Systematic Reviews最新文献

{"title":"Neurological outcome predictors after extracorporeal cardiopulmonary resuscitation: a systematic review.","authors":"Dawid Woszczyk, Wiktoria Zasada, Hanna Cholerzyńska, Tomasz Kłosiewicz, Mateusz Puślecki","doi":"10.1186/s13643-025-02818-y","DOIUrl":"10.1186/s13643-025-02818-y","url":null,"abstract":"<p><strong>Background: </strong>To consolidate current evidence on predictors of neurological outcome following extracorporeal cardiopulmonary resuscitation (eCPR) in patients with cardiac arrest.</p><p><strong>Methods: </strong>We conducted a systematic review of the literature across databases including PubMed, MEDLINE, Embase, CINAHL, the Cochrane Library, and Web of Science. Studies assessing neurological outcomes post-eCPR were identified, with a total of 10 studies eligible for individual assessment of which 8 comprising 4353 patients allowed to perform collective statistical analysis.</p><p><strong>Results: </strong>Favorable neurological outcomes were associated with age < 65 years (OR = 6.17), shockable rhythm at extracorporeal membrane oxygenation initiation (OR = 6.67) or hospital arrival (OR = 3.68), and initial pH ≥ 7.0 (OR = 2.01). Other factors involved the presence of any life sign (gasping, positive pupillary light reaction, or increased level of consciousness before or throughout cardiopulmonary resuscitation) (OR = 9.63; Se 0.89, Sp 0.46, PPV 0.22, NPV 0.96), transient return of spontaneous circulation, non-hypoxic mechanism of occurred hepatitis, public location, and hypothermic etiology of cardiac arrest; however, each of those findings was supported by only one study. Unfavorable outcomes were linked to hypoxic brain injury on computed tomography (OR = 12.40; Se 0.366, Sp 0.955, PPV 0.767, NPV 0.787) and elevated serum creatinine (OR = 2.22). The TiPS65 scale showed high predictive accuracy in two studies when the cut-off point was set at 4 points (88.4% and 88.6%; Se 0.172, Sp 0.971, PPV 0.423, and NPV 0.906, and Se 0.193, Sp 0.985, PPV 0.646, and NPV 0.896, respectively). Some predictors, like call-to-hospital time and bystander cardiopulmonary resuscitation, had mixed results across studies.</p><p><strong>Conclusion: </strong>Neurological prognostication in eCPR patients is a complex problem requiring the consideration of multiple variables regarding patient's and cardiac arrest characteristics. Future research should focus on the determination of outcome-affecting factors and assessment of their applicability in clinical settings. New knowledge on this ground will help to create recommendations for eCPR initiation and termination, consequently contributing to treatment results improvement.</p><p><strong>Trial registration: </strong>PROSPERO CRD42024530305.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"67"},"PeriodicalIF":6.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locally adapted guidelines: a scoping review.","authors":"Dawid Pieper, Alexander Pachanov, Carolin Bahns, Robert Prill, Christian Kopkow, Eni Shehu, Kyung-Eun Anna Choi","doi":"10.1186/s13643-025-02808-0","DOIUrl":"10.1186/s13643-025-02808-0","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Clinical practice guidelines (CPGs) often fail to be fully implemented in practice. One barrier to CPG implementation is inconsistency between recommendations and existing practice patterns. This can include patients, personnel, structure, availability of resources, cultural and ethical values. To account for this, it is feasible to tailor national CPGs to a regional or local context (e.g. hospital). Local ownership can be beneficial and help to implement the guideline without affecting guideline validity. This process is also known as guideline adaptation. We aimed to identify randomized controlled trials (RCTs) investigating the effectiveness of locally adapted CPGs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We performed a scoping review, following the JBI guidance. The scoping review was registered with the Open Science Framework ( https://osf.io/3ed2w ). The intervention had to be a locally adapted guideline (locally meaning adapted to any delineated area and/or entity at subnational and/or transnational level). Co-interventions were accepted. We did not restrict the control group. As we considered locally adapted guidelines as an intervention, and it seems feasible to test locally adapted guidelines in trials, we only considered RCTs, including cluster-RCTs. PubMed and Embase were searched in November 2024. Two reviewers independently screened titles and abstracts, full-text articles, and charted data. Conflicts were resolved by involving a third reviewer. Data were summarized descriptively. The findings were discussed with knowledge users.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Five cluster RCTs reported in 8 publications and published between 2000 and 2010, were included. The trials originated from the UK, Scotland, Australia, the US, and the Netherlands. The adapted CPGs focused on diabetes, asthma, smoking cessation, mental disorders, and menorrhagia and urinary incontinence. The number of sites (e.g. practices) ranged from 4 to 30. Reporting was mostly insufficient to understand how adaptation was performed. Interventions always included some form of dissemination, such as educational meetings or workshops.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;There is a lack of RCTs investigating the effectiveness of locally adapted guidelines. A systematic review is unwarranted due to the clinical and methodological heterogeneity of these trials. The identified studies were largely conducted over 20 years ago, highlighting a significant knowledge gap. The reasons for the lack of similar studies today are unclear, which is surprising given advances in adaptation frameworks in guideline development. As the importance of contextualization is emphasized, future studies on locally adapted guidelines should be conducted with strong rationale supported by local data. Without a sound rationale, there is a risk that evidence-based, high-quality guidelines could be undermined. In future trials, authors should closely adhere to reporting guidelines","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"66"},"PeriodicalIF":6.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human animal contact, land use change and zoonotic disease risk: a protocol for systematic review.","authors":"Aliyu N Ahmed, Kimberly M Fornace, Takuya Iwamura, Kris A Murray","doi":"10.1186/s13643-025-02805-3","DOIUrl":"10.1186/s13643-025-02805-3","url":null,"abstract":"<p><strong>Background: </strong>Zoonotic diseases pose a significant risk to human health globally. The interrelationship between humans, animals, and the environment plays a key role in the transmission of zoonotic infections. Human-animal contact (HAC) is particularly important in this relationship, where it serves as the pivotal interaction for pathogen spillover to occur from an animal reservoir to a human. In the context of disease emergence linked to land-use change, increased HAC as a result of land changes (e.g., deforestation, agricultural expansion, habitat degradation) is frequently cited as a key mechanism. We propose to conduct a systematic literature review to map and assess the quality of current evidence linking changes in HAC to zoonotic disease emergence as a result of land-use change.</p><p><strong>Method: </strong>We developed a search protocol to be conducted in eight (8) databases: Medline, Embase, Global Health, Web of Science, Scopus, AGRIS, Africa-Wide Info, and Global Index Medicus. The review will follow standard systematic review methods and will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. The search will consist of building a search strategy, database search, and a snowballing search of references from retrieved relevant articles. The search strategy will be developed for Medline (through PubMed) and EMBASE databases. The search strategy will then be applied to all eight (8) databases. Retrieved articles will be exported to EndNote 20 where duplicates will be removed and exported to Rayyan®, to screen papers using their title and abstract. Screening will be conducted by two independent reviewers and data extraction will be performed using a data extraction form. Articles retrieved will be assessed using study quality appraisal tools (OHAT-Office for Health Assessment and Technology Risk of Bias Rating Tool for Human and Animal Studies, CCS-Case Control Studies, OCCSS-Observational Cohort and Cross-Sectional Studies, and CIS-Controlled interventional studies). Data will be analysed using descriptive statistics and a meta-analysis where data permits.</p><p><strong>Discussion: </strong>The review will provide an important systematic literature aggregate of existing evidence on the role and evidence quality linking HAC to the emergence of zoonoses via land-use change. The outcome of the proposed review will produce a high-level evidence document that could inform intervention points and further research priorities.</p><p><strong>Registration: </strong>The review will be registered with PROSPERO.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"65"},"PeriodicalIF":6.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Athlete monitoring in handball (ATHMON HB): a systematic review protocol.","authors":"Alexander-Stephan Henze, Johannes Kirsten, Lynn Matits, Daniel Alexander Bizjak, Sebastian Viktor Waldemar Schulz","doi":"10.1186/s13643-025-02806-2","DOIUrl":"10.1186/s13643-025-02806-2","url":null,"abstract":"<p><strong>Background: </strong>Athlete monitoring has become an important aspect of demanding indoor team sports like handball. Monitoring external and internal load and well-being should help coaches to optimize load management and recovery strategies to improve athletic performance and maintain athlete health. However, there is a large variety in the methods described, their coherence, and their effect on performance and health. This systematic review will summarize the methods currently used to monitor external and internal load and well-being during training and competition in team handball.</p><p><strong>Methods: </strong>This systematic review will follow the current Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search of electronic databases, including MEDLINE, Embase, and Web of Science, will be conducted until 30 April 2024. Original articles in English, German, or Spanish that assess methods for monitoring the external and/or internal load and/or well-being of healthy team handball players during training and/or competition will be considered. In addition, a backward search of all relevant full-text articles identified through the search will be conducted. Two reviewers will independently perform study selection, data extraction, and risk-of-bias assessment for included studies. Included studies will be assessed for risk of bias using the Newcastle-Ottawa scale. It is anticipated that the number of eligible studies will be limited, and that the data extracted from them will be highly heterogeneous. Consequently, a narrative synthesis of the extracted data will be presented.</p><p><strong>Discussion: </strong>This systematic review will provide the current evidence on methods for monitoring external and internal load and well-being in competitive team handball players. The results may assist practitioners in implementing an athlete monitoring. We will share our findings through scientific conferences, educational meetings for coaches and medical staff, expert meetings, and publication in a peer-reviewed journal.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024540676.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"64"},"PeriodicalIF":6.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring health-related quality of life among university students: a scoping review protocol.","authors":"Marcelo Couto Jorge Rodrigues, Augusto Cezar Rodrigues Rocha, Crislaine Rangel Couto, Filipe Manuel Clemente, Matias Noll, Auro Barreiros Freire, Claudio Andre Barbosa de Lira, Katja Weiss, Thomas Rosemann, Beat Knechtle, Gustavo De Conti Teixeira Costa","doi":"10.1186/s13643-025-02787-2","DOIUrl":"10.1186/s13643-025-02787-2","url":null,"abstract":"<p><strong>Background: </strong>Understanding university students' health-related quality of life (HRQoL) can help propose strategies that support targeted care for this population and identify issues affecting these individuals. Therefore, it is necessary to identify the commonly used instruments and possible study designs for the university population, enabling the standardization of interventions and instruments to evaluate the HRQoL of university students. We aim to conduct a scoping review to identify the main measurement instruments and key characteristics in studies using HRQoL measures among university students. It is also aimed at identifying the foundations for guiding future research priorities.</p><p><strong>Methods: </strong>This review will consider original peer-reviewed articles that used any generic HRQoL measurement instruments exclusively used with university students aged 18-59. Validation, qualitative, language translation, or adaptation studies will be excluded. This review will follow the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). The research will be conducted in five electronic databases (PubMed, Embase, Web of Science, Scopus, and SPORTDiscus). Two reviewers will independently screen records using predefined eligibility criteria and extract data using tables. The extracted data will include specific details about the title, authors, year of publication, HRQoL instrument utilized, participants, intervention design, and critical findings. The results will be presented in a narrative summary with data displayed in tabular and diagrammatic formats.</p><p><strong>Discussion: </strong>This proposed scoping review aims to provide a comprehensive overview of the existing methods for assessing health-related quality of life in university students. The results will help identify gaps in the literature and establish a foundation for guiding future research priorities.</p><p><strong>Scoping review registration: </strong>Registration with Open Science Framework can be found under registration number https://doi.org/10.17605/OSF.IO/FY9GU .</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"63"},"PeriodicalIF":6.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global output of clinical application research on artificial intelligence in the past decade: a scientometric study and science mapping.","authors":"Ji-Yuan Shi, Shu-Jin Yue, Hong-Shuang Chen, Fei-Yu Fang, Xue-Lian Wang, Jia-Jun Xue, Yang Zhao, Zheng Li, Chao Sun","doi":"10.1186/s13643-025-02779-2","DOIUrl":"10.1186/s13643-025-02779-2","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) has shown immense potential in the field of medicine, but its actual effectiveness and safety still need to be validated through clinical trials. Currently, the research themes, methodologies, and development trends of AI-related clinical trials remain unclear, and further exploration of these studies will be crucial for uncovering AI's practical application potential and promoting its broader adoption in clinical settings.</p><p><strong>Objective: </strong>To analyze the current status, hotspots, and trends of published clinical research on AI applications.</p><p><strong>Methods: </strong>Publications related to AI clinical applications were retrieved from the Web of Science database. Relevant data were extracted using VOSviewer 1.6.17 to generate visual cooperation network maps for countries, organizations, authors, and keywords. Burst citation detection for keywords and citations was performed using CiteSpace 5.8.R3 to identify sudden surges in citation frequency within a short period, and the theme evolution was analyzed using SciMAT to track the development and trends of research topics over time.</p><p><strong>Results: </strong>A total of 22,583 articles were obtained from the Web of Science database. Seven-hundred and thirty-five AI clinical application research were published by 1764 institutions from 53 countries. The majority of publications were contributed by the United States, China, and the UK. Active collaborations were noted among leading authors, particularly those from developed countries. The publications mainly focused on evaluating the application value of AI technology in the fields of disease diagnosis and classification, disease risk prediction and management, assisted surgery, and rehabilitation. Deep learning and chatbot technologies were identified as emerging research hotspots in recent studies on AI applications.</p><p><strong>Conclusions: </strong>A total of 735 articles on AI in clinical research were analyzed, with publication volume and citation counts steadily increasing each year. Institutions and researchers from the United States contributed the most to the research output in this field. Key areas of focus included AI applications in surgery, rehabilitation, disease diagnosis, risk prediction, and health management, with emerging trends in deep learning and chatbots. This study also provides detailed and intuitive information about important articles, journals, core authors, institutions, and topics in the field through visualization maps, which will help researchers quickly understand the current status, hotspots, and trends of artificial intelligence clinical application research. Future clinical trials of artificial intelligence should strengthen scientific design, ethical compliance, and interdisciplinary and international cooperation and pay more attention to its practical clinical value and reliable application in diverse scenarios.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"62"},"PeriodicalIF":6.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summarizing attributable factors and evaluating risk of bias of Mendelian randomization studies for Alzheimer's dementia and cognitive status: a systematic review and meta-analysis.","authors":"Xiaoni Meng, Xiaochun Li, Meiling Cao, Jing Dong, Haotian Wang, Weijie Cao, Di Liu, Youxin Wang","doi":"10.1186/s13643-025-02792-5","DOIUrl":"10.1186/s13643-025-02792-5","url":null,"abstract":"<p><strong>Background: </strong>No effective treatment is available to delay or reverse the onset and progression of Alzheimer's dementia (AD). Mild cognitive impairment, a clinical state between normal aging and AD, may offer the proper window for AD intervention and treatment. This systematic review aimed to summarize evidence from Mendelian randomization (MR) studies exploring factors attributable to AD and related cognitive status and to assess its credibility.</p><p><strong>Methods: </strong>We searched PubMed, Embase, MEDLINE, and the Cochrane Library to identify MR studies investigating the associations between any factor and AD and related cognitive status. The risk of bias in MR studies was evaluated using nine signaling questions tailored to identify potential biases based on the STROBE-MR guidelines.</p><p><strong>Results: </strong>A total of 125 eligible publications were examined, including 106 AD-related MR studies reporting 674 records and 28 cognition-related MR studies reporting 141 records. We identified 185 unique causal risk factors for AD and 49 for cognitive status. More than half of the MR studies reporting AD or cognitive status outcomes exhibited poor methodological quality, with a high risk of bias observed in 59% of the AD-related studies and 64% of the cognitive-related studies.</p><p><strong>Conclusions: </strong>This systematic review summarized modifiable factors and omics signatures, providing a database of MR studies on AD and related cognitive status. The evaluation of bias risk in MR studies serves to raise awareness and improve overall quality. A critical appraisal checklist for assessing the risk of bias may pave the way for the development of a standardized tool.</p><p><strong>Systematic review registration: </strong>The review protocol was registered with the Prospective Register of Systematic Reviews (PROSPERO) under the registration number CRD42023213990.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"61"},"PeriodicalIF":6.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of transcranial direct current stimulation (tDCS) on motor function among people with stroke: evidence mapping.","authors":"Yu Qin, Jianguo Xu, Shamay Sheung Mei Ng","doi":"10.1186/s13643-025-02795-2","DOIUrl":"10.1186/s13643-025-02795-2","url":null,"abstract":"<p><strong>Objective: </strong>To present, organize, and assess the methodological quality of the current research related to tDCS on motor function after a stroke and to identify gaps and clinical implications using an evidence mapping approach.</p><p><strong>Methods: </strong>Six electronic databases (PubMed, Embase, Cochrane Library, Web of Science, CINAHL, PEDro), gray literature, and reference lists of articles were searched from inception until October 2023. The Assessment of Multiple Systematic Reviews 2 (AMSTAR-2) checklist and PEDro scale were used to assess the methodology quality of systematic reviews (SRs) and randomized controlled trials (RCTs).</p><p><strong>Results: </strong>A total of 172 articles met the inclusion criteria from 5759 records, including 46 SRs and 126 RCTs. Related studies came from 29 countries around the world, and China has performed the most, with 12 SRs and 21 RCTs. More than half of SRs (65.22%) were evaluated with low or critically low quality, while 78.58% of RCTs have shown excellent or good quality. A total of 26 SRs and 93 RCTs have reported outcomes on upper limb motor function with kinds of tDCS, and 15 SRs and 44 RCTs have focused on lower extremity function. Studies with safety concerns have reported no or mild adverse events.</p><p><strong>Conclusions: </strong>This study systematically identified gaps and indicated that tDCS is a kind of potential and safe intervention. Given potential concerns on the clinical application, more high-quality research with large sample size and kinds of objectives is needed in the future.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"60"},"PeriodicalIF":6.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of nutrient supplements in managing malnutrition and sarcopenia in Chronic Obstructive Pulmonary Disease (COPD) patients: a protocol for systematic review and meta-analysis.","authors":"Hong-Yan Zheng, Hao-Yu Zhang, Kuang-Hao Wu, Wen-Jie Cai, Zhou-Zhou Li, Xin-Yu Song","doi":"10.1186/s13643-025-02801-7","DOIUrl":"10.1186/s13643-025-02801-7","url":null,"abstract":"<p><strong>Background: </strong>COPD patients suffering from malnutrition or sarcopenia often incur higher healthcare costs and experience adverse clinical outcomes. Despite this, the effectiveness of nutrient supplements in this population remains uncertain.</p><p><strong>Methods and analysis: </strong>Two reviewers will independently search seven databases-PubMed, Embase, Web of Science, China National Knowledge Infrastructure, Wanfang, Chinese Biomedical Literature Database, and the Cochrane Library-for randomized controlled trials (RCTs) published before August 31, 2024. These RCTs should compare the effects of nutrient supplements against either a standard diet or placebo supplements in patients with COPD. The risk of bias in the included studies will be evaluated using the modified Jadad scale and the Cochrane Collaboration's risk of bias tool. Data synthesis will be conducted using RevMan software. Trial sequential analysis (TSA) will be applied to the primary outcomes. Additionally, subgroup and sensitivity analyses will be performed to assess the robustness of the findings.</p><p><strong>Ethics and dissemination: </strong>Ethical approval is not required because this study is a secondary analysis of existing data. We will disseminate the findings through peer- reviewed publications.</p><p><strong>Systematic review registration: </strong>CRD42024585694.</p><p><strong>Strengths and limitations of this study: </strong>This systematic review and meta-analysis provides a thorough assessment of the efficacy of nutrient supplements in COPD patients, covering a wide range of studies. ·The use of the modified Jadad scale and the Cochrane Collaboration's risk of bias tool ensures a robust evaluation of study quality. Additionally, trial sequential analysis and subgroup analyses are employed to enhance the robustness of the findings. ·The credibility of the evidence may be compromised due to the potential for uncertain study quality and limited sample sizes in some included trials.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"58"},"PeriodicalIF":6.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Chinese classical prescriptions for dilated cardiomyopathy: a systematic review and Bayesian network meta-analysis.","authors":"Shiyi Tao, Lintong Yu, Jun Li, Ji Wu, Xiao Xia, Yonghao Li, Deshuang Yang, Wenjie Zhang","doi":"10.1186/s13643-025-02802-6","DOIUrl":"10.1186/s13643-025-02802-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Chinese classical prescriptions (CCPs) are commonly utilized in China as an adjuvant treatment for dilated cardiomyopathy (DCM). Nevertheless, there was insufficient systematic evidence data to show the advantages of CCPs plus current conventional therapy (CT) against DCM. This network meta-analysis (NMA) sought to evaluate and prioritize the six different CCP types' respective efficacies for DCM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A comprehensive search was conducted from the databases' inception to November 30, 2024, to extract RCTs that addressed the use of CCPs in conjunction with CT for DCM. The databases included PubMed, Embase, Web of Science Core Collection, Cochrane Library, ProQuest, China National Knowledge Infrastructure (CNKI), China Science Periodical Database (CSPD), Chinese Citation Database (CCD), Chinese Biomedical Literature Database (CBM), and ClinicalTrials.gov. The Cochrane Risk of Bias assessment tool was used to evaluate the quality of the included RCTs. Surface under the cumulative ranking curve (SUCRA) probability values was employed to rank the relative efficacy. Bayesian network meta-analysis was applied to evaluate the efficacy of various CCPs. This review was registered with PROSPERO (CRD42024586365).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Following the application of inclusion and exclusion criteria, 27 eligible RCTs involving 2019 patients were included. The evaluated outcomes included clinical effectiveness rate (CER), left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD), brain natriuretic peptide (BNP), cardiac output (CO), hypersensitive C-reactive protein (hs-CRP), and six-min walk test (6MWT). According to the NMA, Zhigancao decoction (ZGCD), Zhenwu decoction (ZWD), Shenfu decoction (SFD), Shengmai powder (SMP), Yangxin decoction (YXD), and Buyang Huanwu decoction (BYHW) in addition to CT considerably enhanced DCM treatment outcomes when compared to CT alone. SMP + CT (MD = 12.75, 95%CI 8.28-17.22) showed the highest probability of being the best treatment on account of the enhancement of LVEF. SFD + CT was most likely to be the optimal intervention for LVEDD decrease (MD = -4.68, 95%CI -8.73 to -0.62). YXD + CT (MD = -4.47, 95%CI -4.47 to -4.47) had the highest likelihood of being the optimal therapy for reducing LVESD. ZGCD + CT seemed to be the most promising intervention on the improvement in hs-CRP (MD = -2.82, 95%CI -3.60 to -2.04) and 6MWT (MD = 141.00, 95%CI 136.57 to 145.43). However, the optimal CCP for improving BNP and CO could not be identified based on the present studies. No significant adverse events emerged in the included studies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This NMA indicated that adding CCPs to current CT treatment had a favorable effect on DCM. In light of the clinical efficacy and other outcomes, SMP + CT, SFD + CT, YXD + CT, and ZGCD + CT demonstrated a preferred improveme","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"59"},"PeriodicalIF":6.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}