IF 13.3 2区材料科学

Small Pub Date : 2024-11-22 DOI: 10.1002/smll.202408095

Chao Jia, Qirui Liu, Man Zhang, Cong Han, Xuantong Luo, Yu Zhou, Yi Liu, Liyun Zhang

{"title":"Engineering Nano-Pills to Inhibit Ovarian Cancer Proliferation and Migration through a Combination of Chemical/Nucleic Acid Therapy","authors":"Chao Jia, Qirui Liu, Man Zhang, Cong Han, Xuantong Luo, Yu Zhou, Yi Liu, Liyun Zhang","doi":"10.1002/smll.202408095","DOIUrl":"https://doi.org/10.1002/smll.202408095","url":null,"abstract":"Ovarian cancer (OC) is the most fatal of all gynecological malignancies, presenting a significant threat to women's health. Its treatment is complicated by severe dose-dependent chemotherapy toxicity, drug resistance, and tumor migration. Herein, an intelligent combination strategy of chemotherapy and nucleic acid therapy, named ApMEmiR&D is developed. This integrated system consists of three parts: the nano-pill, the protective membrane, and the navigation element. Nano-pills are nanospheres assembled from miRNA and doxorubicin (DOX) with the help of ferrous ions (Fe2+). The protective membrane is derived from tumor-associated macrophages (TAMs membrane) originating from the primary tumor microenvironment (TME). The navigation element is the cholesterol-conjugated AS1411 aptamer. The resulting ApMEmiR&D nanoparticles exhibit uniform size, a well-defined nanosphere structure, robust serum stability, and ultra-high drug loading efficiency and capacity. The system can efficiently accumulate in the tumor, allowing for the synergistic inhibition of tumor growth and metastasis without apparent systemic toxicity. The results demonstrate the homing effect of tumor microenvironment-derived macrophage cell membrane and the targeting effect of aptamer, leading to precise drug targeting and immune compatibility, thereby enhancing therapeutic efficacy. The success of this strategy paves the way for metastasis inhibition and targeted cancer therapy.","PeriodicalId":228,"journal":{"name":"Small","volume":"68 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Materials for Antibacterial Applications 用于抗菌应用的仿生材料

IF 13.3 2区材料科学

Small Pub Date : 2024-11-22 DOI: 10.1002/smll.202408543

Junjie Zhang, Heng Dong, Bing Liu, Dongliang Yang

{"title":"Biomimetic Materials for Antibacterial Applications","authors":"Junjie Zhang, Heng Dong, Bing Liu, Dongliang Yang","doi":"10.1002/smll.202408543","DOIUrl":"https://doi.org/10.1002/smll.202408543","url":null,"abstract":"The rise of antibiotic resistance poses a critical threat to global health, necessitating the development of novel antibacterial strategies to mitigate this growing challenge. Biomimetic materials, inspired by natural biological systems, have emerged as a promising solution in this context. These materials, by mimicking biological entities such as plants, animals, cells, viruses, and enzymes, offer innovative approaches to combat bacterial infections effectively. This review delves into the integration of biomimicry with materials science to develop antibacterial agents that are not only effective but also biocompatible and less likely to induce resistance. The study explores the design and function of various biomimetic antibacterial materials, highlighting their therapeutic potential in anti-infection applications. Further, the study provides a comprehensive summary of recent advancements in this field, illustrating how these materials have been engineered to enhance their efficacy and safety. The review also discusses the critical challenges facing the transition of these biomimetic strategies from the laboratory to clinical settings, such as scalability, cost-effectiveness, and long-term stability. Lastly, the study discusses the vast opportunities that biomimetic materials hold for the future of antibacterial therapy, suggesting that continued research and multidisciplinary collaboration will be essential to realize their full potential.","PeriodicalId":228,"journal":{"name":"Small","volume":"129 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extreme Toughening of Conductive Hydrogels Through Synergistic Effects of Mineralization, Salting-Out, and Ion Coordination Induced by Multivalent Anions 通过多价阴离子诱导的矿化、脱盐和离子配位协同效应实现导电水凝胶的极度增韧

IF 13.3 2区材料科学

Small Pub Date : 2024-11-22 DOI: 10.1002/smll.202409565

Hongmei Luo, Lichao Jiang, Yuxin Guo, Min Li, Longyu Hu, Hao Wu, Wei Cui, Rong Ran

{"title":"Extreme Toughening of Conductive Hydrogels Through Synergistic Effects of Mineralization, Salting-Out, and Ion Coordination Induced by Multivalent Anions","authors":"Hongmei Luo, Lichao Jiang, Yuxin Guo, Min Li, Longyu Hu, Hao Wu, Wei Cui, Rong Ran","doi":"10.1002/smll.202409565","DOIUrl":"https://doi.org/10.1002/smll.202409565","url":null,"abstract":"Developing conductive hydrogels with both high strength and fracture toughness for diverse applications remains a significant challenge. In this work, an efficient toughening strategy is presented that exploits the multiple enhancement effects of anions through a synergistic combination of mineralization, salting-out, and ion coordination. The approach centers on a hydrogel system comprising two polymers and a cation that is highly responsive to anions. Specifically, polyvinyl alcohol (PVA) and chitosan quaternary ammonium (HACC) are used, as PVA benefits from salting-out effects and HACC undergoes ion coordination with multivalent anions. After just 1 h of immersion in an anionic solution, the hydrogel undergoes a dramatic improvement in mechanical properties, increasing by more than three orders of magnitude. The optimized hydrogel achieves high strength (26 MPa), a high Young's modulus (45 MPa), and remarkable fracture toughness (67.3 kJ m−2), representing enhancements of 860, 3200, and 1200 times, respectively, compared to its initial state. This breakthrough overcomes the typical trade-off between stiffness and toughness. Additionally, the ionic conductivity of the hydrogel enables reliable strain sensing and supports the development of durable supercapacitors. This work presents a simple and effective pathway for developing hydrogels with exceptional strength, toughness, and conductivity.","PeriodicalId":228,"journal":{"name":"Small","volume":"19 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesopore-Augmented Electrochemical CO₂ Reduction on Nitrogen-Doped Carbon. 掺氮碳上的介孔增强电化学二氧化碳还原。

IF 13 2区材料科学

Small Pub Date : 2024-11-22 DOI: 10.1002/smll.202406883

Xu Han, Ting Zhang, Martí Biset-Peiró, Alberto Roldan, Marcel Ceccato, Nina Lock, Steen Uttrup Pedersen, Joan Ramon Morante, Jordi Arbiol, Kim Daasbjerg

{"title":"Mesopore-Augmented Electrochemical CO2 Reduction on Nitrogen-Doped Carbon.","authors":"Xu Han, Ting Zhang, Martí Biset-Peiró, Alberto Roldan, Marcel Ceccato, Nina Lock, Steen Uttrup Pedersen, Joan Ramon Morante, Jordi Arbiol, Kim Daasbjerg","doi":"10.1002/smll.202406883","DOIUrl":"https://doi.org/10.1002/smll.202406883","url":null,"abstract":"The electrochemical carbon dioxide reduction reaction (eCO2RR) using nitrogen-doped carbon (N-C) materials offers a promising and cost-effective approach to global carbon neutrality. Regulating the porosity of N-C materials can potentially increase the catalytic performance by suppressing the concurrence of the hydrogen evolution reaction (HER). However, the augmentation of porosity usually alters the active sites or the chemical composition of catalysts, resulting in intertwined influences of various structural factors and catalytic performance. In this study, incorporating secondary carbon sources into the metal-organic framework (MOF) precursor through nanocasting aimed to selectively enhance the mesoporous structure, allowing for deciphering this effect from other changes in the catalyst composition. Consequently, the developed N-C catalyst exhibited a significant surface area with abundant mesopores, leading to a maximum Faradaic efficiency (FE) for carbon monoxide (CO) of 95% at -0.50 V versus the reversible hydrogen electrode (vs. RHE). Furthermore, the FE for CO is enhanced across a wide potential range, surpassing previously reported metal-free N-C eCO2RR catalysts. The investigation reveals that constructing mesoporous structures can induce excellent CO2 catalysis by enhancing the accessibility of active sites while establishing an elevated local pH at these sites.","PeriodicalId":228,"journal":{"name":"Small","volume":" ","pages":"e2406883"},"PeriodicalIF":13.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Microstructure with Anti-Slip and Anti-Adhesion for Efficient Handling of Brittle Material Surfaces in High-Temperature Environments. 具有防滑和防粘附功能的仿生微结构，用于在高温环境下有效处理脆性材料表面。

IF 13 2区材料科学

Small Pub Date : 2024-11-22 DOI: 10.1002/smll.202408236

Haozhen Zhan, Jianming Wu, Jiachun Zhang, Qianqian Li, Shixun Fu, Jian Chen, Jiahui Zhao, Yuanming Ji, Xipeng Wang, Kai Deng, Keju Ji

引用次数: 0

Multifunctional Scaffold Comprising Metal–Organic Framework, Hydrogel, and Demineralized Bone Matrix for the Treatment of Steroid-Induced Femoral Head Necrosis 由金属有机框架、水凝胶和脱矿骨基质组成的多功能支架用于治疗类固醇引起的股骨头坏死

IF 13.3 2区材料科学

Small Pub Date : 2024-11-22 DOI: 10.1002/smll.202407758

Liangjie Bai, Xiaolei Zhang, Wei Shen, Peng Wang, Xin Yin, Jianing Liu, Hailun Xu, Bing Liu, Zhentao Man, Wei Li

{"title":"Multifunctional Scaffold Comprising Metal–Organic Framework, Hydrogel, and Demineralized Bone Matrix for the Treatment of Steroid-Induced Femoral Head Necrosis","authors":"Liangjie Bai, Xiaolei Zhang, Wei Shen, Peng Wang, Xin Yin, Jianing Liu, Hailun Xu, Bing Liu, Zhentao Man, Wei Li","doi":"10.1002/smll.202407758","DOIUrl":"https://doi.org/10.1002/smll.202407758","url":null,"abstract":"Overproduction of reactive oxygen species (ROS) results in oxidative stress, a critical factor in the pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH). Excess ROS not only hinders the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) but also impairs mitochondrial structure and function, resulting in irreversible cellular damage. Herein, a biomimetic multifunctional scaffold comprising Zn-modified metal–organic framework 818 (Zn-MOF-818) loaded with deferoxamine (DFO), gelatin methacryloyl (GelMA) hydrogel, and demineralized bone matrix (DBM) is shown to scavenge excess ROS, promote angiogenesis, and regulate immunity. Introduced Zn significantly enhances the superoxide dismutase- and catalase-like activities of MOF-818, which increases ROS-scavenging efficiency. Zn-MOF-818 disrupts the vicious intracellular cycle of mitochondrial dysfunction and ROS accumulation by enhancing mitophagy, stabilizing mitochondrial function, and upregulating antioxidant genes. Additionally, Zn-MOF-818 facilitates the polarization of macrophages toward the M2 phenotype and alleviates inflammation, creating an advantageous immune microenvironment for osteogenic differentiation of BMSCs. The release of DFO, an activator of the HIF-1α pathway, and Zn2+ from Zn-MOF-818, along with the secretion of various cytokines from DBM (such as bone morphogenetic proteins and vascular endothelial growth factors), enhances angiogenesis and osteogenesis. This scaffold targets multiple factors concurrently, offering a promising new approach for treating SONFH.","PeriodicalId":228,"journal":{"name":"Small","volume":"4 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interface Engineering for Improved Large-Current Oxygen Evolution via Partial Phosphorization of Ce-MOF/NiCo-MOF Heterostructure 通过对 Ce-MOF/NiCo-MOF 异质结构进行部分磷化来改善大电流氧进化的界面工程设计

IF 13.3 2区材料科学

Small Pub Date : 2024-11-22 DOI: 10.1002/smll.202408897

Dan Liu, Xuewen Xia, Xueqiang Zhang, Fei Wang, Li Tao, Ya Gao, Shujuan Wang, Zhongya Pang, Xing Yu, Guangshi Li, Hsien-Yi Hsu, Shen Hu, Li Ji, Xionggang Lu, Xingli Zou

{"title":"Interface Engineering for Improved Large-Current Oxygen Evolution via Partial Phosphorization of Ce-MOF/NiCo-MOF Heterostructure","authors":"Dan Liu, Xuewen Xia, Xueqiang Zhang, Fei Wang, Li Tao, Ya Gao, Shujuan Wang, Zhongya Pang, Xing Yu, Guangshi Li, Hsien-Yi Hsu, Shen Hu, Li Ji, Xionggang Lu, Xingli Zou","doi":"10.1002/smll.202408897","DOIUrl":"https://doi.org/10.1002/smll.202408897","url":null,"abstract":"Interface engineering for electrocatalysts has proven to be an effective method for modulating electrocatalytic properties, yet a more efficient and straightforward strategy to construct a valid heterointerface for further enhancing interface effects is urgently needed for boosting oxygen evolution reactions (OER) at large current. Herein, a closely compacted heterostructure combining NiCo-metal-organic framework (MOF) and Ce-MOF is in situ formed through a one-step hydrothermal treatment, and partial phosphorization is employed to further enhance the interface effect between the newly formed urchin-shaped NiCoP shells and hexagonal rod-like Ce-MOF cores on nickel foam (NiCoP/Ce-MOF@NF). Experimental and theoretical results indicate that the heterogeneous NiCoP/Ce-MOF@NF, characterized by a more intensive interface rather than a simple physical mixture, generates an OER-beneficial electronic structure, significantly facilitates charge transfer and reaction kinetics, and creates a synergistically stable structure. The optimal NiCoP/Ce-MOF@NF exhibits remarkable electrocatalytic activity for OER, achieving an ultralow overpotential of 268 mV at a current density of 500 mA cm−2, and also delivers satisfactory large-current stability of up to 120 h. This work offers a novel approach for designing heterogeneous catalysts with strong interface effects for potential applications in industrial water electrolysis.","PeriodicalId":228,"journal":{"name":"Small","volume":"23 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supercrystal Engineering of Nanoarrows Enabled by Tailored Concavity (Small 47/2024) 通过定制凹面实现纳米弧的超晶工程（47/2024 小号）

IF 13.3 2区材料科学

Small Pub Date : 2024-11-21 DOI: 10.1002/smll.202470345

Cheng Chen, Qian Wang, Peijian Wang, Mengqi Dai, Xin Jiang, Jihan Zhou, Limin Qi

引用次数: 0

Recent Advances of Bio-Based Hydrogel Derived Interfacial Evaporator for Sustainable Water and Collaborative Energy Storage Applications (Small 47/2024) 生物基水凝胶衍生界面蒸发器在可持续水和协同储能应用方面的最新进展（47/2024 号小论文）

IF 13.3 2区材料科学

Small Pub Date : 2024-11-21 DOI: 10.1002/smll.202470350

Jiachuan Chen, Xiaofa Wang, Baobin Wang, Ting Wu, Lei Zhang, Kai Zhang, Guigan Fang, Yueying Wang, Yu Zhao, Guihua Yang

引用次数: 0

Copper-Graphene Composite (CGC) Conductors: Synthesis, Microstructure, and Electrical Performance (Small 47/2024) 铜石墨烯复合导体（CGC）：合成、微观结构和电气性能（47/2024 号小册子）