Survey of ophthalmology最新文献_第2页

Intraocular seeds in retinoblastoma: A review of classification, management, and outcomes. 视网膜母细胞瘤的眼内种子：分类、处理和结果综述。

IF 5.9 2区医学

Survey of ophthalmology Pub Date : 2025-08-15 DOI: 10.1016/j.survophthal.2025.08.008

Mrittika Sen, Francis L Munier, Santosh G Honavar

引用次数: 0

Macular hole after anti-Vascular Endothelial Growth factor injection: A review. 抗血管内皮生长因子注射后黄斑裂孔的研究进展。

IF 5.9 2区医学

Survey of ophthalmology Pub Date : 2025-08-14 DOI: 10.1016/j.survophthal.2025.08.009

Vivian Rajeswaren, Vichar Trivedi, Pradeepa Yoganathan

{"title":"Macular hole after anti-Vascular Endothelial Growth factor injection: A review.","authors":"Vivian Rajeswaren, Vichar Trivedi, Pradeepa Yoganathan","doi":"10.1016/j.survophthal.2025.08.009","DOIUrl":"https://doi.org/10.1016/j.survophthal.2025.08.009","url":null,"abstract":"Introduction: Anti-vascular endothelial growth factor (VEGF) injections are a crucial treatment for neovascular age-related macular degeneration (nvAMD). However, each injection carries the risk of complications, including macular hole (MH) formation. A comprehensive literature search of the PubMed, Embase, and Google Scholar databases identified studies reporting MH formation after anti-VEGF injections for nvAMD. Demographic characteristics included age, sex and affected eye. The presence of intraretinal fluid, subretinal fluid (SRF), pigment epithelial detachment (PED), posterior vitreous detachment, epiretinal membrane, vitreomacular adhesion (VMA), vitreomacular traction (VMT), and retinal pigment epithelial (RPE) tears was recorded. This review includes 15 articles, encompassing 50 eyes. Median patient age was 76.0 years, and 54% were female. Prior to MH formation, SRF and PED were present in 68% of eyes. VMA or VMT was observed in 36% of eyes and the median number of injections before MH development was 3, with a median time to diagnosis of 60 days. While anti-VEGF is an essential therapy, clinicians must be aware of the risk of MH. Predisposing factors including PEDs, VMT, and significant intra- or subretinal fluid, should be considered. Further research is needed to fully understand the mechanisms and explore preventative strategies.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The human amniotic membrane in vitreoretinal surgery: Applications, outcomes and limitations. 人羊膜在玻璃体视网膜手术中的应用、结果和局限性。

IF 5.9 2区医学

Survey of ophthalmology Pub Date : 2025-08-06 DOI: 10.1016/j.survophthal.2025.08.004

Matteo Mario Carlà, Federico Giannuzzi, Lorenzo Hu, Clara Rizzo, Emanuele Crincoli, Fiammetta Catania, Gloria Gambini, Tomaso Caporossi, Carlos Mateo, Stanislao Rizzo

{"title":"The human amniotic membrane in vitreoretinal surgery: Applications, outcomes and limitations.","authors":"Matteo Mario Carlà, Federico Giannuzzi, Lorenzo Hu, Clara Rizzo, Emanuele Crincoli, Fiammetta Catania, Gloria Gambini, Tomaso Caporossi, Carlos Mateo, Stanislao Rizzo","doi":"10.1016/j.survophthal.2025.08.004","DOIUrl":"10.1016/j.survophthal.2025.08.004","url":null,"abstract":"The human amniotic membrane (hAM) has gained recognition as a valuable biological adjunct in vitreoretinal surgery, with its applications rapidly expanding since its initial use for macular holes (MHs). We examine the development and present applications of hAM in vitreoretinal surgery, assessing its use in treating various pathological conditions such as MHs, retinal detachments (RDs) with proliferative vitreoretinopathy (PVR), high myopia-associated MHs with posterior staphyloma, optic pit maculopathy, and other vitreoretinal disorders. We evaluate the differences between cryopreserved and lyophilized hAM preparations and compares outcomes of subretinal and epiretinal placement techniques. Evidence from the literature suggests that hAM serves as an important therapeutic option for complex vitreoretinal conditions, demonstrating anatomical success rates ranging from 80 % to 95 % across various indications. The strongest evidence indicates its efficacy in refractory MHs (closure rates 85-100 %), myopic macular holes associated with posterior staphyloma (86-92 %), and complex RDs with proliferative vitreoretinopathy (76-92 %). Both cryopreserved and lyophilized preparations exhibit efficacy; however, their surgical handling characteristics and biological properties vary, which may affect outcomes in particular indications. Current evidence suggests that subretinal positioning is typically used for large, highly myopic, or refractory MHs, whereas epiretinal placement is preferred in cases of PVR and optic pit maculopathy. While the results are promising, it is essential to standardize techniques, obtain long-term follow-up data, and conduct randomized controlled trials comparing hAM to conventional approaches to establish definitive recommendations.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal degenerative diseases: Complement system-microglia crosstalk. 视网膜退行性疾病：补体系统-小胶质细胞串扰。

IF 5.9 2区医学

Survey of ophthalmology Pub Date : 2025-08-06 DOI: 10.1016/j.survophthal.2025.08.005

Jia Gao, Wei Wang, Ya Mo

{"title":"Retinal degenerative diseases: Complement system-microglia crosstalk.","authors":"Jia Gao, Wei Wang, Ya Mo","doi":"10.1016/j.survophthal.2025.08.005","DOIUrl":"10.1016/j.survophthal.2025.08.005","url":null,"abstract":"Retinal degenerative diseases (RDD) are a group of age-related blinding eye diseases characterized by progressive degeneration and functional impairment of retinal photoreceptors or ganglion cells, for which there are currently no effective treatments. The complement system is an important innate immune system in the human body, activated through 3 pathways (classical pathway, lectin pathway, and alternative pathway) to ultimately form a membrane attack complex that acts on target cells. Microglia are the innate immune cells of the retina, responsible for maintaining retinal homeostasis. Complement system activation and microglial activation have been identified in RDD. Complement activation products C3 and C5 generate anaphylatoxins C3a and C5a, whose receptors C3aR and C5aR1 can activate microglia. Activated microglia can further produce complement C1q to activate the complement system, forming a positive feedback loop that exacerbates retinal damage. In this review, we focus on the crosstalk between the complement system and microglia in age-related macular degeneration, diabetic retinopathy, glaucoma, and pathological myopia-related retinal degeneration, and summarize clinical studies targeting the complement system and microglia for the treatment of RDD.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laser-induced histopathological changes to the retina: A review. 激光诱导视网膜的组织病理学改变：综述。

IF 5.9 2区医学

Survey of ophthalmology Pub Date : 2025-08-05 DOI: 10.1016/j.survophthal.2025.08.002

Akash Gowda, John P M Wood, Glyn Chidlow, Robert J Casson

引用次数: 0

Clinical features, management, and prognosis factors of traumatic optic neuropathy. 外伤性视神经病变的临床特点、治疗及预后因素。

IF 5.9 2区医学

Survey of ophthalmology Pub Date : 2025-07-30 DOI: 10.1016/j.survophthal.2025.07.012

Meiqian He, Zuyi Yang, Zhengming Shi, Youxin Chen, Xinyu Zhao

{"title":"Clinical features, management, and prognosis factors of traumatic optic neuropathy.","authors":"Meiqian He, Zuyi Yang, Zhengming Shi, Youxin Chen, Xinyu Zhao","doi":"10.1016/j.survophthal.2025.07.012","DOIUrl":"10.1016/j.survophthal.2025.07.012","url":null,"abstract":"We provide a comprehensive clarification of the demographics, clinical features, management, prognostic factors, and complications of traumatic optic neuropathy (TON). About 6068 patients from 109 studies were included. The pooling results indicated that TON was male-dominated (84 %) with road traffic accidents as the leading cause (67 %). After trauma, 46 % of cases had no light perception (NLP), and the most frequent associated injury was craniofacial fractures (70 %). Optic canal fractures (OCF) were detected in 34 % of cases via computed tomography and in 47 % intraoperatively. The general visual improvement rate of conservative treatment, steroid pulse therapy (SPT), optic nerve decompression (OND) and intravenous erythropoietin injection were 34 %, 48 %, 56 %, and 61 %, respectively. OND and SPT showed similar efficacy in patients with both NLP (37 % vs. 28 %) and residual vision (76 % vs. 73 %), but were superior to observation only in patients with residual vision. Patients without OCF also responded similarly to OND (57 %) and SPT (62 %), whereas those with OCF showed a higher response rate to OND (53 %) compared to SPT (24 %). Early intervention (within 7 days post-trauma) improved outcomes for both OND and SPT. Complications from OND were rare. TON mainly affects males, causes severe vision impairment, and is often associated with craniofacial fractures. OND may provide greater benefit than SPT for patients with OCF, while both treatments appear similarly effective for those without OCF, regardless of baseline vision status; however, heterogeneity in the definition and diagnostic criteria of TON, as well as variability in study designs, warrants cautious interpretation of these findings.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitreoretinal interface abnormalities in age-related macular degeneration: Prevalence, pathophysiology, and reciprocal influence. 年龄相关性黄斑变性的玻璃体视网膜界面异常：患病率、病理生理学和相互影响。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2025-07-23 DOI: 10.1016/j.survophthal.2025.07.010

Matteo Mario Carlà, Francesco Mottola, Mattia Cusato, Gianmarco Oreste, Giorgia Campaniello, Carlos Mateo, Aude Couturier, Elise Philippakis, Tomaso Caporossi, Stanislao Rizzo

{"title":"Vitreoretinal interface abnormalities in age-related macular degeneration: Prevalence, pathophysiology, and reciprocal influence.","authors":"Matteo Mario Carlà, Francesco Mottola, Mattia Cusato, Gianmarco Oreste, Giorgia Campaniello, Carlos Mateo, Aude Couturier, Elise Philippakis, Tomaso Caporossi, Stanislao Rizzo","doi":"10.1016/j.survophthal.2025.07.010","DOIUrl":"https://doi.org/10.1016/j.survophthal.2025.07.010","url":null,"abstract":"Age-related macular degeneration (AMD) represents a leading cause of vision loss worldwide, while vitreoretinal interface (VRI) abnormalities constitute a dynamic boundary where posterior vitreous interacts with the retinal surface. We explore the intricate relationship between VRI abnormalities and AMD, examining prevalence, underlying pathophysiological mechanisms, and their reciprocal influence on disease development, progression, and treatment outcomes. Evidence suggests a higher prevalence of vitreomacular adhesion in exudative versus nonexudative AMD, while complete posterior vitreous detachment may exert protective effects against AMD progression. Tractional forces, inflammatory mediators, and structural disruption associated with VRI abnormalities may promote AMD progression and confound assessment of anti-vascular endothelial growth factor therapy efficacy. Recent findings underscore that epiretinal membranes might act as physical barriers reducing drug penetration, while VMT/VMA can alter macular morphology, potentially mimicking or obscuring therapeutic response. Surgical management of VRI abnormalities in AMD can achieve anatomical success, though visual outcomes may be limited by underlying macular pathology. Early detection and characterization of VRI abnormalities in AMD patients could improve risk stratification, guide treatment timing, and potentially lead to novel preventive strategies, highlighting the importance of comprehensive evaluation and individualized management approaches for optimizing outcomes in this complex patient population.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence in thyroid eye disease imaging: A systematic review. 人工智能在甲状腺眼病成像中的应用：系统综述。

IF 5.9 2区医学

Survey of ophthalmology Pub Date : 2025-07-22 DOI: 10.1016/j.survophthal.2025.07.008

Haiyang Zhang, Ziyuan Li, Hoi Chi Chan, Xuefei Song, Huifang Zhou, Xianqun Fan

{"title":"Artificial intelligence in thyroid eye disease imaging: A systematic review.","authors":"Haiyang Zhang, Ziyuan Li, Hoi Chi Chan, Xuefei Song, Huifang Zhou, Xianqun Fan","doi":"10.1016/j.survophthal.2025.07.008","DOIUrl":"10.1016/j.survophthal.2025.07.008","url":null,"abstract":"Thyroid eye disease (TED) is a common, complex orbital disorder characterized by soft-tissue changes visible on imaging. Artificial intelligence (AI) offers promises for improving TED diagnosis and treatment; however, no systematic review has yet characterized the research landscape, key challenges, and future directions. We followed PRISMA guidelines to search multiple databases until January, 2025, for studies applying AI to computed tomography (CT), magnetic resonance imaging, and nuclear, facial or retinal imaging in TED patients. Using the APPRAISE-AI tool, we assessed study quality and included 41 studies covering various AI applications. Sample sizes ranged from 33 to 2288 participants, predominantly East Asian. CT and facial imaging were the most common modalities, reported in 16 and 13 articles, respectively. Studies addressed clinical tasks-diagnosis, activity assessment, severity classification, and treatment prediction-and technical tasks-classification, segmentation, and image generation-with classification being the most frequent. Researchers primarily employed deep-learning models, such as residual network (ResNet) and Visual Geometry Group (VGG). Overall, the majority of the studies were of moderate quality. Image-based AI shows strong potential to improve diagnostic accuracy and guide personalized treatment strategies in TED. Future research should prioritize robust study designs, the creation of public datasets, multimodal imaging integration, and interdisciplinary collaboration to accelerate clinical translation.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relentless placoid chorioretinitis. 顽固性胎盘样脉络膜视网膜炎。

IF 5.9 2区医学

Survey of ophthalmology Pub Date : 2025-07-22 DOI: 10.1016/j.survophthal.2025.07.009

Claire Y Hooper, Lisia Barros Ferreira, Anagha Vaze, Daniel V Vasconcelos-Santos, Debra A Goldstein, Demi Gertig, Justine R Smith

{"title":"Relentless placoid chorioretinitis.","authors":"Claire Y Hooper, Lisia Barros Ferreira, Anagha Vaze, Daniel V Vasconcelos-Santos, Debra A Goldstein, Demi Gertig, Justine R Smith","doi":"10.1016/j.survophthal.2025.07.009","DOIUrl":"10.1016/j.survophthal.2025.07.009","url":null,"abstract":"Relentless placoid chorioretinitis (RPC) is a rare, vision-threatening posterior uveitis that predominantly affects young adults. The hallmark clinical findings are numerous scattered placoid chorioretinal lesions involving the midperipheral and far peripheral fundus as well as the posterior pole and a persistent or recurrent course resulting in lesions at different chronological stages, with fresh creamy placoid lesions and healing pigmented lesions being present at the same time. Although RPC is frequently described as a disease that is intermediate between acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and serpiginous choroiditis, it more closely resembles APMPPE. It is important to identify those patients with RPC who present with an APMPPE phenotype so that appropriate immunomodulatory therapy is instituted without delay, as most cases of RPC are refractory to corticosteroid monotherapy. Examination findings may help differentiate RPC and APMPPE. Multimodal imaging, including ultra-widefield imaging, and selective investigations aid in distinguishing RPC from other placoid diseases and types of posterior uveitis.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative ophthalmic posterior segment optical coherence tomography angiography and systemic conditions. 定量眼后段光学相干断层血管造影和全身状况。

IF 5.9 2区医学

Survey of ophthalmology Pub Date : 2025-07-21 DOI: 10.1016/j.survophthal.2025.07.005

Michael Drakopoulos, Arnold Nadel, Harnaina K Bains, Jay B Bisen, Hayden Sikora, Kevin X Zhang, Alessandro Marchese, Joseph Fahey, Rukhsana G Mirza

{"title":"Quantitative ophthalmic posterior segment optical coherence tomography angiography and systemic conditions.","authors":"Michael Drakopoulos, Arnold Nadel, Harnaina K Bains, Jay B Bisen, Hayden Sikora, Kevin X Zhang, Alessandro Marchese, Joseph Fahey, Rukhsana G Mirza","doi":"10.1016/j.survophthal.2025.07.005","DOIUrl":"10.1016/j.survophthal.2025.07.005","url":null,"abstract":"Optical coherence tomography angiography (OCTA) noninvasively and quantitatively images the microvasculature of the eye's posterior segment in 3 dimensions. OCTA has known utility in the diagnosis and management of certain ocular conditions and is now being used to assess systemic conditions, including respiratory, cardiovascular, renal, obstetric, neurologic, rheumatologic, and genetic conditions, among others. OCTA may improve our understanding of the pathophysiology of systemic conditions and identify biomarkers useful in their diagnosis, prognosis, and management. We detail known associations between quantitative retinal, optic nerve head, and choriocapillaris OCTA findings and clinically relevant features of systemic conditions, including laboratory markers and disease severity and prognosis. We find that the breadth and depth of such correlations solidify OCTA's role in the emerging field of oculomics, which seeks to identify ocular imaging biomarkers for use in the study and management of nonocular conditions.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0