Electronic dynamic cellular sensor used to measure gold nanoparticles enhanced radiotherapy

Abstract

Conventional cellular test, such as clonogenic assay and MTT assay, can only be used to determine the cell effects at one certain time point and impossible for dynamic monitoring. Real time electronic cellular sensor (RT-CES) has been developed for real-time and dynamic cellular monitoring. In this paper, we described how to use RT-CES for real-time monitoring the dynamic change induced by the toxicants and radiotherapy. The gold nanoparticles enhanced radiotherapy was evaluated. Radiation therapy resistance was measured in real time and the dynamic data were used to guide radiotherapy on cancer cells in vitro.