Surgery Today最新文献_第3页

Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath.

IF 1.7 4区医学

Surgery Today Pub Date : 2025-03-24 DOI: 10.1007/s00595-025-03024-y

Akiisa Omura, Toru Kimura, Tomohiro Maniwa, Tadashi Watabe, Keiichiro Honma, Yasushi Shintani, Jiro Okami

{"title":"Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath.","authors":"Akiisa Omura, Toru Kimura, Tomohiro Maniwa, Tadashi Watabe, Keiichiro Honma, Yasushi Shintani, Jiro Okami","doi":"10.1007/s00595-025-03024-y","DOIUrl":"https://doi.org/10.1007/s00595-025-03024-y","url":null,"abstract":"Purpose: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP) is a serine protease, overexpressed in various cancers, which has been explored as a diagnostic and therapeutic target. We analyzed patients who underwent resection of an intrathoracic SFT, including metastatic pulmonary nodules from extrathoracic organs.Methods: The subjects of this retrospective study were seven patients with a primary SFT and two with metastatic SFTs in the lungs. After immunohistochemical staining of the resected tumors, quantification of the stained area was performed using QuPath.Results: Immunohistochemical quantification of FAP showed that it was expressed to varying degrees in the intrathoracic SFTs, with higher expression levels observed in metastatic SFTs than in primary pleural SFTs. Pathological examination confirmed the expression of FAP.Conclusion: Our results support the potential usefulness of FAP in the diagnosis of intrathoracic SFTs, including metastatic pulmonary nodules.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projection of future demand for non-cancerous gastrointestinal surgery in Japan: challenges and workforce planning in an aging society.

IF 1.7 4区医学

Surgery Today Pub Date : 2025-03-20 DOI: 10.1007/s00595-025-03027-9

Masakazu Fujii, Toru Nakamura, Yasuyuki Okumura, Yoichi M Ito, Toshimichi Asano, Satoshi Hirano

{"title":"Projection of future demand for non-cancerous gastrointestinal surgery in Japan: challenges and workforce planning in an aging society.","authors":"Masakazu Fujii, Toru Nakamura, Yasuyuki Okumura, Yoichi M Ito, Toshimichi Asano, Satoshi Hirano","doi":"10.1007/s00595-025-03027-9","DOIUrl":"https://doi.org/10.1007/s00595-025-03027-9","url":null,"abstract":"Purpose: Japan's aging population poses challenges for balancing healthcare demands and workforce supply. The aim of this study was to project the future demand for major non-cancerous gastrointestinal surgeries such as cholecystectomy, inguinal hernia repair, and appendectomy up until 2050 and examine the impact of a shrinking working-age population on surgical workforce needs.Methods: We used data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan Open Data (2018-2022) and population projections to calculate age- and sex-specific procedure rates. These rates were applied to population forecasts for 2030, 2040, and 2050 under high, low, and average demand scenarios. Working-age population (15-65 years) trends were included for comparison.Results: The projected demand for appendectomy, most common in people aged 20-39, is expected to decrease by 16.6% by 2050, whereas cholecystectomy and inguinal hernia repair demand, concentrated in people aged 60 and above, are projected to decrease by 5.8% and 7.1%, respectively. The working-age population is anticipated to decline by 25.3%, potentially posing significant challenges to maintaining an adequate surgical workforce.Conclusions: While the absolute number of gastrointestinal surgeries is projected to decrease, Japan faces substantial demographic changes that may impact surgical workforce capacity. Strategic workforce planning is essential to address these demographic challenges.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of social media on the career choices of medical students and junior residents in Japan: a prospective study to strategize an increase in the number of aspiring surgeons.

IF 1.7 4区医学

Surgery Today Pub Date : 2025-03-19 DOI: 10.1007/s00595-025-03023-z

Naoya Kitamura, Naru Kitade, Ryo Yokoyama, Toshihiro Ojima, Koichiro Shimoyama, Keitaro Tanabe, Yoshifumi Shimada, Yushi Akemoto, Yoshinori Doki, Tomoshi Tsuchiya

{"title":"Impact of social media on the career choices of medical students and junior residents in Japan: a prospective study to strategize an increase in the number of aspiring surgeons.","authors":"Naoya Kitamura, Naru Kitade, Ryo Yokoyama, Toshihiro Ojima, Koichiro Shimoyama, Keitaro Tanabe, Yoshifumi Shimada, Yushi Akemoto, Yoshinori Doki, Tomoshi Tsuchiya","doi":"10.1007/s00595-025-03023-z","DOIUrl":"https://doi.org/10.1007/s00595-025-03023-z","url":null,"abstract":"Purpose: To identify the most effective use of social media to increase the number of aspiring surgeons, we evaluated the impact of social media on the career choices of medical students and junior residents.Methods: We conducted a single-center prospective observational questionnaire-based study on medical students and junior residents from March, 2023 to August, 2024. Following overall aggregation, statistical intergroup comparisons were made between students and junior residents, as well as between those who were, or were not influenced by social media.Results: Among the 101 participants (77 students, 24 junior residents), approximately 75% reported that social media influenced their career choices. The most frequently used platforms were YouTube (85.1%), Instagram (71.3%), and X (67.3%). A total of 46.5% of the respondents expressed an interest in surgical specialties. Junior residents were more likely than students to gather information related to medicine (p = 0.0442). The group influenced by social media showed a higher interest in surgical specialties (p = 0.0475), and many desired parental leave policies to increase the number of surgeons (p = 0.0376).Conclusion: Social media influences the career choices of medical students and junior residents, and its effective use could increase the number of aspiring surgeons.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of systemic redox homeostasis biomarkers and transcription factors in patients undergoing open-heart surgery with cardiopulmonary bypass.

IF 1.7 4区医学

Surgery Today Pub Date : 2025-03-18 DOI: 10.1007/s00595-025-03026-w

Jamila Tahmazli, Şeydanur Turgut, Tamer Cebe, Fatih Kızılyel, Erdem Atasever, Ayhan Üğüden, Bülend Ketenci, Gülnur Andican, Ufuk Çakatay

{"title":"Importance of systemic redox homeostasis biomarkers and transcription factors in patients undergoing open-heart surgery with cardiopulmonary bypass.","authors":"Jamila Tahmazli, Şeydanur Turgut, Tamer Cebe, Fatih Kızılyel, Erdem Atasever, Ayhan Üğüden, Bülend Ketenci, Gülnur Andican, Ufuk Çakatay","doi":"10.1007/s00595-025-03026-w","DOIUrl":"https://doi.org/10.1007/s00595-025-03026-w","url":null,"abstract":"Purpose: Patients undergoing coronary artery bypass graft surgery and isolated valve disease surgery may experience redox dyshomeostasis associated with cardiopulmonary bypass (CPB).Methods: We investigated the impact of CPB on systemic redox homeostasis by analyzing redox biomarkers and antioxidant transcription factors preoperatively and postoperatively using spectrophotometric and immunochemical methods.Results: Our findings indicate significant variations in protein oxidation biomarkers, antioxidant capacity biomarkers, and transcription coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) levels after CPB. The ROC analysis indicated that protein carbonyl was valuable in the preoperative (p = 0.009) and postoperative (p = 0.013) periods. We also found that glutathione peroxidase was a valuable redox biomarker during the postoperative period (p = 0.000). An ROC analysis of catalase activity (p = 0.017) before CPB indicated the importance of catalase in eliminating increased hydroperoxide load. The ROC graphs reinforced the value of PGC-1α (p = 0.000) as a biomarker, showing a similar trend to that of catalase before CPB.Conclusion: The earlier view of \"increased oxidative stress and decreased biofunction\" has shifted to exploring the physiological role of redox signaling regulation. We believe that future studies on the effects of CPB on systemic redox regulation processes through redox signaling mechanisms will significantly contribute to the relevant literature.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of perioperative oral care on postoperative infection in patients with esophageal cancer: a retrospective cohort study before and during COVID-19.

IF 1.7 4区医学

Surgery Today Pub Date : 2025-03-14 DOI: 10.1007/s00595-025-03025-x

Aoi Kubo, Kimie Fujita, Satomi Tanaka, Yasue Kimura, Naohisa Wada

{"title":"The impact of perioperative oral care on postoperative infection in patients with esophageal cancer: a retrospective cohort study before and during COVID-19.","authors":"Aoi Kubo, Kimie Fujita, Satomi Tanaka, Yasue Kimura, Naohisa Wada","doi":"10.1007/s00595-025-03025-x","DOIUrl":"https://doi.org/10.1007/s00595-025-03025-x","url":null,"abstract":"Purpose: This study evaluated the impact of preoperative oral hygiene on the incidence of postoperative pneumonia (PP) and surgical site infection (SSI) in patients undergoing esophageal cancer surgery considering the influence of COVID-19 and developing effective perioperative oral care methods.Methods: The medical records of patients who underwent esophageal cancer surgery between January 2017 and March 2022 were analyzed. Patient characteristics and the incidence of PP and SSI before and during COVID-19 were compared. A multiple logistic regression analysis was performed with PP and SSI as the dependent variables.Results: This analysis included 207 participants. The mean age was 66.6 ± 8.3 years old, and 78.3% were male. There were no significant changes in the incidence of PP or SSI before and during the COVID-19 pandemic. Preoperative xerostomia significantly increased the risk of PP (odds ratio = 3.34, 95% confidence interval 1.10-10.08, p = 0.033), an advanced cancer stage, and recurrent laryngeal nerve palsy. Surgical procedures and reconstructive organs, but not preoperative oral hygiene factors, were associated with SSI.Conclusions: The incidence of PP and SSI in patients with esophageal cancer showed no marked changes before or during the COVID-19 pandemic. Managing preoperative xerostomia may be crucial for reducing the risk of PP.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in surgical versus nonsurgical treatments for gastrointestinal cancers during the COVID-19 pandemic: a nationwide analysis in Japan.

IF 1.7 4区医学

Surgery Today Pub Date : 2025-03-03 DOI: 10.1007/s00595-025-03021-1

Ryo Seishima, Taizo Hibi, Masashi Takeuchi, Yusuke Takemura, Hiromichi Maeda, Masahiro Kondo, Shoko Ukita, Ryusei Kimura, Akinobu Taketomi, Yoshihiro Kakeji, Yasuyuki Seto, Hideki Ueno, Masaki Mori, Ken Shirabe, Yuko Kitagawa

{"title":"Changes in surgical versus nonsurgical treatments for gastrointestinal cancers during the COVID-19 pandemic: a nationwide analysis in Japan.","authors":"Ryo Seishima, Taizo Hibi, Masashi Takeuchi, Yusuke Takemura, Hiromichi Maeda, Masahiro Kondo, Shoko Ukita, Ryusei Kimura, Akinobu Taketomi, Yoshihiro Kakeji, Yasuyuki Seto, Hideki Ueno, Masaki Mori, Ken Shirabe, Yuko Kitagawa","doi":"10.1007/s00595-025-03021-1","DOIUrl":"https://doi.org/10.1007/s00595-025-03021-1","url":null,"abstract":"Purpose: To investigate the impact of the COVID-19 pandemic on the treatment landscape of gastrointestinal cancers in Japan, focusing on the use of nonsurgical treatments.Methods: We conducted a retrospective cohort study using a nationwide insurance database and analyzed data for esophageal, gastric, colon, rectal, liver, and pancreatic cancers treated between July, 2019 and December, 2020. We calculated the surgical-to-nonsurgical-treatment ratio (SNR) for each type of cancer during the pandemic and defined April, 2020 as the pandemic onset. We used regression discontinuity designs to assess changes in the SNR.Results: A total of 31,169 cases were included. At the pandemic onset, the SNR decreased for gastric, colon, rectal, and liver cancers, indicating a shift toward nonsurgical treatments. Thereafter, these cancers showed a gradual increase in the SNR, returning to pre-pandemic levels. Notably, esophageal cancer showed an increase in the SNR at the pandemic onset, whereas pancreatic cancer showed no significant changes during the study period.Conclusion: The COVID-19 pandemic led to a significant decrease in gastrointestinal cancer surgeries in Japan, prompting a temporary shift toward nonsurgical treatments. However, most cancers showed a gradual recovery in the SNR, highlighting the resilience of the healthcare system.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of intraoperative and postoperative air leakage in anatomical pulmonary resection.

IF 1.7 4区医学

Surgery Today Pub Date : 2025-03-03 DOI: 10.1007/s00595-025-03004-2

Jotaro Yusa, Kazuhisa Tanaka, Yuki Sata, Takahide Toyoda, Terunaga Inage, Hajime Tamura, Masako Chiyo, Yukiko Matsui, Ichiro Yoshino, Hidemi Suzuki

{"title":"Predictors of intraoperative and postoperative air leakage in anatomical pulmonary resection.","authors":"Jotaro Yusa, Kazuhisa Tanaka, Yuki Sata, Takahide Toyoda, Terunaga Inage, Hajime Tamura, Masako Chiyo, Yukiko Matsui, Ichiro Yoshino, Hidemi Suzuki","doi":"10.1007/s00595-025-03004-2","DOIUrl":"https://doi.org/10.1007/s00595-025-03004-2","url":null,"abstract":"Purpose: Air leakage is a common complication of lung surgery that sometimes requires medical intervention and leads to a prolonged hospital stay. This study assessed the risk factors associated with air leakage following anatomical pulmonary resection.Methods: We retrospectively analyzed 194 patients who underwent anatomical pulmonary resection in 2020. A risk factor analysis was performed separately for intraoperative air leakage (IAL) and postoperative air leakage (PAL) by examining patient characteristics and operative findings.Results: Of 194 patients, IAL was observed in 94 (48.4%). The number of staplers used for pulmonary resection and Brinkman index were significantly higher in the IAL group than in the non-IAL group (3.2 vs. 2.5, p = 0.005 and 696.2 vs. 477.1, p = 0.013, respectively). PAL was observed in 40 (20.6%) patients (25 IAL and 15 non-IAL patients). There were more lobectomy cases in the PAL group than in the non-PAL group (77.5 vs 60.4%, p = 0.0447). Pleurodesis was performed in 18 (45%) patients in the PAL group.Conclusion: The risk factors differed between IAL and PAL. Since most PAL cases involve the IAL, and approximately half of the PAL cases require pleurodesis, attention should be paid to PAL prevention, especially during stapling procedures in the lung parenchyma.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative risk-factors for secondary spontaneous pneumothorax surgery in Japan: a nationwide database study. 日本继发性自发性气胸手术的术前风险因素：一项全国性数据库研究。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-03-01 Epub Date: 2024-08-27 DOI: 10.1007/s00595-024-02926-7

Ryuichi Waseda, Hiroyuki Yamamoto, Yasushi Shintani, Toshihiko Sato, Kenji Suzuki, Yoshimasa Maniwa, Yukio Sato, Ichiro Yoshino, Masayuki Chida

{"title":"Preoperative risk-factors for secondary spontaneous pneumothorax surgery in Japan: a nationwide database study.","authors":"Ryuichi Waseda, Hiroyuki Yamamoto, Yasushi Shintani, Toshihiko Sato, Kenji Suzuki, Yoshimasa Maniwa, Yukio Sato, Ichiro Yoshino, Masayuki Chida","doi":"10.1007/s00595-024-02926-7","DOIUrl":"10.1007/s00595-024-02926-7","url":null,"abstract":"Purpose: We aimed to identify preoperative risk factors for secondary spontaneous pneumothorax surgery.Methods: The National Clinical Database of Japan, with six annual datasets from 2014 to 2019, was used. All patients who underwent surgery for secondary spontaneous pneumothorax were included, excluding those < 15 years old and those with incomplete data. The effects of preoperative risk factors were analyzed for operative mortality (mortality during hospitalization or within 30 days, regardless of hospitalization status), 30-day mortality, and postoperative respiratory morbidities.Results: Of the 18,309 patients enrolled in the study, operative mortality, 30-day mortality, and postoperative respiratory morbidities were observed in 654 (3.6%), 343 (1.9%), and 2258 (12.3%) patients, respectively. Increasing age, male sex, body mass index < 18.5 or > 30, performance status > 2, emergent surgery, interstitial pneumonia, and diabetes in preoperative co-morbidity, tumors, and other diseases in underlying lung disease were significant risk factors for operative mortality. Those for 30-day mortality included autoimmune disease instead of male sex and diabetes, while those for postoperative respiratory morbidities included lymphangiomyomatosis instead of a body mass index > 30.Conclusion: We identified many preoperative risk factors for operative mortality, 30-day mortality, and postoperative respiratory morbidities in secondary spontaneous pneumothorax surgery. These findings will assist in selecting appropriate surgical candidates.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"393-404"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic impact of combination therapy with gemcitabine and cisplatin plus S-1 and subsequent conversion surgery for initially unresectable upper biliary tract cancers. 吉西他滨和顺铂加S-1联合疗法以及随后的转换手术对最初无法切除的上胆道癌的预后影响。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-03-01 Epub Date: 2024-08-13 DOI: 10.1007/s00595-024-02912-z

Hisashi Kosaka, Kosuke Matsui, Tsukasa Ikeura, Takashi Ito, Chisato Ohe, Yumiko Kono, Hideyuki Matsushima, Hidekazu Yamamoto, Mitsugu Sekimoto, Masaki Kaibori

{"title":"Prognostic impact of combination therapy with gemcitabine and cisplatin plus S-1 and subsequent conversion surgery for initially unresectable upper biliary tract cancers.","authors":"Hisashi Kosaka, Kosuke Matsui, Tsukasa Ikeura, Takashi Ito, Chisato Ohe, Yumiko Kono, Hideyuki Matsushima, Hidekazu Yamamoto, Mitsugu Sekimoto, Masaki Kaibori","doi":"10.1007/s00595-024-02912-z","DOIUrl":"10.1007/s00595-024-02912-z","url":null,"abstract":"Purpose and background: For the past decade, there have been few chemotherapy options for unresectable biliary tract cancer (BTC). Recently, however, combination therapy with gemcitabine and cisplatin plus S-1 (GCS) has been identified as a promising strategy. This retrospective study analyzes the clinical results of GCS therapy and subsequent conversion surgery (CS).Method: We analyzed the clinical data of 60 consecutive patients who received GCS therapy for unresectable upper BTC at our university hospital during the 5 years between September, 2018 and December, 2022.Results: All patients received GCS therapy as first-line chemotherapy. The response rate was 33.9% and subsequent CS was performed in 35.0%. Of the patients who underwent CS, 81% required more than bisectionectomy of the liver with extrahepatic bile duct resection. The median overall survival of the patients who received GCS therapy and underwent subsequent CS was significantly longer than that of the patients who received GCS therapy alone (28.0 months vs. 12.4 months, respectively; p < 0.001). A decrease in the CA19-9 level 1 month after chemotherapy and RECIST PR were independent positive predictors of CS, whereas unresectable gallbladder cancer and pretreatment ALBI grade 3 were negative predictors of CS.Conclusion: GCS therapy and subsequent CS may contribute to the longer term survival of patients with unresectable upper BTC.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"351-359"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indocyanine green fluorescence imaging as a predictor of long-term testicular atrophy in testicular torsion: a pilot study. 吲哚菁绿荧光成像作为睾丸扭转长期睾丸萎缩的预测指标：一项试点研究。

IF 1.7 4区医学

Surgery Today Pub Date : 2025-03-01 Epub Date: 2024-07-31 DOI: 10.1007/s00595-024-02908-9

Shugo Komatsu, Keita Terui, Ayako Takenouchi, Yunosuke Kawaguchi, Katsuhiro Nishimura, Satoru Oita, Hiroko Yoshizawa, Shota Takiguchi, Tomoro Hishiki

{"title":"Indocyanine green fluorescence imaging as a predictor of long-term testicular atrophy in testicular torsion: a pilot study.","authors":"Shugo Komatsu, Keita Terui, Ayako Takenouchi, Yunosuke Kawaguchi, Katsuhiro Nishimura, Satoru Oita, Hiroko Yoshizawa, Shota Takiguchi, Tomoro Hishiki","doi":"10.1007/s00595-024-02908-9","DOIUrl":"10.1007/s00595-024-02908-9","url":null,"abstract":"Purpose: This pilot study evaluated indocyanine green-guided near-infrared fluorescence (ICG-NIRF) imaging of testicular blood flow to predict long-term testicular atrophy after testicular torsion (TT) surgery.Methods: The subjects of this retrospective study were patients who underwent surgery for TT at our hospital between December, 2020 and July, 2022. After detorsion, testicular blood flow was evaluated by ICG-NIRF imaging and classified into three categories: fluorescence detected, no fluorescence detected, and fluorescence detected only in the tunica albuginea vessels. Testicular volume was measured by ultrasonography up to 12 months after surgery to evaluate long-term outcomes.Results: Twelve patients were included in this analysis. We found a 100% correlation between the absence of ICG-NIRF signals and subsequent testicular atrophy. In three patients without an ICG-NIRF signal, the median testis size 12 months postoperatively was significantly smaller (16.5% of the contralateral testis; range 13-20%) than that in six patients with an ICG-NIRF signal (96%; 89-115%) (p = 0.013). Mild atrophy (74.5%; 73-76%) was also observed in the three patients for whom an ICG-NIRF signal was detected only in the tunica albuginea vessels.Conclusions: Our pilot study highlights the potential of ICG-NIRF imaging as a prognostic tool for guiding surgical decision-making for patients with TT, by predicting postoperative testicular atrophy.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"386-392"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0