用于控制药物释放和提高抗细菌感染效力的水瘤纳米制剂。

IF 3 Q2 PHARMACOLOGY & PHARMACY

Therapeutic delivery Pub Date : 2024-02-01 Epub Date: 2024-01-04 DOI:10.4155/tde-2023-0096

Bhuvaneshwari Shanmugam, Umashankar Marakanam Srinivasan

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引用次数: 0

摘要

目的：本研究旨在开发和评估用于控制头孢丙烯一水合物给药的水体给药系统。材料与方法：采用脊柱法制备了以磷酸钙为核心的水瘤，使用纤维生物糖进行糖包衣，并通过吸附载药。对制剂的尺寸、形态和药物释放进行了表征。对革兰氏阳性菌和阴性菌进行了抗菌研究。结果显示结果表明，该制剂的粒径为 2791.9 nm，zeta 电位为-0.3 mV，具有良好的稳定性，药物负载率为 99.08%，药物释放可控且持续时间长，8 小时内药物释放率达到 56%，12 小时后药物释放率可达 100%：该研究开发了一种水体给药系统，用于药物抗生素治疗的新型可控给药。

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Aquasomes nanoformulation for controlled release of drug and improved effectiveness against bacterial infections.

Aim: The study aimed to develop and evaluate an aquasome drug-delivery system for controlled drug delivery of cefprozil monohydrate. Materials & methods: Aquasomes were prepared by the spinal method with a calcium phosphate core, sugar-coated using cellobiose and drug-loaded by adsorption. The formulations were characterized for size, morphology and drug release. An antibacterial study was conducted for Gram-positive and -negative bacteria. Results: It showed particle size of 2791.9 nm, zeta potential of -0.3 mV with good stability, and 99.08% of drug loading and drug release were controlled and prolonged, achieving 56% within 8 h and possessing potential for 100% release beyond 12 h. Conclusion: An aquasome drug-delivery system was developed for novel controlled drug delivery for pharmaceutical antibiotic therapeutics.

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来源期刊

Therapeutic delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.