Therapeutic delivery最新文献_第8页

Modeling and evaluation of ivermectin release kinetics from 3D-printed tablets. 三维打印片剂伊维菌素释放动力学的建模与评估。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-10-16 DOI: 10.1080/20415990.2024.2412511

Cintia Alejandra Briones Nieva, Juan Pablo Real, Santiago Nicolás Campos, Analía Irma Romero, Mercedes Villegas, Elio Emilio Gonzo, José María Bermúdez, Santiago Daniel Palma, Alicia Graciela Cid

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Fabrication and evaluation of nanoemulsion based insulin loaded microneedles for transdermal drug delivery. 用于透皮给药的基于纳米乳液的胰岛素微针的制造和评估。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI: 10.1080/20415990.2024.2377065

Fatima Ramzan Ali, Muhammad Harris Shoaib, Syed Abid Ali, Rabia Ismail Yousuf, Farrukh Rafiq Ahmed, Fahad Siddiqui, Sana Sarfaraz, Rameez Raja

{"title":"Fabrication and evaluation of nanoemulsion based insulin loaded microneedles for transdermal drug delivery.","authors":"Fatima Ramzan Ali, Muhammad Harris Shoaib, Syed Abid Ali, Rabia Ismail Yousuf, Farrukh Rafiq Ahmed, Fahad Siddiqui, Sana Sarfaraz, Rameez Raja","doi":"10.1080/20415990.2024.2377065","DOIUrl":"10.1080/20415990.2024.2377065","url":null,"abstract":"Aim: Insulin therapy require self-administration of subcutaneous injection leading to painful and inconvenient drug therapy. The aim is to fabricate nanoemulsion (NE) based insulin loaded microneedles with improved bioavailability and patient compliance.Materials & methods: Different ratios of polyvinyl alcohol and polyvinylpyrrolidone as polymers were prepared through micro-molding technique for microneedles. Characterization of were performed using scanning electron microscope, differential scanning calorimetry, Fourier-transform infrared spectroscopy and circular dichroism. Mechanical strength, hygroscopicity and pain perception of these microneedles were also evaluated. In vitro release, permeation and in vivo PK/PD study of NE-based microneedles were conducted.Results: NE-based microneedles of insulin have improved bioavailability and quick response.Conclusion: Microneedles loaded with insulin can be effectively delivered insulin transdermally to treat diabetes with increased convenience and patient compliance.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"605-617"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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January 2024 industry update. 2024 年 1 月行业更新。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-05-09 DOI: 10.1080/20415990.2024.2346045

Patrick Lim, Nebojsa Stilinovic, Armin Mooranian, Hani Al-Salami

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A novel liposomal formulation for ocular delivery of caspofungin: an experimental study by quality by design-based approach. 一种用于眼部给药卡泊芬净的新型脂质体配方：基于设计质量方法的实验研究。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-08-05 DOI: 10.1080/20415990.2024.2379756

Mercy Macwan, Himanshu Paliwal, Bhupendra G Prajapati

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Dual combination of resveratrol and pterostilbene aqueous core nanocapsules for integrated prostate cancer targeting. 白藜芦醇和紫檀素水芯纳米胶囊的双重组合，用于前列腺癌的综合靶向治疗。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-08-12 DOI: 10.1080/20415990.2024.2380239

Alok Nath Sharma, Prabhat Kumar Upadhyay, Hitesh Kumar Dewangan

{"title":"Dual combination of resveratrol and pterostilbene aqueous core nanocapsules for integrated prostate cancer targeting.","authors":"Alok Nath Sharma, Prabhat Kumar Upadhyay, Hitesh Kumar Dewangan","doi":"10.1080/20415990.2024.2380239","DOIUrl":"10.1080/20415990.2024.2380239","url":null,"abstract":"Aim: Development and evaluation of aqueous core nanocapsules (ACNs) of BCS-II-class drug like resveratrol (RSV) and pterostilbene (PTE) for prostate cancer.Materials & methods: Identify synergistic effects of molar ratios of RSV and PTE against PC-3 cell. Selected ratio of drugs was added to ACNs by double-emulsification-method using Box-Behnken design. Further, assessed for physicochemical characterization, release kinetics, compatibility, in vitro cytotoxicity, in vivo pharmacokinetic and biodistribution studies.Results: Selected 1:1 ratio of RSV and PTE had greatest synergy potential have smaller particle-size (128.1 ± 3.21 nm), zeta-potential (-22.12 ± 0.2 mV), 0.53 PDI, improved encapsulation (87% for RSV, 72% for PTE), stable, no systemic toxicity, high biodistributed/accumulated in prostate cells.Conclusion: ACNs exhibited high t1/2 (12.42 ± 1.92 hs) and 8.20 ± 8.21 hs Mean Residence Time and lower clearance, proving the high effectiveness for prostate cancer.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"685-698"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Delivery - Industry Update covering February 2024. 治疗传递--2024 年 2 月行业更新。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-03 DOI: 10.1080/20415990.2024.2365614

Iain Simpson

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Artemisinin emulgel ameliorates cartilage degradation in knee osteoarthritis: in vitro and in vivo studies. 青蒿素凝胶改善膝关节骨关节炎软骨退化：体外和体内研究

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-11-06 DOI: 10.1080/20415990.2024.2418281

Samiksha Thote, Atul Mourya, Shristi Arya, Hoshiyar Singh, Prashanth Kumar, Santosh Kumar Guru, Jitender Madan

{"title":"Artemisinin emulgel ameliorates cartilage degradation in knee osteoarthritis: in vitro and in vivo studies.","authors":"Samiksha Thote, Atul Mourya, Shristi Arya, Hoshiyar Singh, Prashanth Kumar, Santosh Kumar Guru, Jitender Madan","doi":"10.1080/20415990.2024.2418281","DOIUrl":"10.1080/20415990.2024.2418281","url":null,"abstract":"Aim: Laboratory scale-up of artemisinin-loaded emulgel (ART-emulgel) was carried out and characterized for therapeutic performance in osteoarthritis (OA).Materials & methods: The solubility of ART in various oils, surfactants and co-surfactants were screened for construction of pseudo ternary phase diagram (TPD), followed by scale-up of artemisinin loaded nanoemulsion (ART-NE). ART-NE was amalgamated with Carbopol Ultrez 10-NF to prepare ART-emulgel that was later characterized in vitro and in vivo to analyze therapeutic efficacy in monosodium-iodoacetate (MIA) induced knee OA.Results: The droplet diameter of ART-NE was estimated to be 104.3 ± 2.593 nm with a polydispersity index of 0.245 ± 0.019 in addition to ζ-potential of 0.434 ± 0.028 mV. Steady-state flux and permeability coefficient for ART-emulgel were estimated to be 0.651 ± 0.031 µg.cm2/h and 0.245 ± 0.011 cm/h, respectively. ART-emulgel demonstrated 43.18% reduction in COX-2 level; 52.28% drop in IL-1β, and 88.78% alleviation of Tumor Necrosis Factor-α (TNF-α) level when compared with monosodium-iodoacetate induced OA rats. ART-emulgel and injectable ART (intra-articular; I.A) portrayed minor synovial erosion compared with blank and diclofenac emulgel. Histopathological evidences indicated restoration of cartilage integrity followed by reduction of OARSI scores in ART-emulgel when compared with disease control animals.Conclusion: ART-emulgel is a potential dosage form for translating into a clinically viable product for the management of OA.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"939-955"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing. 海藻酸钠/羧甲基纤维素凝胶配方，含用于伤口愈合的蓝花楹植物提取物。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-11-12 DOI: 10.1080/20415990.2024.2418800

Sindi P Ndlovu, Shirley C M Motaung, Samson A Adeyemi, Philemon Ubanako, Lindokuhle M Ngema, Thierry Youmbi Fonkui, Derek Tantoh Ndinteh, Pradeep Kumar, Yahya E Choonara, Blessing A Aderibigbe

{"title":"Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing.","authors":"Sindi P Ndlovu, Shirley C M Motaung, Samson A Adeyemi, Philemon Ubanako, Lindokuhle M Ngema, Thierry Youmbi Fonkui, Derek Tantoh Ndinteh, Pradeep Kumar, Yahya E Choonara, Blessing A Aderibigbe","doi":"10.1080/20415990.2024.2418800","DOIUrl":"10.1080/20415990.2024.2418800","url":null,"abstract":"Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing.Materials & methods: Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of Capparis sepiaria. The formulations were characterized using appropriate techniques.Results: The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and in vitro whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study.Conclusion: The gels' distinct features reveal their potential application as wound dressings for burn wounds.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"921-937"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Exploring delivery systems for targeted nanotechnology-based gene therapy in the inner ear. 探索基于纳米技术的内耳靶向基因治疗输送系统。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-26 DOI: 10.1080/20415990.2024.2389032

Thomas Foster, Patrick Lim, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Armin Mooranian, Hani Al-Salami

引用次数: 0

Enhancing Rose Bengal penetration in ex vivo human corneas using iontophoresis. 利用离子透入技术提高罗斯孟加拉红在体外人类角膜中的渗透率。

IF 3

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-07-18 DOI: 10.1080/20415990.2024.2371778

James M Lai, Justin Chen, Juan Carlos Navia, Heather Durkee, Alex Gonzalez, Cornelis Rowaan, Timothy Arcari, Mariela C Aguilar, Katrina Llanes, Noel Ziebarth, Jaime D Martinez, Darlene Miller, Harry W Flynn, Guillermo Amescua, Jean-Marie Parel

{"title":"Enhancing Rose Bengal penetration in ex vivo human corneas using iontophoresis.","authors":"James M Lai, Justin Chen, Juan Carlos Navia, Heather Durkee, Alex Gonzalez, Cornelis Rowaan, Timothy Arcari, Mariela C Aguilar, Katrina Llanes, Noel Ziebarth, Jaime D Martinez, Darlene Miller, Harry W Flynn, Guillermo Amescua, Jean-Marie Parel","doi":"10.1080/20415990.2024.2371778","DOIUrl":"10.1080/20415990.2024.2371778","url":null,"abstract":"Aim: Rose Bengal photodynamic antimicrobial therapy (RB-PDAT) has poor corneal penetration, limiting its efficacy against acanthamoeba keratitis (AK). Iontophoresis enhances corneal permeation of charged molecules, piquing interest in its effects on RB in ex vivo human corneas.Methods: Five donor whole globes each underwent iontophoresis with RB, soaking in RB, or were soaked in normal saline (controls). RB penetration and corneal thickness was assessed using confocal microscopy.Results: Iontophoresis increased RB penetration compared with soaking (177 ± 9.5 μm vs. 100 ± 5.7 μm, p < 0.001), with no significant differences in corneal thickness between groups (460 ± 87 μm vs. 407 ± 69 μm, p = 0.432).Conclusion: Iontophoresis significantly improves RB penetration and its use in PDAT could offer a novel therapy for acanthamoeba keratitis. Further studies are needed to validate clinical efficacy.","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"567-575"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0