Surgery Today最新文献_第3页

The prevalence and risk factors associated with zinc deficiency after pancreatic surgery. 胰腺手术后锌缺乏症的发病率和相关风险因素。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-09-02 DOI: 10.1007/s00595-024-02935-6

Chihoko Nobori, Ippei Matsumoto, Masaya Nakano, Katsuya Ami, Yuta Yoshida, Dongha Lee, Takaaki Murase, Keiko Kamei, Atsushi Takebe, Takuya Nakai, Yoshifumi Takeyama

{"title":"The prevalence and risk factors associated with zinc deficiency after pancreatic surgery.","authors":"Chihoko Nobori, Ippei Matsumoto, Masaya Nakano, Katsuya Ami, Yuta Yoshida, Dongha Lee, Takaaki Murase, Keiko Kamei, Atsushi Takebe, Takuya Nakai, Yoshifumi Takeyama","doi":"10.1007/s00595-024-02935-6","DOIUrl":"https://doi.org/10.1007/s00595-024-02935-6","url":null,"abstract":"Purpose: To clarify the prevalence, risk factors, and clinical implications associated with zinc deficiency in patients undergoing pancreatic surgery.Methods: The serum zinc levels were measured in 329 patients post-pancreatic surgery between January and April 2021. The postoperative serum zinc levels and clinicopathological variables were retrospectively analyzed.Results: The median serum zinc level was 73 µg/dL (33-218). Zinc deficiency (zinc level < 60 µg/dL) was observed in 52 patients (16%). A total of 329 patients were classified into zinc-deficient (n = 52) and non-deficient (zinc ≥ 60 µg/dL, n = 277) groups. A univariate analysis revealed significant differences in sex, postoperative body mass index, serum albumin, total cholesterol, creatinine, aspartate aminotransferase (AST), HbA1c levels, diabetes, surgical procedures, and operative blood loss. According to a multivariate analysis, male sex [odds ratio (OR) 3.70; 95% confidence interval (CI) 1.67-8.20; p = 0.001], postoperative serum albumin levels < 3.9 g/dL (OR 6.39; 95% CI 3.30-12.37; p < 0.001), postoperative serum AST ≥ 51 U/L (OR, 4.6; 95% CI 0.07-0.29; p < 0.001), and total pancreatectomy (OR 3.68; 95% CI 1.37-9.85; p = 0.009) were found to be independent predictors of zinc deficiency after pancreatic surgery.Conclusions: Zinc deficiency frequently occurs in patients undergoing pancreatic surgery. Lower postoperative zinc levels could be linked to sex, the serum albumin and AST levels, and surgery type.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes of 5-year survivors without recurrence after the complete resection of non-small cell lung cancer after lobectomy: a landmark analysis in consideration of competing risks. 非小细胞肺癌肺叶切除术后完全切除且未复发的 5 年存活者的长期预后：考虑竞争风险的里程碑式分析。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-09-01 Epub Date: 2024-03-02 DOI: 10.1007/s00595-024-02804-2

Yutaro Koike, Keiju Aokage, Masashi Wakabayashi, Takashi Ikeno, Ken Onodera, Joji Samejima, Tomohiro Miyoshi, Kenta Tane, Kenji Suzuki, Masahiro Tsuboi

{"title":"Long-term outcomes of 5-year survivors without recurrence after the complete resection of non-small cell lung cancer after lobectomy: a landmark analysis in consideration of competing risks.","authors":"Yutaro Koike, Keiju Aokage, Masashi Wakabayashi, Takashi Ikeno, Ken Onodera, Joji Samejima, Tomohiro Miyoshi, Kenta Tane, Kenji Suzuki, Masahiro Tsuboi","doi":"10.1007/s00595-024-02804-2","DOIUrl":"10.1007/s00595-024-02804-2","url":null,"abstract":"Purpose: Among non-small cell lung cancers (NSCLC), 5 years is a benchmark in cancer control and treatment, but a certain percentage of cases recur after 5 years. The long-term post-recurrence outcomes remain controversial. To examine the accurate prognostic factors associated with survival and cancer recurrence among 5-year survivors, a landmark analysis that considered competing risks was performed.Methods: Complete resection of NSCLC was performed in 2482 patients between January 2003 and December 2015. A total of 1431 patients were 5-year survivors without recurrence. A landmark time analysis was applied to the overall survival (OS) and recurrence-free survival (RFS) from 5 years after surgery, and the findings were calculated using the Kaplan-Meier method. The cumulative incidence of cause-specific death and recurrence was estimated using the cumulative incidence function, while carefully considering the competing risks.Results: Postoperative recurrence was detected in 732 patients, of whom 68 (9.3%) had recurrence after 5 years. The median follow-up period was 8.2 years. In the competing risk analysis, the independent poor prognostic factors associated with cause-specific death were age ≥ 75 years, lymph node metastasis and pleural invasion.Conclusions: Patients requiring a follow-up for > 5 years were aged ≥ 75 years and had either lymph node metastasis or pleural invasion.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncologic investigation of the interval from stent placement to surgery in patients with obstructive colorectal cancer. 阻塞性结直肠癌患者从支架植入到手术间隔时间的肿瘤学调查。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-09-01 Epub Date: 2024-03-25 DOI: 10.1007/s00595-024-02818-w

Shintaro Kanaka, Akihisa Matsuda, Takeshi Yamada, Yasuyuki Yokoyama, Satoshi Matsumoto, Goro Takahashi, Hiromichi Sonoda, Ryo Ohta, Kay Uehara, Seiichi Shinji, Takuma Iwai, Kohki Takeda, Kumiko Sekiguchi, Sho Kuriyama, Toshimitsu Miyasaka, Hiroshi Yoshida

{"title":"Oncologic investigation of the interval from stent placement to surgery in patients with obstructive colorectal cancer.","authors":"Shintaro Kanaka, Akihisa Matsuda, Takeshi Yamada, Yasuyuki Yokoyama, Satoshi Matsumoto, Goro Takahashi, Hiromichi Sonoda, Ryo Ohta, Kay Uehara, Seiichi Shinji, Takuma Iwai, Kohki Takeda, Kumiko Sekiguchi, Sho Kuriyama, Toshimitsu Miyasaka, Hiroshi Yoshida","doi":"10.1007/s00595-024-02818-w","DOIUrl":"10.1007/s00595-024-02818-w","url":null,"abstract":"Purpose: Self-expandable metallic stent (SEMS) placement is widely used as a bridge to surgery (BTS) procedure for obstructive colorectal cancer. However, evidence regarding the optimal interval between SEMS placement and elective surgery is lacking.Methods: We retrospectively collected data from patients with BTS between January 2013 and October 2021. Inverse probability treatment-weighted propensity score analyses were used to compare short- and long-term outcomes between the short-interval (SI) and long-interval (LI) groups, using a cutoff of 20 days.Results: In total, 138 patients were enrolled in this study (SI group, n = 63; LI group, n = 75). In the matched cohort, the patients' backgrounds were well balanced. The incidence of Clavien-Dindo grade ≥ II postoperative complications was not significantly different between the SI and LI groups (19.0% vs. 14.0%, P = 0.47). There were no significant differences between the SI and LI groups in the 3-year recurrence-free survival (68.0% vs. 76.4%, P = 0.73) or 3-year overall survival rates (86.0% vs. 90.6%, P = 0.72).Conclusions: A longer interval did not deteriorate the oncological outcomes. Individual perioperative management with an appropriate interval to improve the patient's condition is required to ensure safe surgery.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of treatment guidelines and pivotal clinical trial results on a surgeon's decision regarding treatment for gastric cancer: a retrospective cohort study using the National Clinical Database. 治疗指南和关键临床试验结果对外科医生做出胃癌治疗决定的影响：利用国家临床数据库进行的回顾性队列研究。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-09-01 Epub Date: 2024-02-24 DOI: 10.1007/s00595-024-02814-0

Souya Nunobe, Hideki Endo, Michitaka Honda, Masayuki Watanabe, Hiroyuki Yamamoto, Shingo Kanaji, Yoshihiro Kakeji, Yasuhiro Kodera, Yuko Kitagawa

{"title":"Impact of treatment guidelines and pivotal clinical trial results on a surgeon's decision regarding treatment for gastric cancer: a retrospective cohort study using the National Clinical Database.","authors":"Souya Nunobe, Hideki Endo, Michitaka Honda, Masayuki Watanabe, Hiroyuki Yamamoto, Shingo Kanaji, Yoshihiro Kakeji, Yasuhiro Kodera, Yuko Kitagawa","doi":"10.1007/s00595-024-02814-0","DOIUrl":"10.1007/s00595-024-02814-0","url":null,"abstract":"Purposes: The present study evaluated the impact of clinical guidelines for gastric cancer surgery on surgeons' choice of procedure in real-world practice. We focused on the 2014 guideline revision recommending laparoscopic surgery and the evidence concerning splenectomy for prophylactic lymphadenectomy reported in 2015 using the National Clinical Database, which is the most comprehensive database in Japan.Methods: We investigated the monthly percentages of laparoscopic distal gastrectomies performed for stage I gastric cancer (LDG%) and splenectomies performed during total gastrectomy for advanced cancer (TGS%) between 2014 and 2017. We evaluated the descriptive statistics of the time-series changes in the LDG%, TGS%, and annual trends of outcomes.Results: In total, 124,787 patients were enrolled. The mean LDG% and TGS% were 69.8% and 9.2%, respectively. The LDG% and TGS% were 66.4% and 16.7%, respectively, in January 2014 and 73.1% and 5.9%, respectively, in December 2017. LDG% consistently increased, and TGS% showed a consistent downward trend throughout the observation period. There was no significant change in this trend after the publication of the guideline recommendations or clinical trial results.Conclusion: No significant changes in surgical procedures were observed after publication of the guidelines or results of clinical trials.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of anterior gastropexy in elderly Japanese hiatal hernia patients. 前胃切除术在日本老年食管裂孔疝患者中的作用。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-09-01 Epub Date: 2024-03-22 DOI: 10.1007/s00595-024-02809-x

Takashi Yokouchi, Kiyokazu Nakajima, Tsuyoshi Takahashi, Kotaro Yamashita, Takuro Saito, Koji Tanaka, Kazuyoshi Yamamoto, Tomoki Makino, Yukinori Kurokawa, Hidetoshi Eguchi, Yuichiro Doki

{"title":"The role of anterior gastropexy in elderly Japanese hiatal hernia patients.","authors":"Takashi Yokouchi, Kiyokazu Nakajima, Tsuyoshi Takahashi, Kotaro Yamashita, Takuro Saito, Koji Tanaka, Kazuyoshi Yamamoto, Tomoki Makino, Yukinori Kurokawa, Hidetoshi Eguchi, Yuichiro Doki","doi":"10.1007/s00595-024-02809-x","DOIUrl":"10.1007/s00595-024-02809-x","url":null,"abstract":"Purpose: As Japanese society ages, the number of surgeries performed in elderly patients with hiatal hernia (HH) is increasing. In this study, we examined the feasibility, safety, and potential effectiveness of the addition of anterior gastropexy to hiatoplasty with or without mesh repair and/or fundoplication in elderly Japanese HH patients.Methods: We retrospectively evaluated 39 patients who underwent laparoscopic HH repair between 2010 and 2021. We divided them into 2 groups according to age: the \"younger\" group (< 75 years old, n = 21), and the \"older\" group (≥ 75 years old, n = 18). The patient characteristics, intraoperative data, and postoperative results were collected.Results: The median ages were 68 and 82 years old in the younger and older groups, respectively, and the female ratio was similar between the groups (younger vs. older: 67% vs. 78%, p = 0.44). The older group had more type III/IV HH cases than the younger group (19% vs. 83%, p < 0.001). The operation time was longer in the older group than in the younger group, but there was no significant difference in blood loss, perioperative complications, or postoperative length of stay between the groups. The older group had significantly more cases of anterior gastropexy (0% vs. 78%, p < 0.001) and less fundoplication (100% vs. 67%, p = 0.004) than the younger group. There was no significant difference in HH recurrence between the groups (5% vs. 11%, p = 0.46).Conclusions: The addition of anterior gastropexy to other procedures is feasible, safe, and potentially effective in elderly Japanese patients with HH.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutting-edge regenerative therapy for Hirschsprung disease and its allied disorders. 治疗赫氏胃肠病及其相关疾病的尖端再生疗法。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-09-01 Epub Date: 2023-09-05 DOI: 10.1007/s00595-023-02741-6

Koichiro Yoshimaru, Toshiharu Matsuura, Yasuyuki Uchida, Soichiro Sonoda, Shohei Maeda, Keisuke Kajihara, Yuki Kawano, Takeshi Shirai, Yukihiro Toriigahara, Alvin Santoso Kalim, Xiu-Ying Zhang, Yoshiaki Takahashi, Naonori Kawakubo, Kouji Nagata, Haruyoshi Yamaza, Takayoshi Yamaza, Tomoaki Taguchi, Tatsuro Tajiri

{"title":"Cutting-edge regenerative therapy for Hirschsprung disease and its allied disorders.","authors":"Koichiro Yoshimaru, Toshiharu Matsuura, Yasuyuki Uchida, Soichiro Sonoda, Shohei Maeda, Keisuke Kajihara, Yuki Kawano, Takeshi Shirai, Yukihiro Toriigahara, Alvin Santoso Kalim, Xiu-Ying Zhang, Yoshiaki Takahashi, Naonori Kawakubo, Kouji Nagata, Haruyoshi Yamaza, Takayoshi Yamaza, Tomoaki Taguchi, Tatsuro Tajiri","doi":"10.1007/s00595-023-02741-6","DOIUrl":"10.1007/s00595-023-02741-6","url":null,"abstract":"Hirschsprung disease (HSCR) and its associated disorders (AD-HSCR) often result in severe hypoperistalsis caused by enteric neuropathy, mesenchymopathy, and myopathy. Notably, HSCR involving the small intestine, isolated hypoganglionosis, chronic idiopathic intestinal pseudo-obstruction, and megacystis-microcolon-intestinal hypoperistalsis syndrome carry a poor prognosis. Ultimately, small-bowel transplantation (SBTx) is necessary for refractory cases, but it is highly invasive and outcomes are less than optimal, despite advances in surgical techniques and management. Thus, regenerative therapy has come to light as a potential form of treatment involving regeneration of the enteric nervous system, mesenchyme, and smooth muscle in affected areas. We review the cutting-edge regenerative therapeutic approaches for managing HSCR and AD-HSCR, including the use of enteric nervous system progenitor cells, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells as cell sources, the recipient intestine's microenvironment, and transplantation methods. Perspectives on the future of these treatments are also discussed.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10210877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of perioperative changes in the prognostic nutritional index in patients with surgically resected non-small cell lung cancer. 手术切除非小细胞肺癌患者围手术期营养指数变化的预后价值。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-09-01 Epub Date: 2024-05-03 DOI: 10.1007/s00595-024-02847-5

Kazuki Hayasaka, Hirotsugu Notsuda, Ken Onodera, Tatsuaki Watanabe, Yui Watanabe, Takaya Suzuki, Takashi Hirama, Hisashi Oishi, Hiromichi Niikawa, Yoshinori Okada

{"title":"Prognostic value of perioperative changes in the prognostic nutritional index in patients with surgically resected non-small cell lung cancer.","authors":"Kazuki Hayasaka, Hirotsugu Notsuda, Ken Onodera, Tatsuaki Watanabe, Yui Watanabe, Takaya Suzuki, Takashi Hirama, Hisashi Oishi, Hiromichi Niikawa, Yoshinori Okada","doi":"10.1007/s00595-024-02847-5","DOIUrl":"10.1007/s00595-024-02847-5","url":null,"abstract":"Purpose: This single-institution retrospective cohort study was conducted to assess the prognostic significance of perioperative changes in the prognostic nutritional index (PNI) in patients who underwent surgery for non-small cell lung cancer (NSCLC).Methods: Clinicopathological data were collected from 441 patients who underwent lobectomy for NSCLC between 2010 and 2016.The PNI ratio (postoperative PNI/preoperative PNI) was used as an indicator of perioperative PNI changes. Prognostic differences were investigated based on PNI ratios.Results: The optimal cut-off value of the PNI ratio for overall survival (OS) was set at 0.88 using a receiver operating characteristic curve. The PNI ratio was inversely related to a high smoking index, interstitial lung disease, and postoperative pulmonary complications. The 5-year OS rates for the high vs. low PNI ratio groups were 88.2% vs. 68.5%, respectively (hazard ratio [HR]: 3.04, 95% confidence interval [CI]: 1.90-4.86). Multivariable analysis revealed that a low PNI ratio was significantly associated with poor prognosis (HR: 2.94, 95% CI: 1.77-4.87). The PNI ratio was a more sensitive indicator than postoperative PNI status alone for identifying patients at high risk of mortality, particularly those with non-lung cancer causes.Conclusion: The perioperative PNI change is a significant prognostic factor for patients with NSCLC.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical resection of advanced intrathoracic tumors through a combination of the hemiclamshell and transmanubrial approaches. 通过半蝶形和跨蝶形方法联合进行晚期胸内肿瘤的手术切除。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-09-01 Epub Date: 2024-05-06 DOI: 10.1007/s00595-024-02838-6

Yudai Miyashita, Eriko Fukui, Hiroto Ishida, Toru Kimura, Takashi Kanou, Naoko Ose, Soichiro Funaki, Yasushi Shintani

{"title":"Surgical resection of advanced intrathoracic tumors through a combination of the hemiclamshell and transmanubrial approaches.","authors":"Yudai Miyashita, Eriko Fukui, Hiroto Ishida, Toru Kimura, Takashi Kanou, Naoko Ose, Soichiro Funaki, Yasushi Shintani","doi":"10.1007/s00595-024-02838-6","DOIUrl":"10.1007/s00595-024-02838-6","url":null,"abstract":"Purpose: The hemiclamshell (HCS) approach provides a comprehensive view of the anterior mediastinum, whereas the transmanubrial osteomuscular sparing approach (TMA) allows sufficient exposure of the cervico-thoracic transition. We assessed the effectiveness and the outcomes of the combined HCS plus TMA approach to resect thoracic malignant tumors.Methods: We reviewed five patients with thoracic malignant tumors invading the thoracic outlet who underwent surgery using an HCS and TMA approach between 2018 and 2021.Results: The preoperative diagnosis was myxofibrosarcoma, lung cancer, thymic cancer, thymoma, and neurofibromatosis type1 in one patient each, respectively. Cardiovascular reconstruction was done on the aortic arch in two patients, on the descending aorta in one, and on the superior vena cava in one, combined with resection of the vagus nerve in three patients, of the phrenic nerve in two, and of vertebra in one, with overlap in some cases. The TMA was added because all patients required dissection of the periphery of the subclavian artery, and two had tumor extension to the neck. Macroscopic complete resection was achieved in four patients. There was no postoperative mortality.Conclusion: The combination of the HCS and TMA approaches at the same operation provides a comprehensive view of the mediastinum, lung, and cervico-thoracic transition and allows safe access to the thoracic great vessels and subclavian vessels.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery. 局部晚期非小细胞肺癌患者在接受诱导化放疗和手术治疗期间出现放射性肺炎时，中性粒细胞与淋巴细胞比值对患者的影响。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-09-01 Epub Date: 2024-03-07 DOI: 10.1007/s00595-024-02816-y

Yujiro Kubo, Hiromasa Yamamoto, Kei Matsubara, Kohei Hashimoto, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Kuniaki Katsui, Takao Hiraki, Katsuyuki Kiura, Shinichi Toyooka

{"title":"Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery.","authors":"Yujiro Kubo, Hiromasa Yamamoto, Kei Matsubara, Kohei Hashimoto, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Kuniaki Katsui, Takao Hiraki, Katsuyuki Kiura, Shinichi Toyooka","doi":"10.1007/s00595-024-02816-y","DOIUrl":"10.1007/s00595-024-02816-y","url":null,"abstract":"Purpose: Radiation pneumonitis (RP) is an obstacle for patients after surgery following induction chemoradiotherapy for locally advanced non-small cell lung cancer (LA-NSCLC). We performed a comparative analysis of the association between clinicopathological factors, including the neutrophil-to-lymphocyte ratio (NLR) and prognosis, in LA-NSCLC patients with or without RP during induction chemoradiotherapy followed by surgery.Methods: The subjects of this analysis were 168 patients undergoing trimodality therapy for LA-NSCLC between January, 1999 and May, 2019. Patients were divided into two groups: the RP group (n = 41) and the non-RP group (n = 127). We compared the clinicopathological factors including the NLR between the groups and analyzed the association between the NLR and prognosis.Results: The RP group had more patients with tumors located in the lower lobe, more bilobar resections, shorter operative times, no implementation of postoperative adjuvant chemotherapy, and a higher postoperative NLR than the non-RP group. There were no significant differences in serious postoperative complications and the prognosis. Patients with a low postoperative NLR had a significantly better prognosis in the non-RP group, and a trend toward a better prognosis even in the RP group.Conclusion: Postoperative NLR may be a useful prognostic factor, even for patients who suffer RP after trimodality therapy for LA-NSCLC.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for and prognostic impact of lateral pelvic lymph node metastasis in patients with rectal neuroendocrine tumors: a single-center retrospective analysis of 214 cases with radical resection. 直肠神经内分泌肿瘤患者盆腔侧淋巴结转移的风险因素和预后影响：对214例根治性切除病例的单中心回顾性分析。

IF 1.7 4区医学

Surgery Today Pub Date : 2024-08-28 DOI: 10.1007/s00595-024-02905-y

Tsubasa Sakurai, Y Hiyoshi, N Daitoku, S Matsui, T Mukai, T Nagasaki, T Yamaguchi, T Akiyoshi, H Kawachi, Y Fukunaga

{"title":"Risk factors for and prognostic impact of lateral pelvic lymph node metastasis in patients with rectal neuroendocrine tumors: a single-center retrospective analysis of 214 cases with radical resection.","authors":"Tsubasa Sakurai, Y Hiyoshi, N Daitoku, S Matsui, T Mukai, T Nagasaki, T Yamaguchi, T Akiyoshi, H Kawachi, Y Fukunaga","doi":"10.1007/s00595-024-02905-y","DOIUrl":"https://doi.org/10.1007/s00595-024-02905-y","url":null,"abstract":"Purpose: Lateral pelvic lymph node (LPLN) metastasis of rectal neuroendocrine tumors (NETs) is rare, with unknown oncological features. We investigated the oncological impact of LPLN metastasis in patients with rectal NETs.Methods: This study included 214 patients with rectal NETs who underwent curative surgery. We evaluated their clinicopathological characteristics and short- and long-term outcomes.Results: LPLN dissection was performed in 15 patients with LPLN swelling ≥ 7 mm (preoperative imaging); 12 patients had LPLN metastases, 6 of whom had LPLN metastases without mesorectal lymph node metastases (skip metastasis). The short-term outcomes were similar between the groups with and without LPLN dissection. The median follow-up period was 59.4 months, and patients with LPLN metastasis showed significantly shorter disease-free and overall survival rates than those without metastasis. Among 199 patients who did not undergo LPLN dissection, only 1 had LPLN recurrence. In a univariate analysis, tumor depth, tumor grade, and LPLN metastasis were associated with the overall survival. In the multivariate analysis, only LPLN metastasis was an independent predictor of the overall survival.Conclusions: LPLN metastasis is a poor prognostic factor for patients with rectal NETs. LPLN enlargement can be considered an indication for dissection, owing to its high rate of metastasis and associated poor prognosis.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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