Work-up in patients with retinal vasculitis: A systematic review and meta-analysis: International Uveitis Study Group (IUSG) Retinal Vasculitis Study (ReViSe) Report 2.

IF 5.9 2区 医学 Q1 OPHTHALMOLOGY
Carlos Cifuentes-González, Ikhwanuliman Putera, Cheong Fu Yuan Walter, Germán Mejía-Salgado, Yong Le Tong, Reo Chan, William Rojas-Carabali, Xin Ying Rachel Song, Azadeh Mobasserian, Rina La Distia Nora, Jyotirmay Biswas, Sapna Gangaputra, Jose S Pulido, John H Kempen, Quan Dong Nguyen, Alejandra de-la-Torre, Vishali Gupta, James T Rosenbaum, Rupesh Agrawal
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引用次数: 0

Abstract

This systematic review and meta-analysis investigate global diagnostic approaches for retinal vasculitis (RV), with a focus on infectious and non-infectious causes. As in our prior report, systematic searches were conducted in 5 databases and registered in PROSPERO (CRD42023489232). Studies included articles on at least 10 patients with RV without publication date or language restrictions. RV was categorized as secondary RV if they were associated with systemic disease, syndromic if they were associated with a syndromic ocular disease without systemic disease, idiopathic RV without association to systemic or syndromic ocular diseases. This report includes 84 studies analyzing 3480 patients with RV. Among infectious causes, tuberculosis tests were frequently reported, with TST/IGRA positivity observed in 31.4 % (95 % CI: 17.2-50.2 %) of de novo RV cases, increasing to 64.7 % (95 % CI: 47.8-78.9 %) in confirmed tubercular RV and 65.7 % (95 % CI: 39.0-85.1 %) in Eales disease. Chest radiograph abnormalities were present in 21.8 % (95 % CI: 12.9-33.8 %) of tubercular RV cases. Non-infectious causes showed notable regional variability. HLA-B51 positivity was 1 % (95 % CI: 0.03-3.1 %) in de novo RV, but rose to 61.4 % (95 % CI: 23.1-89.4 %) in Behçet's RV. Sarcoidosis RV revealed noncaseating granulomas in 80.5 % (95 % CI: 9.7-99.4 %), with angiotensin-converting enzyme elevation in 4.6 % (95 % CI: 2.3-9.1 %). This study highlights significant geographic variability in RV etiologies. Tuberculosis remains a key infectious cause, while non-infectious causes vary regionally. Region-specific diagnostics and Bayesian testing protocols are critical to improving diagnostic accuracy and patient outcomes.

视网膜血管炎患者的随访:一项系统回顾和荟萃分析:国际葡萄膜炎研究组(IUSG)视网膜血管炎研究(修订)报告2。
本系统综述和荟萃分析调查了视网膜血管炎(RV)的全球诊断方法,重点是感染性和非感染性原因。与我们之前的报告一样,系统搜索在五个数据库中进行,并在PROSPERO (CRD42023489232)中注册。研究纳入了至少10例RV患者的文章,没有发表日期或语言限制。如果与全身性疾病相关,则将RV归类为继发性RV,如果与综合征性眼部疾病相关,则将其归类为综合征性RV,无全身性疾病的累及性RV,与全身性或综合征性眼部疾病无关的特发性RV。这包括84项研究,分析了3480例RV患者。在感染原因中,经常报告结核试验,在新发RV病例中31.4% (95% CI: 17.2-50.2%)观察到TST/IGRA阳性,在确诊的结核性RV中增加到64.7% (95% CI: 47.8-78.9%),在Eales病中增加到65.7% (95% CI: 39.0-85.1%)。21.8% (95% CI: 12.9-33.8%)的结核性RV病例出现胸片异常。非传染性原因表现出显著的区域差异。HLA-B51阳性在新生RV中为1% (95% CI: 0.03-3.1%),但在behet RV中上升至61.4% (95% CI: 23.1-89.4%)。结节病RV显示非干酪化肉芽肿的发生率为80.5% (95% CI: 9.7-99.4%), ACE升高的发生率为4.6% (95% CI: 2.3-9.1%)。这项研究强调了RV病因的显著地理差异。结核病仍然是一个主要的传染原因,而非传染原因因区域而异。区域特异性诊断和贝叶斯检测方案对于提高诊断准确性和患者预后至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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