Survey of ophthalmology最新文献

Enhancing anti-vascular endothelial growth factor with photodynamic therapy for polypoidal choroidal vasculopathy: A meta-analysis.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-12-19 DOI: 10.1016/j.survophthal.2024.12.006

Ting-Han Lin, Hung-Yi Lin, Po-Chen Tseng

{"title":"Enhancing anti-vascular endothelial growth factor with photodynamic therapy for polypoidal choroidal vasculopathy: A meta-analysis.","authors":"Ting-Han Lin, Hung-Yi Lin, Po-Chen Tseng","doi":"10.1016/j.survophthal.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.12.006","url":null,"abstract":"Anti-vascular endothelial growth factor (VEGF) agents administered as either monotherapy or combination with verteporfin photodynamic therapy (PDT) are the 2 dominant treatment for polypoidal choroidal vasculopathy (PCV); However, controversies remain due to small sample sizes and inconsistency in prognosis from randomized controlled trials (RCTs). In accordance with the PRISMA statement, we investigated the efficacy of PDT plus anti-VEGF combination with anti-VEGF monotherapy. This study was accepted by the International Prospective Register of Systematic Reviews (CRD42023471362). Studies published up to July, 2024, were retrieved from PubMed, Embase, and Cochrane databases. A total of 7 RCTs with 926 eyes were reviewed. In 6 trials, combination therapy showed significantly higher rate of complete polyp regression (risk ratio [RR]: 1.56, 95% CI: 1.15-2.13, p = 0.005). In 5 trials, combination therapy also significantly reduced the number of anti-VEGF injections (SMD: -0.65, 95% CI: -0.95 to -0.35, p < 0.0001). For best corrected visual acuity improvement, central retinal thickness reduction, and rate of ocular adverse events, the performance of the 2 modalities were comparable. We conclude that PDT plus anti-VEGF combination therapy constitutes a safe and effective modality and should be considered the first-line treatment for PCV.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Penetrating keratoplasty versus deep anteriror lamellar keratoplasty for macular corneal dystrophy: A meta-analysis.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-12-19 DOI: 10.1016/j.survophthal.2024.12.005

Le Ngoc Van Anh, Nguyen Ngoc Cong, Kasetsuwan Ngamjit, Reinprayoon Usanee

{"title":"Penetrating keratoplasty versus deep anteriror lamellar keratoplasty for macular corneal dystrophy: A meta-analysis.","authors":"Le Ngoc Van Anh, Nguyen Ngoc Cong, Kasetsuwan Ngamjit, Reinprayoon Usanee","doi":"10.1016/j.survophthal.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.12.005","url":null,"abstract":"Study design: Systematic review and meta-analysis We assessed the efficacy of deep anterior lamellar keratoplasty (DALK) and penetrating (PK) for macular corneal dystrophy (MCD) We searched on 4 databases for articles published up to the end of April 2024. The study's outcome was postoperative visual acuity and other factors that may affect visual outcomes (e.g., spherical equivalent and postoperative complications). Meta-analysis was performed using random-effects or fixed-effect model according to the heterogeneity. We included 6 studies (1 RCT and 5 retrospective studies) comparing DALK (139 eyes) and PK (507 eyes) for MCD. No significant differences were found between the two procedures in uncorrected visual acuity, best-corrected visual acuity, and spherical equivalent (p = 0.58, 0.11 and 0.2, respectively). The risk of graft rejection was significantly higher in the PK group than in the DALK group (RR = 0.33; P = 0.001); however, MCD recurrence results were considerably higher in the DALK group than in the PK group (RR = 2.69, p < 0.001). The risk ratio for complications and graft survival have no significant difference between the two interventions (p = 0.9 and 0.62, respectively). Among the studies reviewed, 5 had a moderate risk of bias, while the remaining had a high risk. Our results showed that both PK and DALK have comparable outcomes of postoperative visual acuity, spherical equivalent, graft survival, and complication rate when treating MCD. Although the PK group had a higher rate of graft rejection, the DALK group had a higher recurrence rate.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory choroidal neovascularization: An evidence-based update.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-12-18 DOI: 10.1016/j.survophthal.2024.12.004

Andrea Servillo, Pierluigi Scandale, Gloria Oldoni, Pinar Guran Begar, Francesco Bandello, Elisabetta Miserocchi, Maria Vittoria Cicinelli

{"title":"Inflammatory choroidal neovascularization: An evidence-based update.","authors":"Andrea Servillo, Pierluigi Scandale, Gloria Oldoni, Pinar Guran Begar, Francesco Bandello, Elisabetta Miserocchi, Maria Vittoria Cicinelli","doi":"10.1016/j.survophthal.2024.12.004","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.12.004","url":null,"abstract":"Inflammatory choroidal neovascularization (iCNV) significantly contributes to vision impairment and ranks as the third primary cause of CNV. Arising from both infectious and noninfectious uveitis, iCNV's pathogenesis involves Bruch membrane rupture, local inflammation, and choriocapillaris ischemia. The diagnosis of iCNV is challenging due to its symptomatic overlap with other uveitis-related conditions. We emphasize the importance of advanced multimodal imaging techniques, particularly optical coherence tomography (OCT) and OCT angiography (OCTA), for early detection and differentiation of iCNV from other types of CNV. Although anti-vascular endothelial growth factor agents have shown high efficacy in treatment, the integration of these treatments with anti-inflammatory therapies remains a critical area of active research. The diversity of uveitis presentations and the rarity of iCNV have resulted in a scarcity of randomized clinical trials, leading to reliance on fragmented data from case reports and series. We consolidate the most recent studies to provide a comprehensive, updated overview of the epidemiology, risk factors, pathogenesis, imaging techniques, and treatment modalities for iCNV, aiming to support clinical decision-making. The absence of standardized guidelines highlights the need for further research to establish best practices for managing iCNV effectively.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating glaucoma in myopic eyes: Challenges and opportunities.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-12-17 DOI: 10.1016/j.survophthal.2024.12.003

Anuwat Jiravarnsirikul, Akram Belghith, Jasmin Rezapour, Christopher Bowd, Sasan Moghimi, Jost B Jonas, Mark Christopher, Massimo A Fazio, Hongli Yang, Claude F Burgoyne, Robert N Weinreb, Linda M Zangwill

{"title":"Evaluating glaucoma in myopic eyes: Challenges and opportunities.","authors":"Anuwat Jiravarnsirikul, Akram Belghith, Jasmin Rezapour, Christopher Bowd, Sasan Moghimi, Jost B Jonas, Mark Christopher, Massimo A Fazio, Hongli Yang, Claude F Burgoyne, Robert N Weinreb, Linda M Zangwill","doi":"10.1016/j.survophthal.2024.12.003","DOIUrl":"10.1016/j.survophthal.2024.12.003","url":null,"abstract":"The increasing global prevalence of myopia presents a significant public health concern, and growing evidence has demonstrated that myopia is a major risk factor for the development of open-angle glaucoma. Therefore, timely detection and management of glaucoma in myopic patients are crucial; however, identifying the structural alterations of glaucoma in the optic nerve head (ONH) and retinal tissues of myopic eyes using standard diagnostic tools such as fundus photography, optical coherence tomography (OCT), and OCT angiography (OCTA) presents challenges. Additionally, myopia-related perimetric defects can be confounded with glaucoma-related defects. We comprehensively examine the challenges encountered in evaluating glaucoma in myopic eyes through various diagnostic tools, including fundus photography, OCT of the ONH, retinal nerve fiber layer, and macular ganglion cell layer, OCTA, and perimetry. We also explore potential opportunities to address these challenges, providing insights for clinicians to effectively manage myopic glaucoma patients in clinical practice.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative complications of intrascleral intraocular lens fixation: A systematic review and meta-analysis.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-12-12 DOI: 10.1016/j.survophthal.2024.12.001

Ken Nagino, Takenori Inomata, Toshihiko Ohta, Jaemyoung Sung, Akie Midorikawa-Inomata, Atsuko Eguchi, Gaku Ishida, Keiji Inagaki, Masahiro Yamaguchi, Satoru Nakatani, Kenta Fujio, Hiroyuki Kobayashi, Shintaro Nakao

{"title":"Postoperative complications of intrascleral intraocular lens fixation: A systematic review and meta-analysis.","authors":"Ken Nagino, Takenori Inomata, Toshihiko Ohta, Jaemyoung Sung, Akie Midorikawa-Inomata, Atsuko Eguchi, Gaku Ishida, Keiji Inagaki, Masahiro Yamaguchi, Satoru Nakatani, Kenta Fujio, Hiroyuki Kobayashi, Shintaro Nakao","doi":"10.1016/j.survophthal.2024.12.001","DOIUrl":"10.1016/j.survophthal.2024.12.001","url":null,"abstract":"Our systematic review and meta-analysis elucidates the postoperative complication rates associated with 3 major surgical approaches, including the scleral tunnel, glued, and flanged techniques, for sutureless intrascleral intraocular lens (IOL) fixation. An online search was performed for articles published in PubMed and EMBASE between January 1, 1975, and January 7, 2023. Original studies reporting postoperative complications of sutureless intrascleral IOL fixation were included. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. The initial search yielded 1854 articles, from which 1797 were excluded; 57 and 51 were included in the qualitative synthesis and meta-analysis, respectively. Based on the meta-analysis, the postoperative complication rates of cystoid macular edema (5.7 %), retinal detachment (3.5 %), vitreous hemorrhage (8.8 %), and hypotony (5.5 %) were highest with the scleral tunnel technique. The glued technique had the highest complication rate for corneal edema (14.2 %). The rates of temporarily elevated intraocular pressure (9.9 %), iris capture (5.4 %), haptic exposure (6.5 %), and IOL decentration (7.3 %) were the highest with the flanged technique. The flanged technique had a significantly shorter operative time (median, 17.1 min) compared with the scleral tunnel (42.7 min) and glued (56.5 min) techniques. Postoperative best-corrected visual acuity with the flanged technique was significantly better than that with the other techniques (P = 0.017). This meta-analysis identified high postoperative complication rates related to the impact of surgical manipulations with the scleral tunnel technique and IOL placement stability with the flanged technique. These findings enable surgeons to minimize postoperative complications in high-risk patients.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pentosan polysulfate sodium maculopathy: Final analysis of a prospective cohort, updated review, and association with inflammatory bowel disease.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-12-12 DOI: 10.1016/j.survophthal.2024.12.002

Ahmad Santina, Alessandro Feo, Elodie Bousquet, Swetha B Velaga, Néda Abraham, Meira Fogel-Levin, Veronica Romero-Morales, Swathi Somisetty, Alice Wong, Anthony Lu, Muneeswar Nittala, Jay Chhablani, Shilo Voichanski, Adrian Au, SriniVas Sadda, David Sarraf

{"title":"Pentosan polysulfate sodium maculopathy: Final analysis of a prospective cohort, updated review, and association with inflammatory bowel disease.","authors":"Ahmad Santina, Alessandro Feo, Elodie Bousquet, Swetha B Velaga, Néda Abraham, Meira Fogel-Levin, Veronica Romero-Morales, Swathi Somisetty, Alice Wong, Anthony Lu, Muneeswar Nittala, Jay Chhablani, Shilo Voichanski, Adrian Au, SriniVas Sadda, David Sarraf","doi":"10.1016/j.survophthal.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.12.002","url":null,"abstract":"Pentosan polysulfate sodium (PPS) maculopathy is a recently described condition of macular toxicity. We report the prevalence (15%), the clinical characteristics, and the multimodal imaging (MMI) features of PPS maculopathy based on a final prospective analysis of a cohort of 154 subjects and highlight the association with inflammatory bowel disease (IBD). In addition, we summarize the most recent and relevant literature on PPS maculopathy. This study and other recent analyses provide solid evidence of the toxic effects of PPS on the retina and choroid and refute the concept that the maculopathy is an association of the underlying disease, interstitial cystitis. Moreover, this study and others raise a major concern that PPS may also be toxic to the bowel. Vigilant surveillance of patients receiving this potentially harmful drug is critical. We review the recommended screening guidelines, the pathophysiology and MMI spectrum of disease, the differential diagnosis including MMI clues to an accurate diagnosis, and the progression of retinopathy that can take place despite discontinuation of the drug, emphasizing the critical importance of early detection of toxicity.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal vessel analysis to assess microvascular function in the healthy eye: A systematic review on the response to acute physiological and pathological stressors. 视网膜血管分析评估健康眼睛的微血管功能：对急性生理和病理应激反应的系统综述。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-11-24 DOI: 10.1016/j.survophthal.2024.11.008

Jan Van Eijgen, Lien Van Winckel, Henner Hanssen, Konstantin Kotliar, Thomas Vanassche, Emeline M Van Craenenbroeck, Véronique Cornelissen, Amaryllis H Van Craenenbroeck, Elisabeth Jones, Ingeborg Stalmans

{"title":"Retinal vessel analysis to assess microvascular function in the healthy eye: A systematic review on the response to acute physiological and pathological stressors.","authors":"Jan Van Eijgen, Lien Van Winckel, Henner Hanssen, Konstantin Kotliar, Thomas Vanassche, Emeline M Van Craenenbroeck, Véronique Cornelissen, Amaryllis H Van Craenenbroeck, Elisabeth Jones, Ingeborg Stalmans","doi":"10.1016/j.survophthal.2024.11.008","DOIUrl":"10.1016/j.survophthal.2024.11.008","url":null,"abstract":"The retina allows noninvasive in vivo assessment of the microcirculation. Autoregulation of the retinal microvasculature meets the changing requirements of local metabolic demand and maintains adequate blood flow. Analysis of the retinal vascular reactivity contributes to the understanding of regulatory physiology and its relationship to the systemic microcirculation. We conducted a literature review on the effect of different acute stimuli onto the retinal vasculature was conducted in accordance with the PRISMA guidelines. A literature search between 1-1-2005 and 17-10-2022 was performed in Medline, Embase, Web of Science and the Cochrane Library. We report the retinal vascular behavior of healthy individuals in response to both physiological and pathological stressors in 106 included articles. We provide ables of methodological characteristics for each stressor. Hypoxia, hypercapnia, high altitude, flicker light stimulation, rise of core temperature, blood pressure lowering, and the condition immediately after endurance exercise associate with larger retinal vessels. Hyperoxia, hypocapnia, blood pressure rise (Bayliss effect), and the condition during isometric exercise associate with smaller retinal vessels. The retinal vasculature is highly reactive to physiological and pathological stressors. This autoregulatory capacity is hypothesized to be a source of biomarkers for vascular health. Dynamic and static retinal vessel analysis are noninvasive methods to assess this (micro)vascular function. Exploring its diagnostic potential and application into clinical practice requires the development of standardized assessment methods, for which some recommendations are made.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional diabetic retinopathy: A new concept to improve management of diabetic retinal diseases. 功能性糖尿病视网膜病变：改善糖尿病视网膜疾病管理的新概念。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-11-23 DOI: 10.1016/j.survophthal.2024.11.010

Bhim B Rai, Ted Maddess, Christopher J Nolan

{"title":"Functional diabetic retinopathy: A new concept to improve management of diabetic retinal diseases.","authors":"Bhim B Rai, Ted Maddess, Christopher J Nolan","doi":"10.1016/j.survophthal.2024.11.010","DOIUrl":"10.1016/j.survophthal.2024.11.010","url":null,"abstract":"Multifocal functional tests are not routinely performed in diabetic retinopathy (DR) and diabetic macular edema (DME) management. We emphasise their importance and coin the term functional diabetic retinopathy (FDR). We reviewed current guidelines on management of DR/DME, and literature on diabetic retinal neurodegeneration (DRN) and functional deficits in DR/DME. Functional visual loss due to DRN precedes vasculopathy and clinical DR; however, currently the diagnosis and management of DR/DME are based on classical signs of retinal vasculopathy and structural changes shown by funduscopy, fundus photographs, and optical coherence tomography (OCT). Furthermore, DME can mask DRN-based retinal layer thinning by OCT and is focussed on the macular region. The only functional test recommended in national and international guidelines on DR/DME is best-corrected visual acuity, a test of foveal function (<1 % of retina). Multifocal functional tests can objectively characterize both foveal and extrafoveal, localized and global, function. Current recommendations for DR/DME screening are inadequate to detect FDR affecting the greater retina. Early detection of FDR using multifocal functional tests could bring DR/DME management strategies forward enabling prevention of the later stage vision-threatening complications. After all, the end point of patient care is functional outcomes.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of artificial intelligence to inherited retinal diseases: A systematic review. 人工智能在遗传性视网膜疾病中的应用：系统综述。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-11-19 DOI: 10.1016/j.survophthal.2024.11.007

Mohamad Issa, Georges Sukkarieh, Mathias Gallardo, Ilias Sarbout, Sophie Bonnin, Ramin Tadayoni, Dan Milea

引用次数: 0

Presumed phototoxicity from macular vital staining with Brilliant Blue G and Trypan Blue: A post-market surveillance study, systematic review, and synthesis of the literature. 用亮蓝 G 和胰蓝对黄斑要害染色推测的光毒性：一项上市后监测研究、系统回顾和文献综述。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-11-19 DOI: 10.1016/j.survophthal.2024.11.006

James E Neffendorf, Timothy L Jackson

{"title":"Presumed phototoxicity from macular vital staining with Brilliant Blue G and Trypan Blue: A post-market surveillance study, systematic review, and synthesis of the literature.","authors":"James E Neffendorf, Timothy L Jackson","doi":"10.1016/j.survophthal.2024.11.006","DOIUrl":"10.1016/j.survophthal.2024.11.006","url":null,"abstract":"Vital dyes are used to help visualise the retinal surface during macular surgery; however, they have been associated with phototoxicity. We sythesize and collate post-market surveillance data considered 2 of the most commonly used dyes, Brilliant Blue G and Trypan Blue. We identified 69 cases, 59 of which were from the literature and 10 from manufacturer post-market surveillance. Of 69 vitrectomies, 39 were for macular hole, 24 for epiretinal membrane, 2 for vitreomacular traction, and 4 were not specified. The incidence of dye-mediated phototoxicity is likely rare, but is not possible to quantify, due to potential reporting and publication bias favouring dissemination of unusual safety events, but conversely underreporting is possible. Additionally, phototoxicity was reported prior to the introduction of vital stains, so it can be difficult to establish whether vital staining was contributory. Prolonged surgery and repeat staining were identified as risk factors. Characteristic clinical features were macular pigmentary change with hypo- and hyper-autofluoresence, often sparing the fovea. Final visual acuity tended to be worse than preoperatively, with some cases reduced to counting fingers. A reporting template is provided to encourage complete and standardised toxicity reporting and help build a robust evidence base.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0