherol polyethylene glycol 1000 succinate-incorporated gefitinib-loaded cationic liposome(s).","authors":"Lopamudra Mishra, Shuvadip Bhowmik, Rajveer Singh, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi","doi":"10.4155/tde-2023-0075","DOIUrl":"10.4155/tde-2023-0075","url":null,"abstract":"<p><p><b>Aim:</b> Gefitinib-loaded D-α-tocopherol polyethylene glycol 1000 succinate (TPGS)-coated cationic liposomes (GEF-TPGS-LIPO<sup>+</sup>) were developed and optimized by the quality by design (QbD) approach for its potential anticancer effect. <b>Methods/materials:</b> Box-Behnken design (BBD) a systematic design of experiments was added to screen and optimize the formulation variables. <b>Results:</b> GEF-TPGS-LIPO<sup>+</sup> shows vesicle size (210 ± 4.82 nm), polydispersity index (0.271 ± 0.002), zeta potential (22.2 ± 0.84 mV) and entrapment efficiency (82.3 ± 1.95). MTT result shows the enhanced cytotoxicity and higher intracellular drug uptake with highest and lowest levels of the reactive oxygen species and NF-κB expressions on A549 lung cancer cells, determined by fluorescence-activated cell sorting flow cytometry. <b>Conclusion:</b> Potential anticancer effect on A549 cells might be found due to cationic liposomal interaction with cancer cells.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"745-761"},"PeriodicalIF":4.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the role of nanocarriers in oral drug delivery. 纳米载体在口服给药中的作用。
IF 4.2
Therapeutic delivery Pub Date : 2023-12-01 Epub Date: 2023-12-13 DOI: 10.4155/tde-2023-0117
Qin Yu, Wei Wu
{"title":"On the role of nanocarriers in oral drug delivery.","authors":"Qin Yu, Wei Wu","doi":"10.4155/tde-2023-0117","DOIUrl":"10.4155/tde-2023-0117","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"741-744"},"PeriodicalIF":4.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anthocyanin-enriched extract from Ribes nigrum inhibits triglyceride and cholesterol accumulation in adipocytes. 富含花青素的黑肋提取物抑制甘油三酯和胆固醇在脂肪细胞中的积累。
IF 4.2
Therapeutic delivery Pub Date : 2023-11-01 Epub Date: 2023-11-29 DOI: 10.4155/tde-2023-0018
Laura Montaldo, Alicia Gallo, Gabriela Rocha, Cecilia Csernoch, Mauricio De Marzi, Liliana N Guerra
{"title":"Anthocyanin-enriched extract from <i>Ribes nigrum</i> inhibits triglyceride and cholesterol accumulation in adipocytes.","authors":"Laura Montaldo, Alicia Gallo, Gabriela Rocha, Cecilia Csernoch, Mauricio De Marzi, Liliana N Guerra","doi":"10.4155/tde-2023-0018","DOIUrl":"10.4155/tde-2023-0018","url":null,"abstract":"<p><p><b>Aim:</b> Obesity is a chronic pathology of epidemic proportions. Mature adipocytes from a 3T3-L1 cell line were used as <i>in vitro</i> obesity model to test different bioactive compounds. We aim to evaluate cassis (<i>Ribes nigrum</i>) extract antioxidant activity and its antiadipogenic effect on mature adipocytes. <b>Results:</b> We produced an extract by using enzyme that combines cellulase and pectinase; we obtained high yield of the bioactive compound anthocyanin. Extract showed high antioxidant capacity. We conducted <i>in vitro</i> assays by adding the extract to adipocytes culture medium. Extract reduced intracellular levels of triglyceride by 62% and cholesterol by 32%. <b>Conclusion:</b> Enzymatic extract's high antioxidant activity was likely attributable to its high concentration of anthocyanin. This extract inhibits lipid accumulation in adipocytes.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"675-687"},"PeriodicalIF":4.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
September industry news update. 9月行业新闻更新。
IF 4.2
Therapeutic delivery Pub Date : 2023-11-01 Epub Date: 2023-12-07 DOI: 10.4155/tde-2023-0120
Fiona McCartney
{"title":"September industry news update.","authors":"Fiona McCartney","doi":"10.4155/tde-2023-0120","DOIUrl":"10.4155/tde-2023-0120","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"669-673"},"PeriodicalIF":4.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and release of isoniazid from inhalable alginate/carrageenan microspheres. 可吸入海藻酸/卡拉胶微球中异烟肼的特性和释放。
IF 4.2
Therapeutic delivery Pub Date : 2023-11-01 Epub Date: 2023-12-12 DOI: 10.4155/tde-2023-0064
Yotomi Desia Eka Rani, Mahardian Rahmadi, Dewi Melani Hariyadi
{"title":"Characteristics and release of isoniazid from inhalable alginate/carrageenan microspheres.","authors":"Yotomi Desia Eka Rani, Mahardian Rahmadi, Dewi Melani Hariyadi","doi":"10.4155/tde-2023-0064","DOIUrl":"10.4155/tde-2023-0064","url":null,"abstract":"<p><p><b>Aim:</b> Inhalable microspheres made of polymers as a targeted drug delivery system have been developed to overcome the limitation of current treatments in Tuberculosis. <b>Materials & methods:</b> Isoniazid inhalable microspheres were created using a gelation ionotropic method with sodium alginate, carrageenan and calcium chloride in four different formulations. <b>Result:</b> The particle morphology has smooth surfaces and round spherical shapes with sizes below 5 μm; good flowability. The drug loading and entrapment efficiency values ranged from 1.69 to 2.75% and 62.44 to 85.30%, respectively. The microspheres drug release followed the Korsmeyer-Peppas model, indicating Fickian diffusion. <b>Conclusion:</b> Isoniazid inhalable microspheres achieved as targeted lung delivery for tuberculosis treatment.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":"14 11","pages":"689-704"},"PeriodicalIF":4.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microemulsions, nanoemulsions and emulgels as carriers for antifungal antibiotics. 微乳剂、纳米乳剂和乳剂作为抗真菌抗生素的载体。
IF 4.2
Therapeutic delivery Pub Date : 2023-11-01 Epub Date: 2023-11-28 DOI: 10.4155/tde-2023-0076
Annapurna Padaraju, Falguni Dwivedi, Gautam Kumar
{"title":"Microemulsions, nanoemulsions and emulgels as carriers for antifungal antibiotics.","authors":"Annapurna Padaraju, Falguni Dwivedi, Gautam Kumar","doi":"10.4155/tde-2023-0076","DOIUrl":"10.4155/tde-2023-0076","url":null,"abstract":"<p><p>According to estimates, up to 25% of the world's population has fungal skin diseases, making them the most prevalent infectious disease. Several chemical classes of antifungal drugs are available to treat fungal infections. However, the major challenges of conventional formulations of antifungal drugs include poor pharmacokinetic profiles like solubility, low permeability, side effects and decreased efficacy. Novel drug delivery is a promising approach for overcoming pharmacokinetic limitations and increasing the effectiveness of antibiotics. In this review, we have shed light on microemulsions, nanoemulsions, and emulgels as novel drug delivery approaches for the topical delivery of antifungal antibiotics. We believe these formulations have potential translational value and could be developed for treating fungal infections in humans.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"721-740"},"PeriodicalIF":4.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138446321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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