Surgery Today最新文献_第5页

Correlation between the C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index and the prognosis of gastric cancer patients after gastrectomy: a systematic review and meta-analysis. C反应蛋白（CRP）-白蛋白-淋巴细胞（CALLY）指数与胃切除术后胃癌患者预后的相关性：系统综述和荟萃分析。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-19 DOI: 10.1007/s00595-024-02921-y

Jinquan Li, Shanzhong Zhang, Xiaosheng Hu, Tao Huang, Mingmin Chen

{"title":"Correlation between the C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index and the prognosis of gastric cancer patients after gastrectomy: a systematic review and meta-analysis.","authors":"Jinquan Li, Shanzhong Zhang, Xiaosheng Hu, Tao Huang, Mingmin Chen","doi":"10.1007/s00595-024-02921-y","DOIUrl":"https://doi.org/10.1007/s00595-024-02921-y","url":null,"abstract":"The C-Reactive Protein (CRP)-Albumin-Lymphocyte (CALLY) index is an established immuno-nutritional scoring system. We screened relevant literature from the major databases up until May, 2024, and extracted the data for analysis. A total of 2829 gastric cancer (GC) patients from six studies were included in this meta-analysis, the results of which revealed that the CALLY index was an independent prognostic factor for OS and RFS in both univariate analyses and multivariate analyses, and that a high CALLY index was a favorable prognostic factor. Moreover, GC patients in the high CALLY index group seemed to have better 5-year OS and 5-year RFS than those in the low CALLY index group. There was a higher proportion of patients with T1 status in the high CALLY index group than in the low CALLY index group. However, the opposite results were found in the analyses of lymph node metastasis positivity, lymph-vascular invasion positivity, postoperative complications, differentiated histological type, anastomotic leakage, and adjuvant chemotherapy. The present meta-analysis concluded that the CALLY index was a simple and useful independent prognostic biomarker for GC patients after gastrectomy.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proposal of "borderline resectable" colorectal liver metastases based on analysis of risk factors for early surgical failure. 根据早期手术失败风险因素分析，提出 "边缘可切除 "结直肠肝转移瘤的建议。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-19 DOI: 10.1007/s00595-024-02920-z

Mizuki Ninomiya, Shinji Itoh, Kazuki Takeishi, Takeo Toshima, Shohei Yoshiya, Kazutoyo Morita, Ryosuke Minagawa, Tomohiro Iguchi, Eiji Oki, Tomoharu Yoshizumi

{"title":"Proposal of \"borderline resectable\" colorectal liver metastases based on analysis of risk factors for early surgical failure.","authors":"Mizuki Ninomiya, Shinji Itoh, Kazuki Takeishi, Takeo Toshima, Shohei Yoshiya, Kazutoyo Morita, Ryosuke Minagawa, Tomohiro Iguchi, Eiji Oki, Tomoharu Yoshizumi","doi":"10.1007/s00595-024-02920-z","DOIUrl":"https://doi.org/10.1007/s00595-024-02920-z","url":null,"abstract":"Purpose: We aimed to define borderline resectable colorectal liver metastases (CRLM) based on the analysis of risk factors for early surgical failure and investigate the efficacy of neoadjuvant chemotherapy in these patients.Methods: This was a retrospective analysis of a multi-institutional cohort of patients diagnosed with technically resectable CRLM. Early surgical failure within 6 months of liver surgery was defined as ESF6. We classified CRLM into three grades (A, B, and C) according to the definition of the Japanese Society for Cancer of the Colon and Rectum.Results: Among the 249 patients with technically resectable CRLM, 46 (18.5%) developed ESF6. The survival rate of these patients was significantly lower than that of the patients without ESF6. In the multivariate analysis of synchronous CRLM patients, no neoadjuvant chemotherapy, Grade B/C, and Charlson comorbidity index ≥ 3 were independent predictors of ESF6. Among patients with synchronous and Grade B/C CRLM, ESF6 rates, surgical failure-free survival, and overall survival in the neoadjuvant chemotherapy group were significantly better relative to the upfront surgery group.Conclusions: Patients with synchronous and Grade B/C CRLM are at a high risk of early surgical failure, have a poor long-term prognosis, and can be defined as borderline resectable and good candidates for neoadjuvant chemotherapy.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of perioperative synbiotics treatment in living-donor liver transplantation after induction of early enteral nutrition. 早期肠内营养诱导后，活体肝移植围手术期合成益生菌治疗的影响。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-19 DOI: 10.1007/s00595-024-02918-7

Shohei Yoshiya, Shinji Itoh, Takeo Toshima, Yuki Bekki, Takuma Izumi, Norifumi Iseda, Yuriko Tsutsui, Katsuya Toshida, Yuki Nakayama, Takuma Ishikawa, Tomoharu Yoshizumi

{"title":"The impact of perioperative synbiotics treatment in living-donor liver transplantation after induction of early enteral nutrition.","authors":"Shohei Yoshiya, Shinji Itoh, Takeo Toshima, Yuki Bekki, Takuma Izumi, Norifumi Iseda, Yuriko Tsutsui, Katsuya Toshida, Yuki Nakayama, Takuma Ishikawa, Tomoharu Yoshizumi","doi":"10.1007/s00595-024-02918-7","DOIUrl":"https://doi.org/10.1007/s00595-024-02918-7","url":null,"abstract":"Purpose: Infectious complications, particularly post-transplant sepsis, have a critical impact on postoperative outcomes. This study examined the effects of perioperative synbiotic treatment on postoperative outcomes in patients receiving early enteral nutrition.Methods: We reviewed 210 living-donor liver transplantation procedures and retrospectively analyzed the postoperative outcomes with and without perioperative synbiotic treatment (live lactic acid bacteria, bifidobacteria, and oligosaccharides) 5 days before and after living-donor liver transplantation.Results: The synbiotic group (n = 34) had significantly fewer male donors (38.2% vs. 61.9%, p = 0.011) and a higher proportion of ABO-incompatible grafts (52.9% vs. 25.6%, p = 0.021) than the non-synbiotic group (n = 176). The incidence of sepsis was significantly lower in the synbiotic group than in the non-synbiotic group (0% vs. 7.4%, p = 0.029), with a lower incidence rate of sepsis due to bacteremia with intestinal bacteria (0% vs. 4.6%, p = 0.089). There were no significant differences in the proportions of acute rejection, small-for-size graft syndrome, or postoperative liver function between the two groups. Furthermore, there was no significant difference in the graft survival rates after LDLT between two groups. (p = 0.24).Conclusion: Perioperative synbiotic treatment prevents post-transplant sepsis, even with early enteral nutrition.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of surgical complications on outcomes of children with hepatoblastoma: a retrospective cohort study. 手术并发症对肝母细胞瘤患儿预后的影响：一项回顾性队列研究。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-16 DOI: 10.1007/s00595-024-02906-x

Masahiro Zenitani, Masanori Nishikawa, Ririko Takemura, Daichi Sakai, Masayuki Yoshida, Yuki Noguchi, Rei Matsuura, Satoshi Umeda, Noriaki Usui

{"title":"Effect of surgical complications on outcomes of children with hepatoblastoma: a retrospective cohort study.","authors":"Masahiro Zenitani, Masanori Nishikawa, Ririko Takemura, Daichi Sakai, Masayuki Yoshida, Yuki Noguchi, Rei Matsuura, Satoshi Umeda, Noriaki Usui","doi":"10.1007/s00595-024-02906-x","DOIUrl":"https://doi.org/10.1007/s00595-024-02906-x","url":null,"abstract":"Purpose: This study aimed to investigate the incidence of severe surgical complications among children with hepatoblastoma, identify their risk factors, and evaluate the influence of surgical complications on long-term outcomes.Methods: Children with hepatoblastoma who underwent liver resection at our hospital between September 1992 and January 2023 were included in this study. Clinical data were retrospectively reviewed, and patients were categorized into complication and non-complication groups based on the need for radiological or surgical interventions or massive intraoperative blood loss (> 80 mL/kg).Results: Out of the 40 patients, 9 experienced severe complications (massive blood loss, n = 7; bile leakage, n = 3; and common bile duct stricture, n = 1). The participation of experienced liver surgeons was significantly greater in the non-complication group than in the complication group. The median duration from surgery to the start of postoperative chemotherapy was significantly shorter in the non-complication group than in the complication group. The overall 5-year survival rate was significantly higher in the non-complication group than in the complication group.Conclusion: Severe surgical complications were associated with a worse prognosis. An experienced liver surgeon should participate in technically demanding liver resections.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic impact of combination therapy with gemcitabine and cisplatin plus S-1 and subsequent conversion surgery for initially unresectable upper biliary tract cancers. 吉西他滨和顺铂加S-1联合疗法以及随后的转换手术对最初无法切除的上胆道癌的预后影响。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-13 DOI: 10.1007/s00595-024-02912-z

Hisashi Kosaka, Kosuke Matsui, Tsukasa Ikeura, Takashi Ito, Chisato Ohe, Yumiko Kono, Hideyuki Matsushima, Hidekazu Yamamoto, Mitsugu Sekimoto, Masaki Kaibori

{"title":"Prognostic impact of combination therapy with gemcitabine and cisplatin plus S-1 and subsequent conversion surgery for initially unresectable upper biliary tract cancers.","authors":"Hisashi Kosaka, Kosuke Matsui, Tsukasa Ikeura, Takashi Ito, Chisato Ohe, Yumiko Kono, Hideyuki Matsushima, Hidekazu Yamamoto, Mitsugu Sekimoto, Masaki Kaibori","doi":"10.1007/s00595-024-02912-z","DOIUrl":"https://doi.org/10.1007/s00595-024-02912-z","url":null,"abstract":"Purpose and background: For the past decade, there have been few chemotherapy options for unresectable biliary tract cancer (BTC). Recently, however, combination therapy with gemcitabine and cisplatin plus S-1 (GCS) has been identified as a promising strategy. This retrospective study analyzes the clinical results of GCS therapy and subsequent conversion surgery (CS).Method: We analyzed the clinical data of 60 consecutive patients who received GCS therapy for unresectable upper BTC at our university hospital during the 5 years between September, 2018 and December, 2022.Results: All patients received GCS therapy as first-line chemotherapy. The response rate was 33.9% and subsequent CS was performed in 35.0%. Of the patients who underwent CS, 81% required more than bisectionectomy of the liver with extrahepatic bile duct resection. The median overall survival of the patients who received GCS therapy and underwent subsequent CS was significantly longer than that of the patients who received GCS therapy alone (28.0 months vs. 12.4 months, respectively; p < 0.001). A decrease in the CA19-9 level 1 month after chemotherapy and RECIST PR were independent positive predictors of CS, whereas unresectable gallbladder cancer and pretreatment ALBI grade 3 were negative predictors of CS.Conclusion: GCS therapy and subsequent CS may contribute to the longer term survival of patients with unresectable upper BTC.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Specialized educational program for high-grade liver injury management: a three-dimensional printed model approach. 高级肝损伤管理的专门教育计划：三维打印模型方法。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-10 DOI: 10.1007/s00595-024-02911-0

David Aranovich, Yifat Fainzilber Goldman, Neev Tchernin, Ricardo Alfici, Mickey Dudkiewicz, Mansoor Khan, Yoram Ohana, Boris Kessel

{"title":"Specialized educational program for high-grade liver injury management: a three-dimensional printed model approach.","authors":"David Aranovich, Yifat Fainzilber Goldman, Neev Tchernin, Ricardo Alfici, Mickey Dudkiewicz, Mansoor Khan, Yoram Ohana, Boris Kessel","doi":"10.1007/s00595-024-02911-0","DOIUrl":"https://doi.org/10.1007/s00595-024-02911-0","url":null,"abstract":"Purpose: The study aims to present a specialized educational program using a 3D printed model for managing Grade IV and V liver injuries. Hepatic packing, a common technique, may not always achieve sufficient hemostasis in these cases, warranting alternative solutions such as mesh liver wrapping. However, mastering this procedure is challenging due to limited teaching resources and the need for repeated practice.Methods: A computer-based model was created from an abdominal CT scan to produce a real-sized injured liver model using thermoplastic elastomer TPU-95. Trainees received systematic instruction from an instructor, allowing them to perform the procedure under supervision and independently.Results: Eight surgical residents at Hillel Yaffe Medical Center participated in the program, with the majority successfully completing the procedure under supervision. Furthermore, trainees demonstrated reduced procedure times when performing independently, indicating improved proficiency.Conclusion: This educational approach offers a simple and repeatable method for continuous training in managing high-grade liver injuries, holding potential for enhanced patient outcomes.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic factors for pediatric patients with severe intestinal motility disorders: a single institution's experience. 严重肠道运动障碍儿科患者的预后因素：一家医疗机构的经验。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-07 DOI: 10.1007/s00595-024-02910-1

Keisuke Yano, Mitsuru Muto, Koshiro Sugita, Masakazu Murakami, Shun Onishi, Toshio Harumatsu, Yumiko Iwamoto, Masato Ogata, Lynne Takada, Nanako Nishida, Chihiro Kedoin, Ayaka Nagano, Mayu Matsui, Koji Yamada, Waka Yamada, Makoto Matsukubo, Takafumi Kawano, Tatsuru Kaji, Satoshi Ieiri

{"title":"Prognostic factors for pediatric patients with severe intestinal motility disorders: a single institution's experience.","authors":"Keisuke Yano, Mitsuru Muto, Koshiro Sugita, Masakazu Murakami, Shun Onishi, Toshio Harumatsu, Yumiko Iwamoto, Masato Ogata, Lynne Takada, Nanako Nishida, Chihiro Kedoin, Ayaka Nagano, Mayu Matsui, Koji Yamada, Waka Yamada, Makoto Matsukubo, Takafumi Kawano, Tatsuru Kaji, Satoshi Ieiri","doi":"10.1007/s00595-024-02910-1","DOIUrl":"https://doi.org/10.1007/s00595-024-02910-1","url":null,"abstract":"Purpose: To identify the prognostic factors for pediatric severe intestinal motility disorder (IMD).Methods: We reviewed the medical records of patients with severe IMD, who required total parenteral nutrition (TPN) for ≥ 60 days at our institution between April, 1984 and March, 2023, examining their characteristics to identify prognostic factors.Results: The types of IMD in the 14 patients enrolled in this study were as follows: isolated hypoganglionosis (IHG, n = 6), extensive aganglionosis (EAG: n = 6), and chronic idiopathic intestinal pseudo-obstruction (CIIP, n = 2). There was no significant difference in mortality among the three types of severe IMD. Weaning-off TPN and the use of the colon were not significant prognostic factors, but cholestasis was a significant prognostic factor (p = 0.005). There was a high mortality rate (50%), with the major causes of death being intestinal failure-associated liver disease (IFALD) following hepatic failure, and catheter-related blood stream infection (CRBSI). One IHG patient underwent small bowel transplantation but died of acute rejection.Conclusion: Severe IMD is still associated with a high mortality rate and cholestasis predicts the prognosis. Thus, preventing or improving IFALD and CRBSI caused by long-term TPN is important for reducing the mortality rate.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' response to Letter to the Editor. 作者对致函编辑的回复。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-06 DOI: 10.1007/s00595-024-02916-9

Yoko Azuma, Akira Iyoda

引用次数: 0

Laparoscopic vs. open surgery for rectal cancer in patients with obesity: short-term outcomes and relapse-free survival across age groups. 肥胖症患者直肠癌腹腔镜手术与开腹手术：不同年龄组的短期疗效和无复发生存率。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-05 DOI: 10.1007/s00595-024-02901-2

Yusuke Fujita, Koya Hida, Nobuaki Hoshino, Tomonori Akagi, Kentaro Nakajima, Masafumi Inomata, Seiichiro Yamamoto, Yoshiharu Sakai, Takeshi Naitoh, Kazutaka Obama

{"title":"Laparoscopic vs. open surgery for rectal cancer in patients with obesity: short-term outcomes and relapse-free survival across age groups.","authors":"Yusuke Fujita, Koya Hida, Nobuaki Hoshino, Tomonori Akagi, Kentaro Nakajima, Masafumi Inomata, Seiichiro Yamamoto, Yoshiharu Sakai, Takeshi Naitoh, Kazutaka Obama","doi":"10.1007/s00595-024-02901-2","DOIUrl":"https://doi.org/10.1007/s00595-024-02901-2","url":null,"abstract":"Purpose: To investigate the efficacy of laparoscopic surgery for rectal cancer in obese and older patients, who are often characterized by a higher prevalence of comorbidities and physical decline.Methods: This large-scale multicenter retrospective cohort study included 524 patients with a body mass index of 25 or higher who underwent either open or laparoscopic surgery for stage II or III rectal cancer between 2009 and 2013. We assessed the short-term outcomes and relapse-free survival by comparing these surgical modalities. The patients were stratified into 404 non-elderly (< 70 years) and 120 elderly (≥ 70 years) patients.Results: In both patient groups, laparoscopic surgery was associated with a significantly reduced blood loss (non-elderly: 41 vs. 545 ml; elderly: 50 vs. 445 ml) and shorter hospital stays (non-elderly: 10 vs. 19 days; elderly: 15 vs. 20 days) than open surgery. The overall complications and relapse-free survival showed no significant differences between the two surgical techniques in either age group. Additionally, the impact of the laparoscopic procedure on the relapse-free survival remained consistent between the age groups.Conclusion: Laparoscopic surgery offers short-term benefits for patients with obesity and rectal cancer compared to open surgery, regardless of age, without influencing the long-term prognosis.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of serum lactate dehydrogenase with prognosis and tumor metabolism in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab therapy. 接受阿特珠单抗加贝伐单抗治疗的肝细胞癌患者血清乳酸脱氢酶与预后和肿瘤代谢的关系

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-04 DOI: 10.1007/s00595-024-02914-x

Katsuya Toshida, Shinji Itoh, Takeo Toshima, Shohei Yoshiya, Yuki Bekki, Takuma Izumi, Norifumi Iseda, Yuki Nakayama, Takuma Ishikawa, Tomoharu Yoshizumi

{"title":"Association of serum lactate dehydrogenase with prognosis and tumor metabolism in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab therapy.","authors":"Katsuya Toshida, Shinji Itoh, Takeo Toshima, Shohei Yoshiya, Yuki Bekki, Takuma Izumi, Norifumi Iseda, Yuki Nakayama, Takuma Ishikawa, Tomoharu Yoshizumi","doi":"10.1007/s00595-024-02914-x","DOIUrl":"https://doi.org/10.1007/s00595-024-02914-x","url":null,"abstract":"Purpose: Treatment outcomes are predicted by analyzing peripheral blood markers such as serum lactate dehydrogenase (LDH). We conducted this study to investigate whether serum LDH levels can predict the prognosis of patients treated with atezolizumab plus bevacizumab (ATZ/BEV) therapy for hepatocellular carcinoma (HCC) and whether LDH levels correlate with metabolic changes.Methods: We enrolled 66 HCC patients treated with ATZ/BEV. Based on the change in serum LDH levels before and after treatment, the patients were divided into two groups, and the prognosis of each group was examined. Moreover, the association of LDH levels with tumor metabolism was analyzed by fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT).Results: There were 32 patients categorized as the LDH-decrease group. Kaplan-Meier survival analysis indicated worse progression-free survival (PFS) in the LDH-increase group than in the LDH-decrease group (p = 0.0029). Multivariate analysis showed that an increase in the LDH level was an independent risk factor for worse PFS (p = 0.0045). The baseline LDH level correlated significantly with a high maximum standardized uptake value of 18F-FDG, according to the PET/CT findings. Transcriptomic analyses of specimens resected after ATZ/BEV therapy showed downregulated mitochondria-related pathways.Conclusion: Serum LDH levels are a potential prognostic marker and an indicator of tumor metabolism.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0