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Nano-sensor and circuit design for anti-cancer drug detection 抗癌药物检测纳米传感器及电路设计
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754147
S. Ghoreishizadeh, C. Baj-Rossi, S. Carrara, G. De Micheli
{"title":"Nano-sensor and circuit design for anti-cancer drug detection","authors":"S. Ghoreishizadeh, C. Baj-Rossi, S. Carrara, G. De Micheli","doi":"10.1109/LISSA.2011.5754147","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754147","url":null,"abstract":"The development of new technologies to monitor drugs concentration directly in patient's blood is absolutely required to succeed in personalized drug therapies. In this study, Etoposide - a well-known anti-cancer drug - has been chosen as model for cyclic voltammetry detection of drugs. Carbon nanotubes are chosen as electron-transfer mediators to enhance the system sensitivity. A very low frequency and low slope triangular-wave potential is required to acquire cyclic voltammograms. Cyclic voltammograms are definitely needed for a correct identification and quantification of the drug concentration in the patient serum. The aim of the paper is to investigate the feasibility of VLSI fully-integration of cyclic voltammetry measurements as a tool to develop a low-cost chip for drug monitoring in personalized therapy. A triangular wave generator CMOS circuit is proposed by using Direct Digital Synthesis (DDS) method. The circuit is implemented in 0.18 µm technology and it presents the possibility of changing the slope of the triangular voltage in a wide range of 10 to 100mV/s.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116988231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Study of automatic biosounds detection and classification using SVM and GMM 基于SVM和GMM的生物声音自动检测与分类研究
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754182
Bor Jenq. Chua, Xue Li, H. D. Tran
{"title":"Study of automatic biosounds detection and classification using SVM and GMM","authors":"Bor Jenq. Chua, Xue Li, H. D. Tran","doi":"10.1109/LISSA.2011.5754182","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754182","url":null,"abstract":"Ambulatory devices can be used to detect heart diseases and save lives in critical time. These devices are based on sound classification that usually adopts a suitable data mining algorithm. This paper investigates the performance of Support Vector Machine (SVM) and Gaussian Mixture Model (GMM) classifiers in classifying sound samples. SVM classifier makes use of a linearly separable hyperplane to classify data into different classes, while GMM utilizes a probabilistic model for density estimation through probability density functions. Feature vectors of sound samples were extracted using the Mel-frequency cepstral coefficients (MFCCs) and fed to the classifiers. Our experimental results showed that SVM is more robust than GMM, and SVM achieved >80% classification accuracy in all classes of sound samples collected in this study.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116303098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A reliable ultra low power merged LNA and Mixer design for medical implant communication services 一种可靠的超低功耗合并LNA和Mixer设计，用于医疗植入物通信服务
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754153
Jihoon Jeong, Jeong-Ki Kim, D. Ha, Hyung-Soo Lee
{"title":"A reliable ultra low power merged LNA and Mixer design for medical implant communication services","authors":"Jihoon Jeong, Jeong-Ki Kim, D. Ha, Hyung-Soo Lee","doi":"10.1109/LISSA.2011.5754153","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754153","url":null,"abstract":"This paper presents an ultra low power merged LNA and Mixer design for MICS (Medical Implant Communication Services) applications. A capacitor cross-coupled common gate LNA is implemented for an easy input matching and reasonable noise performance. The mixer operates in weak inversion, which significantly reduces power consumption and relaxes the voltage headroom without sacrificing the LNA performance. The relaxed voltage headroom enables the stacking of the LNA and the mixer with a low supply voltage of 1.2 V. The merged LNA and mixer consumes only 1.83 mW, and achieves 21.6 dB power gain. A NF of the circuit is 3.55 dB at 1 MHz IF, and the IIP3 is −6.08 dBm.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121540659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Solid-state nanopores integrated with low-noise preamplifiers for high-bandwidth DNA analysis 固体纳米孔集成低噪声前置放大器，用于高带宽DNA分析
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754155
J. Rosenstein, V. Ray, M. Drndić, K. Shepard
{"title":"Solid-state nanopores integrated with low-noise preamplifiers for high-bandwidth DNA analysis","authors":"J. Rosenstein, V. Ray, M. Drndić, K. Shepard","doi":"10.1109/LISSA.2011.5754155","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754155","url":null,"abstract":"Nanopore sensing platforms have been limited in bandwidth and noise performance by the use of external measurement electronics with significant parasitic impedances. In this work, we describe progress toward integrating detection electronics with solid-state nanopore sensors. This new platform for high-bandwidth single-molecule electrochemical DNA analysis includes a low-noise 8-channel 0.13µm CMOS preamplifier with integrated Ag/AgCl microelectrodes. We also demonstrate monolithic integration of solid-state nanopores in the amplifier chip. This arrangement provides an opportunity to extend the useful bandwidth of nanopore sensors by a factor of ten or more.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126254475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
An electrically-stimulate optically-record microsystem based on active CMOS multi-electrode array for dissociated cell cultures 基于有源CMOS多电极阵列的离解细胞培养电刺激光记录微系统
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754184
N. Lei, S. Ramakrishnan, P. Shi, J. Orcutt, L. Kam, R. Yuste, K. Shepard
{"title":"An electrically-stimulate optically-record microsystem based on active CMOS multi-electrode array for dissociated cell cultures","authors":"N. Lei, S. Ramakrishnan, P. Shi, J. Orcutt, L. Kam, R. Yuste, K. Shepard","doi":"10.1109/LISSA.2011.5754184","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754184","url":null,"abstract":"Calcium fluorescence-based optical recording combined with patch-clamp stimulation has become the standard technique for analyzing neural network behavior. At best, stimulation is limited to only a few channels in this case. Passive multielectrode arrays for two-dimensional electrophysiology only offer electrode densities of 60 electrodes per mm2. Here, we report an active multielectrode array, constructed with a standard complementary metal-oxide-semiconductor (CMOS) technology, to perform localized extracellular stimulation of dispersed cell cultures. A 256×256 array integrated with in-pixel stimulators on a 4-by-4 mm2 CMOS chip noninvasively stimulate hippocampal cells cultured on chip at cellular resolution. Combined with calcium imaging using high-affinity indicators, we demonstrate the ability to observe spatiotemporal dynamics of neural activity.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125470483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
An in-silico approach for drug repositioning to tumour anti-migration using an integrated genomic strategy 使用集成基因组策略的药物重新定位肿瘤抗迁移的计算机方法
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754163
Yong Mao, K. Cui, W. Lulu, Hong Zhao, F. Nie, Miriam Brandl, D. Beck, Liang Gao, Stephen T C Wong
{"title":"An in-silico approach for drug repositioning to tumour anti-migration using an integrated genomic strategy","authors":"Yong Mao, K. Cui, W. Lulu, Hong Zhao, F. Nie, Miriam Brandl, D. Beck, Liang Gao, Stephen T C Wong","doi":"10.1109/LISSA.2011.5754163","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754163","url":null,"abstract":"Cell migration is a key step for deterioration of many in situ or metastasis malignant tumours. Tumour anti-migration is a promising strategy to treat cancer, but corresponding drugs developed under such a strategy are still in dire poverty, partly due to the lengthly process of drug trials and approval required by the US Food and Drug Administration (FDA). Given there are thousands of FDA approved drugs in the market, we believe that drug repositioning may provide a fast and cost-effective way to identify potential anti-migration drugs. In this paper, an in-silico drug screening method using a genomic strategy is proposed for the goal, in which genomic signature identification combined with support vector machine modelling is adopted to estimate drug efficacy. And a high-throughput, sensitive, 3-dimensional invasion assay by quantitative bioluminescence imaging proved the performance of proposed method on in vitro disease models.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116290221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Charge sensing using point-functionalized carbonnanotube transistors for single-molecule detection 利用点功能化碳纳米管晶体管进行单分子检测的电荷传感
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754156
S. Sorgenfrei, C. Chiu, C. Nuckolls, K. Shepard
{"title":"Charge sensing using point-functionalized carbonnanotube transistors for single-molecule detection","authors":"S. Sorgenfrei, C. Chiu, C. Nuckolls, K. Shepard","doi":"10.1109/LISSA.2011.5754156","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754156","url":null,"abstract":"We have demonstrated that carbon-nanotube field-effect transistors act as highly sensitive single-molecule detectors when point functionalized. The hybridization kinetics of two complementary strands of DNA are associated with two-level fluctuations in the conductance of the nanotube to which the DNA is bound. We have studied the temperature dependence of the nanotube conductance and shown that the transport mechanism is consistent with Frenkel Poole emission, in which negatively charged DNA modulates a tunnel barrier at the point functionalized defect site. These transistors represent an important potential sensing platform for label-free single-molecule diagnostics.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128627167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
An inexpensive, battery powered and portable instrument for the optical detection of pathogens 一种廉价的、电池供电的便携式仪器，用于光学检测病原体
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754181
R. Khanna, W. Stanchina, A. Jones, A. Vats
{"title":"An inexpensive, battery powered and portable instrument for the optical detection of pathogens","authors":"R. Khanna, W. Stanchina, A. Jones, A. Vats","doi":"10.1109/LISSA.2011.5754181","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754181","url":null,"abstract":"In order to satisfy an emergent demand in point of care (POC) diagnostics as well as low resource settings such as in developing countries, we have integrated optical and bio-medical engineering to implement a device, which detects pathogens and displays test results using cell phones. The device employs DNA amplification and off-the-shelf components to obtain the diagnosis.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128671903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A high-resolution hybrid randomized modulation scheme for switched-mode DC-DC converters 一种用于开关模式DC-DC转换器的高分辨率混合随机调制方案
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754149
V. Adrian, J. Chang, Lim Geok Soon
{"title":"A high-resolution hybrid randomized modulation scheme for switched-mode DC-DC converters","authors":"V. Adrian, J. Chang, Lim Geok Soon","doi":"10.1109/LISSA.2011.5754149","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754149","url":null,"abstract":"Switched-mode dc-dc converters are routinely employed in the power supply section of low-power electronic systems, such as biomedical implants, to convert a supply voltage from one voltage level to another voltage level. The switched-mode dc-dc converter employs a modulator to modulate the output pulses. In Pulse Width Modulation (PWM)-based digital modulators, an N-bit counter is employed to generate 2N possible pulse widths, where the value of N is relatively small (≤10). As a consequence of small N, the output has limited resolution that may cause steady-state limit cycles in closed-loop converters [1]. The limit cycles translate to harmonic distortion in the output power spectrum. The impetus is, therefore, to improve the output resolution without increasing N that would otherwise increase the clock frequency and power dissipation of the counter, and without causing harmonic distortion or limit cycles.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133433454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ultralow-power analog front-end circuits and system design for an implantable cardioverter defibrillator (ICD) 植入式心律转复除颤器(ICD)超低功耗模拟前端电路及系统设计
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754148
Weibo Hu, Tam Q. Nguyen, Yen-Ting Liu, D. Lie
{"title":"Ultralow-power analog front-end circuits and system design for an implantable cardioverter defibrillator (ICD)","authors":"Weibo Hu, Tam Q. Nguyen, Yen-Ting Liu, D. Lie","doi":"10.1109/LISSA.2011.5754148","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754148","url":null,"abstract":"This paper proposes some novel ultralow-power system and circuit designs and trade-offs on the analog front-end integrated circuit (IC) for an implantable cardioverter defibrillators (ICD). The major front-end analog IC components include low-power pre-amplifier, filters, a variable-gain-amplifier (VGA) and an Analog-to-Digital Converter (ADC). We avoided the use of clock signals in the analog IC design (except in the ADC) to reduce the common-mode and switching noise as much as possible. Therefore, the pre-amplifier is designed with low-noise bipolar transistors, rather than using chopper or auto-zero techniques; the filters are designed with the gm-C topology. The VGA includes a high-pass filter (HPF) and a DC shifter designed with a differential difference amplifier (DDA). An ultralow-power successive-approximation-register (SAR) ADC with a novel DAC design is used to digitize signals and to reduce SAR ADC's input capacitance by half. SPICE simulation results of each circuit block and of the entire front-end IC demonstrate that the ultralow-power analog front-end circuitry can effectively filter out the undesired T-wave in patients' electrogram (EGM) to enable proper heartbeat detection in the ICD.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123784312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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