IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202502929

Yuchen Jin,Xiaoyuan Zhang,Xin Zhao,Youyin Xu,Gang Wei,Zhiqiang Su

{"title":"Two-Dimensional Biomaterials Applied as Functional Bio-Platforms and Devices: Revolutionizing Biomedical Applications.","authors":"Yuchen Jin,Xiaoyuan Zhang,Xin Zhao,Youyin Xu,Gang Wei,Zhiqiang Su","doi":"10.1002/smll.202502929","DOIUrl":"https://doi.org/10.1002/smll.202502929","url":null,"abstract":"Two-dimensional biomaterials (2DBMs), both synthetic and biological, have garnered significant attention due to their unique properties and versatile applications, particularly in biomedical engineering. This review provides an overview of both synthetic and biological 2DBMs, focusing on their fabrication methods, properties, and integration strategies for advanced device applications. The review first analyzes synthetic two-dimensional nanomaterials (2DNMs) such as graphene, transition metal dichalcogenides, black phosphorus, 2D metal oxides, and MXenes, exploring their properties and functionalization regulation (including covalent and non-covalent bonding, polymer bridging, and the incorporation of biorecognition elements). Next, the review discusses biological 2DBMs, highlighting their unique structures and synthesis processes. Strategies for tailoring these materials, such as surface functionalization, heterojunction formation, and integration with other nanostructures, are also covered. Moreover, the review outlines the fabrication approaches for 2DBM-based devices, covering chemical vapor deposition, templated synthesis, self-assembly, 3D printing, electrospinning, and liquid-phase spalling. Furthermore, the biomedical applications of 2DBM-based bio-platforms and devices are presented, where their roles in drug delivery, tissue engineering, bioimaging, diagnostics, biosensing, and neural interfaces are discussed in detail. Finally, the review concludes with insights into the current challenges and future directions for the development of 2DBM-based platforms and devices, emphasizing their potential to revolutionize healthcare and diagnostics.","PeriodicalId":228,"journal":{"name":"Small","volume":"19 1","pages":"e2502929"},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterned Backbone Elongation of Symmetrized Saccharin for Unexpected Enhancement in Redox Activity 对称糖精的主链伸长对氧化还原活性的意外增强

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202502029

Songi Song, Min Kyu Choi, Ki Chul Kim

{"title":"Patterned Backbone Elongation of Symmetrized Saccharin for Unexpected Enhancement in Redox Activity","authors":"Songi Song, Min Kyu Choi, Ki Chul Kim","doi":"10.1002/smll.202502029","DOIUrl":"https://doi.org/10.1002/smll.202502029","url":null,"abstract":"Despite significant efforts, the development of sustainable high‐performance organic cathodes for Li‐ion and Na‐ion battery technologies remains a challenge. This study proposes a comprehensive approach to enhance the redox properties and performance of food‐inspired saccharin compounds by modifying their redox‐active core and backbone, along with functionality‐based decoration. Through validated computational protocols, the backbone elongation of saccharin derivatives with symmetrized redox‐active cores is achieved, observing an uncommon yet beneficial V‐shaped trend in redox potential. This trend is attributed to the “local” inductive effect of the aromatic backbone facilitating electronic transport, which plays a major role in modulating redox chemistry. This suggests that, in contrast to conventional quinones, sufficiently elongated, cyclically beneficial architectures promote enhanced redox activity. Further investigation, screening 40 functional groups, identifies NO, NO2, NHO, and CN as the top four functionality candidates with exceptional performance and favorable redox activities, offering promise as structurally stable candidates for Na‐ion battery technologies. These findings open up new avenues into the design of advanced organic cathodes with high‐performance and structural sustainability to develop next‐generation energy‐storage technologies.","PeriodicalId":228,"journal":{"name":"Small","volume":"26 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent Polyamines for Efficient DNA Condensation and Cellular Uptake. 高效DNA凝聚和细胞摄取的荧光多胺。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202503144

Yogesh Dubey,Haritha Dilip,Sivapriya Kirubakaran,Sriram Kanvah

引用次数: 0

Conformation-Dependent Dynamics of Polymer Capture and Translocation through Solid-State Nanopores. 固体纳米孔中聚合物捕获和转移的构象依赖动力学。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202501362

Yadong Li,Wanyi Xie,Shaoxi Fang,Rong Tian,Yajie Yin,Ting Weng,Daming Zhou,Bohua Yin,Yunjiao Wang,Shixuan He,Deqiang Wang

{"title":"Conformation-Dependent Dynamics of Polymer Capture and Translocation through Solid-State Nanopores.","authors":"Yadong Li,Wanyi Xie,Shaoxi Fang,Rong Tian,Yajie Yin,Ting Weng,Daming Zhou,Bohua Yin,Yunjiao Wang,Shixuan He,Deqiang Wang","doi":"10.1002/smll.202501362","DOIUrl":"https://doi.org/10.1002/smll.202501362","url":null,"abstract":"Polymer translocation through solid-state nanopores has attracted widespread attention in many biological processes. However, the dynamics of capture and translocation through nanopores are highly correlated with polymer conformation. Using plasmid pBR322 DNA with supercoiled and linear structures, this work explores the effects of polymer conformation on capture and translocation through nanopores. The polymer translocation dynamics are discussed with the relationship between current blockage characteristics and applied voltages across various pore sizes. Subsequently, linear plasmids are used to clarify the effect of polymer conformation on nanopore capture and translocation. The nonlinear relationships between current blockage amplitudes and voltages demonstrate that the linear conformation affects the plasmid DNA capture process. A decrease in the ratio of supercoiled plasmids improved the frequency of folding translocation and decreased the standard deviation of blockage current amplitudes. As the proportion of supercoiled plasmids rises, the impact of partially folding linear conformation on mixed plasmids translocation is enhanced with increasing applied voltage. Furthermore, the results reveal a polymer conformation-dependent bias in capture and translocation processes, named the \"crowding effect\". This study provides valuable insights into the dynamics of polymer conformational transitions through solid-state nanopores, that have significant implications for improving sequencing and sensing technologies.","PeriodicalId":228,"journal":{"name":"Small","volume":"27 1","pages":"e2501362"},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of All-Optical Bidirectional Self-Powered Synaptic Devices for Neuromorphic Computing Applications. 面向神经形态计算应用的全光双向自供电突触器件的设计。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202505327

Wen Huang,Jiawei Tang,Biao Li,Xin Zhang,Zhengjian Lin,Huixing Zhang,Pengjie Hang,Xuegong Yu,Xing'ao Li,Lei Wang

{"title":"Design of All-Optical Bidirectional Self-Powered Synaptic Devices for Neuromorphic Computing Applications.","authors":"Wen Huang,Jiawei Tang,Biao Li,Xin Zhang,Zhengjian Lin,Huixing Zhang,Pengjie Hang,Xuegong Yu,Xing'ao Li,Lei Wang","doi":"10.1002/smll.202505327","DOIUrl":"https://doi.org/10.1002/smll.202505327","url":null,"abstract":"Self-powered optoelectronic synaptic devices have garnered significant attention due to their ultra-low energy consumption and self-rectification properties. However, the mechanism of mimicking their inhibitory behaviors remains unclear, presenting a challenge in attempting to realize optically inhibitory behaviors. This study fabricates formamidinium lead iodide perovskite-based synaptic devices that exhibit self-powered-optical potentiation and electrical inhibition behaviors. The mechanism underlying the inhibitory behaviors is argued to be the defect trap at room temperature and iodine ion migration at lower temperatures. Considering the optical potentiation behaviors and inhibitory mechanism clarified here, ethanediamine dihydroiodide is incorporated into the perovskite layer to regulate the synaptic behaviors. Impressively, this additive results in a shift of the self-powered-optical potentiation to its inhibition. First-principles calculations reveal that an increase of iodide vacancy formation energies facilitates this transformation by possibly modulating the carrier trap and ion migration behaviors. Additionally, the optically excitatory and optically inhibitory synaptic behaviors of the integrated systems with and without EDADI are exploited to implement MINIST and CIFAR-10 recognition tasks and achieve the high recognition rates of 97.95% and 77.36%, respectively. This work significantly advances the understanding of mimicking self-powered optically inhibitory synaptic behaviors and contributes to the development of all-optical bidirectional self-powered neuromorphic computing systems.","PeriodicalId":228,"journal":{"name":"Small","volume":"65 1","pages":"e2505327"},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Electronic Modulation via Dual-Atomic Site Engineering in RuCo Hybrids for Optimized Hydrogen Adsorption and Enhanced Overall Water Splitting. 基于双原子位点工程的RuCo杂化体协同电子调制优化氢吸附和增强整体水分解。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202505821

Fei Cai,Rajapriya Andavar,Anuj Kumar,Yanzhi Sun,Xinyue Yong,Junqing Pan

{"title":"Synergistic Electronic Modulation via Dual-Atomic Site Engineering in RuCo Hybrids for Optimized Hydrogen Adsorption and Enhanced Overall Water Splitting.","authors":"Fei Cai,Rajapriya Andavar,Anuj Kumar,Yanzhi Sun,Xinyue Yong,Junqing Pan","doi":"10.1002/smll.202505821","DOIUrl":"https://doi.org/10.1002/smll.202505821","url":null,"abstract":"Developing hydrogen as a clean, sustainable energy carrier relies on green electricity-derived large-scale water splitting production. However, it is greatly limited by the inherently sluggish reaction kinetics and high energy barriers associated with proton reduction. Herein, the study proposes heterostructured RuCo-nanocubes (RuCo-NC) engineered through phase control and metal integration to optimize hydrogen adsorption, enhancing catalytic efficiency by reducing energy barriers and improving mass and charge transport. Experimental and theoretical analyses revealed that incorporating Ru into Co-NC induces electron redistribution and enhances the proton source, while reducing the adsorption of H* on RuCo-NC, thereby facilitating hydrogen spillover and accelerating HER kinetics. Consequently, the RuCo-NC catalyst achieves 10 and 100 mA cm⁻2 current densities with overpotentials of just 15 and 76 mV, under alkaline conditions, outperforming most Ru-based catalysts and benchmark Pt/C. The assembled RuCo-NC || Ir/C electrolyzer shows an excellent energy-saving effect for water-splitting, achieving the cell voltages of 1.510 and 1.731 V, at 10 and 100 mA cm-2 current densities, respectively, with stable operation for over 120 h. This novel approach offers designing highly efficient HER electrocatalysts with low noble metal content through tailored structural features and interfacial synergy to accelerate proton reduction kinetics.","PeriodicalId":228,"journal":{"name":"Small","volume":"51 1","pages":"e2505821"},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size and Chemical Environment Control Nanopore Geometry in 2D MoS2: From Irregular to Triangular Defects. 尺寸和化学环境控制二维二硫化钼纳米孔几何结构：从不规则缺陷到三角形缺陷。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202504611

Sayan Bhowmik,Ananth Govind Rajan

{"title":"Size and Chemical Environment Control Nanopore Geometry in 2D MoS2: From Irregular to Triangular Defects.","authors":"Sayan Bhowmik,Ananth Govind Rajan","doi":"10.1002/smll.202504611","DOIUrl":"https://doi.org/10.1002/smll.202504611","url":null,"abstract":"Defects in 2D transition metal dichalcogenides (TMDs), such as molybdenum disulfide (MoS2), can modulate their optoelectronic and membrane properties. Increased structural complexity and a quasi-2D nature complicate the study of extended defects in MoS2. To address this knowledge gap, coordination-dependent atomic fingerprints are advanced for undercoordinated atoms in TMDs, enabling the cataloging of nanopore isomers in MoS2. Combining the introduced fingerprints with extensive density functional theory calculations of etching energies, stochastic kinetic Monte Carlo simulations of defect formation, and chemical graph theory for distinguishing nanopore shapes, predicts the most probable nanopores in MoS2. A range of size-dependent topologies are revealed from elongated to perfectly triangular, where smaller defects are irregular, while larger ones are more symmetric, exhibiting qualitative agreement with experiments. Moving toward a sulfur-rich chemical environment slows down the growth of larger pores and makes them perfectly triangular, providing an experimental route to control nanopore synthesis. The size-dependent structural order in MoS2 nanopores elucidated here will enable precise control over the defect shape and size distribution in the material for various application areas, including seawater desalination, gas separations, DNA sequencing, and optoelectronic devices.","PeriodicalId":228,"journal":{"name":"Small","volume":"36 1","pages":"e2504611"},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heteroatom Doping Strategy for Enhanced Sodium-Ion Storage in Na2Fe1.5Mn1.5(PO4)3. Na2Fe1.5Mn1.5(PO4)3中增强钠离子存储的杂原子掺杂策略

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202502979

Archana Rajendra Kanwade,Jena Akash Kumar Satrughna,Shraddha Manohar Rajore,Pratik Pawar,Sawanta S Mali,Jyoti V Patil,Chang Kook Hong,Ravi Chandra Dutta,Parasharam Maruti Shirage

{"title":"Heteroatom Doping Strategy for Enhanced Sodium-Ion Storage in Na2Fe1.5Mn1.5(PO4)3.","authors":"Archana Rajendra Kanwade,Jena Akash Kumar Satrughna,Shraddha Manohar Rajore,Pratik Pawar,Sawanta S Mali,Jyoti V Patil,Chang Kook Hong,Ravi Chandra Dutta,Parasharam Maruti Shirage","doi":"10.1002/smll.202502979","DOIUrl":"https://doi.org/10.1002/smll.202502979","url":null,"abstract":"Sodium-ion batteries (SIBs) are promising and cost-effective substitutes for lithium-ion batteries for large-scale energy storage. Hence, exploring novel anode materials is crucial to developing sustainable SIBs. Herein, a nitrogen and sulfur co-doped carbon layer wrapped alluaudite Na2Fe1.5Mn1.5(PO4)3 (NFMP@SNC) with uniform 3D urchin-like morphology is successfully synthesized via a simple hydrothermal technique. For the first time, this study examines their electrochemical properties as an anode for SIBs. The N, S-doped carbon layer forms a conductive network that enhances electron transport, facilitates Na+ diffusion, and prevents particle aggregation and side reactions. As a result, NFMP@SNC displays an irreversible capacity of 774.52 mAh g-1 and a reversible capacity of 253.40 mAh g-1 at 0.05C, retaining 61.2% of its theoretical capacity (414 mAh g-1). Furthermore, it shows an excellent rate capability of 71.76% at 0.1C (25 cycles) and retention of 48.49% at 0.2C (100 cycles). Additionally, density functional theory (DFT) calculations are conducted to evaluate the electronic band structure, density of states, charge density distribution, and Na+ diffusion energy barriers of pristine NFMP, providing fundamental insights into its electrochemical behavior. With a low average voltage of ≈0.7 V, NFMP@SNC emerges as a promising intercalation-type anode material enabled by 3D architecture and N,S co-doping for high-performance SIBs.","PeriodicalId":228,"journal":{"name":"Small","volume":"41 1","pages":"e2502979"},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Boosting Glioblastoma Therapy with Targeted Pyroptosis Induction". 更正“用靶向焦亡诱导促进胶质母细胞瘤治疗”。

IF 13 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202503860

Xinggang Fang, Zhuo Chen, Wenhui Zhou, Tongfei Li, Man Wang, Yujiu Gao, Shinan Ma, Ying Feng, Shiming Du, Peimin Lan, Hanyu Chen, Jiarui Wei, Sisi Zhang, Zixiang Li, Xinglin Liu, Hongbo Zhang, Xingrong Guo, Jie Luo

引用次数: 0

Lignin-Derived Melanin-Like Nanosheets: Modulating the Microscopic Morphology and Photothermal Conversion Property through the Substituent Effect. 木质素衍生的类黑色素纳米片：通过取代基效应调节微观形态和光热转换性能。

IF 13.3 2区材料科学

Small Pub Date : 2025-07-01 DOI: 10.1002/smll.202504520

Jia Xin Yu,Yu Zeng,Chun Hui Xie,Yun Qi Li,Ya Lin Cao,Ji Qin Zhang,Hai Bo Xie,Cai Juan Huang,Ying Tan,Yang You

{"title":"Lignin-Derived Melanin-Like Nanosheets: Modulating the Microscopic Morphology and Photothermal Conversion Property through the Substituent Effect.","authors":"Jia Xin Yu,Yu Zeng,Chun Hui Xie,Yun Qi Li,Ya Lin Cao,Ji Qin Zhang,Hai Bo Xie,Cai Juan Huang,Ying Tan,Yang You","doi":"10.1002/smll.202504520","DOIUrl":"https://doi.org/10.1002/smll.202504520","url":null,"abstract":"Artificial melanin-like materials have attracted significant attention due to their bioactivity and photothermal conversion capability. The regulation of their morphology is essential for optimizing performance; however, this presents considerable challenges. In this study, a novel template-free approach is introduced that utilizes the Scholl reaction in conjunction with a demethylation reaction to synthesize melanin-like nanosheets. Lignin-derived triaryl-imidazole is employed as the monomer, in contrast to the commonly used phenolic monomers. The methoxy groups present in the monomers, which are derived from the original lignin structure, significantly influence the resulting polymers' characteristics, including microscopic morphology, chemical structure, optical absorption, specific heat capacity, and hydrophilicity. When veratraldehyde-derived triaryl-imidazole is utilized as the monomer, melanin-like nanosheets with a uniform thickness of 5 nm are produced, demonstrating commendable photothermal conversion performance in both bulk and suspension states, showing the potential value in solar evaporation and photothermal therapy. It is anticipated that these findings will not only facilitate the preparation of artificial melanin-like materials with tailored morphologies but also contribute to the development of lignin-derived materials with enhanced functionalities.","PeriodicalId":228,"journal":{"name":"Small","volume":"65 1","pages":"e2504520"},"PeriodicalIF":13.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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