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Ultrasound-mediated gene delivery into hard-to-transfect KG-1 cells 超声介导的基因传递到难以转染的KG-1细胞
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754179
Peter Wong, Michael Choi, H. Gul-Uludağ, W. Ang, P. Xu, J. Xing, Jie Chen
{"title":"Ultrasound-mediated gene delivery into hard-to-transfect KG-1 cells","authors":"Peter Wong, Michael Choi, H. Gul-Uludağ, W. Ang, P. Xu, J. Xing, Jie Chen","doi":"10.1109/LISSA.2011.5754179","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754179","url":null,"abstract":"In this paper, we explore the possibility of increasing the transfection rate of hard-to-transfect cells (such as KG-1 cells) using ultrasound-mediated gene delivery (USD). Single application ultrasound induced as well as the synergistic properties of ultrasound with commonly used transfection reagents and repeated sessions USD were investigated and evaluated using GFP plasmid. KG-1 cells were not transfected by combining a commonly used transfection reagent and USD. However, repeated ultrasound-mediated treatments were able to increase transfection rate to 15% with a viability of 97%, as compared to 2% with the transfection reagent, Lipofectamine, alone.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129124844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Chimeric ferritin nanocages-based imaging probes 嵌合铁蛋白纳米成像探针
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754175
Xin Lin, Jin Xie, Xiaoyuan Chen
{"title":"Chimeric ferritin nanocages-based imaging probes","authors":"Xin Lin, Jin Xie, Xiaoyuan Chen","doi":"10.1109/LISSA.2011.5754175","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754175","url":null,"abstract":"Ferritin is a family of proteins found in different forms in most living organisms. Each ferritin is made up of 24 subunits, which self-assemble to form a cage-like nanostructure, with external and internal diameters of 12 and 8 nm, respectively. This unique architecture provides two interfaces—one outside and one inside—for possible functional loading. These interesting features make ferritin a powerful, capacious nanoplatform with potential in a wide spectrum of applications.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127317740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of fluorescence activatable nanosensors 荧光活化纳米传感器的研制
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754162
M. Swierczewska, Xiaoyuan Chen
{"title":"Development of fluorescence activatable nanosensors","authors":"M. Swierczewska, Xiaoyuan Chen","doi":"10.1109/LISSA.2011.5754162","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754162","url":null,"abstract":"As new biomarkers and relationships among biomarkers for diseases are identified, the demand for highly sensitive and multiplexed detection increases. The goal of this study is to take advantage of the unique properties of nanoparticles to advance biomedical sensor systems of various bio- and environmental markers. Among the various detection signals, fluorescence is a major focus since it can be readily used as a research tool. More importantly, fluorescent dyes have unique interactions with nanoparticles. For example, when fluorophores are in close proximity of gold nanoparticles (AuNPs), 99.8% of fluorescence is quenched. Fluorophores can be released from the AuNP surface for an enhanced “on” fluorescence signal. The fluorophore-AuNP interaction has been adapted for use as an in vivo imaging probe for drug screening and protease activity.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123473752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A fast image reconstruction algorithm for continuous wave diffuse optical tomography 连续波漫射光学层析成像的快速图像重建算法
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754164
J. Tsai, N. Chen, W. Fang, Jian-Shiang Chen
{"title":"A fast image reconstruction algorithm for continuous wave diffuse optical tomography","authors":"J. Tsai, N. Chen, W. Fang, Jian-Shiang Chen","doi":"10.1109/LISSA.2011.5754164","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754164","url":null,"abstract":"In this paper, we propose a fast high resolution image reconstruction algorithm for continuous wave (CW) diffuse optical tomography (DOT). First, we devise the overlapped-truncated-Jacobi singular value decomposition (OSVD) scheme for the image reconstruction. Second, we adopt the cubic interpolation to enhance the image quality. Simulation results show that our proposed algorithm effectively reduces the computing complexity, keeps the confidence of the image and enhances the image resolution.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126598610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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