Surgery Today最新文献_第6页

Appendectomy followed by two-stage right-sided colectomy with lymph node dissection for appendiceal cancer and risk factors for peritoneal recurrence: a single high-volume cancer center study in Japan. 阑尾切除术后两期右侧结肠切除术伴淋巴结清扫治疗阑尾癌和腹膜复发的危险因素：日本一项单一的大容量癌症中心研究。

IF 1.6 4区医学

Surgery Today Pub Date : 2025-09-01 Epub Date: 2025-03-28 DOI: 10.1007/s00595-025-03031-z

Kentaro Sato, Shimpei Matsui, Manabu Takamatsu, Tatsuki Noguchi, Takashi Sakamoto, Toshiki Mukai, Tomohiro Yamaguchi, Takashi Akiyoshi

{"title":"Appendectomy followed by two-stage right-sided colectomy with lymph node dissection for appendiceal cancer and risk factors for peritoneal recurrence: a single high-volume cancer center study in Japan.","authors":"Kentaro Sato, Shimpei Matsui, Manabu Takamatsu, Tatsuki Noguchi, Takashi Sakamoto, Toshiki Mukai, Tomohiro Yamaguchi, Takashi Akiyoshi","doi":"10.1007/s00595-025-03031-z","DOIUrl":"10.1007/s00595-025-03031-z","url":null,"abstract":"Purpose: Few studies have evaluated whether the timing of colectomy affects the prognosis of appendiceal cancer. This study compared long-term outcomes and recurrence patterns between initial appendectomy followed by two-stage colectomy and one-stage colectomy for appendiceal cancer.Methods: We retrospectively evaluated 65 patients who underwent 2-stage (n = 17) or 1-stage (n = 48) right-sided colectomy with lymph node dissection for stage 0-III appendiceal cancer between August 2005 and December 2022. The recurrence types and risk factors were compared.Results: The 2-stage colectomy group had a more advanced disease stage than the 1-stage group (stage III cases: 29.4% vs. 14.6%, P = 0.03). The 5-year overall recurrence rates were similar between the groups (29.4% vs. 19.2%, P = 0.39). All peritoneal recurrence cases (n = 9) had pT3 or T4 depth. Among pT3 and T4 cases (n = 46), the peritoneal recurrence rates did not differ significantly (31.2% vs. 13.8%, P = 0.17). A multivariate analysis identified preoperative serum CA19-9 level of > 37 ng/mL (hazard ratio [HR], 35.4; 95% confidence interval [CI], 3.08-406.8; P = 0.004) and lymph node metastasis (HR, 42.6; 95% CI, 9.90-183.6; P < 0.001) as independent risk factors for peritoneal recurrence.Conclusions: Serum CA19-9 levels and lymph node metastasis are risk factors for peritoneal recurrence. The effect of colectomy timing on recurrence was not definitive.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"1303-1312"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of intraoperative and postoperative air leakage in anatomical pulmonary resection. 解剖肺切除术术中及术后漏气的预测因素。

IF 1.6 4区医学

Surgery Today Pub Date : 2025-09-01 Epub Date: 2025-03-03 DOI: 10.1007/s00595-025-03004-2

Jotaro Yusa, Kazuhisa Tanaka, Yuki Sata, Takahide Toyoda, Terunaga Inage, Hajime Tamura, Masako Chiyo, Yukiko Matsui, Ichiro Yoshino, Hidemi Suzuki

{"title":"Predictors of intraoperative and postoperative air leakage in anatomical pulmonary resection.","authors":"Jotaro Yusa, Kazuhisa Tanaka, Yuki Sata, Takahide Toyoda, Terunaga Inage, Hajime Tamura, Masako Chiyo, Yukiko Matsui, Ichiro Yoshino, Hidemi Suzuki","doi":"10.1007/s00595-025-03004-2","DOIUrl":"10.1007/s00595-025-03004-2","url":null,"abstract":"Purpose: Air leakage is a common complication of lung surgery that sometimes requires medical intervention and leads to a prolonged hospital stay. This study assessed the risk factors associated with air leakage following anatomical pulmonary resection.Methods: We retrospectively analyzed 194 patients who underwent anatomical pulmonary resection in 2020. A risk factor analysis was performed separately for intraoperative air leakage (IAL) and postoperative air leakage (PAL) by examining patient characteristics and operative findings.Results: Of 194 patients, IAL was observed in 94 (48.4%). The number of staplers used for pulmonary resection and Brinkman index were significantly higher in the IAL group than in the non-IAL group (3.2 vs. 2.5, p = 0.005 and 696.2 vs. 477.1, p = 0.013, respectively). PAL was observed in 40 (20.6%) patients (25 IAL and 15 non-IAL patients). There were more lobectomy cases in the PAL group than in the non-PAL group (77.5 vs 60.4%, p = 0.0447). Pleurodesis was performed in 18 (45%) patients in the PAL group.Conclusion: The risk factors differed between IAL and PAL. Since most PAL cases involve the IAL, and approximately half of the PAL cases require pleurodesis, attention should be paid to PAL prevention, especially during stapling procedures in the lung parenchyma.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"1226-1234"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncoplastic breast-conserving surgery using a modified Grisotti's flap for a patient with central breast cancer in a non-ptotic breast. 改良格里索蒂皮瓣用于非上睑下垂乳腺中心癌的保乳手术。

IF 1.6 4区医学

Surgery Today Pub Date : 2025-09-01 Epub Date: 2025-04-25 DOI: 10.1007/s00595-025-03047-5

Yuko Kijima, Munetsugu Hirata, Yumika Nakazawa, Kazuya Shinmura, Naoki Hayashi, Ryunosuke Kijima, Hisamitsu Zaha

引用次数: 0

Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath. QuPath定量定量胸内孤立性纤维性肿瘤成纤维细胞活化蛋白免疫组化染色。

IF 1.6 4区医学

Surgery Today Pub Date : 2025-09-01 Epub Date: 2025-03-24 DOI: 10.1007/s00595-025-03024-y

Akiisa Omura, Toru Kimura, Tomohiro Maniwa, Tadashi Watabe, Keiichiro Honma, Yasushi Shintani, Jiro Okami

{"title":"Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath.","authors":"Akiisa Omura, Toru Kimura, Tomohiro Maniwa, Tadashi Watabe, Keiichiro Honma, Yasushi Shintani, Jiro Okami","doi":"10.1007/s00595-025-03024-y","DOIUrl":"10.1007/s00595-025-03024-y","url":null,"abstract":"Purpose: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP) is a serine protease, overexpressed in various cancers, which has been explored as a diagnostic and therapeutic target. We analyzed patients who underwent resection of an intrathoracic SFT, including metastatic pulmonary nodules from extrathoracic organs.Methods: The subjects of this retrospective study were seven patients with a primary SFT and two with metastatic SFTs in the lungs. After immunohistochemical staining of the resected tumors, quantification of the stained area was performed using QuPath.Results: Immunohistochemical quantification of FAP showed that it was expressed to varying degrees in the intrathoracic SFTs, with higher expression levels observed in metastatic SFTs than in primary pleural SFTs. Pathological examination confirmed the expression of FAP.Conclusion: Our results support the potential usefulness of FAP in the diagnosis of intrathoracic SFTs, including metastatic pulmonary nodules.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"1269-1273"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projection of future demand for non-cancerous gastrointestinal surgery in Japan: challenges and workforce planning in an aging society. 日本未来对非癌性胃肠手术的需求预测：老龄化社会的挑战和劳动力规划。

IF 1.6 4区医学

Surgery Today Pub Date : 2025-09-01 Epub Date: 2025-03-20 DOI: 10.1007/s00595-025-03027-9

Masakazu Fujii, Toru Nakamura, Yasuyuki Okumura, Yoichi M Ito, Toshimichi Asano, Satoshi Hirano

{"title":"Projection of future demand for non-cancerous gastrointestinal surgery in Japan: challenges and workforce planning in an aging society.","authors":"Masakazu Fujii, Toru Nakamura, Yasuyuki Okumura, Yoichi M Ito, Toshimichi Asano, Satoshi Hirano","doi":"10.1007/s00595-025-03027-9","DOIUrl":"10.1007/s00595-025-03027-9","url":null,"abstract":"Purpose: Japan's aging population poses challenges for balancing healthcare demands and workforce supply. The aim of this study was to project the future demand for major non-cancerous gastrointestinal surgeries such as cholecystectomy, inguinal hernia repair, and appendectomy up until 2050 and examine the impact of a shrinking working-age population on surgical workforce needs.Methods: We used data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan Open Data (2018-2022) and population projections to calculate age- and sex-specific procedure rates. These rates were applied to population forecasts for 2030, 2040, and 2050 under high, low, and average demand scenarios. Working-age population (15-65 years) trends were included for comparison.Results: The projected demand for appendectomy, most common in people aged 20-39, is expected to decrease by 16.6% by 2050, whereas cholecystectomy and inguinal hernia repair demand, concentrated in people aged 60 and above, are projected to decrease by 5.8% and 7.1%, respectively. The working-age population is anticipated to decline by 25.3%, potentially posing significant challenges to maintaining an adequate surgical workforce.Conclusions: While the absolute number of gastrointestinal surgeries is projected to decrease, Japan faces substantial demographic changes that may impact surgical workforce capacity. Strategic workforce planning is essential to address these demographic challenges.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"1262-1268"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of social media on the career choices of medical students and junior residents in Japan: a prospective study to strategize an increase in the number of aspiring surgeons. 社交媒体对日本医学生和初级住院医师职业选择的影响：一项前瞻性研究，旨在为有抱负的外科医生数量的增加制定策略。

IF 1.6 4区医学

Surgery Today Pub Date : 2025-09-01 Epub Date: 2025-03-19 DOI: 10.1007/s00595-025-03023-z

Naoya Kitamura, Naru Kitade, Ryo Yokoyama, Toshihiro Ojima, Koichiro Shimoyama, Keitaro Tanabe, Yoshifumi Shimada, Yushi Akemoto, Yoshinori Doki, Tomoshi Tsuchiya

{"title":"Impact of social media on the career choices of medical students and junior residents in Japan: a prospective study to strategize an increase in the number of aspiring surgeons.","authors":"Naoya Kitamura, Naru Kitade, Ryo Yokoyama, Toshihiro Ojima, Koichiro Shimoyama, Keitaro Tanabe, Yoshifumi Shimada, Yushi Akemoto, Yoshinori Doki, Tomoshi Tsuchiya","doi":"10.1007/s00595-025-03023-z","DOIUrl":"10.1007/s00595-025-03023-z","url":null,"abstract":"Purpose: To identify the most effective use of social media to increase the number of aspiring surgeons, we evaluated the impact of social media on the career choices of medical students and junior residents.Methods: We conducted a single-center prospective observational questionnaire-based study on medical students and junior residents from March, 2023 to August, 2024. Following overall aggregation, statistical intergroup comparisons were made between students and junior residents, as well as between those who were, or were not influenced by social media.Results: Among the 101 participants (77 students, 24 junior residents), approximately 75% reported that social media influenced their career choices. The most frequently used platforms were YouTube (85.1%), Instagram (71.3%), and X (67.3%). A total of 46.5% of the respondents expressed an interest in surgical specialties. Junior residents were more likely than students to gather information related to medicine (p = 0.0442). The group influenced by social media showed a higher interest in surgical specialties (p = 0.0475), and many desired parental leave policies to increase the number of surgeons (p = 0.0376).Conclusion: Social media influences the career choices of medical students and junior residents, and its effective use could increase the number of aspiring surgeons.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"1252-1261"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motivations and factors influencing the choice of a career as a thoracic surgeon in Japan: results of a nationwide questionnaire survey. 影响日本胸外科医生职业选择的动机和因素：一项全国性问卷调查的结果。

IF 1.6 4区医学

Surgery Today Pub Date : 2025-08-30 DOI: 10.1007/s00595-025-03111-0

Takahiro Homma, Ryota Tanaka, Shota Nakamura, Masato Aragaki, Toyofumi Fengshi Chen-Yoshikawa, Tatsuya Kato, Hisahi Saji

{"title":"Motivations and factors influencing the choice of a career as a thoracic surgeon in Japan: results of a nationwide questionnaire survey.","authors":"Takahiro Homma, Ryota Tanaka, Shota Nakamura, Masato Aragaki, Toyofumi Fengshi Chen-Yoshikawa, Tatsuya Kato, Hisahi Saji","doi":"10.1007/s00595-025-03111-0","DOIUrl":"https://doi.org/10.1007/s00595-025-03111-0","url":null,"abstract":"Purpose: Addressing the decline in the number of surgeons in Japan and an uneven specialty distribution is crucial for a sustainable working environment. We conducted this study to investigate the motivations behind the choice of medical specialty among thoracic surgeons across multiple institutions in Japan.Methods: A nationwide online questionnaire survey was distributed by the Japanese Association for Surgical Education's thoracic surgery working group, targeting all thoracic surgeons.Results: Of the 725 respondents, 95.6% decided on thoracic surgery after starting clinical training. The key influencing factors included respectful supervisors and seniors (79.3%), procedures (78.1%), organs (77.9%), diseases (75.4%), and atmosphere (70.3%). The final deciding factors were procedures (37.1%), atmosphere (17.0%), and organs (11.2%), with work-life balance reported by 7.0%. More thoracic surgeons in the 20 s-30 s age group than those in the over 40 s age group prioritized procedures (47.3% vs 31.5%; P < 0.0001), organs (14.3% vs 9.4%; P = 0.049), and work-life balance (11.2% vs 4.7%; P = 0.0014). Only 9.2% of respondents chose a career in thoracic surgery exclusively, whereas 90.8% considered other specialties (81.3% surgical, 18.7% non-surgical).Conclusion: This survey revealed that the broad appeal of thoracic surgery often attracted individuals from diverse backgrounds, sometimes after they had considered other specialties. Increasing the number of thoracic surgeons requires promoting its appeal and fostering a positive work and educational environment.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward equitable parenting in surgery: a response to commentary on the "Daddy Surgeon" case study. 外科手术中的公平育儿：对“爸爸外科医生”案例研究评论的回应。

IF 1.6 4区医学

Surgery Today Pub Date : 2025-08-28 DOI: 10.1007/s00595-025-03115-w

Nobuhiko Kanaya, Shinji Kuroda, Yoshitaka Kondo, Yuko Takehara, Toshiyoshi Fujiwara

引用次数: 0

Use of a reinforced triple-row stapler with a powered stapling system reduces the occurrence of postoperative pancreatic fistula after distal pancreatectomy. 使用带动力吻合器系统的强化三排吻合器可减少远端胰腺切除术后胰瘘的发生。

IF 1.6 4区医学

Surgery Today Pub Date : 2025-08-27 DOI: 10.1007/s00595-025-03123-w

Shinjiro Kobayashi, Keisuke Ida, Saori Umezawa, Kazunari Nakahara, Keisuke Tateishi, Tomoko Norose, Nobuyuki Ohike, Tsuyoshi Morimoto, Shinya Mikami, Takehito Otsubo

{"title":"Use of a reinforced triple-row stapler with a powered stapling system reduces the occurrence of postoperative pancreatic fistula after distal pancreatectomy.","authors":"Shinjiro Kobayashi, Keisuke Ida, Saori Umezawa, Kazunari Nakahara, Keisuke Tateishi, Tomoko Norose, Nobuyuki Ohike, Tsuyoshi Morimoto, Shinya Mikami, Takehito Otsubo","doi":"10.1007/s00595-025-03123-w","DOIUrl":"https://doi.org/10.1007/s00595-025-03123-w","url":null,"abstract":"Purpose: Stapled closure is the standard technique for pancreatic resection via distal pancreatectomy (DP). The Signia™ Stapling System allows for adaptive stapling based on real-time tissue resistance. This study aims to investigate whether DP using the Signia™ system could reduce the incidence of clinically relevant post-operative pancreatic fistula (CR-POPF).Methods: We retrospectively analyzed 53 patients who underwent DP between 2020 and 2025. 26 patients underwent DP using the Signia™ Stapling System (powered stapler group), and 27 patients using a manual stapler (manual stapler group). The primary outcome was the CR-POPF rate.Results: In the powered stapler group, 38.5% of patients developed biochemical leakage, but no cases of CR-POPF were observed. In contrast, the manual stapler group had a CR-POPF rate of 18.5% (p = 0.021). A receiver operating characteristic curve was generated to determine the pancreatic thickness threshold predictive of CR-POPF. The calculated cut-off value was 16 mm. In the powered group, there were no cases of CR-POPF even if the pancreatic thickness at the resection line was ≥ 16 mm.Conclusions: The use of a powered stapler may therefore help reduce the risk of POPF associated with variability in the thickness and hardness of the pancreas during DP.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative chemotherapy with a modified docetaxel, cisplatin, and S-1 regimen, followed by gastrectomy and lymphadenectomy for gastric cancer with bulky lymph nodes. 术前化疗采用改良的多西紫杉醇、顺铂和S-1方案，对伴有肿大淋巴结的胃癌进行胃切除术和淋巴结切除术。

IF 1.6 4区医学

Surgery Today Pub Date : 2025-08-25 DOI: 10.1007/s00595-025-03114-x

Vo Duy Long, Dang Quang Thong, Tran Quang Dat, Doan Thuy Nguyen, Tran Vinh Tho, Tran Duy Phuoc, Nguyen Viet Hai, Nguyen Lam Vuong, Lam Quoc Trung, Nguyen Hoang Bac

{"title":"Preoperative chemotherapy with a modified docetaxel, cisplatin, and S-1 regimen, followed by gastrectomy and lymphadenectomy for gastric cancer with bulky lymph nodes.","authors":"Vo Duy Long, Dang Quang Thong, Tran Quang Dat, Doan Thuy Nguyen, Tran Vinh Tho, Tran Duy Phuoc, Nguyen Viet Hai, Nguyen Lam Vuong, Lam Quoc Trung, Nguyen Hoang Bac","doi":"10.1007/s00595-025-03114-x","DOIUrl":"https://doi.org/10.1007/s00595-025-03114-x","url":null,"abstract":"Purpose: The appropriate regimen and dosage of preoperative chemotherapy for gastric cancer (GC) with bulky lymph nodes (LNs) remain controversial. We conducted this study to evaluate the efficacy of preoperative chemotherapy using a modified regimen of docetaxel, cisplatin, and S-1 (DCS) for GC with bulky LNs, assessing feasibility, toxicity, response rate, and oncological outcomes.Methods: Thirty-two patients who had GC with bulky LNs diagnosed between Jan, 2018 and Oct, 2022 received three or four cycles of modified DCS regimen preoperatively. The primary outcome was 3 year overall survival (OS).Results: The completion rate of preoperative chemotherapy was 90.6% (4 cycles: 50.0%, 3 cycles: 40.6%). The disease control rate (DCR) and clinical response rate (RR) were 87.5% and 81.3%, respectively. Grade-3/4 neutropenia and anemia developed in 6.2% and 9.4%, respectively. Twenty-two patients with partial response (PR) agreed to undergo gastrectomy and LN dissection. Pathologic complete response (CR) was achieved in 15.6%. After surgery, there were no grade > = 3 postoperative complications. The R0-resection rate was 65.6%. The 3 year OS and progression-free survival (PFS) rates were 43.0% and 37%, respectively, for all eligible patients. The 3 year OS and PFS of patients in the surgery group with negative para-aortic LNs were 58% and 47.0%, respectively.Conclusion: Preoperative chemotherapy with a modified DCS regimen demonstrated high tolerance, a clinical response rate, and satisfactory 3 year survival outcomes. Thus, a preoperative modified DCS regimen with 3-4 cycles is a promising approach for GC with bulky LNs.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0