Survey of ophthalmology最新文献

Choroidal hypopigmented lesions: A review. 脉络膜低色素病变：综述。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-05-14 DOI: 10.1016/j.survophthal.2025.05.002

Elham Rahmanipour, Elham Sadeghi, Supriya Arora, Mohammad Ghorbani, Mehrnoosh Maalhagh, Ramesh Venkatesh, Jay Chhablani

{"title":"Choroidal hypopigmented lesions: A review.","authors":"Elham Rahmanipour, Elham Sadeghi, Supriya Arora, Mohammad Ghorbani, Mehrnoosh Maalhagh, Ramesh Venkatesh, Jay Chhablani","doi":"10.1016/j.survophthal.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.survophthal.2025.05.002","url":null,"abstract":"Choroidal hypopigmented lesions (CHLs) represent significant diagnostic and therapeutic challenges due to their diverse and complex etiologies, including neoplastic, infectious, and inflammatory origins. Accurately differentiating between benign lesions with good prognoses and malignant or life-threatening conditions is crucial in directing the appropriate management and avoiding unnecessary invasive interventions. We integrate the latest research and clinical guidelines on advanced multimodal imaging modalities, emphasizing their comparative diagnostic value across varied etiologies of CHLs. In contrast to prior studies, this review comprehensively evaluates the clinical implications of these techniques in accurately differentiating between benign from malignant choroidal lesions. Emphasis is placed on the role of advanced imaging modalities, including swept-source optical coherence tomography, B-scan ultrasound, fundus autofluorescence, fluorescein angiography, and indocyanine green angiography, in enhancing diagnostic precision. These technologies have substantially increased the capability to distinguish between lesion types, improving diagnostic accuracy and giving more targeted therapeutic strategies.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blow. 打击。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-05-14 DOI: 10.1016/j.survophthal.2025.05.004

M Tariq Bhatti, Jeffrey G Moore, Thomas N Hwang, Jurij R Bilyk

{"title":"Blow.","authors":"M Tariq Bhatti, Jeffrey G Moore, Thomas N Hwang, Jurij R Bilyk","doi":"10.1016/j.survophthal.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.survophthal.2025.05.004","url":null,"abstract":"A 59-year-old woman presented with right periorbital frontal headache and vertical binocular diplopia. Computed tomography (CT) angiography of the head and neck with contrast was negative. C-reactive protein was 7.3 mg/dL (normal, <0.9 mg/dL) and erythrocyte sedimentation was 79 mm/hr. Despite a negative temporal artery biopsy, she was treated for biopsy-negative giant cell arteritis. Symptoms worsened over time. A review of the initial CT demonstrated paranasal sinus disease and a mass in the right medial orbit with disruption of the medial orbital wall. Magnetic resonance imaging showed an enhancing lesion in the inferomedial portion of the right orbit associated with opacification and enhancement of the right ethmoid, maxillary and frontal sinuses. Antineutrophil cytoplasmic antibodies (ANCA) were negative for myeloperoxidase (perinuclear ANCA) but positive for proteinase 3 (cytoplasmic ANCA). An intranasal biopsy demonstrated a nonspecific ulcer site reaction with a mixed inflammatory cell composition and focal vascular injury. Upon further questioning, the patient admitted to intranasal insufflation of cocaine confirming the diagnosis of cocaine-induced midline destructive lesions.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent updates in choroidal imaging biomarkers. 脉络膜成像生物标志物的最新进展。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-05-13 DOI: 10.1016/j.survophthal.2025.05.005

Sumit Randhir Singh, Elham Sadeghi, Kiran Kumar Vupparaboina, Jay Chhablani

{"title":"Recent updates in choroidal imaging biomarkers.","authors":"Sumit Randhir Singh, Elham Sadeghi, Kiran Kumar Vupparaboina, Jay Chhablani","doi":"10.1016/j.survophthal.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.survophthal.2025.05.005","url":null,"abstract":"The choroid, a highly vascularized tissue, supplies the outer retina and is responsible for other functions such as thermoregulation, secretion of growth factors, and possibly emmetropization. Choroidal changes, therefore, may play a role in various chorioretinal diseases. The recent surge in publications focusing on the choroid can be attributed to improvements in both resolution and field of view of optical coherence tomography (OCT) and indocyanine green angiography (ICGA). Advancements in imaging have transitioned from manual to semi-automated and now fully automated methods for qualitative and quantitative choroidal analysis. These qualitative parameters include choroidal vascular patterns and focal or diffuse changes in the vascular wall, either bulbosity or tortuosity. Quantitative parameters include choroidal thickness, volume, vascularity index, contour, three-dimensional vessel quantification, and blood flow measurements using laser Doppler holography. We discuss these qualitative and quantitative biomarkers in detail, i.e., the underlying principles, clinical use, changes in normal and disease states, and their limitations. This will provide invaluable insights to clinicians in understanding the choroidal changes in physiological and pathological states.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Augmented and virtual reality in retinal care: A systematic review of their role in training, surgery, and treatment. 增强和虚拟现实在视网膜护理：系统回顾他们在培训，手术和治疗中的作用。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-05-10 DOI: 10.1016/j.survophthal.2025.05.001

Murat Erdag, Mehmet Citirik, Ali Dal

{"title":"Augmented and virtual reality in retinal care: A systematic review of their role in training, surgery, and treatment.","authors":"Murat Erdag, Mehmet Citirik, Ali Dal","doi":"10.1016/j.survophthal.2025.05.001","DOIUrl":"10.1016/j.survophthal.2025.05.001","url":null,"abstract":"Augmented reality (AR) and virtual reality (VR) are game-changing technologies in retinal care, offering significant advancements in surgical training, diagnostic accuracy, and vision rehabilitation. We explore how AR/VR is being used in surgical training, intraoperative guidance, and vision restoration, focusing on their impact on surgical proficiency, diagnostic precision, and the management of retinal diseases. We analyzed studies from the Web of Science Core Collection, adhering to PRISMA 2020 guidelines. We included randomized controlled trials (RCTs) and prospective cohort studies that examined AR/VR applications in retinal surgery, diagnosis, and rehabilitation. Bias was evaluated using RoB 2.0 for RCTs and ROBINS-I for observational studies. Ten studies met our criteria (3 RCTs and 7 prospective cohort studies) with 6-48 participants, focusing on AR/VR's role in surgical simulation, diagnostics, and vision rehabilitation. The Eyesi Surgical Simulator significantly improved surgical skills, reduced complications, and accelerated learning curves. AR-assisted diagnostics enhanced retinal disease detection, while VR rehabilitation programs helped improve contrast sensitivity and visual acuity; however, methodological differences between studies made direct comparisons difficult. AR/VR technologies have the potential to enhance retinal care by improving surgical safety, diagnostic precision, and rehabilitation outcomes. Despite these benefits, high costs, accessibility challenges, and a lack of standardization remain significant barriers. Integrating AR/VR into medical training and clinical practice is recommended, but larger, long-term studies are needed to validate their effectiveness.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing outcomes of local and regional anesthesia in vitreoretinal surgery - A systematic review and network meta-analysis. 比较玻璃体视网膜手术中局部和区域麻醉的效果——系统综述和网络荟萃分析。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-05-10 DOI: 10.1016/j.survophthal.2025.05.003

Abdulrahman Hameed Alsubhi, Saja Alanazi, Sadeem Tariq Atham, Saeed Alshahrani, Abdullah Alhumimidi, Sokinah Almusalami, Essa Alsultan, Wejdan Alghamdi, Ammr Alghamdi

{"title":"Comparing outcomes of local and regional anesthesia in vitreoretinal surgery - A systematic review and network meta-analysis.","authors":"Abdulrahman Hameed Alsubhi, Saja Alanazi, Sadeem Tariq Atham, Saeed Alshahrani, Abdullah Alhumimidi, Sokinah Almusalami, Essa Alsultan, Wejdan Alghamdi, Ammr Alghamdi","doi":"10.1016/j.survophthal.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.survophthal.2025.05.003","url":null,"abstract":"We systematically review and compare the available evidence on the various types of regional anesthesia and topical anesthesia (TA) in vitreoretinal surgery and evaluate their respective outcomes. The principles outlined in the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) extension for network meta-analysis were adhered to throughout this systematic review. The primary outcome measures were intraoperative pain score, the number of patients requiring additional anesthesia, and the number of adverse events. A preestablished protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), ID Number: (CRD42023449755). Fifty-three studies were screened in full text, resulting in 11 with nearly 1076 patients who met our criteria. Most patients had a retrobulbar block, and the average surgical time was 48 minutes. Regarding the pain score, sub-Tenon (ST) injection had the best results, and TA was significantly less effective when compared to ST and peribulbar (PB) injection (SMD=1.28 and 0.88, 95% confidence interval (CI) to 2.46 and 0.18 to 1.58). ST had significantly less risk of requiring additional anesthesia when compared to all other techniques. Six studies reported adverse events, and PB had the least risk of an adverse event. Future research should continue to explore direct comparisons between each type.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of rhegmatogenous retinal detachment. 预防孔源性视网膜脱离。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-05-06 DOI: 10.1016/j.survophthal.2025.04.006

Argyrios Chronopoulos, James S Schutz, Robert P Finger

{"title":"Prevention of rhegmatogenous retinal detachment.","authors":"Argyrios Chronopoulos, James S Schutz, Robert P Finger","doi":"10.1016/j.survophthal.2025.04.006","DOIUrl":"https://doi.org/10.1016/j.survophthal.2025.04.006","url":null,"abstract":"Rhegmatogenous retinal detachment (RRD) is a potentially blinding separation of neurosensory retina from retinal pigment epithelium by fluid passing from the vitreous cavity into the subretinal space through one or more retinal breaks, holes or tears. Although most RRDs can be repaired surgically with one operation, some visual loss often results, especially if the macula has been detached, and a small fraction of RRDs require multiple surgeries with significant morbidity, including permanent severe visual loss. Vitrectomy, the most popular RRD surgery, is associated with temporary visual loss and postoperative positioning with limited activity for 1 or 2 weeks; phakic patients usually require cataract surgery within two years. Consequently, RRD prevention would be ideal, achieved by early accurate diagnosis of retinal tears and prophylactic outpatient retinopexy, easy, highly successful in sealing retinal breaks and usually uncomplicated. The interval between retinal tears and detachment of the retina is often long enough for laser retinopexy; however, the importance of retinal tear symptoms and prompt evaluation is not well known by the public nor nonophthalmic medical providers, causing a delay that prevents retinopexy and results in surgical repair. New educational programs are needed. Most RRDs are idiopathic but traumatic RRDs also can be avoided by protective eye wear in hazardous sports and occupations and also timely eye examination and retinopexy. Suggestions for improved retinal tear diagnosis are offered.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features of retinal vasculitis: A systematic review and meta-analysis from the International Uveitis Study Group (IUSG) Retinal Vasculitis Study (ReViSe) Reportreport 3. 系统评价和荟萃分析：国际葡萄膜炎研究组（IUSG）视网膜血管炎研究（修订）报告3。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-05-02 DOI: 10.1016/j.survophthal.2025.04.001

Carlos Cifuentes-González, Yong Le Tong, William Rojas-Carabali, Germán Mejía-Salgado, Ikhwanuliman Putera, Xin Ying Rachel Song, Cheong Fu Yuan Walter, Zhang Shengjuan, Reo Chan, Azadeh Mobasserian, Rina La Distia Nora, Jyotirmay Biswas, Sapna Gangaputra, Jose S Pulido, John H Kempen, Quan Dong Nguyen, Alejandra de la Torre, Vishali Gupta, James T Rosenbaum, Rupesh Agrawal

{"title":"Clinical features of retinal vasculitis: A systematic review and meta-analysis from the International Uveitis Study Group (IUSG) Retinal Vasculitis Study (ReViSe) Reportreport 3.","authors":"Carlos Cifuentes-González, Yong Le Tong, William Rojas-Carabali, Germán Mejía-Salgado, Ikhwanuliman Putera, Xin Ying Rachel Song, Cheong Fu Yuan Walter, Zhang Shengjuan, Reo Chan, Azadeh Mobasserian, Rina La Distia Nora, Jyotirmay Biswas, Sapna Gangaputra, Jose S Pulido, John H Kempen, Quan Dong Nguyen, Alejandra de la Torre, Vishali Gupta, James T Rosenbaum, Rupesh Agrawal","doi":"10.1016/j.survophthal.2025.04.001","DOIUrl":"10.1016/j.survophthal.2025.04.001","url":null,"abstract":"We investigate the clinical characteristics and complications of retinal vasculitis (RV), categorizing cases into Secondary RV (associated with systemic disease), Syndromic RV (linked to ocular syndromes without systemic disease), Idiopathic RV (without systemic disease or ocular syndrome diagnoses), and Multiple Etiology RV (cohorts of retinal vasculitis with more than one subcategories of the above). A systematic search was conducted on June 14, 2023, across PubMed, Embase, Cochrane (Ovid), VHL, and ProQuest databases, following PRISMA guidelines (PROSPERO registration: CRD42023489232). Out of 5533 screened articles, 97 studies involving 7619 patients with RV met the eligibility criteria. Bilateral involvement (64 %) and reduced vision (52 %) were common across all RV categories, with Idiopathic RV showing the highest rates of bilateral involvement (80 %) and vision loss (79 %). Syndromic RV was characterized by retinal ischemia (76 %) and vitreous hemorrhage (46 %), while Secondary RV exhibited higher incidences of cystoid macular edema (32 %) and neovascular glaucoma (24 %). Geographic variations were evident in Multiple Etiology RV, with inflammation in more than 1 intraocular structure more prevalent in Asia (64 %) than in Europe (29 %). These findings highlight the heterogeneity in RV presentation and complications, illustrating the need for standardized diagnostic criteria and improved clinical reporting to enable better classification, treatment strategies, and patient outcomes.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomic biomarkers as potential endpoints in diabetic macular edema: A systematic literature review with identification of macular volume as a key surrogate for visual acuity. 解剖生物标志物作为糖尿病黄斑水肿的潜在终点：一项系统的文献综述，确定黄斑体积是视力的关键替代指标。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-05-01 DOI: 10.1016/j.survophthal.2025.04.004

Aude Couturier, Charles C Wykoff, Marco Lupidi, Patricia Udaondo, Tunde Peto, Pierre-Jean Pintard

{"title":"Anatomic biomarkers as potential endpoints in diabetic macular edema: A systematic literature review with identification of macular volume as a key surrogate for visual acuity.","authors":"Aude Couturier, Charles C Wykoff, Marco Lupidi, Patricia Udaondo, Tunde Peto, Pierre-Jean Pintard","doi":"10.1016/j.survophthal.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.survophthal.2025.04.004","url":null,"abstract":"Optimization of diabetic macular edema (DME) treatment pathways can aid in the efficient introduction of new therapies that provide value to patients and healthcare systems. We performed a systematic literature review and multicorrelation analysis to identify and evaluate anatomic biomarkers as potential surrogate endpoints (SEs) for visual acuity (VA) in patients with DME. We performed EMBASE and MEDLINE searches to identify studies reporting on 4 priority biomarkers previously identified by clinical experts: hyperreflective foci, intraretinal cyst, macular volume (MV), and subretinal fluid. Endpoint and treatment effect correlation analyses were performed to establish correlation coefficients between MV and VA using Pearson's correlation. A total of 105 studies reported change from baseline data for VA, and at least 1 biomarker, with MV investigated most often (n = 70 studies). Data extracted from 55 studies focusing on the 6-mm zone for MV were used in statistical analyses. A moderate correlation was observed between MV and VA at the endpoint level (r = 0.58; p < 0.01); however, a corresponding treatment effect was not found (r = 0.32; p = 0.19). Our findings suggest MV's potential as an SE for VA in future clinical practice; however, the lack of a significant treatment effect warrants that these findings be interpreted cautiously. Further evidence and improvements in reporting the methods for collecting biomarker data are needed. Analysis of outliers and subanalyses by other optical coherence tomography measures could establish the most meaningful MV values correlating with VA.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The advancements in precision medicine for Leber congenital amaurosis: Breakthroughs from genetic diagnosis to therapy. 莱伯氏先天性黑朦的精准医学进展：从基因诊断到治疗的突破。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-04-29 DOI: 10.1016/j.survophthal.2025.04.005

Pei Zhang, Zhuping Xu

{"title":"The advancements in precision medicine for Leber congenital amaurosis: Breakthroughs from genetic diagnosis to therapy.","authors":"Pei Zhang, Zhuping Xu","doi":"10.1016/j.survophthal.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.survophthal.2025.04.005","url":null,"abstract":"Leber congenital amaurosis (LCA) is a hereditary retinal disease, typically manifesting as severe vision impairment in infancy. With the advancement of precision medicine, genetic diagnosis and targeted therapies offer new hope for LCA patients, significantly improving both diagnostic accuracy and therapeutic efficacy. We summarize the epidemiological characteristics, clinical manifestations, and molecular genetics underlying LCA. It also highlights recent developments in precision treatment strategies, including gene replacement therapy, CRISPR/Cas9-mediated gene editing, and antisense oligonucleotide therapies. In addition, we discuss the applications of induced pluripotent stem cells and retinal organoids in LCA treatment research. Furthermore, we explore preventive strategies and future treatment directions for LCA, including the development of novel gene therapy vectors, the optimization of combinatorial treatment strategies, and the formulation of personalized treatment approaches. These advancements hold significant potential to offer improved treatment options and enhance the quality of life for LCA patients.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential of rho kinase inhibitors in ophthalmology: From mechanisms to clinical practice. 探索rho激酶抑制剂在眼科中的潜力：从机制到临床实践。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-04-16 DOI: 10.1016/j.survophthal.2025.03.008

Jit Kai Tan, David H Steel, Sajjad Ahmad, Ananth Viswanathan, Rashmi G Mathew, Peng Tee Khaw, Christin Henein

{"title":"Exploring the potential of rho kinase inhibitors in ophthalmology: From mechanisms to clinical practice.","authors":"Jit Kai Tan, David H Steel, Sajjad Ahmad, Ananth Viswanathan, Rashmi G Mathew, Peng Tee Khaw, Christin Henein","doi":"10.1016/j.survophthal.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.survophthal.2025.03.008","url":null,"abstract":"Introduction: The therapeutic potential of rho kinase (ROCK) inhibitors in ophthalmology is gaining attention, given their multifaceted role in cellular regulation, particularly within ocular pathologies. This review synthesizes findings from clinical and preclinical studies on the efficacy and safety of ROCK inhibitors across glaucoma, corneal, and retinal diseases. We performed a systematic database search in Ovid MEDLINE and Ovid Embase on 5th April 2022 using the following keywords: 'primary open angle glaucoma', 'glaucoma surgery', 'corneal wound healing', 'corneal endothelial dysfunction', 'diabetic retinopathy', 'diabetic macular oedema', 'age-related macular degeneration', 'rho kinase inhibitor', 'rho-kinase inhibitor', rock inhibitor', 'ripasudil', 'netarsudil' and 'fasudil'. Abstracts were screened for relevant studies and results summarized in tables. The analysis of trials done for ROCK inhibitors reveals that they are safe and efficacious drugs, demonstrating noninferiority to existing medical treatments and effective when combined with existing treatments, and are approved for use in treating glaucoma, but not corneal or retinal diseases. Questions remain, however, regarding optimal dosage, patient selection, and cost-effectiveness. ROCK inhibitors demonstrate significant efficacy in reducing intraocular pressure by improving aqueous humour outflow. Additionally, ROCK inhibitors show promise in enhancing endothelial cell migration, thus providing a novel treatment avenue for corneal diseases such as Fuchs endothelial dystrophy. In retinal conditions, including diabetic retinopathy and age-related macular degeneration, ROCK inhibitors reduce vascular permeability, inflammation, and fibrosis, stabilising disease progression.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0