Clinical relevance of the red blood cell distribution width measured preoperatively as a prognostic marker in patients with distal cholangiocarcinoma undergoing pancreaticoduodenectomy.
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Abstract
Purpose: The clinical relevance of the red blood cell distribution width (RDW) in patients with distal cholangiocarcinoma (DCC) undergoing pancreaticoduodenectomy (PD) has not been clearly investigated.
Methods: The relationship between the preoperatively measured RDW and prognosis for the recurrence/survival was evaluated in patients with DCC undergoing PD. A subgroup analysis was also performed in patients with pathological stage I DCC.
Results: A total of 77 patients were included in the analysis. The cutoff value of the preoperatively measured RDW was set at 14%, and the normal reference range at our center was ≤ 14%. The patient group with an RDW > 14% (n = 30) had a significantly lower mean serum albumin level, higher mean serum carbohydrate antigen 19-9 level, and a higher proportion of cases with pathological lymphatic invasion and showed a significantly worse overall survival than the patient group with an RDW ≤ 14% (n = 47). Similar findings were noted in both the overall study population and patients with pathological stage I disease. Multivariate analysis identified an RDW > 14% and pathological lymph node metastasis as independent risk factors for a poor postoperative survival.
Conclusion: The preoperatively measured RDW is a promising prognostic predictor in patients with DCC undergoing PD.
期刊介绍：
Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it").
The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.
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