Surgery Today最新文献_第10页

First report: International proctoring of robotic colorectal surgery using TELEPRO^®. 第一份报告：使用TELEPRO®进行机器人结直肠手术的国际监测。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-05-05 DOI: 10.1007/s00595-025-03017-x

Ruben Gregory Xavier, Satoru Takayama, Shoryu Takayama, Ken Ishikawa, Takuya Banba, Masataka Nakano, April Camilla Roslani, Seon Hahn Kim

{"title":"First report: International proctoring of robotic colorectal surgery using TELEPRO®.","authors":"Ruben Gregory Xavier, Satoru Takayama, Shoryu Takayama, Ken Ishikawa, Takuya Banba, Masataka Nakano, April Camilla Roslani, Seon Hahn Kim","doi":"10.1007/s00595-025-03017-x","DOIUrl":"https://doi.org/10.1007/s00595-025-03017-x","url":null,"abstract":"Robot-assisted minimally invasive surgery (RAMIS) requires a novice trainee to be proctored by an experienced surgeon. However, there are some obstacles to the traditional method of proctorship, namely costs, geographical barriers, time, and travel logistics. Teleproctoring is a novel method in which a proctor can remotely guide a surgeon during RAMIS. The advantages of teleproctoring include standardization of techniques, reduction in cost and travel time, and overcoming geographical barriers. We herein report our experiences with teleproctoring in RAMIS using TELEPRO® (Tenmashimon Co., Ltd, Tokyo, Japan). TELEPRO® provides a real-time telementoring system that enables ultra-low-latency communication between mentors and operating theatres. One of the significant advantages of using TELEPRO® is its use of shared internet access (SIA), whereby low-latency bidirectional communication can be established. Our experience with international teleproctoring using TELEPRO® in RAMIS for colorectal surgery found no major glitches.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of an improvement in the early left ventricular ejection fraction on the 1-year clinical outcomes and its predictors after transcatheter aortic valve replacement. 早期左室射血分数改善对经导管主动脉瓣置换术后1年临床结果及其预测因素的影响

IF 1.7 4区医学

Surgery Today Pub Date : 2025-05-03 DOI: 10.1007/s00595-025-03036-8

Ikuko Shibasaki, Yusuke Takei, Suguru Hirose, Michiaki Tokura, Masahiro Tezuka, Shohei Yokoyama, Ryujiro Suzuki, Riichi Nishikawa, Shu Inami, Yasuo Haruyama, Shigeru Toyoda, Hirotsugu Fukuda

{"title":"Impact of an improvement in the early left ventricular ejection fraction on the 1-year clinical outcomes and its predictors after transcatheter aortic valve replacement.","authors":"Ikuko Shibasaki, Yusuke Takei, Suguru Hirose, Michiaki Tokura, Masahiro Tezuka, Shohei Yokoyama, Ryujiro Suzuki, Riichi Nishikawa, Shu Inami, Yasuo Haruyama, Shigeru Toyoda, Hirotsugu Fukuda","doi":"10.1007/s00595-025-03036-8","DOIUrl":"https://doi.org/10.1007/s00595-025-03036-8","url":null,"abstract":"Purpose: We evaluated the 1-year clinical outcomes (all-cause mortality, heart failure rehospitalization, and their composite) in patients with severe aortic stenosis (AS) and a preoperative left ventricular ejection fraction (LVEF) < 50% who underwent transcatheter aortic valve replacement (TAVR), and examined the baseline factors predicting ≥ 10% early LVEF improvement.Methods: We retrospectively analyzed 44 patients who underwent TAVR and divided them into Group R (≥ 10% LVEF improvement, n = 25) or Group N (< 10% improvement, n = 19). A Kaplan-Meier analysis was used to assess the survival rates, and multivariable logistic regression was applied to identify the predictors of LVEF improvement.Results: The mean patient age was 84.8 ± 4.8 years, and 40.9% were male. Post-TAVR, 56.8% of patients showed ≥ 10% LVEF improvement (mean increase: 16.7 ± 6.1%). The one-year mortality was similar between the groups (p = 0.383), whereas the composite endpoint tended to be higher in Group N (0.4% vs. 21.1%, p = 0.072). The peak aortic valve velocity was the only significant predictor (OR = 0.255, p = 0.048; cutoff: 4.45 m/s, sensitivity, 0.840; specificity, 0.684).Conclusion: In patients with severe AS and a preoperative LVEF of < 50%, 56.8% demonstrated a significant early LVEF improvement post-TAVR. Patients with a ≥ 10% improvement had a significantly lower 1-year mortality rate.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ninjin'yoeito improves respiratory symptoms after lung cancer surgery: a prospective randomized study. 忍仁益汤改善肺癌手术后呼吸道症状：一项前瞻性随机研究

IF 1.7 4区医学

Surgery Today Pub Date : 2025-05-01 Epub Date: 2024-12-24 DOI: 10.1007/s00595-024-02977-w

Suguru Mitsui, Yugo Tanaka, Megumi Nishikubo, Takefumi Doi, Shinya Tane, Daisuke Hokka, Takumi Imai, Yoshimasa Maniwa

{"title":"Ninjin'yoeito improves respiratory symptoms after lung cancer surgery: a prospective randomized study.","authors":"Suguru Mitsui, Yugo Tanaka, Megumi Nishikubo, Takefumi Doi, Shinya Tane, Daisuke Hokka, Takumi Imai, Yoshimasa Maniwa","doi":"10.1007/s00595-024-02977-w","DOIUrl":"10.1007/s00595-024-02977-w","url":null,"abstract":"Purpose: This study evaluated the efficacy of ninjin'yoeito for alleviating postoperative symptoms after lung cancer surgery.Methods: Overall, 140 patients who underwent lobectomy were randomized into a conventional treatment group and a ninjin'yoeito group. The primary endpoint was change in the Cancer Fatigue Scale (CFS) score from baseline and the secondary endpoints were the Cancer Dyspnea Scale (CDS) scores, the Kihon Checklist, and respiratory function.Results: The mean change in the CFS score 8 weeks postoperatively was - 5.56 in the ninjin'yoeito group and - 5.53 in the conventional treatment group (P = 0.425), but this outcome did not meet the primary endpoint. Changes in the mean CDS scores 8 weeks postoperatively were - 5.60 and - 3.38 in the ninjin'yoeito and conventional groups, respectively, with a difference of - 1.95 (P = 0.049). The changes in the mean vital capacity 8 weeks postoperatively were - 340.5 mL in the ninjin'yoeito group and - 473.5 mL in the conventional treatment group, with a difference of + 135.1 mL (P = 0.041). The ninjin'yoeito group had a significantly lower proportion of patients with malnutrition 16 weeks postoperatively than the conventional treatment group (P = 0.040).Conclusion: The results of this study show that ninjin'yoeito is effective for alleviating respiratory symptoms and improving malnutrition after lung cancer surgery.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"693-704"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Database study of risk factors for breast cancer-related lymphedema: a statistical analysis of 2359 cases over 10 years. 乳腺癌相关淋巴水肿风险因素的数据库研究：10 年间 2359 例病例的统计分析。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-05-01 Epub Date: 2024-11-19 DOI: 10.1007/s00595-024-02960-5

Akihiro Matsumoto, Kai Ushio, Hiroaki Kimura, Shinichi Tomioka, Shinsuke Sasada, Makoto Asaeda, Yuki Nakashima, Koki Fukuhara, Yukio Mikami

{"title":"Database study of risk factors for breast cancer-related lymphedema: a statistical analysis of 2359 cases over 10 years.","authors":"Akihiro Matsumoto, Kai Ushio, Hiroaki Kimura, Shinichi Tomioka, Shinsuke Sasada, Makoto Asaeda, Yuki Nakashima, Koki Fukuhara, Yukio Mikami","doi":"10.1007/s00595-024-02960-5","DOIUrl":"10.1007/s00595-024-02960-5","url":null,"abstract":"Purpose: Identifying risk factors for breast cancer-related lymphedema (BCRL) is crucial for its prevention, necessitating large-scale epidemiological studies. Despite their suitability for large-scale surveys, to our knowledge, databases have not been the basis of any study done to investigate BCRL risk factors. This study aimed to test the hypothesis that a database-based study would be useful for identifying BCRL risk factors.Methods: Patients with breast cancer diagnosed between April 2009 and March 2020 were identified from the Hiroshima University Hospital's medical database. This retrospective observational study validated the risk factors for BCRL using logistic regression analysis (p < 0.05).Results: Among the total 4471 breast cancer patients identified, 2359 met the study criteria, with a BCRL incidence of 4.8%. Identified risk factors included obesity with a BMI of 25-30 (OR = 3.066, 95% CI 1.408-6.677), severe obesity with a BMI > 30 (OR = 5.791, 95% CI 2.239-14.97), surgical axillary lymph node dissection (OR = 3.212, 95% CI 1.918-5.378), chemotherapy with docetaxel (OR = 1.795, 95% CI 1.062-3.032), and conventional radiation to the breast or chest wall including lymph nodes in the irradiated area (OR = 3.299, 95% CI 1.842-5.910).Conclusions: The BCRL risk factors identified by our database analysis were in line with those documented in previous studies, indicating the usefulness of database-based studies. Future studies should include more patients and study items.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"685-692"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors of poor long-term outcomes in elderly patients with esophageal squamous cell carcinoma after minimally invasive esophagectomy. 老年食管鳞状细胞癌微创食管切除术后远期预后不良的危险因素

IF 1.7 4区医学

Surgery Today Pub Date : 2025-05-01 Epub Date: 2025-02-07 DOI: 10.1007/s00595-024-02947-2

Yasufumi Koterazawa, Hironobu Goto, Tatsuya Kaneko, Yuki Azumi, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji

{"title":"Risk factors of poor long-term outcomes in elderly patients with esophageal squamous cell carcinoma after minimally invasive esophagectomy.","authors":"Yasufumi Koterazawa, Hironobu Goto, Tatsuya Kaneko, Yuki Azumi, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji","doi":"10.1007/s00595-024-02947-2","DOIUrl":"10.1007/s00595-024-02947-2","url":null,"abstract":"Purpose: Elderly patients with esophageal squamous cell carcinoma (ESCC) have more comorbidities than young patients do. Elderly smokers have a high mortality rate owing to physical dysfunction. This study aimed to identify risk factors for long-term outcomes after minimally invasive esophagectomy (MIE) in elderly patients with ESCC.Methods: This study included 110 elderly patients (aged ≥ 75 years) with ESCC who underwent MIE at Kobe University Hospital. Multivariate Cox proportional hazards regression analyses were performed to identify risk factors, including the geriatric nutritional risk index (GNRI), Charlson comorbidity index, and elderly smoker status, defined as smoking at the age of 70 years.Results: Multivariate analysis identified that elderly smokers, cT or cN status (≥ cT2 or cN-positive), and GNRI (≤ 92) were independent prognostic factors for overall survival (p = 0.026, 0.019, and 0.038, respectively). For patients with ≥ cT2 or cN-positive ESCC, elderly smokers or patients with GNRI (≤ 92) have significantly worse survival (p = 0.038). Elderly smokers were at risk of death from other diseases five years postoperatively (p = 0.016).Conclusions: Elderly smokers, cT2 or cN positivity, and low GNRI were risk factors for poor survival. Furthermore, for patients with ≥ cT2 or cN-positive ESCC, these risk factors were associated with poor survival.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"659-667"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporary loop end ileostomy reduces the risk of stoma outlet obstruction: a comparative clinical study in patients undergoing restorative proctocolectomy and ileal pouch-anal anastomosis. 临时环端回肠造口术可降低造口出口梗阻的风险：对接受恢复性直肠切除术和回肠袋-肛门吻合术患者的临床对比研究。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-05-01 Epub Date: 2024-10-23 DOI: 10.1007/s00595-024-02944-5

Takayuki Ogino, Yuki Sekido, Tsunekazu Mizushima, Makoto Fujii, Ryota Mori, Mitsunobu Takeda, Tsuyoshi Hata, Atsushi Hamabe, Norikatsu Miyoshi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi

{"title":"Temporary loop end ileostomy reduces the risk of stoma outlet obstruction: a comparative clinical study in patients undergoing restorative proctocolectomy and ileal pouch-anal anastomosis.","authors":"Takayuki Ogino, Yuki Sekido, Tsunekazu Mizushima, Makoto Fujii, Ryota Mori, Mitsunobu Takeda, Tsuyoshi Hata, Atsushi Hamabe, Norikatsu Miyoshi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi","doi":"10.1007/s00595-024-02944-5","DOIUrl":"10.1007/s00595-024-02944-5","url":null,"abstract":"Purpose: Stoma outlet obstruction (SOO) is a serious complication of restorative proctocolectomy (RPC) and ileal pouch-anal anastomosis (IPAA). When the ileal mesentery to the pouch is under excessive tension, the ileum near the ileostomy twists easily, causing SOO. Loop-end ileostomy (EI) for fecal diversion was introduced in 2021 to prevent SOO, and we aimed to verify whether temporary EI reduces the incidence of SOO in RPC and IPAA patients relative to loop ileostomy (LI).Methods: This study included 106 consecutive RPC and IPAA patients with a diverting ileostomy and categorized them into LI (n = 75) or EI (n = 31) groups. The clinical characteristics of the patients were analyzed and compared.Results: Patient characteristics were similar between the groups, except for higher preoperative steroid use in the LI group (38.7%; p = 0.0116). There were no significant differences between the groups in anatomical factors, such as abdominal wall thickness and the height-adjusted distance between the root of the superior mesenteric artery and the bottom of the external anal sphincter. There were no significant differences in surgery-related factors, with ≥ 90% of the patients in each group undergoing laparoscopic procedures. A multivariate logistic regression analysis revealed that EI significantly reduced the risk of SOO relative to LI (OR, 0.18; 95% CI 0.03-0.92; p = 0.0399).Conclusion: EI reduced SOO levels after RPC and IPAA and may be beneficial for cases in which anastomosis is challenging.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"638-645"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of laparoscopic resection of colorectal cancer in non-elite cases. 非精英病例腹腔镜结直肠癌切除术的有效性和安全性。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-05-01 Epub Date: 2024-10-29 DOI: 10.1007/s00595-024-02951-6

Ryota Aoki, Satoshi Maruyama, Yasumasa Takii, Hitoshi Nogami

{"title":"Efficacy and safety of laparoscopic resection of colorectal cancer in non-elite cases.","authors":"Ryota Aoki, Satoshi Maruyama, Yasumasa Takii, Hitoshi Nogami","doi":"10.1007/s00595-024-02951-6","DOIUrl":"10.1007/s00595-024-02951-6","url":null,"abstract":"Purpose: To evaluate the outcomes of laparoscopic resection of colorectal cancer in non-elite cases.Methods: We defined patients whose clinical characteristics conformed to the criteria of the JCOG0404 trial as \"elite\" and those whose clinical characteristics did not conform to these criteria as \"non-elite\". Patients with Stage II/III colorectal cancer (n = 450) were analyzed. The elite (E) and non-elite (NE) groups were further divided into open (E-Open, NE-Open) and laparoscopic (E-Lap, NE-Lap) surgery groups. We compared the short- and long-term outcomes of these groups. Propensity score matching (PSM) was performed when comparing the NE groups.Results: The E group included 163 patients and the NE group included 287 patients. Before and after PSM, the NE-Lap group had significantly longer operative times, lower postoperative complication rates, earlier recovery of bowel function, and shorter postoperative hospital stays than the NE-Open group. After PSM, the Clavien-Dindo classification Grade ≥ III complications and reoperation rates in the NE-Lap group were significantly lower than those in the NE-Open group. The short-term outcomes of the NE-Lap group were comparable with those of the E-Lap group. The 5-year overall survival rates were not significantly different among the groups.Conclusion: Laparoscopic resection of colorectal cancer is effective and safe, even in non-elite cases.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"676-684"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical validation of preoperative serum markers for liver fibrosis in living donor liver transplantation recipients. 活体肝移植受者术前肝纤维化血清标志物的临床验证。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-05-01 Epub Date: 2024-09-24 DOI: 10.1007/s00595-024-02941-8

Takahiro Tomino, Shinji Itoh, Takeo Toshima, Shohei Yoshiya, Yuki Bekki, Norifumi Iseda, Takuma Izumi, Yuriko Tsutsui, Katsuya Toshida, Tomoharu Yoshizumi

{"title":"Clinical validation of preoperative serum markers for liver fibrosis in living donor liver transplantation recipients.","authors":"Takahiro Tomino, Shinji Itoh, Takeo Toshima, Shohei Yoshiya, Yuki Bekki, Norifumi Iseda, Takuma Izumi, Yuriko Tsutsui, Katsuya Toshida, Tomoharu Yoshizumi","doi":"10.1007/s00595-024-02941-8","DOIUrl":"10.1007/s00595-024-02941-8","url":null,"abstract":"Purpose: To validate the reliability of fibrosis markers as predictors of graft survival in living donor liver transplantation (LDLT) recipients.Methods: We reviewed data retrospectively, from 163 patients who underwent adult LDLT with preoperative measurements of type IV collagen (CIV), Mac-2 binding protein glycosylation isomer (M2BPGi), and hyaluronic acid (HA). Patients were divided into high and low groups for each biomarker, based on optimal cutoff values, and graft loss within 6 months was evaluated in each group.Results: The high CIV level group showed significantly lower 6-month graft survival rates and significantly higher rates of postoperative sepsis and sepsis from pneumonia. However, the groups with high and low M2BPGi levels and those with high and low HA levels did not show significant differences in 6-month graft survival rates or rates of postoperative sepsis. Multivariate analysis revealed that a CIV level ≥ 590 was a significant predictor of graft loss within 6 months, postoperative sepsis, and sepsis from pneumonia.Conclusion: Unlike other fibrosis markers, preoperative CIV levels can predict graft survival, postoperative sepsis, and sepsis from pneumonia after LDLT.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"627-637"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of carcinoembryonic antigen (CEA) and CA 19-9 levels in patients with obstructive colorectal cancer treated with a self-expandable metallic stent and curative surgery. 癌胚抗原 (CEA) 和 CA 19-9 水平在采用自膨胀金属支架和根治性手术治疗的阻塞性结直肠癌患者中的预后价值。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-05-01 Epub Date: 2024-10-15 DOI: 10.1007/s00595-024-02943-6

Ryuichiro Sato, Masaya Oikawa, Tetsuya Kakita, Tomoya Abe, Naoya Akazawa, Haruka Okano, Kei Ito, Takashi Tsuchiya

{"title":"Prognostic value of carcinoembryonic antigen (CEA) and CA 19-9 levels in patients with obstructive colorectal cancer treated with a self-expandable metallic stent and curative surgery.","authors":"Ryuichiro Sato, Masaya Oikawa, Tetsuya Kakita, Tomoya Abe, Naoya Akazawa, Haruka Okano, Kei Ito, Takashi Tsuchiya","doi":"10.1007/s00595-024-02943-6","DOIUrl":"10.1007/s00595-024-02943-6","url":null,"abstract":"Purpose: The importance of tumor markers is well established; yet little is known about their prognostic value for patients with obstructive colorectal cancer (OCRC). We investigated the clinical significance of carcinoembryonic antigen (CEA) and CA 19-9 levels in patients with non-metastatic OCRC, who underwent insertion of a self-expandable metallic stent and curative surgery.Methods: Clinical data on 91 patients with OCRC were analyzed retrospectively to evaluate the associations of preoperative serum values of tumor makers with short- and long-term outcomes.Results: The 91 patients comprised 53 men and 38 women, with a median age of 71 years. Twelve patients had an elevated preoperative CA 19-9 level. Multivariate analyses revealed that an elevated CA 19-9 level was independently associated with poor disease-free survival (DFS) [hazard ratio (HR) = 4.57, 95% confidence interval (CI) 2.06-10.14, P < 0.001] and overall survival (HR = 4.06, 95% CI 1.46-11.24, P = 0.007). A CEA level > 5 ng/ml had no prognostic value, whereas a CEA level > 10.8 ng/ml was significantly associated with worse DFS (P = 0.032).Conclusion: Measuring the CA 19-9 level concomitantly with the CEA level for patients with advanced CRC, including OCRC, may provide a valuable means to improve prognostication.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"618-626"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiographical consolidation tumor size and preoperative clinical characteristics are significantly correlated with the postoperative survival of patients with part-solid and pure-solid adenocarcinomas: a propensity score-matched analysis. 放射学合并肿瘤大小和术前临床特征与部分实性腺癌和纯实性腺癌患者的术后生存率显著相关：倾向评分匹配分析。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-05-01 Epub Date: 2024-09-21 DOI: 10.1007/s00595-024-02939-2

Haruaki Hino, Natsumi Maru, Takahiro Utsumi, Hiroshi Matsui, Yohei Taniguchi, Tomohito Saito, Katsuyasu Kouda, Tomohiro Murakawa

{"title":"Radiographical consolidation tumor size and preoperative clinical characteristics are significantly correlated with the postoperative survival of patients with part-solid and pure-solid adenocarcinomas: a propensity score-matched analysis.","authors":"Haruaki Hino, Natsumi Maru, Takahiro Utsumi, Hiroshi Matsui, Yohei Taniguchi, Tomohito Saito, Katsuyasu Kouda, Tomohiro Murakawa","doi":"10.1007/s00595-024-02939-2","DOIUrl":"10.1007/s00595-024-02939-2","url":null,"abstract":"Purpose: Patients with part-solid adenocarcinomas treated by surgery generally have more favorable outcomes than those with pure-solid adenocarcinomas. We conducted this study to understand the effects of the lepidic components and preoperative characteristics on the postoperative survival of patients with part-solid adenocarcinomas.Methods: The subjects of this retrospective study were 313 patients with stage 1 part-solid adenocarcinomas and 634 patients with pure-solid adenocarcinomas, treated at our institution between 2006 and 2020. Propensity score matching was performed to analyze survival in an unmatched cohort (PSM0, n = 313 vs. 634); a matched cohort based on the consolidation diameter (PSM1, n = 217 each); and a matched cohort based on 11 clinical characteristics (PSM2, n = 103 each). Multivariate analysis was also performed. RESULTS: The 5-year overall/recurrence-free survival rates for part-solid and pure-solid adenocarcinomas were 90.2%/79.3% and 80.8%/66.0% in the PSM0 cohort (P < 0.0001), 87.4%/79.2% and 76.3%/68.6% in the PSM1 cohort (P < 0.05), and 91.6%/92.1% and 76.6%/79.0% in the PSM2 cohort (P > 0.05), respectively. Multivariate analysis revealed that male sex (P = 0.04) and the carcinoembryonic antigen value (P < 0.0001) were significant factors affecting overall survival, while the carcinoembryonic antigen value (P = 0.0002) and consolidation tumor size (P = 0.002) affected recurrence-free survival. The lepidic component was not related to overall (P = 0.45) or recurrence-free (P = 0.78) survival.Conclusions: Preoperative factors are strongly associated with \"consolidation size\", which could be the \"representative factor\" indicating the malignant potential in adenocarcinomas being consistent with the current eighth edition of the TNM.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"607-617"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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