Surgery Today最新文献_第8页

A comparison of pancreatojejunostomy using the modified Blumgart anastomosis with or without a four-needle three-loop suture device and continuous sutures for duct-to-mucosa anastomosis in robotic pancreaticoduodenectomy. 在机器人胰十二指肠切除术中使用改良Blumgart吻合器进行胰空肠吻合术与使用或不使用四针三环缝合装置和连续缝合进行导管到粘膜吻合术的比较。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-07-30 DOI: 10.1007/s00595-024-02904-z

Naohisa Kuriyama, Akihiro Tanemura, Benson Kaluba, Tatsuya Sakamoto, Yu Fujimura, Takuya Yuge, Daisuke Noguchi, Takahiro Ito, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Yasuhiro Murata, Masashi Kishiwada, Shugo Mizuno

{"title":"A comparison of pancreatojejunostomy using the modified Blumgart anastomosis with or without a four-needle three-loop suture device and continuous sutures for duct-to-mucosa anastomosis in robotic pancreaticoduodenectomy.","authors":"Naohisa Kuriyama, Akihiro Tanemura, Benson Kaluba, Tatsuya Sakamoto, Yu Fujimura, Takuya Yuge, Daisuke Noguchi, Takahiro Ito, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Yasuhiro Murata, Masashi Kishiwada, Shugo Mizuno","doi":"10.1007/s00595-024-02904-z","DOIUrl":"https://doi.org/10.1007/s00595-024-02904-z","url":null,"abstract":"Purpose: Despite descriptions of different pancreatojejunostomy procedures using robotic pancreaticoduodenectomy (RPD), a standardized procedure has not yet been established. No prior report has described pancreatojejunostomy by RPD combined with modified Blumgart anastomosis with continuous suturing for duct-to-mucosa anastomosis. This study investigated this surgical technique and evaluated the short-term outcomes of the simplified pancreatojejunostomy procedure.Methods: Between December 2021 and March 2024, 36 patients underwent pancreatojejunostomy using modified Blumgart anastomosis with continuous suturing for duct-to-mucosa anastomosis using RPD. Patients were divided into an early group (n = 15), without the use of the new four-needle three-loop suture device during the modified Blumgart anastomosis and a late group (n = 21) that did use this device.Results: The late group had a significantly shorter pancreatojejunostomy duration (60 min vs. 49 min, p = 0.004) than the early group. Both groups showed equivalent postoperative outcomes; however, the late group exhibited a trend toward a lower rate of postoperative pancreatic fistula grade ≥ B (26.7% vs. 4.8%, p = 0.138).Conclusions: Pancreatojejunostomy using modified Blumgart anastomosis with a four-needle three-loop suture device and continuous suture for duct-to-mucosa anastomosis in patients undergoing RPD is simple and effective. This new suturing device may further reduce the incidence of postoperative pancreatic fistulas.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of vacuum-assisted wound closure and mesh-mediated fascial traction in open abdomen management. 真空辅助伤口闭合和网片筋膜牵引在开腹手术中的效果。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-07-24 DOI: 10.1007/s00595-024-02899-7

Kenta Shigeta, Shiei Kim, Ryuta Nakae, Yutaka Igarashi, Taigo Sakamoto, Tomoko Ogasawara, Tomohiko Masuno, Masatoku Arai, Shoji Yokobori

{"title":"Effectiveness of vacuum-assisted wound closure and mesh-mediated fascial traction in open abdomen management.","authors":"Kenta Shigeta, Shiei Kim, Ryuta Nakae, Yutaka Igarashi, Taigo Sakamoto, Tomoko Ogasawara, Tomohiko Masuno, Masatoku Arai, Shoji Yokobori","doi":"10.1007/s00595-024-02899-7","DOIUrl":"https://doi.org/10.1007/s00595-024-02899-7","url":null,"abstract":"Purpose: To determine the effectiveness of vacuum-assisted wound closure and mesh-mediated fascial traction (VAWCM) in patients undergoing open abdomen management (OAM).Methods: Data from cases with OAM for at least five days who were admitted to our institution between January 2011 and December 2020 were included. We compared the patient's age, sex, medical history, indication for initial surgery, APACHE II scores, indication for OAM, operative time, intraoperative blood loss, intraoperative transfusion, success of primary fascial closure (rectus fascial closure and bilateral anterior rectus abdominis sheath turnover flap method), success of planned ventral hernia, duration of OAM, and in-hospital mortality between patients undergoing VAWCM (VAWCM cases, n = 27) and vacuum-assisted wound closure (VAWC) alone (VAWC cases, n = 25).Results: VAWCM cases had a significantly higher success rate of primary fascial closure (70% vs. 36%, p = 0.030) and lower in-hospital mortality (26% vs. 72%, p = 0.002) than VAWC cases. A multivariate logistic regression analysis showed that VAWCM was an independent factor influencing in-hospital mortality (odds ratio, 0.14; 95% confidence interval: 0.04-0.53; p = 0.004).Conclusion: VAWCM is associated with an increased rate of successful primary fascial closure and may reduce in-hospital mortality.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Key Ripper: a specialized fixed suture-cutting device to facilitate drain removal. 钥匙撕裂器：一种专门的固定缝线切割装置，用于方便移除引流管。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-07-20 DOI: 10.1007/s00595-024-02897-9

Shogo Nagamatsu, Ayano Sasaki, Yumiwo Fujioka, Yoshiaki Shibata, Ken Nomimura, Yuki Aoki, Isao Koshima

引用次数: 0

Long-term outcomes of below-the-knee bypass surgery using heparin-bonded expanded polytetrafluoroethylene grafts. 使用肝素粘合膨体聚四氟乙烯移植物进行膝下搭桥手术的长期疗效。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-07-17 DOI: 10.1007/s00595-024-02898-8

Yohei Yamamoto, Hidetoshi Uchiyama, Masahiro Oonuki, Kazuki Tsukuda, Ai Kazama, Yoshiki Wada, Hiroki Uchiyama, Toru Kikuchi, Masato Nishizawa, Toshifumi Kudo

{"title":"Long-term outcomes of below-the-knee bypass surgery using heparin-bonded expanded polytetrafluoroethylene grafts.","authors":"Yohei Yamamoto, Hidetoshi Uchiyama, Masahiro Oonuki, Kazuki Tsukuda, Ai Kazama, Yoshiki Wada, Hiroki Uchiyama, Toru Kikuchi, Masato Nishizawa, Toshifumi Kudo","doi":"10.1007/s00595-024-02898-8","DOIUrl":"https://doi.org/10.1007/s00595-024-02898-8","url":null,"abstract":"Purpose: To report the outcomes of below-the-knee (BK) bypass surgery using heparin-bonded expanded polytetrafluoroethylene (ePTFE) grafts, performed in two centers since its launch in Japan.Methods: We conducted a retrospective analysis of databases from two medical centers, evaluating 51 limbs in 42 consecutive patients with peripheral arterial disease (PAD), who underwent BK bypass surgery using heparin-bonded ePTFE grafts between October, 2013 and April, 2023.Results: Thirty-three limbs (64.7%) were classified as Rutherford category 4-6 and 33 limbs (64.7%) had a history of ipsilateral revascularization. Technical success was achieved in 98% of the patients. The 30 day mortality rate was 2.4% (n = 1) and the overall 30 day complication rate was 9.5% (n = 4). The median follow-up period was 38 (interquartile range 13-67) months. Three patients required major amputation and 14 died during follow-up. Primary patency rates at 1, 3, and 5 years were 67.8%, 57.5%, and 46.5%, respectively, while secondary patency rates for these periods were 84.6%, 70.0%, and 66.0%, respectively. Overall survival rates at 1, 3, and 5 years were 90.1%, 74.5%, and 70.9%, respectively.Conclusions: BK bypass surgery using heparin-bonded ePTFE graft is a viable and durable option for patients with PAD, who are deemed unsuitable for autologous vein bypass surgery.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreas-left gastric artery angle predicts difficulty of suprapancreatic lymph node dissection in gastrectomy for gastric cancer: a cross-sectional study. 胰腺-胃左动脉角度预测胃癌胃切除术中胰上淋巴结清扫的难度：一项横断面研究。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-07-16 DOI: 10.1007/s00595-024-02890-2

Ryugo Teranishi, Tsuyoshi Takahashi, Yukinori Kurokawa, Takuro Saito, Kazuyoshi Yamamoto, Kota Momose, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki

{"title":"Pancreas-left gastric artery angle predicts difficulty of suprapancreatic lymph node dissection in gastrectomy for gastric cancer: a cross-sectional study.","authors":"Ryugo Teranishi, Tsuyoshi Takahashi, Yukinori Kurokawa, Takuro Saito, Kazuyoshi Yamamoto, Kota Momose, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki","doi":"10.1007/s00595-024-02890-2","DOIUrl":"https://doi.org/10.1007/s00595-024-02890-2","url":null,"abstract":"Purpose: Suprapancreatic lymph node dissection is one of the most challenging procedures performed in the treatment of gastric cancer. This study aimed to investigate whether the pancreas-left gastric artery angle (PLA) can be used to predict the difficulty of the procedure.Methods: This was a single-center cross-sectional study. Before gastrectomy, the patients were classified according to the size of the PLA into the small PLA (s-PLA; < 30°) and large PLA (l-PLA; ≥ 30°) groups in a surgeon-blinded manner. After gastrectomy, a surgeon evaluated suprapancreatic lymph node dissection as hard, normal, or easy to perform.Results: Seventy-three patients were enrolled in the study. Surgeons evaluated lymph node dissection as hard in 43.8 and 8.7% of patients in the s-PLA and l-PLA groups, respectively (p = 0.002). The time taken for suprapancreatic lymph node dissection was also significantly longer in the s-PLA group than in the l-PLA group (p = 0.040). In patients who underwent laparoscopic gastrectomy, the time for node dissection in the s-PLA group was also significantly longer than that in the s-PLA group (p = 0.021), while there was no difference in those who underwent robotic surgery (p = 0.815).Conclusion: PLA is useful for predicting the degree of difficulty of suprapancreatic lymph node dissection during gastrectomy for gastric cancer.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of hepatic steatosis with the preoperative treatment of pancreatic cancer and the short-term postoperative outcomes. 胰腺癌术前治疗的肝脂肪变性风险及术后短期疗效。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-07-09 DOI: 10.1007/s00595-024-02895-x

Kazuki Kobayashi, Yoji Kishi, Takazumi Tsunenari, Naoto Yonamine, Yasuhiro Takihata, Akiko Nakazawa, Mikiya Takao, Takahiro Einama, Hironori Tsujimoto, Hideki Ueno

{"title":"Risk of hepatic steatosis with the preoperative treatment of pancreatic cancer and the short-term postoperative outcomes.","authors":"Kazuki Kobayashi, Yoji Kishi, Takazumi Tsunenari, Naoto Yonamine, Yasuhiro Takihata, Akiko Nakazawa, Mikiya Takao, Takahiro Einama, Hironori Tsujimoto, Hideki Ueno","doi":"10.1007/s00595-024-02895-x","DOIUrl":"https://doi.org/10.1007/s00595-024-02895-x","url":null,"abstract":"Purpose: We investigated whether the preoperative treatment of patients with pancreatic cancer is a risk factor for hepatic steatosis (HS), and whether preoperative HS affects the short-term postoperative outcomes.Methods: Patients who underwent radical surgery for pancreatic cancer between 2010 and 2023 were enrolled. The patients' medical records were reviewed. Albumin and carbohydrate antigen 19-9 were measured before and after chemotherapy in the patients who received preoperative chemotherapy. A logistic regression univariate analysis was performed to analyze the factors associated with new-onset HS.Results: A total of 230 patients who underwent surgery were included. HS was observed on the date of surgery in 11 (10%) and two (2%) patients with and without preoperative chemotherapy, respectively. Female sex, initially borderline resectable or unresectable disease, history of cholangitis, presence of PEI, long-term (≥ 3 months) biliary drainage, preoperative chemotherapy, and serum albumin ≥ 3.9 mg/dl before chemotherapy were identified as risk factors for HS. The incidence of postoperative morbidity did not differ between the patients with and without preoperative steatosis.Conclusions: Preoperative chemotherapy, a history of cholangitis, the presence of PEI, and ≥ 3 months' duration of biliary drainage were risk factors for the development of HS before surgery for pancreatic cancer. However, preoperative HS did not affect the short-term postoperative outcomes.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive modeling for the germline pathogenic variant of the APC gene in patients with adenomatous polyposis: proposing a new APC score. 腺瘤性息肉病患者 APC 基因种系致病变体的预测模型：提出新的 APC 评分。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-07-06 DOI: 10.1007/s00595-024-02894-y

Misato Takao, Tatsuro Yamaguchi, Hidetaka Eguchi, Okihide Suzuki, Yoshiko Mori, Noriyasu Chika, Takeshi Yamada, Yasushi Okazaki, Naohiro Tomita, Tadashi Nomizu, Tomoyuki Momma, Tetsuji Takayama, Kohji Tanakaya, Kiwamu Akagi, Noriko Tanabe, Hideyuki Ishida

{"title":"Predictive modeling for the germline pathogenic variant of the APC gene in patients with adenomatous polyposis: proposing a new APC score.","authors":"Misato Takao, Tatsuro Yamaguchi, Hidetaka Eguchi, Okihide Suzuki, Yoshiko Mori, Noriyasu Chika, Takeshi Yamada, Yasushi Okazaki, Naohiro Tomita, Tadashi Nomizu, Tomoyuki Momma, Tetsuji Takayama, Kohji Tanakaya, Kiwamu Akagi, Noriko Tanabe, Hideyuki Ishida","doi":"10.1007/s00595-024-02894-y","DOIUrl":"https://doi.org/10.1007/s00595-024-02894-y","url":null,"abstract":"Background: The precise diagnosis and medical management of patients with suspected familial adenomatous polyposis should be based on genetic testing, which may not always be available. Therefore, establishing a new model for predicting the likelihood of a germline pathogenic variant (GPV) of APC based on its clinical manifestations could prove to be useful in clinical practice.Methods: The presence of GPVs of APC gene was investigated in 162 patients with adenomatous polyposis (≥ 10 polyps) using a multigene panel or single-gene testing. To generate a predictive model for GPV of the APC gene, a logistic regression analysis was performed using the clinicopathological variables available at the time of the diagnosis of adenomatous polyposis.Results: Ninety (55.6%) patients had GPV of the APC gene. According to a multivariate logistic regression analysis, age < 40 years, polyps ≥ 100, fundic gland polyposis, and a family history of colorectal polyposis were found to be independent predictors of the GPV of APC and were used to establish a formula for predicting the GPV of APC using the four predictors. The prediction model had an area under the curve of 0.91 (0.86-0.96) according to a receiver operating characteristic analysis.Conclusion: The model for predicting the GPV of APC will help patients with adenomatous polyposis and physicians make decisions about genetic testing.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nipple reconstruction using spiral-peeling technique during oncoplastic breast-conserving surgery for a patient with small breasts. 在为小乳房患者进行肿瘤整形保乳手术时，使用螺旋剥离技术重建乳头。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-07-05 DOI: 10.1007/s00595-024-02892-0

Yuko Kijima, Munetsugu Hirata, Naotomo Higo, Yumika Nakazawa, Kazuya Shinmura

引用次数: 0

Factors prolonging the operative time for transumbilical laparoscopic-assisted appendectomy in pediatric patients: a retrospective single-center study. 延长小儿经脐腹腔镜辅助阑尾切除术手术时间的因素：一项回顾性单中心研究。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-07-04 DOI: 10.1007/s00595-024-02896-w

Yohei Sanmoto, Yudai Goto, Kazuki Shirane, Akio Kawami, Kouji Masumoto

{"title":"Factors prolonging the operative time for transumbilical laparoscopic-assisted appendectomy in pediatric patients: a retrospective single-center study.","authors":"Yohei Sanmoto, Yudai Goto, Kazuki Shirane, Akio Kawami, Kouji Masumoto","doi":"10.1007/s00595-024-02896-w","DOIUrl":"https://doi.org/10.1007/s00595-024-02896-w","url":null,"abstract":"Purpose: Transumbilical laparoscopic-assisted appendectomy (TULAA) is one of the first endoscopic surgeries performed by trainee pediatric surgeons. While the operative time is generally shorter than for conventional laparoscopic appendectomy, the indications for this procedure are unclear and many unknown factors can prolong the operative time. We conducted this study to identify the factors that may prolong the operative time for TULAA.Methods: This retrospective, single-center study was conducted between 2015 and 2023. We performed multivariate analysis to identify the factors associated with prolonged operative time by analyzing TULAA procedures performed by trainees.Results: The study included 243 patients. The median operative time was 84 min (interquartile range, 69-114 min). Multivariate analysis revealed that an increased body mass index, elevated C-reactive protein level, a history of conservative treatment for acute appendicitis, and appendix perforation, for the patient; < 6 years' experience since graduation for the operating surgeon; and lack of board certification as a supervisor from the Japanese Society of Pediatric Surgeons for the attending surgeon were independent risk factors for prolonging the operative time.Conclusion: Having an attending surgeon with board certification as a supervisor by the Japanese Society of Pediatric Surgeons contributes to reducing the operative time required for TULAA.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of peripheral blood test parameters predicting the response to palbociclib and endocrine therapy for metastatic breast cancer: a retrospective study in a single institution. 鉴定预测转移性乳腺癌患者对帕博西尼（palbociclib）和内分泌治疗反应的外周血检测参数：一项在单一机构进行的回顾性研究。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-07-04 DOI: 10.1007/s00595-024-02893-z

Misato Yamamoto, Masahiro Shibata, Aya Tanaka, Nobuyuki Tsunoda, Norikazu Masuda

{"title":"Identification of peripheral blood test parameters predicting the response to palbociclib and endocrine therapy for metastatic breast cancer: a retrospective study in a single institution.","authors":"Misato Yamamoto, Masahiro Shibata, Aya Tanaka, Nobuyuki Tsunoda, Norikazu Masuda","doi":"10.1007/s00595-024-02893-z","DOIUrl":"https://doi.org/10.1007/s00595-024-02893-z","url":null,"abstract":"Purpose: Cyclin-dependent kinase 4/6 inhibitors have been used in endocrine therapy for patients with estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. Although randomized trials have shown that combined therapies prolong progression-free survival (PFS) in comparison to endocrine monotherapy, the predictors of efficacy are unknown. This study aimed to identify the blood test parameters to predict the effects of palbociclib and endocrine therapy.Methods: Seventy-nine patients treated with palbociclib and endocrine therapy between December 2017 and June 2022 were reviewed. We assessed PFS in patients according to factors evaluated based on patient characteristics and peripheral blood tests.Results: Patients in the C-reactive protein (CRP)-high, lactate dehydrogenase (LDH)-high, and albumin (Alb)-low groups had significantly shorter PFS than those in the normal group. A multivariate analysis revealed that high LDH and low Alb levels were independent factors that affected PFS. The Alb-low group had an inferior disease control rate. Patients in the CRP-high, LDH-high, and Alb-low groups who received these therapies as first- or second-line treatments showed poor PFS.Conclusions: Several predictors of the efficacy of palbociclib and endocrine therapy were identified in the peripheral blood test parameters of patients with ER-positive and HER2-negative subtypes of metastatic breast cancer.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0