{"title":"A journey through the world of vitreous","authors":"","doi":"10.1016/j.survophthal.2024.06.004","DOIUrl":"10.1016/j.survophthal.2024.06.004","url":null,"abstract":"<div><p>Vitreous, one of the largest components of the human eye, mostly contains water. Despite decades of studying the vitreous structure, numerous unanswered questions still remain, fueling ongoing active research. We attempt to provide a comprehensive overview of the current understanding of the development, morphology, biochemical composition, and function of the vitreous. We emphasize the impact of the vitreous structure and composition on the distribution of drugs. Fast-developing imaging technologies, such as modern optical coherence tomography, unlocked multiple new approaches, offering the potential for <em>in vivo</em> study of the vitreous structure. They allowed to analyze <em>in vivo</em> a range of vitreous structures, such as posterior precortical vitreous pockets, Cloquet canal, channels that interconnect them, perivascular vitreous fissures, and cisterns. We provide an overview of such imaging techniques and their principles and of some challenges in visualizing vitreous structures. Finally, we explores the potential of combining the latest technologies and machine learning to enhance our understanding of vitreous structures.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 6","pages":"Pages 957-966"},"PeriodicalIF":5.1,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625724000705/pdfft?md5=0b104d701bf1b0d59cdb60e9360bcfa8&pid=1-s2.0-S0039625724000705-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141390800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to “Fibrosis in neovascular age-related macular degeneration: a review of definitions based on clinical imaging” [Surv Ophthalmol 68 (2023) 835–848/5]","authors":"","doi":"10.1016/j.survophthal.2023.10.007","DOIUrl":"10.1016/j.survophthal.2023.10.007","url":null,"abstract":"","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 6","pages":"Page 990"},"PeriodicalIF":5.1,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625723001376/pdfft?md5=9cf44f5cbc32c5f21ead6b8331306bb6&pid=1-s2.0-S0039625723001376-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Not everything is ischemic optic neuropathy","authors":"","doi":"10.1016/j.survophthal.2024.05.005","DOIUrl":"10.1016/j.survophthal.2024.05.005","url":null,"abstract":"<div><p>A 71-year-old woman developed sudden, painful, decreased vision in the left eye accompanied by progressive instability. Initial examination revealed left optic disc edema, and macular optical coherence tomography confirmed the presence of intraretinal and subretinal fluid, as well as hyperreflective material under the retinal pigment epithelium. Subsequent investigations, including brain magnetic resonance imaging and a comprehensive serological analysis, ruled out infectious and autoimmune causes, further complicating the diagnostic picture. The patient's vision in both eyes continued to deteriorate, prompting empirical corticosteroid treatment. While the vision improved, the case took an unexpected turn with worsening neurological symptoms. Ultimately a brain biopsy was consistent with diffuse large B-cell lymphoma.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 6","pages":"Pages 984-989"},"PeriodicalIF":5.1,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625724000547/pdfft?md5=1a336f54537ba049676c5e4767c7695a&pid=1-s2.0-S0039625724000547-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ethan Waisberg , Joshua Ong , Sharif Amit Kamran , Mouayad Masalkhi , Phani Paladugu , Nasif Zaman , Andrew G. Lee , Alireza Tavakkoli
{"title":"Generative artificial intelligence in ophthalmology","authors":"Ethan Waisberg , Joshua Ong , Sharif Amit Kamran , Mouayad Masalkhi , Phani Paladugu , Nasif Zaman , Andrew G. Lee , Alireza Tavakkoli","doi":"10.1016/j.survophthal.2024.04.009","DOIUrl":"10.1016/j.survophthal.2024.04.009","url":null,"abstract":"<div><div>Generative artificial intelligence (AI) has revolutionized medicine over the past several years. A generative adversarial network (GAN) is a deep learning framework that has become a powerful technique in medicine, particularly in ophthalmology for image analysis. In this paper we review the current ophthalmic literature involving GANs, and highlight key contributions in the field. We briefly touch on ChatGPT, another application of generative AI, and its potential in ophthalmology. We also explore the potential uses for GANs in ocular imaging, with a specific emphasis on 3 primary domains: image enhancement, disease identification, and generating of synthetic data. PubMed, Ovid MEDLINE, Google Scholar were searched from inception to October 30, 2022, to identify applications of GAN in ophthalmology. A total of 40 papers were included in this review. We cover various applications of GANs in ophthalmic-related imaging including optical coherence tomography, orbital magnetic resonance imaging, fundus photography, and ultrasound; however, we also highlight several challenges that resulted in the generation of inaccurate and atypical results during certain iterations. Finally, we examine future directions and considerations for generative AI in ophthalmology.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 1","pages":"Pages 1-11"},"PeriodicalIF":5.1,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Tariq Bhatti , Jennifer R. Long , Andrew R. Carey
{"title":"Denial","authors":"M. Tariq Bhatti , Jennifer R. Long , Andrew R. Carey","doi":"10.1016/j.survophthal.2024.05.003","DOIUrl":"10.1016/j.survophthal.2024.05.003","url":null,"abstract":"<div><div><span><span><span>A 51-year-old man presented with decreased vision, fever, confusion, headaches, agitation, nausea, vomiting and diarrhea. Magnetic resonance imaging of the brain demonstrated bilateral T2 hyperintense lesions in the region of the mesial </span>temporal lobe<span> and optic radiations. There was a predominantly polymorphonuclear leukocyte </span></span>pleocytosis in the </span>cerebrospinal fluid<span><span><span><span> (CSF) with hyperproteinorachia. A meningoencephalitis was diagnosed. Intravenous </span>fluorescein angiography (IVFA) demonstrated a multifocal </span>chorioretinitis that was in a linear pattern in the left eye. CSF enzyme-linked immunosorbent assay was positive for </span>West Nile virus (WNV) IgM. We review the clinical manifestations of WNV disease and highlight the value of IVFA in determining the diagnosis.</span></div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 1","pages":"Pages 162-166"},"PeriodicalIF":5.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chaerim Kang , Matthew J. Lee BA , Amy Chomsky MD , Thomas A. Oetting MS, MD , Paul B. Greenberg MD, MPH
{"title":"Risk factors for complications in resident-performed cataract surgery: A systematic review","authors":"Chaerim Kang , Matthew J. Lee BA , Amy Chomsky MD , Thomas A. Oetting MS, MD , Paul B. Greenberg MD, MPH","doi":"10.1016/j.survophthal.2024.04.002","DOIUrl":"10.1016/j.survophthal.2024.04.002","url":null,"abstract":"<div><p>We assessed risk factors for complications associated with resident-performed cataract surgery. Using the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, we searched 4databases in September, 2023. We included peer-reviewed, full-text, English-language articles assessing risk factors for complications in resident performed cataract surgery. We excluded studies describing cataract surgeries performed by fellows, combined surgeries, and studies with insufficient information. Our initial search yielded 6244 articles; 15 articles were included after title/abstract and full-text review. Patient-related risk factors included older age, hypertension, prior vitrectomy, zonular pathology, pseudoexfoliation, poor preoperative visual acuity, small pupils, and selected types of cataracts. Surgeon-related risk factors included resident postgraduate year and surgeon right-handedness. Other risk factors included absence of supervision, long phacoemulsification time, and phacoemulsification with high power and torsion. The quality of the studies was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation; most studies graded as moderate, primarily due to risk of bias. When assigning cases to residents, graduate medical educators should consider general and resident-specific risk factors to facilitate teaching and preserve patient safety.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 4","pages":"Pages 638-645"},"PeriodicalIF":5.1,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140793251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Amin Salehi , Negin Frounchi , Seyed Sina Zakavi , Soheil Mohammadi , Hamid Harandi , Shayan Shojaei , Mahdi Gouravani , J. Fernando Arevalo
{"title":"Retinal and choroidal changes after anti-VEGF therapy in neovascular-AMD patients: A systematic review and meta-analysis of SD-OCT studies","authors":"Mohammad Amin Salehi , Negin Frounchi , Seyed Sina Zakavi , Soheil Mohammadi , Hamid Harandi , Shayan Shojaei , Mahdi Gouravani , J. Fernando Arevalo","doi":"10.1016/j.survophthal.2024.04.001","DOIUrl":"10.1016/j.survophthal.2024.04.001","url":null,"abstract":"<div><h3>Background</h3><p>In recent years, the progress made in the field of optical coherence tomography has helped to understand the changes in eye layers in patients with exudative age-related macular degeneration (nAMD). Early diagnosis of nAMD, a leading cause of irreversible vision impairment, is helpful. Therefore, we performed a meta-analysis on OCT measurement alterations before and after anti-VEGF therapy in patients with nAMD and controls.</p></div><div><h3>Method</h3><p>We systematically searched Scopus, PubMed, Cochrane, and Web of Science to find articles that measured choroidal and retinal layer changes after anti-VEGF therapy in nAMD Patients. We chose either a fixed-effects or random-effects model based on the assessed heterogeneity level to perform a meta-analysis. In addition, we conducted meta-regression, subgroup analyses, publication bias, and quality assessment for included studies.</p></div><div><h3>Results</h3><p>Thirteen studies were included in the meta-analysis, with 733 total participants. Foveal thickness and subfoveal choroidal thickness (CT) decreased significantly in the first 3 years after injections, except for subfoveal CT in the third year after injection. It also showed that CT at 1500 µm temporal and nasal to the fovea did not significantly change.</p></div><div><h3>Conclusion</h3><p>Our results showed anti-VEGF treatment for nAMD patients was associated with a significant reduction in foveal thickness and subfoveal CT in the first 2 years after treatment. Our analysis did not reveal any correlation between changes in foveal thickness and subfoveal CT with best-corrected visual acuity or other factors.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 4","pages":"Pages 547-557"},"PeriodicalIF":5.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140761066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in management strategies for large and persistent macular hole: An update","authors":"Helin Arda , Mathias Maier , Maximilian Schultheiß , Christos Haritoglou","doi":"10.1016/j.survophthal.2024.03.010","DOIUrl":"10.1016/j.survophthal.2024.03.010","url":null,"abstract":"<div><p>The standard of care to treat small- and medium-sized macular holes (<400 µm diameter) consists of a conventional transconjunctival sutureless pars plana vitrectomy followed by ILM peeling and endotamponade, mainly with gas or in some cases with silicone oil, resulting in closure rates of over 90% and good functional results. Large (>400 µm diameter), chronic and persistent macular holes remain a surgical challenge since closure rates and functional results decrease with larger macular hole diameters. Various modifications of the conventional surgical technique were introduced to improve anatomic and functional success in refractory cases not suitable for conventional macular hole surgery. These techniques comprise the positioning of tissue at the top of the hole to improve closure as performed by an inner limiting membrane flap and free flap preparation or the transplantation of autologous retinal tissue, lens capsule or amniotic membrane. For the treatment of very large and persistent macular holes, the induction of a localized retinal detachment at the posterior pole by subretinal injection of balanced salt solution and a subsequent attenuation of the rim of the hole during fluid-air exchange has been suggested as a promising surgical technique. In particular, accurate patient education about the expected surgical outcome in this specific group of patients appears important.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 4","pages":"Pages 539-546"},"PeriodicalIF":5.1,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hosein Nouri , Seyed-Hossein Abtahi , Mehdi Mazloumi , Sanam Samadikhadem , J. Fernando Arevalo , Hamid Ahmadieh
{"title":"Optical coherence tomography angiography in diabetic retinopathy: A major review","authors":"Hosein Nouri , Seyed-Hossein Abtahi , Mehdi Mazloumi , Sanam Samadikhadem , J. Fernando Arevalo , Hamid Ahmadieh","doi":"10.1016/j.survophthal.2024.03.004","DOIUrl":"10.1016/j.survophthal.2024.03.004","url":null,"abstract":"<div><p>Diabetic retinopathy (DR) is characterized by retinal vasculopathy and is a leading cause of visual impairment. Optical coherence tomography angiography (OCTA) is an innovative imaging technology that can detect various pathologies and quantifiable changes in retinal microvasculature. We briefly describe its functional principles and advantages over fluorescein angiography and perform a comprehensive review on its clinical applications in the screening or management of people with prediabetes, diabetes without clinical retinopathy (NDR), nonproliferative DR (NPDR), proliferative DR (PDR), and diabetic macular edema (DME). OCTA reveals early microvascular alterations in prediabetic and NDR eyes, which may coexist with sub-clinical neuroretinal dysfunction. Its applications in NPDR include measuring ischemia, detecting retinal neovascularization, and timing of early treatment through predicting the risk of retinopathy worsening or development of DME. In PDR, OCTA helps characterize the flow within neovascular complexes and evaluate their progression or regression in response to treatment. In eyes with DME, OCTA perfusion parameters may be of predictive value regarding the visual and anatomical gains associated with treatment. We further discussed the limitations of OCTA and the benefits of its incorporation into an updated DR severity scale.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 4","pages":"Pages 558-574"},"PeriodicalIF":5.1,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neil M. Bressler , Peter K. Kaiser , Diana V. Do , Quan Dong Nguyen , Kyu Hyung Park , Se Joon Woo , Min Sagong , Mario Bradvica , Mercy Yeeun Kim , Seungkee Kim , SriniVas R. Sadda
{"title":"Biosimilars of anti-vascular endothelial growth factor for ophthalmic diseases: A review","authors":"Neil M. Bressler , Peter K. Kaiser , Diana V. Do , Quan Dong Nguyen , Kyu Hyung Park , Se Joon Woo , Min Sagong , Mario Bradvica , Mercy Yeeun Kim , Seungkee Kim , SriniVas R. Sadda","doi":"10.1016/j.survophthal.2024.03.009","DOIUrl":"10.1016/j.survophthal.2024.03.009","url":null,"abstract":"<div><p>The development of intravitreally injected biologic medicines (biologics) acting against vascular endothelial growth factor (VEGF) substantially improved the clinical outcomes of patients with common VEGF-driven retinal diseases. The relatively high cost of branded agents, however, represents a financial burden for most healthcare systems and patients, likely resulting in impaired access to treatment and poorer clinical outcomes for some patients. Biosimilar medicines (biosimilars) are clinically equivalent, potentially economic alternatives to reference products. Biosimilars approved by leading health authorities have been demonstrated to be similar to the reference product in a comprehensive comparability exercise, generating the totality of evidence necessary to support analytical, pre-clinical, and clinical biosimilarity. Anti-VEGF biosimilars have been entering the field of ophthalmology in the US since 2022. We review regulatory and scientific concepts of biosimilars, the biosimilar development landscape in ophthalmology, with a specific focus on anti-VEGF biosimilars, and discuss opportunities and challenges facing the uptake of biosimilars.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 4","pages":"Pages 521-538"},"PeriodicalIF":5.1,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625724000298/pdfft?md5=3d98e8329dfc4dcfb85d696499bf50e5&pid=1-s2.0-S0039625724000298-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}