Survey of ophthalmology最新文献

Unveiling the Therapeutic Potential and Mechanisms of Stanniocalcin-1 in Retinal Degeneration.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-11 DOI: 10.1016/j.survophthal.2024.08.001

Kexin Wang,Yashuang Liu,Siyu Li,Na Zhao,Fangyuan Qin,Ye Tao,Zongming Song

{"title":"Unveiling the Therapeutic Potential and Mechanisms of Stanniocalcin-1 in Retinal Degeneration.","authors":"Kexin Wang,Yashuang Liu,Siyu Li,Na Zhao,Fangyuan Qin,Ye Tao,Zongming Song","doi":"10.1016/j.survophthal.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.08.001","url":null,"abstract":"Retinal degeneration (RD) is a group of ocular diseases characterized by progressive photoreceptor apoptosis and visual impairment. Mitochondrial malfunction, excessive oxidative stress, and chronic activation of neuroglia collectively contribute to the development of RD. Currently, there is a lack of efficacious therapeutic interventions for RD. Stanniocalcin-1 (STC-1) is a promising candidate molecule to decelerate photoreceptor cell death. STC-1 is a secreted calcium/phosphorus regulatory protein that exerts diverse protective effects. Accumulating evidence suggests that STC-1 protects retinal cells from ischemic injury, oxidative stress, and excessive apoptosis through enhancing the expression of uncoupling protein-2 (UCP-2). Furthermore, STC-1 exerts its antiinflammatory effects by inhibiting the activation of microglia and macrophages, as well as the synthesis and secretion of proinflammatory cytokines, such as TNF-α, IL-1, and IL-6. By employing these mechanisms, STC-1 effectively shields the retinal photoreceptors and optic nerve, thereby slowing down the progression of RD. This review summarizes the STC-1 mediated therapeutic effects on the degenerating retina, with a particular focus on its underlying mechanisms. These findings highlight that STC-1 may act as a versatile molecule to treat degenerative retinopathy. Further research on STC-1 is imperative to establish the optimal protocols for its clinical use.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142250844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety protocols, precautions, and countermeasures aboard the International Space Station (ISS) to prevent ocular injury. 国际空间站（ISS）上防止眼部损伤的安全协议、预防措施和对策。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-03 DOI: 10.1016/j.survophthal.2024.08.005

Alex Suh, Sarah Ditelberg, Jonathan J Szeto, Divy Kumar, Joshua Ong, C Robert Gibson, Thomas H Mader, Ethan Waisberg, Andrew G Lee

{"title":"Safety protocols, precautions, and countermeasures aboard the International Space Station (ISS) to prevent ocular injury.","authors":"Alex Suh, Sarah Ditelberg, Jonathan J Szeto, Divy Kumar, Joshua Ong, C Robert Gibson, Thomas H Mader, Ethan Waisberg, Andrew G Lee","doi":"10.1016/j.survophthal.2024.08.005","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.08.005","url":null,"abstract":"The International Space Station (ISS) is a $100 billion epicenter of human activity in the vacuum of space, displaying mankind's collective endeavor to explore the cosmic frontier. Even within the marvels of technological sophistication aboard the ISS, the human eye remains a highly vulnerable structure. In the absence of multiple layers of protection and risk assessments, crewmembers would face a substantial increase in vulnerability to ocular injury. Aside from stringent preflight screening criteria for astronauts, the ISS is equipped with ophthalmic medications, environmental control and life support systems (e.g., humidity regulation, carbon dioxide removal, pressurized device regulators), and radiation protection to reduce ocular injury. Moreover, additional countermeasures are currently being developed to mitigate the effects of spaceflight-associated neuro-ocular syndrome (SANS) and lunar dust toxicity for the Artemis Program missions. The success of future endeavors hinges not only on continued technological innovation, but also respecting the intricate interplay between human physiology and the extraterrestrial environments. Establishing habitations on the Moon and Mars, as well as NASA's Gateway Program (humanity's first space station around the Moon), will introduce a new set of challenges, underscoring the necessity for continuous insights into ocular health in space. We discuss the safety protocols, precautions, and countermeasures implemented on the ISS to prevent ocular injury - an aspect often overshadowed by the grandeur of space exploration.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Looking beyond blurred margins 临床挑战：超越模糊边缘。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.03.001

{"title":"Looking beyond blurred margins","authors":"","doi":"10.1016/j.survophthal.2024.03.001","DOIUrl":"10.1016/j.survophthal.2024.03.001","url":null,"abstract":"<div>A 60-year-old man presented to an outside ophthalmology clinic with 1 month of progressive vision loss in the right eye (OD). Right optic disc edema was noted. Brain and orbit magnetic resonance imaging revealed right optic nerve and left occipital lobe enhancement. He was seen initially by neurology and neurosurgery and subsequently referred to neuro-ophthalmology for consideration of optic nerve biopsy. He was seen 3 months after his initial symptom onset where vision was light perception OD and a relative afferent pupillary defect with optic nerve edema. OS was unremarkable. A lumbar puncture with flow cytometry was negative for multiple sclerosis and lymphoma. At his oculoplastic evaluation for optic nerve biopsy, his vision was noted to be no light perception OD. Optic nerve biopsy demonstrated non-caseating granulomatous inflammation consistent with neurosarcoidosis. The patient was started on high-dose oral steroids with improvement of disc edema, as well as significant improvement in optic nerve and intracranial parenchymal enhancement, although his vision never improved.</div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625724000237/pdfft?md5=46cfb91707f9ebc8b5ffcb891783aae9&pid=1-s2.0-S0039625724000237-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140137304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A major review on punctal stenosis: Part II: Updated therapeutic interventions, complications, and outcomes 关于球囊狭窄的主要综述：第二部分：最新治疗干预、并发症和结果。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.05.007

{"title":"A major review on punctal stenosis: Part II: Updated therapeutic interventions, complications, and outcomes","authors":"","doi":"10.1016/j.survophthal.2024.05.007","DOIUrl":"10.1016/j.survophthal.2024.05.007","url":null,"abstract":"<div>We continue our review of on punctal stenosis by providing a detailed discussion of management modalities, their complications, and outcomes. There is a significant change in the understanding of punctal and peripunctal anatomy, puncto-canalicular junction, and the lacrimal pump mechanisms. While the snip punctoplasty procedures are still practiced, there is an increasing trend toward nonincisional procedures. The nonincisional procedures in select cases appear to be equally effective as the incisional ones. Although simple to use, punctal plugs never became the mainstay of treatment because of design issues and the inability to address the coexisting canalicular stenosis. Placing stents only in the lower punctum in cases of upper and lower punctal stenosis should be discouraged, and management needs to address punctal stenosis and not which punctum is involved. Several types of stents are used in the management of punctal stenosis, mostly based on surgeon’s preference. The benefits of adjuvant mitomycin C are uncertain. In view of literature on how stent biofilms can themselves cause chronic inflammation, placing them for prolonged periods should be reviewed and debated. Enhanced understanding of the molecular pathogenesis of punctal stenosis and addressing the current controversies in management would help standardize the therapeutic interventions available in the lacrimal armamentarium.</div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical coherence tomography angiography measurements in systemic lupus erythematosus: A systematic review and meta-analysis 系统性红斑狼疮的光学相干断层血管造影测量：系统回顾和荟萃分析。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.04.007

{"title":"Optical coherence tomography angiography measurements in systemic lupus erythematosus: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.survophthal.2024.04.007","DOIUrl":"10.1016/j.survophthal.2024.04.007","url":null,"abstract":"<div>Systemic lupus erythematosus (SLE) is an autoimmune disease affecting various organs. Ocular involvement, particularly retinopathy, is common, emphasizing the significance of early detection. Optical coherence tomography angiography (OCTA), a non-invasive imaging technique, reveals microvascular changes, aiding SLE diagnosis and monitoring. This study evaluates OCTA's effectiveness in detecting SLE-related retinal alterations. A systemic search was undertaken across PubMed, Embase, and Scopus databases to identify studies presenting OCTA measurements in SLE patients compared to healthy controls. The meta-analysis, employing either fixed-effects or random-effects models based on heterogeneity levels, was conducted. Additionally, subgroup and sensitivity analyses, meta-regression, and quality assessments were carried out. Thirteen studies of 565 eyes in the SLE group and 560 eyes in the control group were included. The meta-analyses revealed that SLE patients had a significantly lower retinal vessel density in the superficial and deep capillary plexus layers, choriocapillaris flow area, and foveal avascular zone (FAZ) circularity index compared to healthy controls, but that there were no significant differences in the FAZ area and perimeter. These findings highlight how OCTA can provide a noninvasive assessment of SLE effects on the retinal microvasculature, potentially presenting a reliable biomarker for more precise detection of SLE and disease activity monitoring.</div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Future directions of generative artificial intelligence in ophthalmology and vision science 生成式人工智能在眼科学和视觉科学中的未来发展方向。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.06.003

引用次数: 0

Neurotrophic keratopathy: General features and new therapies. 神经营养性角膜病：一般特征和新疗法

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.04.004

引用次数: 0

The potential impact of a vegetarian diet on glaucoma 素食对青光眼的潜在影响。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.05.001

引用次数: 0

Scoping review of nonsurgical treatment options for macular holes 黄斑孔非手术治疗方案的范围界定审查

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.04.005

{"title":"Scoping review of nonsurgical treatment options for macular holes","authors":"","doi":"10.1016/j.survophthal.2024.04.005","DOIUrl":"10.1016/j.survophthal.2024.04.005","url":null,"abstract":"<div>Macular holes (MH) are full-thickness retinal defects affecting central vision. While vitrectomy with inner limiting membrane (ILM) peel is the conventional MH treatment, non-surgical alternatives are gaining interest to mitigate surgical risks. This study conducted a comprehensive literature review and analysis of nonsurgical MH management. A systematic literature search was conducted on PubMed, Embase, Scopus, and the Cochrane Library from January 1, 1973, to September 13, 2023. Treatments included laser therapy, carbonic anhydrase inhibitors (CAIs), nonsteroidal antiinflammatory drugs (NSAIDs), steroids (topical, subtenons, peribulbar, intravitreal), intravitreal gas, anti-vascular endothelial growth factors and ocriplasmin injections. Data extraction covered study details, patient characteristics, MH features, treatment outcomes, and recurrence rates. The initial search yielded 3352 articles, refined to 83 articles that met inclusion criteria following screening. Overall reported anatomical closure rates were 36% with laser photocoagulation, 37% with intravitreal ocriplasmin, 55% with intravitreal gas. Closures were more frequently observed with topical NSAIDs (79%), steroids (84%) and CAIs (73%). Closures were more often observed in patients with smaller MH and in the presence of cystic macular oedema. Although non-surgical MH management approaches show potential for conservative therapy, evidence is limited to support routine use. Stage 1 and traumatic MH may benefit from a short period of observation, but the gold standard approach for full-thickness MH remains to be vitrectomy with ILM peel.</div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140795068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lupus review is misleading about risk of hydroxychloroquine retinal toxicity 狼疮评论在羟氯喹视网膜毒性风险方面存在误导。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.07.007

引用次数: 0