Database study of risk factors for breast cancer-related lymphedema: a statistical analysis of 2359 cases over 10 years.

IF 1.6 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2025-05-01 Epub Date: 2024-11-19 DOI:10.1007/s00595-024-02960-5

Akihiro Matsumoto, Kai Ushio, Hiroaki Kimura, Shinichi Tomioka, Shinsuke Sasada, Makoto Asaeda, Yuki Nakashima, Koki Fukuhara, Yukio Mikami

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引用次数: 0

Abstract

Purpose: Identifying risk factors for breast cancer-related lymphedema (BCRL) is crucial for its prevention, necessitating large-scale epidemiological studies. Despite their suitability for large-scale surveys, to our knowledge, databases have not been the basis of any study done to investigate BCRL risk factors. This study aimed to test the hypothesis that a database-based study would be useful for identifying BCRL risk factors.

Methods: Patients with breast cancer diagnosed between April 2009 and March 2020 were identified from the Hiroshima University Hospital's medical database. This retrospective observational study validated the risk factors for BCRL using logistic regression analysis (p < 0.05).

Results: Among the total 4471 breast cancer patients identified, 2359 met the study criteria, with a BCRL incidence of 4.8%. Identified risk factors included obesity with a BMI of 25-30 (OR = 3.066, 95% CI 1.408-6.677), severe obesity with a BMI > 30 (OR = 5.791, 95% CI 2.239-14.97), surgical axillary lymph node dissection (OR = 3.212, 95% CI 1.918-5.378), chemotherapy with docetaxel (OR = 1.795, 95% CI 1.062-3.032), and conventional radiation to the breast or chest wall including lymph nodes in the irradiated area (OR = 3.299, 95% CI 1.842-5.910).

Conclusions: The BCRL risk factors identified by our database analysis were in line with those documented in previous studies, indicating the usefulness of database-based studies. Future studies should include more patients and study items.

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乳腺癌相关淋巴水肿风险因素的数据库研究：10 年间 2359 例病例的统计分析。

目的：确定乳腺癌相关淋巴水肿（BCRL）的风险因素对于预防乳腺癌相关淋巴水肿至关重要，因此有必要进行大规模的流行病学研究。尽管数据库适用于大规模调查，但据我们所知，还没有任何研究以数据库为基础来调查乳腺癌相关淋巴水肿的风险因素。本研究旨在验证一个假设，即基于数据库的研究将有助于确定 BCRL 风险因素：方法：从广岛大学医院的医疗数据库中筛选出 2009 年 4 月至 2020 年 3 月期间确诊的乳腺癌患者。这项回顾性观察研究采用逻辑回归分析法验证了 BCRL 的风险因素（P 结果）：在已确认的 4471 名乳腺癌患者中，有 2359 人符合研究标准，BCRL 发生率为 4.8%。确定的风险因素包括肥胖，BMI 为 25-30（OR = 3.066，95% CI 1.408-6.677）；严重肥胖，BMI > 30（OR = 5.791，95% CI 2.239-14.97）；手术腋窝淋巴结清扫（OR = 3.212，95% CI 1.918-5.378）、多西他赛化疗（OR = 1.795，95% CI 1.062-3.032）、乳房或胸壁常规放射治疗（包括照射区域的淋巴结）（OR = 3.299，95% CI 1.842-5.910）：我们的数据库分析确定的 BCRL 风险因素与以往研究中记录的因素一致，这表明基于数据库的研究非常有用。未来的研究应纳入更多的患者和研究项目。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.