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2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)最新文献

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A VLSI design of singular value decomposition processor for portable continuous-wave diffusion optical tomography systems 便携式连续波扩散光学层析成像系统奇异值分解处理器的VLSI设计
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754166
Shih Kang, Shih-Yang Wu, Y. Hsu, Chih-Chung Fu, W. Fang
{"title":"A VLSI design of singular value decomposition processor for portable continuous-wave diffusion optical tomography systems","authors":"Shih Kang, Shih-Yang Wu, Y. Hsu, Chih-Chung Fu, W. Fang","doi":"10.1109/LISSA.2011.5754166","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754166","url":null,"abstract":"In recent years, developments in diffuse optical tomography (DOT) technology have rapidly progressed in biomedical applications such as functional brain imaging. Furthermore, during the last decade, singular value decomposition has increasingly found many applications in the engineering field. Our goal is to develop a truly portable DOT system by utilizing system-on-chip design technique. In our DOT system, designing the SVD processor using VLSI technique is very efficient for solving the inverse problem in the DOT algorithm. In this paper, we focus on the hardware architecture design of the Jacobi singular value decomposition (JSVD) for applications in continuous wave diffusion optical tomography (CW-DOT) systems. The design is implemented using 90nm CMOS process technology and simulation results verify the functionality of the JSVD design within the developed CW-DOT system.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117103687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
RMED: A reconfigurable architecture for embedded medical monitoring RMED:用于嵌入式医疗监控的可重构架构
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754169
H. Alemzadeh, Mushfiq Saleheen, Zhanpeng Jin, Z. Kalbarczyk, R. Iyer
{"title":"RMED: A reconfigurable architecture for embedded medical monitoring","authors":"H. Alemzadeh, Mushfiq Saleheen, Zhanpeng Jin, Z. Kalbarczyk, R. Iyer","doi":"10.1109/LISSA.2011.5754169","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754169","url":null,"abstract":"In this paper we propose a multi-parameter reconfigurable architecture framework for patient-specific medical monitoring. This architecture is mainly composed of a set of heterogeneous processing engines and flexible communication interfaces, which enable the run-time configuration of the architecture for optimal diagnosis of different diseases. The flexibility of the proposed framework is evaluated by demonstrating two different medical applications for monitoring brain and heart status on an FPGA-based hardware prototype. The evaluated epileptic seizure detection application gains a high detection performance with overall accuracy of 98.52% and sensitivity of 99.47%. For the cardiac ICU monitoring application, the experimental results for detecting abnormality of blood pressure and heart rate in selected patients show a high true positive rate of 94.74%. By applying algorithmic enhancements in the detection scheme, we even achieve early detection of abnormalities in blood pressure in the range of few minutes before standard ICU monitor alarms with a true positive rate of 64%. With a balanced mixture of flexibility, patient-specificity, and detection accuracy at small hardware footprint, the proposed architecture can be an attractive framework for embedded monitoring of a wide variety of medical conditions.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126626594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
In vitro versus in vivo impedance modeling for electrochemically deposited iridium oxide electrodes 电化学沉积氧化铱电极的体外与体内阻抗建模
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754144
S. Minnikanti, G. Knaack, R. Samiyi, N. Peixoto
{"title":"In vitro versus in vivo impedance modeling for electrochemically deposited iridium oxide electrodes","authors":"S. Minnikanti, G. Knaack, R. Samiyi, N. Peixoto","doi":"10.1109/LISSA.2011.5754144","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754144","url":null,"abstract":"We present here an electric circuit model that fits the behavior of iridium oxide coated electrodes when tested in vitro and in vivo. Our objective is to understand the interface between the active iridium oxide and the biological tissue. In order to do that we have first measured the impedance and the cyclic voltammetry in five electrodes which we later implanted in the hippocampi of rodents. While implanted, we have again measured the charge delivery through cyclic voltammetry and the impedance through spectroscopy. We later explanted the electrodes and performed the exact same tests, demonstrating that the electrodes had not been damaged either by our tests or by the implant. Here we will present the impedance values and the fit of the models we suggest, which include a solution resistand and a constant phase element. A charge transfer resistance is only present in our in vitro model, and this phenomenon is discussed in the current paper.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131448486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a fiber optic-based CARS exoscope for the in vivo study of spinal cord disorders 用于脊髓疾病体内研究的光纤CARS外窥镜的研制
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754165
S. Murugkar, Brett Smith, C. Brideau, P. Stys, H. Anis
{"title":"Development of a fiber optic-based CARS exoscope for the in vivo study of spinal cord disorders","authors":"S. Murugkar, Brett Smith, C. Brideau, P. Stys, H. Anis","doi":"10.1109/LISSA.2011.5754165","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754165","url":null,"abstract":"This paper describes our development of a fiber optic, MEMS-scanning based multimodal miniature microscope for in vivo nonlinear optical imaging of the spinal cord. The novel design of the exoscope will enable serial examinations of the status of the myelin sheath over time in the same animal by means of CARS microscopy. The basic design concept, major engineering challenges, solutions, and some preliminary results are presented.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122703087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LOMIN: Moving theranostics from bench to bedside LOMIN:将治疗学从实验室转移到床边
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754172
Seulki Lee, Xiaoyuan Chen
{"title":"LOMIN: Moving theranostics from bench to bedside","authors":"Seulki Lee, Xiaoyuan Chen","doi":"10.1109/LISSA.2011.5754172","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754172","url":null,"abstract":"The Laboratory of Molecular Imaging and Nanomedicine (LOMIN) was initiated in 2009 at the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering and has been led by Xiaoyuan (Shawn) Chen. Currently, LOMIN has grown to over 25 members who work together in diverse fields to develop theranostic molecular imaging tools and drug delivery systems. LOMIN is an interdisciplinary group divided into different sections based on expertise, but not divided by research projects. The three interdisciplinary and versatile groups, the PET/Optical Imaging Probe Section, the Biological Molecular Imaging Section and the Theranostic Nanomedicine Section, consist of chemists, engineers, biologists, and clinicians working together to transfer biomedical technology from the bench to the bedside. LOMIN works cohesively on its main mission to improve molecular imaging strategies for better understanding of biology, early diagnosis of disease, monitoring therapies and guiding drug discovery and development. In addition, special emphasis is placed on developing high sensitivity nanosensors for biomarker detection and theranostic nanomedicine for imaging, gene and drug delivery and therapy monitoring. LOMIN has developed novel imaging agents for targeting of various biological processes and monitoring therapies that have been slated for clinical trials. The future of LOMIN is to expand collaborations in order to apply lead imaging and therapeutic agents to the clinic. In this presentation, LOMIN will be introduced with our representative up-to-date research projects.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122737553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrity preservation and privacy protection for medical images with histogram-based reversible data hiding 基于直方图的可逆数据隐藏医学图像的完整性保护和隐私保护
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754168
Hsiang-Cheh Huang, W. Fang
{"title":"Integrity preservation and privacy protection for medical images with histogram-based reversible data hiding","authors":"Hsiang-Cheh Huang, W. Fang","doi":"10.1109/LISSA.2011.5754168","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754168","url":null,"abstract":"For medical treatments, the integrity of the medical images, the authenticity of corresponding medical records, and the privacy of the patients are crucial requirements for the diagnosis of patient's disease. Therefore, how to retain the validity between images and medical records is an important topic for researches and real applications. In this paper, we apply the concept and implementation in digital rights management (DRM) systems, and propose a functional scheme for the above-mentioned goals. We employ the reversible data hiding scheme, a newly developed branch in DRM researches, for combating the goals. With the term of reversibility, it means that data, including patients' private information and the diagnosis data, can be hidden into the medical image by some means. Later on, the medical image containing data might be retrieved while necessary, and both the original image and the hidden data can be perfectly recovered. Data can be authenticated for enhanced privacy protection. Simulation results present the applicability of such an implementation.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125234616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Computing left ventricular hemodynamics from echographic optical flow of CEUS microspheres 从超声造影微球光流计算左室血流动力学
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754157
P. Burlina, B. Hoffmann, T. Abraham
{"title":"Computing left ventricular hemodynamics from echographic optical flow of CEUS microspheres","authors":"P. Burlina, B. Hoffmann, T. Abraham","doi":"10.1109/LISSA.2011.5754157","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754157","url":null,"abstract":"We present a novel ultrasonographic approach to compute hemodynamics in the heart cavities. We estimate blood motion flow by exploiting the apparent visual flow of motion in ultrasonographic image sequences enhanced by the use of an echographic contrast agent. We describe the optical flow and segmentation approaches used specifically for determining blood flow in the left intraventricular cavity. We report preliminary results obtained using contrast enhanced ultrasound (CEUS) data. This method has applications for performing diagnostics (for myocardial or valvular pathologies such as hypertrophic cardiomyopathy or mitral valve insufficiency.) It can be used for validating cardiac biomechanical models. Finally, it can be employed for detecting laceration and hemorrhage, or characterizing the vascularization of metastatic tissues in organs such as the liver.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121707940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Design of a hemispherical antenna array for magnetic field control in the brain 用于大脑磁场控制的半球形天线阵列的设计
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754176
Mohammad Safar, R. Newcomb
{"title":"Design of a hemispherical antenna array for magnetic field control in the brain","authors":"Mohammad Safar, R. Newcomb","doi":"10.1109/LISSA.2011.5754176","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754176","url":null,"abstract":"A hemispherical antenna array consisting of 42 elements operating at a frequency of 1.8 GHz was proposed and simulated. The array elements are distributed on a hemisphere to be placed on a human's head. By considering the problem as a boundary valued problem and finding the electric and magnetic field inside the brain, a beamforming technique was used that made use of the orthogonality property of the transverse electric and transverse magnetic fields in producing a delta like function beampattern in order to direct the magnetic field to the area of interest within the brain to cause magnetic deep brain stimulation.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130665922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A passive intraocular pressure sensor and a wireless sensing technique using an intermediate LC resonator 一种使用中间LC谐振器的无源眼压传感器和无线传感技术
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754141
H. Cao, R. Weber, Nicolas G. Hamouche
{"title":"A passive intraocular pressure sensor and a wireless sensing technique using an intermediate LC resonator","authors":"H. Cao, R. Weber, Nicolas G. Hamouche","doi":"10.1109/LISSA.2011.5754141","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754141","url":null,"abstract":"This paper presents a wireless passive pressure sensor and wireless sensing techniques for intraocular pressure (IOP) measurement. The sensor device consists of a capacitor array and a coil inductor, which form a series LC type resonator. The capacitor array is also a membrane structure, and is fabricated by surface micromachining technique. By using a high permeability ferrite coil detector, the IOP sensor can be wirelessly detected up to 4mm with a sensitivity of 3.78kHz/(10mmHg), under a pressure range 0–70mmHg. This work also demonstrates a new sensing technique using an intermediate LC resonator to improve the sensing distance to 1.5cm, with a sensitivity of about 185Hz/(10mmHg).","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129634444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
On-chip cell culture biosensing with microfluidic feedback control 芯片上细胞培养生物传感与微流控反馈控制
2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Pub Date : 2011-04-07 DOI: 10.1109/LISSA.2011.5754150
D. Welch, J. Christen
{"title":"On-chip cell culture biosensing with microfluidic feedback control","authors":"D. Welch, J. Christen","doi":"10.1109/LISSA.2011.5754150","DOIUrl":"https://doi.org/10.1109/LISSA.2011.5754150","url":null,"abstract":"We present work towards expanding the capabilities of microfluidic cell culture devices through the incorporation of microelectronic sensing systems. A system has been fabricated that includes four sensing regions each consisting of a pH sensor, capacitance sensor, and photodiode. We have demonstrated the incorporation of feedback control systems using computer controlled microfluidics for a pH sensor. Preliminary data for photodiode characterization, pH detection using ISFETs, and capacitance sensing of cell density is presented. Results from this work will be used towards creating a single system that can function as a cell culture platform with programmable control over all of these variables.","PeriodicalId":227469,"journal":{"name":"2011 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122065723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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