Fabrication and evaluation of nanoemulsion based insulin loaded microneedles for transdermal drug delivery.

IF 3 Q2 PHARMACOLOGY & PHARMACY

Therapeutic delivery Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI:10.1080/20415990.2024.2377065

Fatima Ramzan Ali, Muhammad Harris Shoaib, Syed Abid Ali, Rabia Ismail Yousuf, Farrukh Rafiq Ahmed, Fahad Siddiqui, Sana Sarfaraz, Rameez Raja

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引用次数: 0

Abstract

Aim: Insulin therapy require self-administration of subcutaneous injection leading to painful and inconvenient drug therapy. The aim is to fabricate nanoemulsion (NE) based insulin loaded microneedles with improved bioavailability and patient compliance.Materials & methods: Different ratios of polyvinyl alcohol and polyvinylpyrrolidone as polymers were prepared through micro-molding technique for microneedles. Characterization of were performed using scanning electron microscope, differential scanning calorimetry, Fourier-transform infrared spectroscopy and circular dichroism. Mechanical strength, hygroscopicity and pain perception of these microneedles were also evaluated. In vitro release, permeation and in vivo PK/PD study of NE-based microneedles were conducted.Results: NE-based microneedles of insulin have improved bioavailability and quick response.Conclusion: Microneedles loaded with insulin can be effectively delivered insulin transdermally to treat diabetes with increased convenience and patient compliance.

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用于透皮给药的基于纳米乳液的胰岛素微针的制造和评估。

目的：胰岛素治疗需要自行皮下注射，这导致了药物治疗的痛苦和不便。本研究旨在制造基于纳米乳液（NE）的胰岛素微针，以提高生物利用度和患者的依从性。材料与方法：通过微成型技术制备了不同比例的聚乙烯醇和聚乙烯吡咯烷酮聚合物微针。使用扫描电子显微镜、差示扫描量热仪、傅立叶变换红外光谱仪和圆二色性分析仪进行表征。此外，还对这些微针的机械强度、吸湿性和痛感进行了评估。还对 NE 微针进行了体外释放、渗透和体内 PK/PD 研究。研究结果基于 NE 的胰岛素微针具有更好的生物利用度和快速反应能力。结论装载胰岛素的微针可有效地经皮输送胰岛素以治疗糖尿病，并提高了便利性和患者的依从性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.