Surgery Today最新文献_第9页

Impact of the coronavirus disease 2019 pandemic on the number of colorectal cancer surgeries performed: analysis of a nationwide inpatient database in Japan. 冠状病毒病 2019 年大流行对已实施的结直肠癌手术数量的影响：日本全国住院患者数据库分析。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-02-01 Epub Date: 2024-08-20 DOI: 10.1007/s00595-024-02913-y

Miyako Tazawa, Nobutoshi Nawa, Shinichi Yamauchi, Masanori Tokunaga, Kiyohide Fushimi, Yusuke Kinugasa, Takeo Fujiwara

{"title":"Impact of the coronavirus disease 2019 pandemic on the number of colorectal cancer surgeries performed: analysis of a nationwide inpatient database in Japan.","authors":"Miyako Tazawa, Nobutoshi Nawa, Shinichi Yamauchi, Masanori Tokunaga, Kiyohide Fushimi, Yusuke Kinugasa, Takeo Fujiwara","doi":"10.1007/s00595-024-02913-y","DOIUrl":"10.1007/s00595-024-02913-y","url":null,"abstract":"Purpose: This study examined the impact of the COVID-19 pandemic on the number of colorectal cancer surgeries performed in Japan.Methods: We selected patients who underwent colorectal cancer surgeries between January, 2017 and December, 2020 from the Diagnosis Procedure Combination database. The COVID-19 pandemic was divided into three waves. We evaluated the changes in the number of surgeries performed for colorectal cancer during each wave, stratified by cancer stage using Poisson regression.Results: During the first wave, the rate ratio (RR) for stage III colon cancer decreased significantly (RR, 0.94), whereas those for stages 0 to II (RR, 1.01) and stage IV (RR, 1.04) were not different. During the second and third waves, the RR for stage 0 to II colon cancer decreased significantly (RR, 0.96), that for stage IV increased (RR, 1.09), and that for stage III was not different (RR, 0.97). During the first wave, the RR for stage 0 to II rectal cancer increased significantly (RR, 1.09), that for stage IV decreased (RR, 0.84), and that for stage III was not different (RR, 0.97).Conclusions: The number of colorectal cancer surgeries changed during the pandemic and varied according to the stage of disease.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"247-256"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The long-term quality of life after distal and pylorus-preserving gastrectomy for stage I gastric cancer: A prospective multi-institutional study (CCOG1601). I 期胃癌远端和幽门保留胃切除术后的长期生活质量：一项前瞻性多机构研究（CCOG1601）。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-02-01 Epub Date: 2024-06-21 DOI: 10.1007/s00595-024-02881-3

Chie Tanaka, Mitsuro Kanda, Kazunari Misawa, Yoshinari Mochizuki, Takuya Watanabe, Masashi Hattori, Kiyoshi Ishigure, Satoshi Sueoka, Hitoshi Teramoto, Akiharu Ishiyama, Ikue Nonogaki, Hidenobu Matsushita, Kenta Murotani, Yasuhiro Kodera

{"title":"The long-term quality of life after distal and pylorus-preserving gastrectomy for stage I gastric cancer: A prospective multi-institutional study (CCOG1601).","authors":"Chie Tanaka, Mitsuro Kanda, Kazunari Misawa, Yoshinari Mochizuki, Takuya Watanabe, Masashi Hattori, Kiyoshi Ishigure, Satoshi Sueoka, Hitoshi Teramoto, Akiharu Ishiyama, Ikue Nonogaki, Hidenobu Matsushita, Kenta Murotani, Yasuhiro Kodera","doi":"10.1007/s00595-024-02881-3","DOIUrl":"10.1007/s00595-024-02881-3","url":null,"abstract":"Purpose: While regarded as function-preserving gastrectomy, few prospective longitudinal clinical trials have addressed the postoperative quality of life (QOL) after pylorus-preserving gastrectomy (PPG). We prospectively compared chronological changes in postoperative body weight and the QOL between PPG and distal gastrectomy (DG) for pathological Stage I gastric cancer (GC).Methods: We conducted a multi-institutional prospective study (CCOG1601) to evaluate patients who underwent DG and PPG. The QOL was examined using the European Organization for Research and Treatment of Cancer Quality of life questionnaire-C30 (EORTC QLQ-C30) and the Post-Gastrectomy Syndrome Assessment Scale-37 (PGSAS-37). A total of 295 patients were enrolled from 15 institutions, and propensity score matching was performed to adjust for the essential variables for comparison analyses.Results: After propensity score matching, 25 pairs of patients were identified. In the first postoperative month, DG achieved a superior nausea and vomiting score (EORTC QLQ-C30) and meal-related distress, indigestion, and dumping scores (PGSAS-37). No significant differences were noted between DG and PPG in the long-term QOL. Postoperative body weight loss was similar in both groups.Conclusions: This prospective observational study failed to demonstrate the superiority of PPG over DG in terms of postoperative body weight changes and the QOL.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"162-171"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of hepatic steatosis with the preoperative treatment of pancreatic cancer and the short-term postoperative outcomes. 胰腺癌术前治疗的肝脂肪变性风险及术后短期疗效。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-02-01 Epub Date: 2024-07-09 DOI: 10.1007/s00595-024-02895-x

Kazuki Kobayashi, Yoji Kishi, Takazumi Tsunenari, Naoto Yonamine, Yasuhiro Takihata, Akiko Nakazawa, Mikiya Takao, Takahiro Einama, Hironori Tsujimoto, Hideki Ueno

{"title":"Risk of hepatic steatosis with the preoperative treatment of pancreatic cancer and the short-term postoperative outcomes.","authors":"Kazuki Kobayashi, Yoji Kishi, Takazumi Tsunenari, Naoto Yonamine, Yasuhiro Takihata, Akiko Nakazawa, Mikiya Takao, Takahiro Einama, Hironori Tsujimoto, Hideki Ueno","doi":"10.1007/s00595-024-02895-x","DOIUrl":"10.1007/s00595-024-02895-x","url":null,"abstract":"Purpose: We investigated whether the preoperative treatment of patients with pancreatic cancer is a risk factor for hepatic steatosis (HS), and whether preoperative HS affects the short-term postoperative outcomes.Methods: Patients who underwent radical surgery for pancreatic cancer between 2010 and 2023 were enrolled. The patients' medical records were reviewed. Albumin and carbohydrate antigen 19-9 were measured before and after chemotherapy in the patients who received preoperative chemotherapy. A logistic regression univariate analysis was performed to analyze the factors associated with new-onset HS.Results: A total of 230 patients who underwent surgery were included. HS was observed on the date of surgery in 11 (10%) and two (2%) patients with and without preoperative chemotherapy, respectively. Female sex, initially borderline resectable or unresectable disease, history of cholangitis, presence of PEI, long-term (≥ 3 months) biliary drainage, preoperative chemotherapy, and serum albumin ≥ 3.9 mg/dl before chemotherapy were identified as risk factors for HS. The incidence of postoperative morbidity did not differ between the patients with and without preoperative steatosis.Conclusions: Preoperative chemotherapy, a history of cholangitis, the presence of PEI, and ≥ 3 months' duration of biliary drainage were risk factors for the development of HS before surgery for pancreatic cancer. However, preoperative HS did not affect the short-term postoperative outcomes.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"211-221"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoperistaltic hand-sewn side-to-side bowel primary anastomosis: a safe approach after bowel resection in children with neutropenic enterocolitis.

IF 1.7 4区医学

Surgery Today Pub Date : 2025-02-01 DOI: 10.1007/s00595-025-02998-z

Mohammad Taher, Maged Elshafiey, Ahmed Refaat, Eman Nasr, Gehad Ahmed

{"title":"Isoperistaltic hand-sewn side-to-side bowel primary anastomosis: a safe approach after bowel resection in children with neutropenic enterocolitis.","authors":"Mohammad Taher, Maged Elshafiey, Ahmed Refaat, Eman Nasr, Gehad Ahmed","doi":"10.1007/s00595-025-02998-z","DOIUrl":"https://doi.org/10.1007/s00595-025-02998-z","url":null,"abstract":"Background and aim: Whether to perform primary anastomosis (PA) or create a stoma after bowel resection has always been a dilemma in pediatric cancer patients with neutropenic enterocolitis (NEC). The risk of leakage after PA must be weighed against the risk of stoma complications. We evaluated the outcomes of managing NEC patients with either PA or stoma and the utility of the isoperistaltic hand-sewn side-to-side anastomosis (ISSA) technique in PA.Patients and methods: A retrospective study on all Children's Cancer Hospital Egypt patients with NEC who underwent surgical exploration at our hospital from 2008 to 2022.Results: Of 153 children, 80 (52.3%) underwent PA and 73 (47.7%) underwent stoma formation. Among the 80 PA patients, 68 (85%) underwent ISSA, 9 (11.2%) end-to-end anastomosis (EEA), and 3 (3.8%) end-to-side anastomosis (ESA). The perioperative complication rate was 38/73 (52.1%) in the stoma patients and 35/80 (43.8%) in the PA patients. Leakage occurred in 6/68 (8.8%) ISSA patients, 5/9 (55.6%) EEA patients, and 1/3 (33.3%) of ESA patients.Conclusions: In pediatric cancer patients with NEC, PA using ISSA after bowel resection is considered a better approach than any other anastomotic configuration.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of lymph node metastasis and long-term outcomes of splenic flexure colon cancer: a descriptive study from a Japanese high-volume center.

IF 1.7 4区医学

Surgery Today Pub Date : 2025-01-31 DOI: 10.1007/s00595-025-02999-y

Takashi Sakamoto, Toshiki Mukai, Tatsuki Noguchi, Shimpei Matsui, Tomohiro Yamaguchi, Takashi Akiyoshi, Hiroshi Kawachi, Yosuke Fukunaga

{"title":"Patterns of lymph node metastasis and long-term outcomes of splenic flexure colon cancer: a descriptive study from a Japanese high-volume center.","authors":"Takashi Sakamoto, Toshiki Mukai, Tatsuki Noguchi, Shimpei Matsui, Tomohiro Yamaguchi, Takashi Akiyoshi, Hiroshi Kawachi, Yosuke Fukunaga","doi":"10.1007/s00595-025-02999-y","DOIUrl":"https://doi.org/10.1007/s00595-025-02999-y","url":null,"abstract":"Purpose: The pattern of lymph node metastasis and the appropriate extent of lymph node dissection in splenic flexure colon cancer remain unclear. This study aimed to describe the clinical characteristics, lymph node metastasis patterns, and oncological outcomes of patients with splenic flexure colon cancer.Methods: The data of patients with splenic flexure cancer diagnosed with pathological stages I-III were extracted from a hospital database. Lymph nodes were mapped and numbered according to the guidelines of the Japanese Society for Cancer of the Colon and Rectum. Five-year disease-free survival (DFS) and overall survival (OS) rates were estimated using the Kaplan-Meier method.Results: Among 151 patients, 37.1% had lymph node metastasis. The proportion of lymph node metastasis were 30.1% at station 221, 5.1% at station 222, 2.8% at station 223, 19.8% at station 231, 2.7% at station 232, and 0% at station 253. Among the 59 patients with an accessory middle colic artery, 19 had lymph node metastasis only at stations 221 (14/47) and 231 (5/47). The 5-year estimated DFS rates were 100% for stage I, 94.4% (95% CI, 83.6-98.2) for stage II, and 79.9% (95% CI, 65.6-88.8) for stage III. Ten patients experienced distant recurrence: liver (n = 5), peritoneum (n = 2), para-aortic lymph node (n = 2), and lung metastasis (n = 1). No local recurrence was observed.Conclusion: In splenic flexure colon cancer, lymph node dissection around the IMA route may be omitted. Similarly, dissection along the left branch of the middle colic artery or the left colic artery may be unnecessary in the presence of an accessory middle colic artery.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative low prealbumin independently predicts non-gastric cancer death after gastrectomy in elderly and young patients: a retrospective cohort study.

IF 1.7 4区医学

Surgery Today Pub Date : 2025-01-27 DOI: 10.1007/s00595-025-02996-1

Ryota Matsui, Souya Nunobe, Motonari Ri, Rie Makuuchi, Tomoyuki Irino, Masaru Hayami, Manabu Ohashi, Takeshi Sano

{"title":"Preoperative low prealbumin independently predicts non-gastric cancer death after gastrectomy in elderly and young patients: a retrospective cohort study.","authors":"Ryota Matsui, Souya Nunobe, Motonari Ri, Rie Makuuchi, Tomoyuki Irino, Masaru Hayami, Manabu Ohashi, Takeshi Sano","doi":"10.1007/s00595-025-02996-1","DOIUrl":"https://doi.org/10.1007/s00595-025-02996-1","url":null,"abstract":"Purpose: To investigate the effect of preoperative prealbumin levels on long-term survival outcomes after gastrectomy in patients with gastric cancer (GC) dichotomized based on age.Methods: This retrospective cohort study included consecutive patients who underwent radical gastrectomy for primary stage I-III GC between May 2006 and March 2017. Patients were allocated to groups based on age (≥ 70 or < 70 years) and subgroups based on prealbumin levels (high, ≥ 22 mg/dL; moderate, 15-22 mg/dL; or low, < 15 mg/dL), and multivariate Cox regression was used for survival analyses.Results: Of 4732 patients, 3172 (67.0%) were aged < 70 years and 1560 (33.0%) were ≥ 70 years of age. The median follow-up period was 66 months. A low prealbumin level was an independent prognostic factor for poor overall survival in older patients only [hazard ratio, 2.057; 95% confidence interval, 1.528-2.770; P < 0.001]. A low prealbumin level was an independent prognostic factor for poor other-cause survival in the older (hazard ratio: 2.719, 95% confidence interval: 1.887-3.918, P < 0.001) and younger (HR: 4.611, 95% CI 2.424-8.772, P < 0.001) groups.Conclusion: Low preoperative prealbumin levels were associated with poor overall survival in older patients with GC after gastrectomy and with earlier non-GC death in older and younger patients.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic significance of the hemoglobin, albumin, lymphocyte, platelet (HALP) score after hepatectomy for colorectal liver metastases. 结直肠癌肝转移患者肝切除术后血红蛋白、白蛋白、淋巴细胞、血小板（HALP）评分的预后意义。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-01-20 DOI: 10.1007/s00595-025-02993-4

Kohei Okazaki, Kenei Furukawa, Koichiro Haruki, Shinji Onda, Yoshihiro Shirai, Masashi Tsunematsu, Tomohiko Taniai, Michinori Matsumoto, Ryoga Hamura, Munetoshi Akaoka, Tadashi Uwagawa, Toru Ikegami

{"title":"Prognostic significance of the hemoglobin, albumin, lymphocyte, platelet (HALP) score after hepatectomy for colorectal liver metastases.","authors":"Kohei Okazaki, Kenei Furukawa, Koichiro Haruki, Shinji Onda, Yoshihiro Shirai, Masashi Tsunematsu, Tomohiko Taniai, Michinori Matsumoto, Ryoga Hamura, Munetoshi Akaoka, Tadashi Uwagawa, Toru Ikegami","doi":"10.1007/s00595-025-02993-4","DOIUrl":"https://doi.org/10.1007/s00595-025-02993-4","url":null,"abstract":"Purpose: Inflammatory, nutritional, and immune biomarkers are associated with the prognosis of patients with various tumors. Recently, a comprehensive predictive biomarker, the hemoglobin, albumin, lymphocyte, and platelet (HALP) score, was introduced to predict clinical outcomes. We investigated the prognostic impact of preoperative HALP scores in patients who underwent hepatectomy for colorectal liver metastasis (CRLM).Method: The subjects of this study were 209 patients who underwent hepatectomy for CRLM between February, 2005 and September, 2023. The HALP score was defined as (albumin [mg/dL] × hemoglobin [g/L] × lymphocyte [count/L]) / platelet [count/L]. The cutoff value was calculated according to the receiver operating characteristic curve based on 3-year survival.Results: The cutoff value of the HALP score was 35, and a low HALP score was confirmed in 107 patients (51%). Multivariate analysis of disease-free survival identified lymph node metastasis (HR 1.53, p = 0.03), extrahepatic lesions (HR 2.48, p < 0.01), and a low HALP score (HR 2.0, p < 0.01) as independently poor prognostic factors. Multivariate analysis of overall survival identified extrahepatic lesions (HR 2.98, p < 0.01), a high CEA (HR 1.78, p = 0.02), and a low HALP score (HR 1.92, p = 0.02) as independently poor prognostic factors.Conclusions: The HALP score is a useful prognostic factor for patients undergoing hepatectomy for CRLM.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germline variants detected by multigene panel testing in patients with suspected hereditary breast cancer. 用多基因面板检测疑似遗传性乳腺癌患者的种系变异。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-01-20 DOI: 10.1007/s00595-025-02994-3

Yusa Togashi, Masayuki Nagahashi, Mina Kashima, Chiho Okada, Chinatsu Kinjo, Ayako Miyazaki, Mako Ueda, Hiroshi Tsubamoto, Hideaki Sawai, Yasuo Miyoshi

{"title":"Germline variants detected by multigene panel testing in patients with suspected hereditary breast cancer.","authors":"Yusa Togashi, Masayuki Nagahashi, Mina Kashima, Chiho Okada, Chinatsu Kinjo, Ayako Miyazaki, Mako Ueda, Hiroshi Tsubamoto, Hideaki Sawai, Yasuo Miyoshi","doi":"10.1007/s00595-025-02994-3","DOIUrl":"https://doi.org/10.1007/s00595-025-02994-3","url":null,"abstract":"Purpose: To clarify the status of multigene panel testing for suspected hereditary breast cancer in our institute, and disclose the characteristics of the variants detected.Methods: This was a retrospective study of individuals who underwent next-generation sequencing-based multigene panel testing at our institute to investigate hereditary genetic variants for suspected hereditary breast cancer.Results: We identified 36 women who underwent multigene panel testing: 8 (22.2%) had a pathogenic variant, with or without other variants of uncertain significance (VUSs); 15 (41.7%) had VUSs only; and 13 (36.1%) had negative genetic test results. Of the eight pathogenic variants, five were BRCA2 variants and one each were BRCA1, MLH1, and RINT1 variants. The VUSs included BRCA1 and BRCA2, as well as other breast cancer-associated genes, such as ATM, CDH1, CHEK2, and PALB2. Referring to the latest ClinVar database, one of the variants identified as a VUS at diagnosis was re-determined as likely pathogenic, and three of the variants identified as VUSs at diagnosis were re-determined as benign.Conclusion: VUSs are frequently identified during testing and it is important to monitor these individuals because VUS evaluations can change over time.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance of the preoperative prognostic nutritional index in patients with resectable non-small cell lung cancer: a multicenter study. 可切除非小细胞肺癌患者术前预后营养指数的临床意义：一项多中心研究。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-01-16 DOI: 10.1007/s00595-024-02987-8

Mamoru Takahashi, Akihiro Aoyama, Masatsugu Hamaji, Takashi Sozu, Masashi Kobayashi, Tatsuo Nakagawa, Masashi Ishikawa, Ryo Miyahara, Cheng-Long Huang, Takuji Fujinaga, Hiroaki Sakai, Hiromichi Katakura, Makoto Sonobe, Norihito Okumura, Hidenao Kayawake, Toshi Menju, Ei Miyamoto, Ryo Miyata, Harutaro Okada, Tomoya Kono, Ryota Sumitomo, Naoki Date, Takehisa Fukada, Akira Matsumoto, Yasuto Sakaguchi, Hiroshi Date

{"title":"Clinical significance of the preoperative prognostic nutritional index in patients with resectable non-small cell lung cancer: a multicenter study.","authors":"Mamoru Takahashi, Akihiro Aoyama, Masatsugu Hamaji, Takashi Sozu, Masashi Kobayashi, Tatsuo Nakagawa, Masashi Ishikawa, Ryo Miyahara, Cheng-Long Huang, Takuji Fujinaga, Hiroaki Sakai, Hiromichi Katakura, Makoto Sonobe, Norihito Okumura, Hidenao Kayawake, Toshi Menju, Ei Miyamoto, Ryo Miyata, Harutaro Okada, Tomoya Kono, Ryota Sumitomo, Naoki Date, Takehisa Fukada, Akira Matsumoto, Yasuto Sakaguchi, Hiroshi Date","doi":"10.1007/s00595-024-02987-8","DOIUrl":"https://doi.org/10.1007/s00595-024-02987-8","url":null,"abstract":"Purpose: To validate the clinical impacts of the prognostic nutritional index (PNI), an immune-nutritional blood marker, in patients with resectable non-small cell lung cancer (NSCLC) using multicenter cohort data.Methods: The subjects of this retrospective multicenter study, involving 11 hospitals, were patients who underwent curative lung resection for pathological stage IA-IIIA NSCLC. We analyzed the relationship between the preoperative PNI and postoperative outcomes. Patients were divided into a high PNI group and a low PNI group (cutoff: 45). We also performed exact matching and three propensity score-based methods to validate the results.Results: Among the total 2,770 patients, 2,272 (82.0%) had a high PNI (>45) and 498 (18.0%) had a low PNI (≤45). A low preoperative PNI was a predictor of increased overall postoperative complications (relative risk 1.49; 95% confidence interval (CI) 1.31-1.69) and an independent adverse prognostic factor for overall survival (hazard ratio 1.77; 95% CI 1.45-2.17) and recurrence-free survival (1.34; 95% CI 1.14-1.59). All the methods we used (whole cohort, exact matching, and three propensity score methods) showed consistent results.Conclusions: The findings of this multicenter study suggest that immune-nutritional assessment using the PNI will provide useful prognostic information for patients with resectable NSCLC.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for anastomotic leakage in rectal cancer surgery reflecting current practices. 直肠癌手术中吻合口漏的危险因素反映目前的做法。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-01-11 DOI: 10.1007/s00595-024-02988-7

Tatsunosuke Harada, Masakatsu Numata, Yosuke Atsumi, Toshiyuki Fukuda, Shota Izukawa, Yusuke Suwa, Jun Watanabe, Tsutomu Sato, Aya Saito

{"title":"Risk factors for anastomotic leakage in rectal cancer surgery reflecting current practices.","authors":"Tatsunosuke Harada, Masakatsu Numata, Yosuke Atsumi, Toshiyuki Fukuda, Shota Izukawa, Yusuke Suwa, Jun Watanabe, Tsutomu Sato, Aya Saito","doi":"10.1007/s00595-024-02988-7","DOIUrl":"https://doi.org/10.1007/s00595-024-02988-7","url":null,"abstract":"Purpose: In recent years, major advancements have been made in rectal cancer surgery with the introduction of new techniques such as robotic surgery and indocyanine green fluorescence imaging (ICG-FI). This study aimed to evaluate the comprehensive risk factors for anastomotic leakage (AL) following rectal cancer surgery, incorporating recently introduced techniques and other existing factors, to reflect current practices.Methods: A retrospective analysis was conducted of 304 patients who underwent either robotic or laparoscopic anterior resection between January 2019 and December 2023. The study analyzed patient, tumor, and surgical factors, with AL defined by clinical or radiological findings requiring intervention within 30 days after surgery.Results: A univariate analysis indicated that moderate or severe anemia and the non-use of ICG-FI were strongly associated with AL. A multivariate analysis identified moderate or more severe anemia (hemoglobin ≤10.9 g/dL for males and ≤9.9 g/dL for females) (odds ratio [OR]: 9.94, p = 0.002) and non-use of ICG-FI (OR: 10.40, p < 0.001) as independent risk factors for AL.Conclusion: Moderate or severe anemia and absence of ICG-FI were found to significantly increase the risk of AL. Preoperative anemia correction and the routine use of ICG-FI may help mitigate this risk, thus suggesting the need for further research in these areas.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0