The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)最新文献_第4页

Liquid-liquid phase separator for synthesizing gold nanoparticles in toluene 用于在甲苯中合成金纳米颗粒的液-液相分离器

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908812

Ho-Cheng Lee, Che-Hsin Lin

{"title":"Liquid-liquid phase separator for synthesizing gold nanoparticles in toluene","authors":"Ho-Cheng Lee, Che-Hsin Lin","doi":"10.1109/NEMS.2014.6908812","DOIUrl":"https://doi.org/10.1109/NEMS.2014.6908812","url":null,"abstract":"It is challenging to separate the immiscible liquid of low surface tension from water using the microfluidic device. This study presents a microfluidic chip composed of a T-junction, reaction channel and a novel liquid-liquid phase separator for continuously synthesizing fine gold nanoparticles in the organic solvent of toluene. The designed glass chip is used to separate two immiscible liquids via with the microfluidic channels of different depths. The surface tension and the capillary force differences are used to separate the two immiscible fluids. The stable segmented flow is initially produced by the T-junction and the gold salt is then reduced due at the reaction channel. The toluene with reduced AuNPs is finally collected via the designed separator downstream. Results show that the separator is capable for separating water (surface tension = 72.75 mN/m) and toluene (surface tension = 30.9 mN/m) with 92% separation efficiency. Results indicate that the gold nanoparticle (AuNPs) synthesized in the microdevice exhibits a narrower size distribution and better dispersion, comparing to the typical batch synthesis process. This study develops an efficient microfluidic system for stable chemical reaction and liquid-liquid phase separation in the microchannel.","PeriodicalId":22566,"journal":{"name":"The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"23 1","pages":"298-301"},"PeriodicalIF":0.0,"publicationDate":"2014-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85287650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nanorobotic processing of graphene for rapid device prototyping 石墨烯的纳米机器人加工用于快速器件原型设计

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908807

S. Zimmermann, S. A. Barragan, S. Fatikow

引用次数: 2

Silicon microspeaker with out-of-plane displacement 具有面外位移的硅微扬声器

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908749

C. Glacer, A. Dehé, D. Tumpold, R. Laur

引用次数: 8

A microfluidic device for automatic embryo trapping and coculture with stromal cells in vitro 一种用于胚胎自动捕获及与基质细胞体外共培养的微流控装置

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908808

Chi-Fan Chen, Kuo-Wei Chang, Ting-Ru Yueh, Hong-Yuan Huang, Chen-Shien Liu

引用次数: 0

Laser direct nano-structuring assisted by water droplets 水滴辅助激光直接纳米结构

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908772

Y. J. Chang, C. H. Chang, C. Ho, J. Hsu, C. Kuo

引用次数: 0

Study on compatible CMOS-MEMS process with surface micromachining for the application of monolithic integration 面向单片集成应用的表面微加工兼容CMOS-MEMS工艺研究

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908861

D. Zhao, Xian Huang, Jun He, Li Zhang, Peng Liu, Fang Yang, Dacheng Zhang

引用次数: 0

A clogging-free microfluidic platform for size independent single cancer cellular electrical property characterization 一个无堵塞的微流控平台，用于大小无关的单个癌细胞电学特性表征

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908836

Song-Bin Huang, Yang Zhao, Deyong Chen, Yana Luo, Hsin-Chieh Lee, T. Chiu, Junbo Wang, Jing Chen, Min-Hsien Wu

{"title":"A clogging-free microfluidic platform for size independent single cancer cellular electrical property characterization","authors":"Song-Bin Huang, Yang Zhao, Deyong Chen, Yana Luo, Hsin-Chieh Lee, T. Chiu, Junbo Wang, Jing Chen, Min-Hsien Wu","doi":"10.1109/NEMS.2014.6908836","DOIUrl":"https://doi.org/10.1109/NEMS.2014.6908836","url":null,"abstract":"This study reports a microfluidic platform for clogging-free electrical property analysis of cancer cells. A pneumatically-driven membrane-based active valve was integrated in this platform to unblock clogging events of constriction microchannels where pneumatic pressures were used to tune the deformation of a polydimethylsiloxan (PDMS) membrane serving as one wall of the constriction microchannel. The proposed platform was first used to unblock trapped polystyrene beads (30 μm in diameter) at the entrance of constriction microchannels and then the characterization of the cellular electrical properties of lung cancer cells was successfully demonstrated. Results showed that the measured cytoplasm conductivity (0.74±0.20 S/m) and specific membrane capacitance (2.17±0.58 μF/cm2) of cells were consistent with the results from the previous publications (0.73±0.17 S/m, and 2.00±0.60 μF/cm2, respectively). Overall, this study has presented a microfluidic platform for single cell analysis with an enhanced function for unblocking cell aggregates at the entrance of microchannels, which may function as a platform technology enabling cancer-cell electrical property characterization in the near future.","PeriodicalId":22566,"journal":{"name":"The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"95 1","pages":"398-402"},"PeriodicalIF":0.0,"publicationDate":"2014-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82683542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficiency of transdermal α-Arbutin delivery after albumin microbubbles treatment with ultrasound in mice 超声处理白蛋白微泡后小鼠经皮α-熊果苷的传递效率

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908782

A. Liao, Wan-Chun Ma, H. Chuang, C. Yeh, Chih-Chung Huang

{"title":"The efficiency of transdermal α-Arbutin delivery after albumin microbubbles treatment with ultrasound in mice","authors":"A. Liao, Wan-Chun Ma, H. Chuang, C. Yeh, Chih-Chung Huang","doi":"10.1109/NEMS.2014.6908782","DOIUrl":"https://doi.org/10.1109/NEMS.2014.6908782","url":null,"abstract":"The application of transdermal delivery to a wider range of drugs is limited due to the significant barrier to penetration across the skin which is associated with the stratum corneum layer of the epidermis. In previous study in the literature, the feasibility and effects of the ultrasound (US) contrast agent, microbubbles (MBs) as the penetration enhancers for transdermal delivery in vivo were firstly demonstrated. In this study, the penetration depth, concentration, and efficiency of transdermal α-Arbutin delivery after MBs treatment with US in mice were demonstrated for 4 weeks. The penetration of α-arbutin on skin was enhanced by using ultrasound energy and MBs either for in vitro or for in vivo experiments. Experiment parameters were randomly divided into four groups (n=5 animals per group): (1) only penetrating α-Arbutin (C); (2) US combines with penetrating α-arbutin (U) (3) US combines with MBs contrast agent and penetrating α-arbutin (UB); (4) US combines with diluted MBs and penetrating α-arbutin (UBD). According to the results, the penetration depth of agarose phantom and pigskin of UBD group increase 47% and 84%, respectively. The in vitro skin permeation of 2% α-arbutin, UBD group was 83% greater than control group after 3 hour of permeation study. For in vivo study, the whitening effect (luminosity index) of mice skin in UBD group significantly increase 25% in one week, 34% in two weeks and tends towards stability in three weeks (37%) in C57BL/6J mice over a 4-week experimental period. Our results investigated that the treatments of ultrasound and MBs can increase skin permeability, enhance α-arbutin delivery to inhibit melanogenesis and not damage the skin in mice.","PeriodicalId":22566,"journal":{"name":"The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"9 1","pages":"163-167"},"PeriodicalIF":0.0,"publicationDate":"2014-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88737205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulse mode actuation-readout system based on MEMS resonator for liquid sensing 基于MEMS谐振器的脉冲驱动读出系统用于液体传感

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908794

Meng Tang, A. Cagliani, Z. Davis, Lin He

引用次数: 0

The demand model of electric field strength on microelectrode designed for AC electrokinetic applications 为交流电动应用设计了微电极的电场强度需求模型

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908890

N. A. M. Yunus, H. Jaafar, I. Halin, J. Jasni

引用次数: 3