Clinical relevance of the red blood cell distribution width measured preoperatively as a prognostic marker in patients with distal cholangiocarcinoma undergoing pancreaticoduodenectomy.

IF 1.6 4区 医学 Q2 SURGERY
Surgery Today Pub Date : 2025-09-01 Epub Date: 2025-03-29 DOI:10.1007/s00595-025-03005-1
Maiko Niki, Shozo Mori, Shotaro Miyashita, Tomoaki Hayakawa, Genki Tanaka, Takayuki Shimizu, Takamune Yamaguchi, Kyung-Hwa Park, Takayuki Shiraki, Takatsugu Matsumoto, Taku Aoki
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Abstract

Purpose: The clinical relevance of the red blood cell distribution width (RDW) in patients with distal cholangiocarcinoma (DCC) undergoing pancreaticoduodenectomy (PD) has not been clearly investigated.

Methods: The relationship between the preoperatively measured RDW and prognosis for the recurrence/survival was evaluated in patients with DCC undergoing PD. A subgroup analysis was also performed in patients with pathological stage I DCC.

Results: A total of 77 patients were included in the analysis. The cutoff value of the preoperatively measured RDW was set at 14%, and the normal reference range at our center was ≤ 14%. The patient group with an RDW > 14% (n = 30) had a significantly lower mean serum albumin level, higher mean serum carbohydrate antigen 19-9 level, and a higher proportion of cases with pathological lymphatic invasion and showed a significantly worse overall survival than the patient group with an RDW ≤ 14% (n = 47). Similar findings were noted in both the overall study population and patients with pathological stage I disease. Multivariate analysis identified an RDW > 14% and pathological lymph node metastasis as independent risk factors for a poor postoperative survival.

Conclusion: The preoperatively measured RDW is a promising prognostic predictor in patients with DCC undergoing PD.

远端胆管癌行胰十二指肠切除术患者术前测定红细胞分布宽度作为预后指标的临床意义
目的:远端胆管癌(DCC)行胰十二指肠切除术(PD)患者红细胞分布宽度(RDW)的临床相关性尚未明确研究。方法:对行PD的DCC患者术前测量的RDW与复发/生存预后的关系进行评估。病理I期DCC患者也进行了亚组分析。结果:共纳入77例患者。术前测量的RDW临界值设为14%,我们中心的正常参考范围≤14%。RDW≤14%组(n = 30)的平均血清白蛋白水平明显低于RDW≤14%组(n = 47),平均血清碳水化合物抗原19-9水平明显高于RDW≤14%组(n = 47),病理性淋巴浸润比例较高。在总体研究人群和病理性I期疾病患者中也发现了类似的结果。多因素分析发现,RDW >.14%和病理性淋巴结转移是术后生存不良的独立危险因素。结论:术前测量的RDW是DCC行PD的预后预测指标。
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来源期刊
Surgery Today
Surgery Today 医学-外科
CiteScore
4.90
自引率
4.00%
发文量
208
审稿时长
1 months
期刊介绍: Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.
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