SARS-CoV-2 infection in lung transplant recipients: a single-center retrospective study in Japan.

IF 1.6 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2025-09-26 DOI:10.1007/s00595-025-03136-5

Mikihiro Kohno, Akihiro Ohsumi, Jumpei Kimura, Mamoru Takahashi, Satona Tanaka, Yojiro Yutaka, Daisuke Nakajima, Miki Nagao, Hiroshi Date

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引用次数: 0

Abstract

Purpose: Lung transplant (LTx) recipients are at a higher risk of infection and mortality due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The course of coronavirus disease 2019 (COVID-19) in Japanese LTx recipients remains unknown. This study aimed to clarify the incidence, outcomes, and clinical characteristics of COVID-19 in LTx recipients in Japan over a 3-year period.

Methods: This single-center retrospective study enrolled all LTx recipients who underwent LTx at Kyoto University Hospital between June 2008 and December 2022 and who were followed up during the COVID-19 pandemic from March 2020 to June 2023.

Results: Among 230 LTx recipients, 64 (27.8%) developed SARS-CoV-2 infection and one (1.6%) died due to COVID-19. No significant differences in baseline characteristics, except for hypertension, were observed between the LTx recipients with and without COVID-19. Disease severity decreased as variants of concern transitioned but remained high even after 2022. Unilateral LTx, advanced age, and diabetes mellitus were associated with COVID-19 severity.

Conclusions: The incidence of COVID-19 in LTx recipients was similar to that in the general Japanese population, whereas the disease severity in LTx recipients remained high even after the Omicron era. Continuous development of preventive and early therapeutic interventions is required for these vulnerable groups.

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肺移植受者的SARS-CoV-2感染：日本单中心回顾性研究

目的：肺移植（LTx）受者因严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）感染和死亡的风险较高。日本LTx受者的2019冠状病毒病（COVID-19）病程尚不清楚。本研究旨在阐明日本LTx受者3年内COVID-19的发病率、结局和临床特征。方法：这项单中心回顾性研究纳入了2008年6月至2022年12月在京都大学医院接受LTx治疗的所有LTx接受者，并在2020年3月至2023年6月COVID-19大流行期间对其进行了随访。结果：在230例LTx受者中，64例（27.8%）发生SARS-CoV-2感染，1例（1.6%）死于COVID-19。除高血压外，在患有和不患有COVID-19的LTx接受者之间，基线特征没有显著差异。疾病严重程度随着关注变异的转变而下降，但即使在2022年之后仍然很高。单侧LTx、高龄和糖尿病与COVID-19严重程度相关。结论：LTx受者的COVID-19发病率与日本普通人群相似，而LTx受者的疾病严重程度即使在欧米克隆时代之后仍然很高。需要为这些弱势群体不断发展预防和早期治疗干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.