{"title":"Early postnatal neonatal surgery is associated with a low risk of surgical site infections.","authors":"Yuhki Koike, Koki Higashi, Yuki Sato, Shinji Yamashita, Yuka Nagano, Takahito Kitajima, Tabanobu Shimura, Kohei Matsushita, Yoshiki Okita, Yoshinaga Okugawa, Toru Ogura, Yuji Toiyama","doi":"10.1007/s00595-025-03060-8","DOIUrl":"https://doi.org/10.1007/s00595-025-03060-8","url":null,"abstract":"<p><strong>Purpose: </strong>Despite the recognition of the negative effects of surgical site infection (SSI), data on neonatal surgery are limited. This study investigated the risk factors for SSI development in the neonatal period.</p><p><strong>Methods: </strong>Neonatal surgeries performed by pediatric surgeons at the Mie University Hospital between 2007 and 2023 were retrospectively reviewed. The correlation between age at surgery and the presence of SSI was analyzed, and the optimal cutoff value for age at surgery was determined with respect to SSI. The predictors of SSI were analyzed using a logistic regression analysis.</p><p><strong>Results: </strong>Among 272 neonatal surgeries, SSI was identified in 19 patients (7.0%). Patients with SSI were significantly older than those without SSI (P = 0.003), and the optimal cut-off value was age > 3 days. The incidence rate of SSI was 2.05% in the ≤ 3-day-old group and 12.7% in the > 3 day-old group (P < 0.001). A multivariate analysis revealed that intestinal perforation, preoperative elevated C-reactive protein (CRP) level, and surgery at > 3 days old were independent predictors of SSI.</p><p><strong>Conclusion: </strong>Intestinal perforation, preoperative elevated CRP, and surgery after 3 days old are associated with an increased SSI risk in neonatal surgery.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-term outcomes of prophylactic right-half dissection of the superior mesenteric artery nerve plexus in pancreatoduodenectomy for pancreatic ductal adenocarcinoma: five-year results from a randomized phase II trial.","authors":"Yuki Matsui, Daisuke Hashimoto, Nobuhiko Nakagawa, So Yamaki, Masamichi Hayashi, Hideki Takami, Kazuto Shibuya, Suguru Yamada, Sohei Satoi, Tsutomu Fujii","doi":"10.1007/s00595-025-03062-6","DOIUrl":"https://doi.org/10.1007/s00595-025-03062-6","url":null,"abstract":"<p><strong>Purposes: </strong>In pancreaticoduodenectomy for pancreatic ductal adenocarcinoma (PDAC), Prophylactic right-half dissection of the superior mesenteric artery (SMA) nerve plexus has been attempted in pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. In this study, we evaluated the significance of prophylactic right-half dissection of the SMA nerve plexus by extending the observation period to 5 years.</p><p><strong>Methods: </strong>From April 2014 to June 2018, 74 patients with PDAC in the pancreatic head were randomly assigned to either the dissection group, in which the right half of the nerve plexus of the SMA was dissected (n = 37) or the preservation group, in which the nerve plexus of the SMA was completely preserved (n = 37). The 5-year relapse-free survival (RFS), overall survival (OS), and incidence of diarrhea were prospectively compared between groups.</p><p><strong>Results: </strong>The median RFS (20 vs. 16 months, P = 0.503) and OS (37.0 vs. 30.0 months, P = 0.582) did not differ significantly between the dissection and preservation groups. There was no significant difference in locoregional recurrence (27.0% vs. 37.8%, P = 0.320) or distant metastasis (64.9% vs. 83.0%, P = 0.451). Postoperative diarrhea occurred in 64.9% and 62.2% of the cases in the dissection and preservation groups, respectively (P = 0.809).</p><p><strong>Conclusion: </strong>Prophylactic right half dissection of the SMA nerve plexus did not improve the RFS or OS.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Induced pluripotent stem cell-derived stellate cells promote proliferation of induced pluripotent stem cell-derived hepatocytes through the mitogen-activated protein kinase pathway via hepatocyte growth factor.","authors":"Takahiro Tomiyama, Kazuki Takeishi, Shinji Itoh, Katsuya Toshida, Norifumi Iseda, Yuki Nakayama, Takuma Ishikawa, Takashi Motomura, Takeshi Kurihara, Takeo Toshima, Rodrigo M Florentino, Alejandro Soto-Gutierrez, Tomoharu Yoshizumi","doi":"10.1007/s00595-025-03061-7","DOIUrl":"https://doi.org/10.1007/s00595-025-03061-7","url":null,"abstract":"<p><strong>Purpose: </strong>Human-induced pluripotent stem cells (iPSCs) have the potential to differentiate into cells of various organs. Hepatocytes derived from iPSCs (i-Heps) have attracted much attention as an alternative treatment for liver transplantation in patients with liver failure. However, it is challenging to create sufficient i-Heps for clinical treatment, highlighting the need to develop an easier and more efficient culture method. In this study, we examined the effect of quiescent iPSC-derived stellate cells (i-Stes) on i-Hep proliferation.</p><p><strong>Methods: </strong>i-Stes and i-Heps were differentiated from iPSCs.</p><p><strong>Results: </strong>i-Stes expressed higher levels of hepatocyte growth factor (HGF) than the human hepatic stellate cell line LX-2. In addition, quiescent i-Sted promoted i-Hep proliferation via activation of the mitogen-activated protein kinase (MAPK) pathway in i-Heps, which was impaired by the activation of i-Sted with transforming growth factor beta.</p><p><strong>Conclusion: </strong>This study provides evidence that i-Sted can effectively induce i-Hep proliferation through HGF activation of the MAPK signaling pathway. Quiescent-but not activated-i-Stes may contribute to the creation of large numbers of i-Heps.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of the log odds of positive lymph nodes on the prognosis in pathological stage 3 patients with obstructive colorectal cancer treated with colonic stents: a retrospective multicenter study in Japan.","authors":"Toshio Shiraishi, Tetsuro Tominaga, Takashi Nonaka, Yuma Takamura, Kaido Oishi, Shintaro Hashimoto, Keisuke Noda, Rika Ono, Makoto Hisanaga, Akiko Fukuda, Masaaki Moriyama, Fumitake Uchida, Kazuki Motoyama, Masaki Kunizaki, Keitaro Matsumoto","doi":"10.1007/s00595-025-03064-4","DOIUrl":"https://doi.org/10.1007/s00595-025-03064-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the relationship between log odds of positive lymph nodes (LODDS) and the long-term prognosis in pathological stage 3 obstructive colorectal cancer (CRC) patients who underwent self-expandable metal stent (SEMS) insertion as a bridge to surgery (BTS).</p><p><strong>Methods: </strong>This retrospective multicenter study included 75 patients with stage 3 CRC. The patients were classified into high-LODDS (LODDS-H, n = 32) and low-LODDS (LODDS-L, n = 43) groups.</p><p><strong>Results: </strong>Significant differences were found in the 5-year relapse-free survival (RFS) rates (LODDS-H: 34.0% vs. LODDS-L: 53.1%; p = 0.041) and overall survival (OS) rates (52.4% vs. 68.3%; p = 0.012). A multivariate analysis revealed that blood loss [hazard ratio (HR) 2.266, 95% confidence interval (CI), 1.142-4.494; p = 0.019] was an independent predictor of the RFS. Age ≥ 75 years old (HR 2.769, 95% CI 1.206-6.360; p = 0.016), blood loss (HR 3.552, 95% CI 1.460-8.643; p = 0.005), adjuvant chemotherapy (HR 0.415, 95% CI 0.177-0.972; p = 0.043), and LODDS (HR 3.593, 95% CI 1.511-8.544; p = 0.004) were independent predictors of OS.</p><p><strong>Conclusions: </strong>The LODDS appears to be prognostically accurate for patients with stage 3 obstructive CRC undergoing BTS. Incorporating the LODDS into clinical evaluations may enable more accurate prognostic stratification.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Staple line leakage after laparoscopic sleeve gastrectomy in Japan: a nationwide survey.","authors":"Takashi Oshiro, Masayuki Ohta, Taiki Nabekura, Yosuke Seki, Yoshihiro Nagao, Kazuto Tsuboi, Shuji Takiguchi, Fumihiko Hatao, Kengo Kanetaka, Takeshi Togawa, Akiharu Ishiyama, Tsuyoshi Yamaguchi, Hisashi Kanoda, Akira Umemura, Takuro Saito, Kazunori Kasama, Akira Sasaki","doi":"10.1007/s00595-025-03057-3","DOIUrl":"https://doi.org/10.1007/s00595-025-03057-3","url":null,"abstract":"<p><strong>Purpose: </strong>Laparoscopic sleeve gastrectomy (LSG) is the most frequently performed procedure; however, the treatment of staple line leakage is very complicated. Therefore, this study assessed the incidence and treatment outcomes of staple line leakage in Japan.</p><p><strong>Methods: </strong>The first survey of patients with leakage after LSG until September 30, 2022, was sent to 83 Japanese institutions. The second survey was sent to institutions that reported patients with leakage after LSG. The timing of conversion to curative surgery was statistically analyzed.</p><p><strong>Results: </strong>Thirteen institutions (15.7%) reported staple line leakage in 21 patients after LSG. The incidence was 0.41%, and the leakage sites were close to the angle of His in > 90% of the patients. Initial management was successful in 30.0% of patients, while the remaining patients required additional management. After intervention, 25.0% of patients underwent conversion surgery as curative management, and the optimal timing was 83.5 days after leakage detection.</p><p><strong>Conclusions: </strong>The rate of staple line leakage after LSG was low, but difficult to treat. Conversion to curative surgery may be determined after approximately 12 weeks.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical outcomes of initial inside stenting for preoperative malignant hilar biliary obstruction in patients with jaundice.","authors":"Ryo Sugiura, Masaki Kuwatani, Kazumichi Kawakubo, Hiroki Yonemura, Shunichiro Nozawa, Shoya Shiratori, Soichiro Oda, Kimitaka Tanaka, Satoshi Hirano, Naoya Sakamoto","doi":"10.1007/s00595-025-03063-5","DOIUrl":"https://doi.org/10.1007/s00595-025-03063-5","url":null,"abstract":"<p><strong>Purpose: </strong>Endoscopic nasobiliary drainage (ENBD) is a widely used primary approach for preoperative endoscopic biliary drainage (PEBD) for malignant hilar biliary obstruction (MHBO) although the utility of inside stenting (IS) remains unknown. This study aimed to compare the clinical outcomes of IS and ENBD as the initial PEBD.</p><p><strong>Methods: </strong>This retrospective, single-center study included patients with MHBO who underwent IS or ENBD as the initial PEBD and before laparotomy for radical surgical resection at the study institution. The primary outcome was the clinical success rate of the initial PEBD method.</p><p><strong>Results: </strong>The study included 28 and 38 patients who underwent IS and ENBD, respectively, for initial PEBD. The clinical success rates in patients who underwent IS and ENBD were 78.6% and 97.4%, respectively (P = 0.04). Clinical failure was more frequent in patients with jaundice undergoing IS (42.9%) than in those without jaundice undergoing IS and those with or without jaundice undergoing ENBD (0-4.2%; P < 0.01). The rates of cholangitis and PEBD-related adverse events, the cumulative incidence of PEBD dysfunction, and postoperative survival in patients undergoing IS and ENBD did not differ to a statistically significant extent.</p><p><strong>Conclusions: </strong>Clinical failure of initial PEBD was more frequent in patients with jaundice undergoing IS than in those undergoing ENBD during the initial preoperative period of workup and drainage period.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Temporary atypical vascular ultrasound-guided central venous approach in patients with venous occlusion.","authors":"Naonori Kawakubo, Junnosuke Maniwa, Yoshiaki Takahashi, Takuya Kondo, Atsuhisa Fukuta, Koichiro Yoshimaru, Kouji Nagata, Junko Miyata, Toshiharu Matsuura, Tatsuro Tajiri","doi":"10.1007/s00595-025-03056-4","DOIUrl":"https://doi.org/10.1007/s00595-025-03056-4","url":null,"abstract":"<p><p>This study presents an innovative ultrasound-guided technique for central venous access in patients with venous occlusion, particularly in those requiring long-term parenteral nutrition (TPN). Conventional access points often become occluded, necessitating alternative methods for approaching the central vein. A retrospective review of three patients with venous occlusion due to prolonged TPN use was conducted at our institution. The procedure involved ultrasound-guided puncture of atypical vessels, such as the internal mammary, anterior jugular, or innominate veins, using the Seldinger or introducer technique depending on vessel size. All catheters were successfully placed with minimal complications, allowing for continued TPN. The study concluded that ultrasound-guided access to atypical vessels offers a safer and less invasive alternative to central venous access in complex cases, particularly in adolescent and young adult patients.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surgery TodayPub Date : 2025-05-12DOI: 10.1007/s00595-025-03053-7
Fucheng Zhao, Pengliang Wang, Wei Wang, Zhe Sun, Zhenning Wang, Huimian Xu, Zhiwei Zhou, Han Liang, Jingyu Deng
{"title":"Examining more than 35 lymph nodes improves the staging and survival in resectable advanced gastric cancer: a multi-institutional study in China.","authors":"Fucheng Zhao, Pengliang Wang, Wei Wang, Zhe Sun, Zhenning Wang, Huimian Xu, Zhiwei Zhou, Han Liang, Jingyu Deng","doi":"10.1007/s00595-025-03053-7","DOIUrl":"https://doi.org/10.1007/s00595-025-03053-7","url":null,"abstract":"<p><strong>Purpose: </strong>More examined lymph nodes (ELN) are correlated with better staging and a better prognosis of gastric cancer, although the optimal number of ELNs remains under dispute. This study explored the optimal number of ELNs for resectable advanced gastric cancer (AGC).</p><p><strong>Methods: </strong>Clinicopathological characteristics and survival data of 4739 AGC patients were collected from 3 GC centers in China. The series of odds ratios (ORs) for negative-to-positive node stage migration and hazard ratios (HRs) for the disease-specific survival with more ELNs were fitted using locally weighted scatterplot smoothing (LOWESS). The structural breakpoints were determined using the Chow test. A Kaplan-Meier survival analysis was used to validate the cutoff ELN count.</p><p><strong>Results: </strong>With increasing numbers of ELNs, the cohort exhibited significant proportional increases in stage migration (OR = 1.006, p = 0.024) and serial improvements in survival (HR = 0.979, p < 0.001) per additional ELN after adjusting for covariates. The optimal ELN count was identified as 36, which was further validated with good discrimination for survival stratification in an external cohort that included 5796 patients from the SEER database.</p><p><strong>Conclusion: </strong>Having more than 35 LNs to examine could achieve more accurate staging and a better survival for AGC patients with stage N0-N2 disease.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of a zipline skin closure device in gastroenterological surgery: a multicenter randomized controlled trial assessing wound infection incidence, operation time, and cosmesis.","authors":"Ayato Obana, Takuya Minagawa, Ayako Shimada, Junko Mukohyama, Yuki Hirano, Sojun Hoshimoto, Takashi Oyama, Tsuruta Masashi, Takashi Ishida, Takuya Tamura, Kyoichi Matsuzaki, Mitsuru Takaku, Hirotoshi Ohara, Motoi Koyama, Masahiro Shinoda, Tatsushi Suwa, Osamu Itano","doi":"10.1007/s00595-025-03043-9","DOIUrl":"https://doi.org/10.1007/s00595-025-03043-9","url":null,"abstract":"<p><p>Subcuticular sutures, which are effective and cosmetically advantageous in gastroenterological surgery, are time-consuming and heavily dependent on the surgeon's technical expertise. This study aims to evaluate whether Zipline skin closure could be an alternative to subcuticular sutures in gastroenterological surgery. A multicenter randomized controlled trial (UMIN000048169) was conducted on 76 patients who underwent elective gastroenterological surgery. The patients were randomized to either the Zipline group (N = 35) or the subcuticular suture group (N = 41). Primary outcomes included skin closure time and secondary outcomes included postoperative wound complications and cosmetic results, assessed 6 months post-surgery, using the Stony Book Scar Evaluation Scale (SBSES). The Zipline group demonstrated significantly shorter closure times than the suture group (median: 438 s [406-526] vs. 575 s [537-638]; p = 0.003). This difference was more pronounced for incisions > 55 mm (median:399 s [307-533] vs. 605 s [493-736]; p = 0.001). No significant differences were observed in wound infection rates (5.7% vs. 2.4%; p = 0.46) or SBSES scores (median: 4.0 [4.0-5.0] vs. 4.0 [3.0-5.0; p = 0.82) between the two groups. The Zipline device reduced the skin closure time in gastroenterological surgery significantly, particularly for large incisions, without compromising wound healing or cosmetic outcomes. These findings suggest that the Zipline system may be a viable alternative to traditional subcuticular sutures in gastroenterological procedures, potentially promoting operating room efficiency without compromising surgical quality or patient outcomes.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surgery TodayPub Date : 2025-05-07DOI: 10.1007/s00595-025-03055-5
Masahisa Ohkuma, Yasuhiro Takano, Keisuke Goto, Atsuko Okamoto, Muneyuki Koyama, Tadashi Abe, Takafumi Nakano, Yasuhiro Takeda, Makoto Kosuge, Ken Eto
{"title":"Significance of Naples prognostic score for postoperative complications after colorectal cancer surgery.","authors":"Masahisa Ohkuma, Yasuhiro Takano, Keisuke Goto, Atsuko Okamoto, Muneyuki Koyama, Tadashi Abe, Takafumi Nakano, Yasuhiro Takeda, Makoto Kosuge, Ken Eto","doi":"10.1007/s00595-025-03055-5","DOIUrl":"https://doi.org/10.1007/s00595-025-03055-5","url":null,"abstract":"<p><strong>Purpose: </strong>The Naples prognostic score (NPS) is a sensitive scoring system that reflects both inflammatory and nutritional status. This study examined the significance of NPS in predicting postoperative complications following colorectal cancer surgery.</p><p><strong>Methods: </strong>The present study included data from 443 patients who underwent curative resection for colorectal cancer. The patients were classified into low NPS (score 0-2) and high NPS (score 3-4) groups. We retrospectively investigated the relationship between NPS and postoperative complications (Clavien-Dindo classification ≥ II).</p><p><strong>Results: </strong>Among all patients, 57 (13%) developed postoperative complications. A total of 340 patients (77%) were categorized into the low NPS group and 103 (23%) were categorized into the high NPS group. A multivariate analysis identified that high NPS (P < 0.001), tumor location in the rectum (P = 0.025), longer operation time (P = 0.027), and greater blood loss (P = 0.004) were independent risk factors for postoperative complications. Furthermore, high NPS was significantly associated with older age (P < 0.001), higher American Society of Anesthesiologists physical status score (P = 0.029), advanced T stage (P < 0.001), N stage (P = 0.036), and longer length of hospital stay (P < 0.010).</p><p><strong>Conclusions: </strong>NPS is a strong predictor of poor outcomes in patients undergoing curative resection for colorectal cancer, suggesting the importance of systemic inflammation and the nutritional status.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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