Survey of ophthalmology最新文献_第2页

Clinical implications of lowering episcleral venous pressure in the management of glaucoma and the use of Rho kinase inhibitors.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-03-17 DOI: 10.1016/j.survophthal.2025.03.003

Arthur J Sit, Makoto Aihara, Anthony P Khawaja, Shan C Lin, Kaweh Mansouri, Atsuya Miki, Ki Ho Park, Norbert Pfeiffer, Robert N Weinreb

{"title":"Clinical implications of lowering episcleral venous pressure in the management of glaucoma and the use of Rho kinase inhibitors.","authors":"Arthur J Sit, Makoto Aihara, Anthony P Khawaja, Shan C Lin, Kaweh Mansouri, Atsuya Miki, Ki Ho Park, Norbert Pfeiffer, Robert N Weinreb","doi":"10.1016/j.survophthal.2025.03.003","DOIUrl":"10.1016/j.survophthal.2025.03.003","url":null,"abstract":"There has been limited success in both measuring and modifying episcleral venous pressure (EVP) in clinical practice. Understanding the potential role of EVP in the management of glaucoma for different patients may allow for more individualized treatment approaches. To explore the clinical implications of lowering EVP, an international group of 9 glaucoma experts (the ENGAGE Global Expert Working Group) convened to bridge the gap between the current literature and evidence with clinical opinion and best practices. This review summarizes insights from the group on the effect of current medical therapies on EVP and its potential impact. It also discusses unmet investigational needs to enhance the understanding of EVP, as well as the challenges associated with the measurement and treatment of EVP. Regardless of the relatively modest EVP reductions achieved with current treatments, EVP lowering may have clinical significance in patients with glaucoma, particularly those with low intraocular pressure (IOP). Those who might benefit include patients with elevated EVP; normal-tension glaucoma; undergoing trabecular meshwork bypass surgery, goniotomy, or selective laser trabeculoplasty; or requiring additional IOP lowering to the low teens or with a lower-than-usual target IOP.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic procedures for eyelid involvement in facial nerve palsy.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-03-13 DOI: 10.1016/j.survophthal.2025.03.002

Anthony Yao, Ahsen Hussain, Ruben Kannan, Charles Nduka, Raman Malhotra

引用次数: 0

From anatomical and functional observations to molecular dynamics in internal limiting membrane peeling.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-03-13 DOI: 10.1016/j.survophthal.2025.02.008

Axel Petzold

引用次数: 0

The role of retinal pigment epithelial senescence and the potential of senotherapeutics in age-related macular degeneration.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-03-13 DOI: 10.1016/j.survophthal.2025.03.004

Yingying Chen, Feipeng Jiang, Yue Zeng, Meixia Zhang

引用次数: 0

Oral fluorescein angiography in pediatric ophthalmology.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-03-13 DOI: 10.1016/j.survophthal.2025.03.005

Ramsey Ghaleb, Ahmed B Sallam, Florin Grigorian, Paul H Phillips, Abdelrahman M Elhusseiny

{"title":"Oral fluorescein angiography in pediatric ophthalmology.","authors":"Ramsey Ghaleb, Ahmed B Sallam, Florin Grigorian, Paul H Phillips, Abdelrahman M Elhusseiny","doi":"10.1016/j.survophthal.2025.03.005","DOIUrl":"10.1016/j.survophthal.2025.03.005","url":null,"abstract":"We evaluate the administration protocols, diagnostic utility, and safety of oral fluorescein angiography (OFA) in pediatric ophthalmological diseases, with a secondary objective of comparing OFA to intravenous fluorescein angiography (IVFA) in terms of image quality and clinical utility. A comprehensive search of PubMed, Embase, and Web of Science was conducted, focusing on studies involving pediatric patients. Fifteen studies were included, with 11 assessing the utility and safety of OFA and 4 comparing it to IVFA. These studies covered 581 eyes from 464 patients. The most common dosing protocol for OFA involved 25 mg/kg of 10 % fluorescein dye, with various dilution solutions and fasting requirements enhancing image quality. Adverse effects were minimal, with mild reactions such as itching or nausea observed in 0.019 % of patients. OFA demonstrated good diagnostic value across various pathologies, including retinal vasculopathies, uveitis, disc edema, and Coats disease. OFA is a feasible imaging modality that is a less invasive and better-tolerated alternative to IVFA in the pediatric population, providing high-quality diagnostic images with fewer adverse effects. Our review highlights the need for standardized administration protocols and further research into optimizing dosing and ingestion techniques to enhance image quality and diagnostic utility.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The etiologic and pathogenic spectrum of exposure keratopathy: Diagnostic and therapeutic implications. 暴露性角膜病的病因和致病范围：诊断和治疗意义。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-03-09 DOI: 10.1016/j.survophthal.2025.03.001

Alejandro Rodriguez-Garcia, Raul E Ruiz-Lozano, Raul H Barcelo-Canton, Hector M Marines-Sanchez, J Homar Paez-Garza

{"title":"The etiologic and pathogenic spectrum of exposure keratopathy: Diagnostic and therapeutic implications.","authors":"Alejandro Rodriguez-Garcia, Raul E Ruiz-Lozano, Raul H Barcelo-Canton, Hector M Marines-Sanchez, J Homar Paez-Garza","doi":"10.1016/j.survophthal.2025.03.001","DOIUrl":"10.1016/j.survophthal.2025.03.001","url":null,"abstract":"Exposure keratopathy (EK) is an underestimated ocular surface disorder that involves multiple underlying pathophysiologic mechanisms. It results from an exposed cornea due to different causes of eyelid insufficiency or blinking dysfunction, ocular globe protrusion, a negative orbital vector, and diverse contributing factors leading to impaired ocular surface homeostasis and the potential for vision loss. EK can be congenital, acquired, or induced, and various risk factors predispose patients to corneal exposure. These causes can be grouped into those related to proptosis and eyelid malformations, malfunctioning, or acquired deformity. If detected early, EK offers a range of effective treatment options. The superficial punctate keratitis and dryness of the cornea's lower third can be successfully treated at the initial stages; however, if left untreated, EK can progress to extensive epithelial erosion, persistent epithelial defects, stromal melting, vascularization, squamous metaplasia, and opportunistic infections, leading to significant visual loss. Different and varied treatment modalities, including medical and surgical, are available for patients with EK, depending on the disease stage, the underlying mechanism, and the cause. We examine the risk factors, causes, and range of pathologies associated with EK. Exploring the mechanisms that contribute to the development of the disorder's clinical manifestations provides valuable insights that can help clinicians detect and diagnose the disease promptly and plan appropriate targeted treatments.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Letter to the Editor by Professor Axel Petzold.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-03-06 DOI: 10.1016/j.survophthal.2025.02.007

Elham Sadeghi, Jay Chhablani

引用次数: 0

Ocular manifestations secondary to cocaine abuse.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-03-05 DOI: 10.1016/j.survophthal.2025.02.004

Kaersti L Rickels, Ramsey Ghaleb, Abdelrahman M Elhusseiny, Muhammad Z Chauhan, Joseph Toma, Tony Wang, Daniel Cheng, Asim Ali, Ahmed B Sallam

引用次数: 0

Pharmacological agents for treatment of proliferative vitreoretinopathy: A systematic review and network meta-analysis.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-03-01 DOI: 10.1016/j.survophthal.2025.02.005

Sina Khosravi Mirzaei, Firouze Hatami, Sare Safi, Zahra Khorrami, Fatemeh Khosravi Shadmani, Seyed Mohamadmehdi Moshtaghion, Hamid Ahmadieh

{"title":"Pharmacological agents for treatment of proliferative vitreoretinopathy: A systematic review and network meta-analysis.","authors":"Sina Khosravi Mirzaei, Firouze Hatami, Sare Safi, Zahra Khorrami, Fatemeh Khosravi Shadmani, Seyed Mohamadmehdi Moshtaghion, Hamid Ahmadieh","doi":"10.1016/j.survophthal.2025.02.005","DOIUrl":"10.1016/j.survophthal.2025.02.005","url":null,"abstract":"We performed a comprehensive systematic review and network meta-analysis (NMA) to assess the efficacy of pharmacological agents for the treatment of proliferative vitreoretinopathy (PVR) following retinal detachment (RD) surgery. A systematic search was performed across PubMed, Scopus, Web of Science, and Embase. Randomized and non-randomized controlled trials and comparative observational studies evaluating the effect of pharmacological agents in a clinical setting were included. The primary outcome was retinal reattachment rate, and secondary outcomes were PVR recurrence, reoperation, intraocular pressure (IOP), epiretinal membrane (ERM), and macular edema. A total of 23 studies with 1749 eyes were included. Twelve different drugs or drug combinations were assessed. The NMA was performed for retinal reattachment, PVR recurrence, and reoperation rate outcomes. Among the pharmacological agents analyzed, adjunctive therapy with 13-cis-retinoic acid (13-cis-RA) demonstrated a statistically significant improvement in retinal reattachment rates (RR=1.36, 95 % CI: 1-1.84) and a reduction in reoperation rates (RR=0.23, 95 % CI: 0.07-0.69) compared to the control group, while none of the other drugs had statistically significant results. Additionally, adjunctive therapy did not yield significant improvements in IOP, ERM, or macular edema, except for a reduction in macular edema associated with dexamethasone in one study. This systematic review and NMA indicate that most pharmacological agents could not significantly improve retinal reattachment, reduce PVR recurrence, or lower reoperation rates following RD surgery. 13-cis-RA was the only drug that showed a significant impact on lowering retinal detachment and reoperation rates. Further high-quality clinical trials are warranted to confirm these findings.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing ophthalmology with large language models: Applications, challenges, and future directions.

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-03-01 DOI: 10.1016/j.survophthal.2025.02.009

Qi Zhang, Shaopan Wang, Xu Wang, Changsheng Xu, Jiajun Liang, Zuguo Liu

引用次数: 0