{"title":"Innovative purification method to extract magnetic carbon nanotubes from arc-discharged single-walled carbon nanotubes","authors":"Chuan He, Yuzhi Hao, J. Xing, Jie Chen","doi":"10.1109/LISSA.2011.5754159","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754159","url":null,"abstract":"The discovery of carbon nanotubes has opened the door to numerous cutting-edge nanoscaleresearch fields including microelectronic devices, and biomedical application. Although pure nanotubes suffice for most purposes, highly pure magnetic carbon nanotubes are more suitable for specialized applications such as gene delivery. The conventional purification methods of carbon nanotubes are too harsh for the nanotubes to retain any magnetic characteristics, hence to enable the nanotubes be sensitive to magnetic field. It requiresthe reloading of metallic particles inside or on the surface of each tube. Instead, this paper proposes an innovative purification method to extract magnetic carbon nanotubes from arc-discharged single-walled carbon nanotube material. The procedure is easy to execute and time-saving. TEM and AFM images are used to monitor the purification process and prove that the carbon nanotube retain magnetic characteristics after the purification process.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124117903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liang Gao, Yaliang Yang, Jiong Xing, Michael J. Thrall, Zhiyong Wang, Fuhai Li, Pengfei Luo, Kelvin K. Wong, Stephen T. C. Wong
{"title":"Differential diagnosis of human lung cancer — A label-free and chemistry-sensitive approach","authors":"Liang Gao, Yaliang Yang, Jiong Xing, Michael J. Thrall, Zhiyong Wang, Fuhai Li, Pengfei Luo, Kelvin K. Wong, Stephen T. C. Wong","doi":"10.1109/LISSA.2011.5754143","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754143","url":null,"abstract":"Lung carcinoma is the most prevalent type of cancer, and it is responsible for more deaths than other types of cancer [1]. Unlike other imaging modalities used for lung cancer diagnosis, such as magnetic resonance imaging (MRI) and computed tomography (CT), coherent anti-Stokes Raman scattering (CARS) offers submicron spatial resolutions and video-rate temporal resolution along with chemical specificity. This method potentially allows label-free differential diagnosis of lung cancer at high resolution. This study aims at demonstrating the feasibility of using CARS to differentiate normal, benign and different subtypes of lung cancers. Human lung lesions, including small cell carcinoma, adenocarcinoma, squamous cell carcinoma and intestinal fibrosis, were imaged ex vivo using a CARS microscope and compared to their corresponding hematoxylin and eosin (H&E) staining results. Our data shows that CARS is capable of identifying cellular features in a similar way as H&E stain, and these features could be used to characterize different types of lung lesions from each other. Therefore, the CARS technique offers a new strategy for differential diagnosis of lung lesions using pathologically prevalent criteria, and thus could be further developed for in vivo and real time diagnosis of early stage lung cancer.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134338112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predicting tumor-suppressing genes in cancer via clustering the developmental stage gene expression profile","authors":"Nitin K. Singh, M. Vidyasagar, M. White","doi":"10.1109/LISSA.2011.5754170","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754170","url":null,"abstract":"In this paper we study the problem of predicting which genes are likely to have a role in tumor-suppression in lung and colorectal cancer. Mutation frequencies alone cannot serve to differentiate between ‘drivers’ (mutations that cause cancer) and ‘passengers’ (mutations that are caused by cancer) some other features must be added. Our hypothesis is that the developmental stage gene expression profile provides one such additional feature, that can potentially serve to differentiate between drivers and passengers. The developmental stage gene expression profile refers to the seven-dimensional vector of the gene's expression, as found in the Unigene database [15].","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133400590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chia-Yi Lin, W. Fang, Hung-Ming Chen, Zong-Han Hsieh, C. Chen
{"title":"A low noise and robust 3D system-in-package test scheme for highly integrated biomedical systems","authors":"Chia-Yi Lin, W. Fang, Hung-Ming Chen, Zong-Han Hsieh, C. Chen","doi":"10.1109/LISSA.2011.5754142","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754142","url":null,"abstract":"In this paper, a low noise and robust test scheme for 3D stacked integrated circuits based on modified standard IEEE 1149.4 has been proposed. Through the modified standard, this novel test scheme can be more robust to fulfill the microsystem integration requirements. This test scheme also makes the analog pins more observable and testable during and after the integration. The proposed test scheme is validated with preliminary results. This invention provides a useful test method to guide system designers to achieve a low noise and robust test scheme while designing system specifications.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128119351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. C. Bulusu, M. Faezipour, Vincent Ng, M. Nourani, L. Tamil, S. Banerjee
{"title":"Transient ST-segment episode detection for ECG beat classification","authors":"S. C. Bulusu, M. Faezipour, Vincent Ng, M. Nourani, L. Tamil, S. Banerjee","doi":"10.1109/LISSA.2011.5754171","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754171","url":null,"abstract":"Sudden Cardiac Death (SCD) is an unexpected death caused by loss of heart function when the electrical impulses fired from the ventricles become irregular. Most common SCDs are caused by cardiac arrhythmias and coronary heart disease. They are mainly due to Acute Myocardial Infarction (AMI), myocardial ischaemia and cardiac arrhythmia. This paper aims at automating the recognition of ST-segment deviations and transient ST episodes which helps in the diagnosis of myocardial ischaemia and also classifying major cardiac arrhythmia. Our approach is based on the application of signal processing and artificial intelligence to the heart signal known as the ECG (Electrocardiogram). We propose an improved morphological feature vector including ST-segment information for heart beat classification by supervised learning using the support vector machine approach. Our system has been tested and yielded an accuracy of 93.33% for the ST episode detection on the European ST-T Database and 96.35% on MIT-BIH Arrhythmia Database for classifying six major groups, i.e. Normal, Ventricular, Atrial, Fusion, Right Bundle and Left Bundle Branch Block beats.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133160203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. SivaRamaKrishna, B. Amrutur, N. Bhat, K. ChakraPani, S. Srinivasan
{"title":"Detection of glycated hemoglobin using 3-Aminophenylboronic acid modified graphene oxide","authors":"V. SivaRamaKrishna, B. Amrutur, N. Bhat, K. ChakraPani, S. Srinivasan","doi":"10.1109/LISSA.2011.5754140","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754140","url":null,"abstract":"This paper presents the chemical synthesis of 3-Aminophenylboronic acid (APBA) modified graphene oxide (GO) and its application to the electrochemical detection of glycated hemoglobin (GHb). The compound (GO-APBA) was synthesized by forming an amide linkage between the amino group (-NH2) of APBA and the carboxylic group (-COOH) of GO. The compound was characterized using IR spectroscopy. Detection of GHb was carried out using Electrochemical Impedance Spectroscopic (EIS) measurements with GO-APBA modified glassy carbon electrode as the working electrode.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122020583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A current-reuse quadrature VCO for wireless body area networks","authors":"J. Kim, Jihoon Jeong, D. Ha, Hyung-Soo Lee","doi":"10.1109/LISSA.2011.5754154","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754154","url":null,"abstract":"This paper presents implementation of a low-power quadrature voltage controlled oscillator (QVCO) for medical implant communication service (MICS) applications. The proposed QVCO adopts a parallel-coupling scheme to combine two current-reuse VCOs (P-QVCO). The proposed QVCO has been implemented in 180 nm RF CMOS technology. Simulation results show that the P-QVCO consumes 2.6 mA from 1.2 V supply and achieves very low phase noise of −140 dBc/Hz@1MHz when the carrier frequency is 400 MHz.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129505369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Xing, Xiaoyan Yang, Jie Chen, Biao Huang, W. Roa
{"title":"Electronic dynamic cellular sensor used to measure gold nanoparticles enhanced radiotherapy","authors":"J. Xing, Xiaoyan Yang, Jie Chen, Biao Huang, W. Roa","doi":"10.1109/LISSA.2011.5754145","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754145","url":null,"abstract":"Conventional cellular test, such as clonogenic assay and MTT assay, can only be used to determine the cell effects at one certain time point and impossible for dynamic monitoring. Real time electronic cellular sensor (RT-CES) has been developed for real-time and dynamic cellular monitoring. In this paper, we described how to use RT-CES for real-time monitoring the dynamic change induced by the toxicants and radiotherapy. The gold nanoparticles enhanced radiotherapy was evaluated. Radiation therapy resistance was measured in real time and the dynamic data were used to guide radiotherapy on cancer cells in vitro.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124270726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ilyas, W. Asghar, Joseph A. Billo, Ehsan A. Q. Syed, S. Iqbal
{"title":"From molecular electronics to proteonics: Break junctions for biomarker detection","authors":"A. Ilyas, W. Asghar, Joseph A. Billo, Ehsan A. Q. Syed, S. Iqbal","doi":"10.1109/LISSA.2011.5754160","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754160","url":null,"abstract":"Break junctions have emerged as an important tool to interrogate electrical transport properties of molecules. A number of approaches have been reported for the fabrication of break junctions, including optical/e-beam lithography, electromigration, and electrochemical deposition of conductive materials. All of these are either time consuming (due to slow e-beam writing) or give low yield. We report a novel method to fabricate a nanogap between two gold electrodes. A scratch made by focused ion beam (FIB) milling followed by electromigration provides rapid and high throughput break junctions. These nanogap break junctions are used to selectively capture and electrically detect cancer biomarker protein.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133584697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A low-power low-noise CMOS analog front-end IC for portable brain-heart Monitoring applications","authors":"Chung-Han Tsai, Zong-Han Hsieh, W. Fang","doi":"10.1109/LISSA.2011.5754151","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754151","url":null,"abstract":"In this paper, a low power and low noise eight-channel analog front-end (AFE) IC for portable brain-heart monitoring applications is presented. The developed IC features a fully integrated eight-channel design which includes one channel for diffuse optical tomography (DOT), three channels for electrocardiography (ECG), and four channels for electroencephalography (EEG). In order to achieve the targets of lower power, lower noise, and more efficient area utilization, a new programmable readout channel is invented which is composed of a chopper-stabilized differential difference amplifier (CHDDA), an adjustable gain amplifier, and an adjustable low pass filter (LPF). Furthermore, a 10-bit successive approximation register analog-to-digital converter (SAR-ADC) is employed in conjunction with an analog multiplexer to select a particular biosignal for analog-to-digital conversion. The proposed IC has been fabricated in the TSMC 0.18 um CMOS technology and simulated using HSPICE under a 1.8-V supply voltage and an operating frequency of 512 Hz. The power supply rejection ratio (PSRR) +/- of the CHDDA is 113/105 dB. The power consumption of the programmable readout channel and the SAR-ADC is about 71.159 µW and 8.27 µW, respectively. The total power consumption of the full AFE chip is about 506.38 µW and the chip area is about 1733 × 1733 um2.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124057546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}