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Enhanced bioavailability and efficacy in antimalarial treatment through QbD approach enteric encased inclusion delivery. 通过 QbD 方法肠溶包合物给药提高抗疟治疗的生物利用度和疗效。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-03 DOI: 10.1080/20415990.2024.2377948
Neha Bajwa, Preet Amol Singh, Sumant Kumar, Girish Chandra Arya, Ashish Baldi
{"title":"Enhanced bioavailability and efficacy in antimalarial treatment through QbD approach enteric encased inclusion delivery.","authors":"Neha Bajwa, Preet Amol Singh, Sumant Kumar, Girish Chandra Arya, Ashish Baldi","doi":"10.1080/20415990.2024.2377948","DOIUrl":"10.1080/20415990.2024.2377948","url":null,"abstract":"<p><p><b>Aim:</b> In this study, we aimed to prepare enteric encapsulated spheroids containing inclusion complex using quality by design approach.<b>Methods:</b> A Box-Behnken design was employed to determine effects of variables on selected responses. Risk assessment was conducted using Ishikawa fishbone diagram. A model with a <i>p</i>-value was less than 0.5 for being a significant error of model was determined based on significance 'lack of fit' value. Spheroids were formulated using the extrusion spheronization technique and were characterized using analytical techniques.<b>Results:</b> <i>In vitro</i> release was performed in both acidic (pH 1.2) and simulated intestinal (pH 6.8) conditions. Permeability studies demonstrated tenfold enhancement compared with arteether. <i>In vivo</i> studies further validated increase of 51.8% oral bioavailability. <i>Ex vivo</i> studies revealed 3.4-fold enhancement in antimalarial activity compared with arteether.<b>Conclusion:</b> These findings highlight effectiveness of inclusion complexation technique as a viable approach to enhance solubility and bioavailability for drugs with low aqueous solubility.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"653-666"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry update: the latest developments in the field of therapeutic delivery, April 2024. 行业更新：2024 年 4 月治疗传递领域的最新发展。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI: 10.1080/20415990.2024.2376520
Peter Timmins
{"title":"Industry update: the latest developments in the field of therapeutic delivery, April 2024.","authors":"Peter Timmins","doi":"10.1080/20415990.2024.2376520","DOIUrl":"10.1080/20415990.2024.2376520","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"639-651"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and optimization of guaifenesin sustained release mini-tablets for adult and geriatric patients. 开发和优化用于成人和老年患者的愈创木酚缓释小药片。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-10-03 DOI: 10.1080/20415990.2024.2406216
Mahshid Samadi, Mitra Jelvehgari, Sara Salatin
{"title":"Development and optimization of guaifenesin sustained release mini-tablets for adult and geriatric patients.","authors":"Mahshid Samadi, Mitra Jelvehgari, Sara Salatin","doi":"10.1080/20415990.2024.2406216","DOIUrl":"10.1080/20415990.2024.2406216","url":null,"abstract":"<p><p><b>Aim:</b> The main aim of this study was to formulate and optimize sustained release mini-tablets of guaifenesin.<b>Materials & methods:</b> Guaifenesin granules were successfully prepared using different blend ratios of carnauba wax to drug by melt granulation method. The properties of granules were further modified by combining them with ethyl cellulose. The obtained granules were then mixed and compressed into mini-tablets using a tablet press machine. The resulting mini-tablets were characterized in terms of weight, thickness, hardness, drug content and <i>in vitro</i> drug release.<b>Results:</b> Mini-tablets with 1:6 carnauba wax to drug ratio showed superior physicochemical characteristics, releasing about 100.03% of guaifenesin over 8 h. Ethyl cellulose offers a great potential to accurately control drug release from mini-tablets.<b>Conclusion:</b> The prepared mini-tablets seem to be a very promising alternative to guaifenesin conventional formulations and can be used in adults and elderly people.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"859-869"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates in the field of therapeutic delivery in June 2024. 2024 年 6 月治疗给药领域的行业动态。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-10-11 DOI: 10.1080/20415990.2024.2408214
Mengistie Diress, Armin Mooranian, Hani Al-Salami
{"title":"Industry updates in the field of therapeutic delivery in June 2024.","authors":"Mengistie Diress, Armin Mooranian, Hani Al-Salami","doi":"10.1080/20415990.2024.2408214","DOIUrl":"https://doi.org/10.1080/20415990.2024.2408214","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":"15 11","pages":"819-828"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry Update, May 2024. 行业最新情况，2024 年 5 月。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-08-08 DOI: 10.1080/20415990.2024.2383162
Elaine Harris
{"title":"Industry Update, May 2024.","authors":"Elaine Harris","doi":"10.1080/20415990.2024.2383162","DOIUrl":"10.1080/20415990.2024.2383162","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"737-742"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanotechnology-assisted combination drug delivery: a progressive approach for the treatment of acute myeloid leukemia. 纳米技术辅助联合给药：治疗急性髓性白血病的渐进方法。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-13 DOI: 10.1080/20415990.2024.2394012
Neelam Poonia, Nikita Vijay Jadhav, Davuluri Mamatha, Manoj Garg, Atul Kabra, Amit Bhatia, Shreesh Ojha, Viney Lather, Deepti Pandita
{"title":"Nanotechnology-assisted combination drug delivery: a progressive approach for the treatment of acute myeloid leukemia.","authors":"Neelam Poonia, Nikita Vijay Jadhav, Davuluri Mamatha, Manoj Garg, Atul Kabra, Amit Bhatia, Shreesh Ojha, Viney Lather, Deepti Pandita","doi":"10.1080/20415990.2024.2394012","DOIUrl":"10.1080/20415990.2024.2394012","url":null,"abstract":"<p><p>Acute myeloid leukemia (AML), a heterogeneous hematopoietic cancer prevalent in adults, has been a leading cause of leukemia-associated deaths for decades. Despite advancements in understanding its pathology and pharmacological targets, therapeutic strategies have seen minimal change. The standard treatment, combining cytarabine and anthracycline, has persisted, accompanied by challenges such as pharmacokinetic issues and non-specific drug delivery, leading to severe side effects. Nanotechnology offers a promising solution through combination drug delivery. FDA-approved CPX351 (VYXEOS™) a liposomal formulation delivering doxorubicin and cytarabine, exemplifies enhanced therapeutic efficacy. Ongoing research explores various nanocarriers for delivering multiple bioactives, addressing drug targeting, pharmacokinetics and chemoresistance. This review highlights nanotechnology-based combination therapies for the effective management of AML, presenting a potential breakthrough in leukemia.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"893-910"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic delivery of siRNA for the management of breast cancer and triple-negative breast cancer. 将 siRNA 用于治疗乳腺癌和三阴性乳腺癌。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-09-25 DOI: 10.1080/20415990.2024.2400044
Boya Manasa Sai, Yirivinti Hayagreeva Dinakar, Hitesh Kumar, Rupshee Jain, Sharyu Kesharwani, Siddharth S Kesharwani, Shyam Lal Mudavath, Ajmeer Ramkishan, Vikas Jain
{"title":"Therapeutic delivery of siRNA for the management of breast cancer and triple-negative breast cancer.","authors":"Boya Manasa Sai, Yirivinti Hayagreeva Dinakar, Hitesh Kumar, Rupshee Jain, Sharyu Kesharwani, Siddharth S Kesharwani, Shyam Lal Mudavath, Ajmeer Ramkishan, Vikas Jain","doi":"10.1080/20415990.2024.2400044","DOIUrl":"10.1080/20415990.2024.2400044","url":null,"abstract":"<p><p>Breast cancer is the leading cause of cancer-related deaths among women globally. The difficulties with anticancer medications, such as ineffective targeting, larger doses, toxicity to healthy cells and side effects, have prompted attention to alternate approaches to address these difficulties. RNA interference by small interfering RNA (siRNA) is one such tactic. When compared with chemotherapy, siRNA has several advantages, including the ability to quickly modify and suppress the expression of the target gene and display superior efficacy and safety. However, there are known challenges and hurdles that limits their clinical translation. Decomposition by endonucleases, renal clearance, hydrophilicity, negative surface charge, short half-life and off-target effects of naked siRNA are obstacles that hinder the desired biological activity of naked siRNA. Nanoparticulate systems such as polymeric, lipid, lipid-polymeric, metallic, mesoporous silica nanoparticles and several other nanocarriers were used for effective delivery of siRNA and to knock down genes involved in breast cancer and triple-negative breast cancer. The focus of this review is to provide a comprehensive picture of various strategies utilized for delivering siRNA, such as combinatorial delivery, development of modified nanoparticles, smart nanocarriers and nanocarriers that target angiogenesis, cancer stem cells and metastasis of breast cancer.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"871-891"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11498026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeted drug delivery to the thrombus by fusing streptokinase with a fibrin-binding peptide (CREKA): an in silico study. 通过融合链激酶和纤维蛋白结合肽（CREKA）向血栓靶向给药：一项硅学研究。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-04-30 DOI: 10.4155/tde-2023-0107
Mohammad Soroosh Hajizade, Mohammad Javad Raee, Seyed Nooreddin Faraji, Fakhrossadat Farvadi, Maryam Kabiri, Sedigheh Eskandari, Ali Mohammad Tamaddon
{"title":"Targeted drug delivery to the thrombus by fusing streptokinase with a fibrin-binding peptide (CREKA): an <i>in silico</i> study.","authors":"Mohammad Soroosh Hajizade, Mohammad Javad Raee, Seyed Nooreddin Faraji, Fakhrossadat Farvadi, Maryam Kabiri, Sedigheh Eskandari, Ali Mohammad Tamaddon","doi":"10.4155/tde-2023-0107","DOIUrl":"10.4155/tde-2023-0107","url":null,"abstract":"<p><p><b>Aim:</b> Streptokinase has poor selectivity and provokes the immune response. In this study, we used <i>in silico</i> studies to design a fusion protein to achieve targeted delivery to the thrombus. <b>Materials & methods:</b> Streptokinase was analyzed computationally for mapping. The fusion protein modeling and quality assessment were carried out on several servers. The enzymatic activity and the stability of the fusion protein and its complex with plasminogen were assessed through molecular docking analysis and molecular dynamics simulation respectively. <b>Results:</b> Physicochemical properties analysis, protein quality assessments, protein-protein docking and molecular dynamics simulations predicted that the designed fusion protein is functionally active. <b>Conclusion:</b> Our results showed that this fusion protein might be a prospective candidate as a novel thrombolytic agent with better selectivity.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"399-411"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of fexofenadine self-microemulsifying delivery systems: an efficient way to improve intestinal permeability. 开发非索非那定自微乳化给药系统：改善肠道渗透性的有效方法。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-06-28 DOI: 10.1080/20415990.2024.2363635
Ziba Islambulchilar, Ashkan Barfar, Shahla Mirzaeei
{"title":"Development of fexofenadine self-microemulsifying delivery systems: an efficient way to improve intestinal permeability.","authors":"Ziba Islambulchilar, Ashkan Barfar, Shahla Mirzaeei","doi":"10.1080/20415990.2024.2363635","DOIUrl":"10.1080/20415990.2024.2363635","url":null,"abstract":"<p><p><b>Aim:</b> The present study aimed to prepare and evaluate fexofenadine self-microemulsifying drug-delivery systems (SMEDDS) formulation and to determine and compare its intestinal permeability using <i>in situ</i> single-pass intestinal perfusion (SPIP) technique.<b>Methods:</b> Fexofenadine-loaded SMEDDS were prepared and optimized. Droplet size, polydispersity index, zeta potential, drug release and intestinal permeability were evaluated.<b>Results:</b> Optimized formulation consisted of 15% oil, 80% surfactant and 5% cosolvent. Droplet size and drug loading of optimized formulation was 13.77 nm and 60 mg/g and it has released 90% of its drug content. Intestinal permeability of fexofenadine was threefold enhanced in SMEDDS compared with free fexofenadine.<b>Conclusion:</b> The results of our study revealed that SMEDDS could be a promising tool for oral delivery of fexofenadine with enhanced dissolution rate and intestinal permeability.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"593-604"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
March Industry News. 三月行业新闻。
IF 3
Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-06-28 DOI: 10.1080/20415990.2024.2365621
Fiona McCartney
{"title":"March Industry News.","authors":"Fiona McCartney","doi":"10.1080/20415990.2024.2365621","DOIUrl":"10.1080/20415990.2024.2365621","url":null,"abstract":"","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"561-566"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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